Negative social interactions and risk of mild cognitive impairment in old age
Open accessAbstract
OBJECTIVE: To test the hypothesis that negative social interaction is associated with increased risk of mild cognitive impairment and rate of cognitive decline. METHODS: Participants were 529 older people without cognitive impairment at study onset. They completed annual evaluations that included assessment of negative social interactions (e.g., unsympathetic behavior, rejection), cognitive testing, and clinical classification of mild cognitive impairment. RESULTS: During a mean of 4.8 years of follow-up (SD = 2.5), 198 individuals (37.4%) developed mild cognitive impairment. In a proportional hazards model, higher baseline frequency of negative social interactions (M = 1.51, SD = 0.43, skewness = 1.60) was associated with higher risk of developing mild cognitive impairment (hazard ratio = 1.53, 95% confidence interval: 1.13, 2.07). Results were similar after adjustment for depressive symptoms, social network size, social activity, and loneliness. This association was mainly due to neglect and rejection. There was no change in negative social interaction rate over time (estimate = -0.003, SE = 0.004, p = .508). Higher baseline level of negative social interaction was associated with lower initial level of global cognition (estimate = -0.096, SE = 0.034, p = .005) but not with cognitive decline (estimate = -0.018, SE = 0.011, p = .098). A higher mean level of negative interactions across the study period was robustly related to faster cognitive decline (estimate = -0.036, SE = 0.012, p = .002). CONCLUSION: Frequent negative social interactions may be a risk factor for mild cognitive impairment and cognitive decline in old age.
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The authors were unable to retrieve necessary information from one study with insufficient data (Wilson et al., 2015) despite contacting the authors.
“we were not able to retrieve the necessary information from one study with insufficient data (Wilson et al., 2015), despite having contacted the authors.”
From Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies (2019) · cites this paper as Wilson et al., 2015
A meta-analysis for MCI could not be conducted because only two longitudinal studies existed and one did not provide effect sizes.
“We were unable to conduct meta-analyses with MCI as the outcome since there were only two longitudinal studies of which one did not provide effect sizes (Lobo et al., 2008;Wilson et al., 2015), but limited evidence suggests a potential effect of loneliness on MCI.”
From Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies (2019) · cites this paper as Wilson et al., 2015
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- Authors
- Wilson, R. S., Boyle, P. A., James, B. D., Leurgans, S. E., Buchman, A. S., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Neuropsychology
- Published
- 2015-07
- Volume
- 29
- Issue
- 4
- Pages
- 561-570
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- PMC
- PMC4468039
- OpenAlex
- W2321649157
- Cited by
- 87
- References
- 53
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 11 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01AG17917, R01AG15819, R01AG33678, R01AG34374)
- Illinois Department of Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- negative social interactions, mild cognitive impairment, cognitive decline, older adults, social neglect, social rejection, loneliness, social networks, depressive symptoms, social activity
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cognition, Depression, Empathy, Female, Humans, Interpersonal Relations, Life Change Events, Loneliness, Longitudinal Studies, Male, Neuropsychological Tests, Mental Recall, Rejection, Psychology, Risk, Stress, Psychological, Cohort Studies, Cognitive Dysfunction
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