Crosstalk between metabolism and circadian clocks
Abstract
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest (sleep) phases that differ largely in their metabolic requirements. The circadian clock evolved as an autonomous timekeeping system that aligns behavioural patterns with the solar day and supports the body functions by anticipating and coordinating the required metabolic programmes. The key component of this synchronization is a master clock in the brain, which responds to light-darkness cues from the environment. However, to achieve circadian control of the entire organism, each cell of the body is equipped with its own circadian oscillator that is controlled by the master clock and confers rhythmicity to individual cells and organs through the control of rate-limiting steps of metabolic programmes. Importantly, metabolic regulation is not a mere output function of the circadian system, but nutrient, energy and redox levels signal back to cellular clocks in order to reinforce circadian rhythmicity and to adapt physiology to temporal tissue-specific needs. Thus, multiple systemic and molecular mechanisms exist that connect the circadian clock with metabolism at all levels, from cellular organelles to the whole organism, and deregulation of this circadian-metabolic crosstalk can lead to various pathologies.
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Disturbed rest-activity rhythms lead to desynchronization of internal molecular clocks, thereby disturbing circadian biochemical processes, secretion of hormones, metabolic functions, and physiological parameters.
“Existing evidence shows that disturbed rest-activity rhythms, as, for example, in shift workers, lead to desynchronization of internal molecular clocks, thereby disturbing circadian biochemical processes, secretion of hormones, metabolic functions, and physiological parameters [66-68].”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [68]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637 · see citing works
Mitochondria: In Sickness and in Health
Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,637 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
Regulation of cellular metabolism by protein lysine acetylation
Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science · doi:10.1126/science.1179689 · Cited by 1,910 · see citing works
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800 · see citing works
Glucose feeds the TCA cycle via circulating lactate
Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., et al. (2017) · Nature · doi:10.1038/nature24057 · Cited by 1,721 · see citing works
The two‐process model of sleep regulation: a reappraisal
Borbély, A. A., Daan, S., Wirz‐Justice, A., & Deboer, T. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12371 · Cited by 1,577 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
Dodd, A. N., Salathia, N. S., Hall, A. J. W., Kevei, É., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,489 · see citing works
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
Hart, G. W., Housley, M. P., & Slawson, C. (2007) · Nature · doi:10.1038/nature05815 · Cited by 1,418 · see citing works
Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.038 · Cited by 1,407 · see citing works
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works
Self-citationStaphylococcus aureus and food poisoning.
Loir, Y. L., Baron, F., & Gautier, M. (2003) · PubMed · Cited by 1,304 · see citing works
Mitochondrial Dynamics and Metabolic Regulation
Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,304 · see citing works
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works
Circadian Control of the NAD <sup>+</sup> Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD <sup>+</sup> Biosynthesis
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works
Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., & Li, X. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.006 · Cited by 1,112 · see citing works
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works
Physiological significance of a peripheral tissue circadian clock
Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome
Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.008 · Cited by 926 · see citing works
Peroxiredoxins are conserved markers of circadian rhythms
Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works
Leone, V., Gibbons, S. M., Martinez, K., Hutchison, A. L., Huang, E. Y., Cham, C. M., Pierre, J. F., Heneghan, A. F., Nadimpalli, A., Hubert, N., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.006 · Cited by 908 · see citing works
Gill, S., & Panda, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.005 · Cited by 894 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
Thaiss, C. A., Levy, M., Korem, T., Dohnalová, L., Shapiro, H., Jaitin, D. A., David, E., Winter, D. R., Gury-BenAri, M., Tatirovsky, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.003 · Cited by 870 · see citing works
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome
Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell · doi:10.1016/j.cell.2012.02.032 · Cited by 858 · see citing works
