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Negative and competitive social interactions are related to heightened proinflammatory cytokine activity
Open accessAbstract
Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.
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“negative social interactions involving friends, peers, teachers, or family members in daily life are associated with elevations in several markers of inflammatory activity, including CRP, IL-6, and a soluble receptor for TNFα”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Chiang, Eisenberger, Seeman, & Taylor, 2012
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Metadata
- Authors
- Chiang, J. J., Eisenberger, N. I., Seeman, T. E., & Taylor, S. E.
- Affiliations
- University of California, Los Angeles (US)
- Department of Psychology, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-01-23
- Volume
- 109
- Issue
- 6
- Pages
- 1878-1882
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3277534
- OpenAlex
- W2115552364
- Cited by
- 114
- References
- 71
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 15 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 6 · 2012: 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 030309, R01AG030309)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- social interaction, negative social interactions, inflammatory cytokines, interleukin-6, soluble TNF receptor 2, systemic inflammation, social stress
- MeSH terms
- Adult, Competitive Behavior, Female, Humans, Interpersonal Relations, Male, Stress, Psychological, Cytokines, Inflammation Mediators, Racial Groups
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