Cited by 114Stress Responses and CortisolTryptophan and brain disordersHealth disparities and outcomes

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity

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Chiang, Jessica J., Eisenberger, Naomi I., Seeman, Teresa E., Taylor, Shelley E.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1120972109PMC PMC3277534

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Abstract

Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.

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Authors: Chiang, J. J., Eisenberger, N. I., Seeman, T. E., & Taylor, S. E.
Affiliations: University of California, Los Angeles (US)
Department of Psychology, and
ORCID: Chiang, Jessica J.
Eisenberger, Naomi I.
Seeman, Teresa E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-01-23
Volume: 109
Issue: 6
Pages: 1878-1882
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1120972109
PMC: PMC3277534
OpenAlex: W2115552364
Cited by: 114
References: 71
Citations by year: 2026: 4 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 15 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 6 · 2012: 3
FWCI: 4.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 030309, R01AG030309)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Health › Health disparities and outcomes
Keywords: social interaction, negative social interactions, inflammatory cytokines, interleukin-6, soluble TNF receptor 2, systemic inflammation, social stress
MeSH terms: Adult, Competitive Behavior, Female, Humans, Interpersonal Relations, Male, Stress, Psychological, Cytokines, Inflammation Mediators, Racial Groups

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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity

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