Night-Shift Work and Risk of Colorectal Cancer in the Nurses' Health Study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I. I., Fuchs, C. S., & Colditz, G. A. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.11.825 · Cited by 837 · see citing works
Circadian clocks in human red blood cells
O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 830 · see citing works
Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women
Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805 · see citing works
Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
Resonating circadian clocks enhance fitness in cyanobacteria
Ouyang, Y., Andersson, C. R., Kondo, T., Golden, S. S., & Johnson, C. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8660 · Cited by 772 · see citing works
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765 · see citing works
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 731 · see citing works
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
Zhang, C., Hawley, S. A., Zong, Y., Li, M., Wang, Z., Gray, A., Ma, T., Cui, J., Feng, J.-W., Zhu, M., et al. (2017) · Nature · doi:10.1038/nature23275 · Cited by 716 · see citing works
Reprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 711 · see citing works
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707 · see citing works
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
Etchegaray, J.-P., Lee, C., Wade, P. A., & Reppert, S. M. (2003) · Nature · doi:10.1038/nature01314 · Cited by 679 · see citing works
Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 611 · see citing works
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works
Making heads or tails of phospholipids in mitochondria
Osman, C., Voelker, D. R., & Langer, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201006159 · Cited by 580 · see citing works
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works
Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S. A., Ravnskjær, K., Schenk, S., Milne, J. C., Meyers, D. J., Cole, P., Yates, J. R., et al. (2008) · Nature · doi:10.1038/nature07349 · Cited by 556 · see citing works
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524 · see citing works
PER3 polymorphism predicts sleep structure and waking performance
Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520 · see citing works
Circadian rhythms persist without transcription in a eukaryote
O'Neill, J. S., Gerben Van Ooijen, A., Dixon, L. E., Troein, C., Corellou, F., Bouget, F., Reddy, A. B., & Millar, A. J. (2011) · Nature · doi:10.1038/nature09654 · Cited by 514 · see citing works
Hogenesch, J. B., Chan, W. K., Jackiw, V., Brown, R. C., Gu, Y.-Z., Pray-Grant, M. G., Perdew, G. H., & Bradfield, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8581 · Cited by 514 · see citing works
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507 · see citing works
PER2 controls lipid metabolism by direct regulation of PPARγ
Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., & Sassone-Corsi, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.10.005 · Cited by 489 · see citing works
Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
Balsalobre, A., Marcacci, L., & Schibler, U. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00758-2 · Cited by 485 · see citing works
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Cui, H., López, M., & Rahmouni, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.222 · Cited by 482 · see citing works
Rey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., & Naef, F. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000595 · Cited by 473 · see citing works
Self-citationCircadian Organization of Behavior and Physiology in Drosophila
Allada, R., & Chung, B. Y. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135815 · Cited by 456 · see citing works
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock
Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I. P., Gudiksen, A., Solagna, F., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.005 · Cited by 454 · see citing works
Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y., et al. (2013) · Nature Medicine · doi:10.1038/nm.3213 · Cited by 454 · see citing works
Circadian Disruption Leads to Insulin Resistance and Obesity
Shi, S.-Q., Ansari, T. S., McGuinness, O. P., Wasserman, D. H., & Johnson, C. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.048 · Cited by 452 · see citing works
REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 448 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works
Integrating circadian dynamics with physiological processes in plants
Greenham, K. M., & Mcclung, C. (2015) · Nature reviews genetics · doi:10.1038/nrg3976 · Cited by 437 · see citing works
NPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432 · see citing works
A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Zhang, E. E., Liu, A. C., Hirota, T., Miraglia, L. J., Welch, G. L., Pongsawakul, P. Y., Liu, X., Atwood, A., Huss, J. W., Janes, J. O., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.031 · Cited by 432 · see citing works
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909733106 · Cited by 431 · see citing works
Social jetlag, obesity and metabolic disorder: investigation in a cohort study
Parsons, M. J., Moffitt, T. E., Gregory, A. M., Goldman-Mellor, S., Nolan, P. M., Poulton, R., & Caspi, A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.201 · Cited by 426 · see citing works
Peek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M., Ramsey, K. M., & Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.010 · Cited by 415 · see citing works
Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness
Jacobi, D., Liu, S., Burkewitz, K., Kory, N., Knudsen, N. H., Alexander, R., Ünlütürk, U., Li, X., Kong, X., Hyde, A. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.006 · Cited by 411 · see citing works
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410 · see citing works
Self-citationRotating shift work and the metabolic syndrome: a prospective study
De Bacquer, D., Van Risseghem, M., Clays, E., Kittel, F., De Backer, G., & Braeckman, L. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn360 · Cited by 394 · see citing works
Andrews, J. L., Zhang, X., McCarthy, J. J., McDearmon, E. L., Hornberger, T. A., Russell, B., Campbell, K. S., Arbogast, S., Reid, M. B., Walker, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014523107 · Cited by 389 · see citing works
Robles, M. S., Cox, J., & Mann, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004047 · Cited by 383 · see citing works
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder
Patke, A., Murphy, P. J., Onat, O. E., Krieger, A. C., Özçelik, T., Campbell, S. S., & Young, M. W. (2017) · Cell · doi:10.1016/j.cell.2017.03.027 · Cited by 381 · see citing works
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 377 · see citing works
The Adaptive Value of Circadian Clocks
Woelfle, M. A., Ouyang, Y., Phanvijhitsiri, K., & Johnson, C. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.023 · Cited by 375 · see citing works
SCHMID, S. M., HALLSCHMID, M., JAUCH‐CHARA, K., BORN, J., & SCHULTES, B. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00662.x · Cited by 370 · see citing works
Coordination of the transcriptome and metabolome by the circadian clock
Eckel‐Mahan, K. L., Patel, V. R., Mohney, R. P., Vignola, K. S., Baldi, P., & Sassone‐Corsi, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118726109 · Cited by 370 · see citing works
Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes & Development · doi:10.1101/gad.564110 · Cited by 361 · see citing works
Timed high-fat diet resets circadian metabolism and prevents obesity
Sherman, H., Genzer, Y., Cohen, R., Chapnik, N., Madar, Z., & Froy, O. (2012) · The FASEB Journal · doi:10.1096/fj.12-208868 · Cited by 360 · see citing works
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works
Self-citationCircadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics
Schmitt, K., Grimm, A., Dallmann, R., Oettinghaus, B., Restelli, L. M., Witzig, M., Ishihara, N., Mihara, K., Ripperger, J. A., Albrecht, U., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.011 · Cited by 336 · see citing works
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks
Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 335 · see citing works
Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329 · see citing works
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Zhang, Y., Fang, B., Emmett, M. J., Damle, M., Sun, Z., Feng, D., Armour, S. M., Remsberg, J. R., Jager, J., Soccio, R. E., et al. (2015) · Science · doi:10.1126/science.aab3021 · Cited by 321 · see citing works
Circadian Clock Control of Liver Metabolic Functions
Reinke, H., & Asher, G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.11.043 · Cited by 321 · see citing works
Self-citationJung, C. M., Melanson, E. L., Frydendall, E. J., Perreault, L., Eckel, R. H., & Wright, K. P. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197517 · Cited by 318 · see citing works
Hirota, T., Okano, T., Kokame, K., Shirotani-Ikejima, H., Miyata, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206233200 · Cited by 317 · see citing works
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters
Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317 · see citing works
The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels
Kalsbeek, A., Fliers, E., Romijn, J. A., la Fleur, S. E., Wortel, J., Bakker, O., Endert, E., & Buijs, R. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8197 · Cited by 305 · see citing works
Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications
Chung, S., Son, G. H., & Kim, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.003 · Cited by 305 · see citing works
X-Ray Structure of the hRORα LBD at 1.63 Å
Kallen, J. A., Schlaeppi, J.-M., Bitsch, F., Geisse, S., Geiser, M., Delhon, I., & Fournier, B. (2002) · Structure · doi:10.1016/s0969-2126(02)00912-7 · Cited by 299 · see citing works
Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.050 · Cited by 292 · see citing works
Schmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291 · see citing works
Gut clock: implication of circadian rhythms in the gastrointestinal tract.
Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2011) · PubMed · Cited by 286 · see citing works
Wu, Y., Tang, D., Liu, N., Xiong, W., Huang, H., Li, Y., Ma, Z., Zhao, H., Chen, P., Qi, X., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.009 · Cited by 285 · see citing works
Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α
Adamovich, Y., Ladeuix, B., Golik, M., Koeners, M. P., & Asher, G. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.014 · Cited by 283 · see citing works
Self-citationDaily magnesium fluxes regulate cellular timekeeping and energy balance
Feeney, K. A., Hansen, L. L., Putker, M., Olivares-Yáñez, C., Day, J., Eades, L. J., Larrondo, L. F., Hoyle, N. P., O'Neill, J. S., & Gerben Van Ooijen, A. (2016) · Nature · doi:10.1038/nature17407 · Cited by 277 · see citing works
Daily Rhythm in Human Urinary Melatonin
Lynch, H. J., Wurtman, R. J., Moskowitz, M. A., Archer, M. C., & Ho, M. H. (1975) · Science · doi:10.1126/science.1167425 · Cited by 263 · see citing works
Neufeld-Cohen, A., Robles, M. S., Aviram, R., Manella, G., Adamovich, Y., Ladeuix, B., Nir, D., Rousso-Noori, L., Kuperman, Y., Golik, M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519650113 · Cited by 262 · see citing works
Self-citationSleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men
Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier‐Ewert, H. K., Dinges, D. F., & Mantzoros, C. S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01069.x · Cited by 261 · see citing works
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260 · see citing works
Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock
Kaasik, K., Kivimäe, S., Allen, J. J., Chalkley, R. J., Huang, Y., Baer, K., Kissel, H., Burlingame, A. L., Shokat, K. M., Ptáček, L. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.017 · Cited by 260 · see citing works
Atger, F., Gobet, C., Marquis, J., Martín, E., Wang, J., Weger, B. D., Lefebvre, G. C., Descombes, P., Naef, F., & Gachon, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515308112 · Cited by 252 · see citing works
Acosta-Rodríguez, V. A., de Groot, M. H. M., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.007 · Cited by 252 · see citing works
Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244 · see citing works
Food-anticipatory circadian rhythms: concepts and methods
Mistlberger, R. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06965.x · Cited by 224 · see citing works
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li, M., Ruan, H., Hughes, M. E., Lee, J.-S., Singh, J. P., Jones, S. P., Nitabach, M. N., & Yang, X. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.015 · Cited by 215 · see citing works
Mendoza, J., Graff, C., Dardente, H., Pévet, P., & Challet, É. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4397-04.2005 · Cited by 211 · see citing works
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
Krishnaiah, S., Wu, G., Altman, B. J., Growe, J., Rhoades, S. D., Coldren, F., Venkataraman, A., Olarerin-George, A. O., Francey, L. J., Mukherjee, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.019 · Cited by 207 · see citing works
Wang, Y., Kumar, N., Solt, L. A., Richardson, T. I., Helvering, L. M., Crumbley, C., Garcia-Ordoñez, R. D., Stayrook, K. R., Zhang, X., Novick, S. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080614 · Cited by 202 · see citing works
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet
Tognini, P., Murakami, M., Liu, Y., Eckel‐Mahan, K. L., Newman, J. C., Verdin, E. M., Baldi, P., & Sassone‐Corsi, P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.015 · Cited by 202 · see citing works
The emerging roles of melanopsin in behavioral adaptation to light
Hatori, M., & Panda, S. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.07.005 · Cited by 199 · see citing works
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
Lucassen, E. A., Rother, K. I., & Cizza, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06655.x · Cited by 191 · see citing works
A Cryptochrome 2 mutation yields advanced sleep phase in humans
Hirano, A., Shi, G., Jones, C. R., Lipzen, A., Pennacchio, L. A., Xu, Y., Hallows, W. C., McMahon, T., Yamazaki, M., Ptáček, L. J., et al. (2016) · eLife · doi:10.7554/elife.16695 · Cited by 172 · see citing works
The Pentose Phosphate Pathway Regulates the Circadian Clock
Rey, G., Valekunja, U. K., Feeney, K. A., Wulund, L., Milev, N. B., Stangherlin, A., Ansel-Bollepalli, L., Velagapudi, V., O'Neill, J. S., & Reddy, A. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.024 · Cited by 165 · see citing works
Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity
Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
Zwighaft, Z., Aviram, R., Shalev, M., Rousso-Noori, L., Kraut‐Cohen, J., Golik, M., Brandis, A. S., Reinke, H., Aharoni, A., Kahana, C., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.011 · Cited by 159 · see citing works
Self-citationThe Circadian System: A Regulatory Feedback Network of Periphery and Brain
Buijs, F. N., Mercado, L. L., Guzmán‐Ruiz, M. A., Guerrero‐Vargas, N. N., Romo‐Nava, F., & Buijs, R. M. (2016) · Physiology · doi:10.1152/physiol.00037.2015 · Cited by 158 · see citing works
Doi, R., Oishi, K., & Ishida, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110361 · Cited by 157 · see citing works
Murakami, M., Tognini, P., Liu, Y., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2016) · EMBO Reports · doi:10.15252/embr.201642463 · Cited by 155 · see citing works
Dyar, K. A., Hubert, M. J., Mir, A. A., Ciciliot, S., Lutter, D., Greulich, F., Quagliarini, F., Kleinert, M., Fischer, K., Eichmann, T. O., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005886 · Cited by 154 · see citing works
Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems
Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 153 · see citing works
V. An Oscillator Model for Biological Clocks
Pittendrigh, C. S., & Bruce, V. G. (1958) · Princeton University Press eBooks · doi:10.1515/9781400876167-006 · Cited by 151 · see citing works
CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
Zhou, B. Z., Zhang, Y., Zhang, F., Xia, Y., Liu, J., Huang, R., Wang, Y., Hu, Y., Wu, J., Dai, C., et al. (2014) · Hepatology · doi:10.1002/hep.26992 · Cited by 150 · see citing works
Circadian acetylome reveals regulation of mitochondrial metabolic pathways
Masri, S., Patel, V. R., Eckel‐Mahan, K. L., Peleg, S., Forné, I., Ladurner, A. G., Baldi, P., Imhof, A., & Sassone‐Corsi, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217632110 · Cited by 149 · see citing works
Nuclear Receptor Rev-Erbα: A Heme Receptor that Coordinates Circadian Rhythm and Metabolism
Yin, L., Wu, N., & Lazar, M. A. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08001 · Cited by 143 · see citing works
Aviram, R., Manella, G., Kopelman, N. M., Neufeld-Cohen, A., Zwighaft, Z., Elimelech, M., Adamovich, Y., Golik, M., Wang, C., Han, X., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.002 · Cited by 143 · see citing works
Self-citationDemonstration of a dawn phenomenon in normal human volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diabetes.33.12.1150 · Cited by 142 · see citing works
Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
Dang, F., Sun, X., Ma, X., Wu, R., Zhang, D., Chen, Y., Xu, Q., Wu, Y., & Liu, Y. (2016) · Nature Communications · doi:10.1038/ncomms12696 · Cited by 139 · see citing works
Zhao, H., Sifakis, E. G., Sumida, N., Millán-Ariño, L., Scholz, B. A., Svensson, J. P., Chen, X., Ronnegren, A. L., de Lima, C. D. M., Varnoosfaderani, F. S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.019 · Cited by 138 · see citing works
Demonstration of a Dawn Phenomenon in Normal Human Volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P. J., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diab.33.12.1150 · Cited by 129 · see citing works
Circadian Aspects of Postprandial Metabolism
Morgan, L., Hampton, S. M., Gibbs, M. A., & Arendt, J. (2003) · Chronobiology International · doi:10.1081/cbi-120024218 · Cited by 129 · see citing works
A role for clock genes in sleep homeostasis
Franken, P. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.002 · Cited by 125 · see citing works
The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice
Kohsaka, A., Das, P., Hashimoto, I., Nakao, T., Deguchi, Y., Gouraud, S. S., Waki, H., Muragaki, Y., & Maeda, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112811 · Cited by 120 · see citing works
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
Aguilar-Arnal, L., Katada, S., Orozco-Solis, R., & Sassone-Corsi, P. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2990 · Cited by 117 · see citing works
Breathing around the clock: an overview of the circadian pattern of respiration
Mortola, J. P. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0978-0 · Cited by 117 · see citing works
The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure
Orozco-Solís, R., Aguilar‐Arnal, L., Murakami, M., Peruquetti, R. L., Ramadori, G., Coppari, R., & Sassone‐Corsi, P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.003 · Cited by 116 · see citing works
Shift working and risk of lipid disorders: A cross-sectional study
Ghiasvand, M., Heshmat, R., Golpira, R., Haghpanah, V., Soleimani, A., Shoushtarizadeh, P., Tavangar, S. M., & Larijani, B. A. (2006) · Lipids in Health and Disease · doi:10.1186/1476-511x-5-9 · Cited by 113 · see citing works
Circadian Oscillation of Sulfiredoxin in the Mitochondria
Kil, I. S., Ryu, K. W., Lee, S. K., Kim, J. Y., Chu, S. Y., Kim, J. H., Park, S., & Rhee, S. G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.031 · Cited by 105 · see citing works
Perrin, L., Loizides‐Mangold, U., Skarupelova, S., Pulimeno, P., Chanon, S., Robert, M., Bouzakri, K., Modoux, C., Roux‐Lombard, P., Vidal, H., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.009 · Cited by 105 · see citing works
Petrenko, V., Saini, C., Giovannoni, L., Gobet, C., Sage, D., Unser, M., Heddad-Masson, M., Gu, G., Bosco, D., Gachon, F., et al. (2017) · Genes & Development · doi:10.1101/gad.290379.116 · Cited by 105 · see citing works
Kriebs, A., Jordan, S. D., Soto, E., Henriksson, E., Sandate, C. R., Vaughan, M. E., Chan, A. B., Duglan, D., Papp, S. J., Huber, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704955114 · Cited by 105 · see citing works
Loizides‐Mangold, U., Perrin, L., Vandereycken, B., Betts, J. A., Walhin, J., Templeman, I., Chanon, S., Weger, B. D., Durand, C., Robert, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705821114 · Cited by 104 · see citing works
Waldstreicher, J., Duffy, J. F., Brown, E. N., Rogacz, S., Allan, J. S., & Czeisler, C. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636355 · Cited by 100 · see citing works
Circadian Periodicity of Blood Amino-acids in Adult Men
Feigin, R. D., Klainer, A. S., & Beisel, W. R. (1967) · Nature · doi:10.1038/215512b0 · Cited by 99 · see citing works
Zizi, F., Jean‐Louis, G., Brown, C. D., Ogedegbe, G. G., Boutin‐Foster, C., & McFarlane, S. I. (2010) · Current Diabetes Reports · doi:10.1007/s11892-009-0082-x · Cited by 99 · see citing works
The Circadian Clock in the Regulation of Renal Rhythms
Solocinski, K., & Gumz, M. L. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415610879 · Cited by 94 · see citing works
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome
Mauvoisin, D., Atger, F., Dayon, L., Galindo, A. N., Wang, J., Martín, E., Silva, L. D., Montoliu, I., Collino, S., Martin, F., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.065 · Cited by 91 · see citing works
Role of SCN in Daily Rhythms of Plasma Glucose, FFA, Insulin and Glucagon
Yamamoto, H., Nagai, K., & Nakagawa, H. (1987) · Chronobiology International · doi:10.3109/07420528709078539 · Cited by 90 · see citing works
FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice
Hirano, A., Braas, D., Fu, Y., & Ptáček, L. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.041 · Cited by 88 · see citing works
Carbon monoxide protects the kidney through the central circadian clock and CD39
Corrêa-Costa, M., Gallo, D. J., Csizmadia, E., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716747115 · Cited by 84 · see citing works
Philippé, J., & Dibner, C. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414557634 · Cited by 82 · see citing works
Circadian rhythmic variations in serum concentrations of clinically important lipids
Rivera-Coll, A., Fuentes‐Arderiu, X., & Dı́ez-Noguera, A. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.8.1549 · Cited by 79 · see citing works
Circadian rhythm of blood pressure and the renin-angiotensin system in the kidney
Ohashi, N., Isobe, S., Ishigaki, S., & Yasuda, H. (2017) · Hypertension Research · doi:10.1038/hr.2016.166 · Cited by 78 · see citing works
Rhythmic potassium transport regulates the circadian clock in human red blood cells
Henslee, E. A., Crosby, P., Kitcatt, S. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02161-4 · Cited by 78 · see citing works
Disruption of Daily Rhythms by High-Fat Diet Is Reversible
Branecky, K. L., Niswender, K. D., & Pendergast, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137970 · Cited by 77 · see citing works
The Mammalian Circadian Clock Gene Per2 Modulates Cell Death in Response to Oxidative Stress
Magnone, M. C., Langmesser, S., Bezdek, A. C., Tallone, T., Rusconi, S., & Albrecht, U. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2014.00289 · Cited by 73 · see citing works
Sahar, S., Masubuchi, S., Eckel‐Mahan, K. L., Vollmer, S., Galla, L., Ceglia, N., Masri, S., Barth, T. K., Grimaldi, B., Oluyemi, O. I., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537191 · Cited by 72 · see citing works
Abbondante, S., Eckel‐Mahan, K. L., Ceglia, N., Baldi, P., & Sassone‐Corsi, P. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681130 · Cited by 69 · see citing works
Oike, H., Nagai, K., Fukushima, T., Ishida, N., & Kobori, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023709 · Cited by 67 · see citing works
Mammalian clock output mechanisms
Kalsbeek, A., Yi, C., Cailotto, C., et al. (2011) · Essays in Biochemistry · doi:10.1042/bse0490137 · Cited by 67 · see citing works
Benavides, A., Siches, M., & Llobera, M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.3.r811 · Cited by 67 · see citing works
Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats
Eggink, H. M., Oosterman, J. E., de Goede, P., de Vries, E. M., Foppen, E., Koehorst, M., Groen, A. K., Boelen, A., Romijn, J. A., la Fleur, S. E., et al. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1363226 · Cited by 65 · see citing works
Nuclear‐cytoplasmic localization of acetyl coenzyme a synthetase‐1 in the rat brain
Ariyannur, P. S., Moffett, J. R., Madhavarao, C. N., Arun, P., Vishnu, N., Jacobowitz, D. M., Hallows, W. C., Denu, J. M., & Namboodiri, A. M. A. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22373 · Cited by 63 · see citing works
Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos
Cela, O., Scrima, R., Pazienza, V., Merla, G., Benegiamo, G., Augello, B., Fugetto, S., Menga, M., Rubino, R., Fuhr, L., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.018 · Cited by 60 · see citing works
Laermans, J., Vancleef, L., Tack, J. F., & Depoortere, I. (2015) · Scientific Reports · doi:10.1038/srep16748 · Cited by 60 · see citing works
Reciprocal regulation of carbon monoxide metabolism and the circadian clock
Klemz, R., Reischl, S., Wallach, T. E., Witte, N., Jürchott, K., Klemz, S., Lang, V., Lorenzen, S., Knauer, M., Heidenreich, S., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3331 · Cited by 59 · see citing works
Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale
Wang, G.-Z., Hickey, S. L., Shi, L., Huang, H.-C., Nakashe, P., Koike, N., Tu, B. P., Takahashi, J. S., & Konopka, G. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.043 · Cited by 58 · see citing works
Skeletal muscle functions around the clock
Mayeuf-Louchart, A., Staels, B., & Duez, H. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12517 · Cited by 57 · see citing works
Crosstalk of clock gene expression and autophagy in aging
Kalfalah, F. M., Janke, L., Schiavi, A., Tigges, J., Ix, A., Ventura, N., Boege, F., & Reinke, H. (2016) · Aging · doi:10.18632/aging.101018 · Cited by 56 · see citing works
Self-citationYao, Z., DuBois, D. C., Almon, R. R., & Jusko, W. J. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-9608-3 · Cited by 53 · see citing works
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335 · see citing works
Making sense of the ageing methylome
Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00477-6 · Cited by 274 · see citing works
Rykov, Y., Thach, T.-Q., Bojic, I., Christopoulos, G., & Car, J. (2021) · JMIR mHealth and uHealth · doi:10.2196/24872 · Cited by 151 · see citing works
Activity Tracker–Based Metrics as Digital Markers of Cardiometabolic Health: Cross-Sectional Study
Rykov, Y., Thach, T.-Q., Dunleavy, G., Roberts, A. C., Christopoulos, G., Soh, C. K., & Car, J. (2020) · JMIR mHealth and uHealth · doi:10.2196/16409 · Cited by 29 · see citing works
- Authors
- Reinke, H., & Asher, G.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Weizmann Institute of Science (IL)
- Corresponding author
- Reinke, Hans
- Asher, Gad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2019-01-11
- Volume
- 20
- Issue
- 4
- Pages
- 227-241
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2910084517
- Cited by
- 598
- References
- 213
- Citations by year
- 2026: 60 · 2025: 86 · 2024: 81 · 2023: 81 · 2022: 100 · 2021: 85 · 2020: 66 · 2019: 38
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- circadian clock, metabolism, circadian rhythm, circadian pacemaker, light-dark cycle, sleep-wake cycle, redox signaling, nutrient signaling
- MeSH terms
- Animals, Brain, Circadian Rhythm, Humans, Mammals, Circadian Clocks
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