Daily Interpersonal Stress, Sleep Duration, and Gene Regulation during Late Adolescence
Open accessAbstract
Background Psychological stress and poor sleep are associated with a wide range of negative health outcomes, which are thought to be mediated in part by alterations in immune processes. However, the molecular bases of links among stress, sleep, and immune processes are not completely understood, particularly during adolescence when sensitivity to stress and problems with sleep tend to increase. In the current study, we investigated whether various stressors (daily stress, major life events, perceived stress), sleep indices (duration, efficiency), and their interactions (e.g., moderating effects) are associated with expression of genes bearing response elements for transcription factors that regulate inflammatory and anti-viral processes.Method Eighty-seven late adolescents completed daily checklists of their social experiences across a 15-day period and reported on their major life events during the previous year. They also completed actigraphy-based assessments of sleep quality and duration during 8 consecutive nights. An average of 5.5 months later, participants reported on their global perceptions of stress during the previous month and provided blood samples for genome-wide expression profiling of mRNA from peripheral blood mononuclear cells (PBMCs).Results Higher levels of daily interpersonal stress and shorter sleep duration were associated with upregulation of inflammation-related genes bearing response elements for proinflammatory transcription factor nuclear factor kappa B (NF-κB). Shorter sleep duration was also linked to downregulation of antiviral-related genes bearing response elements for interferon response factors (IRFs). Lastly, there was a significant interaction between daily stress and shorter sleep duration, such that the association between daily stress and inflammation-related gene expression was exacerbated in the context of shorter sleep duration. Results were independent of sex, ethnicity, parent education, body mass index, and smoking and alcohol history.Conclusion Everyday interpersonal stress and shortened sleep can be consequential for upstream NF-κB signaling pathways relevant to inflammatory processes during late adolescence. Notably, the occurrence of both may lead to even greater activation of NF-κB signaling.
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The combination of interpersonal stress and inadequate sleep significantly enhances NF-κB activation.
“The combination of these stressors significantly enhances NF-κB activation [110].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [110]
Interpersonal stress and inadequate sleep can activate NF-κB signaling pathways, leading to increased inflammation, especially during late adolescence.
“Interpersonal stress and inadequate sleep can also activate NF-κB signaling pathways, leading to increased inflammation, especially during late adolescence.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [110]
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Sleep duration and depression among adolescents: Mediation effect of collective integration
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Daily Stressors, Emotion Dynamics, and Inflammation in the MIDUS Cohort
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Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study
Apsley, A. T., Lee, S. A., Bhat, A. C., Rush, J., Almeida, D. M., Cole, S. W., & Shalev, I. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.025 · Cited by 9 · see citing works
Stres Akademik dan Perceived Social Support sebagai Prediktor Kesehatan Mental Remaja Akhir
Salsabila, D. F., Hidayat, I. N., & Ramdani, Z. (2022) · Gadjah Mada Journal of Professional Psychology (GamaJPP) · doi:10.22146/gamajpp.76711 · Cited by 9 · see citing works
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Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants
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Research Between Sleep Quality and Interpersonal Sensitivity of Chinese College StudentsPreprint
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Estructura interna e invarianza de medición del Children’s Hassles Scale en adolescentes
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Lifestyles and their association with stress and sleep during the COVID-19 lockdown in students
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Peer victimization, pro-inflammatory, and antiviral gene expression pathways in adolescents
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- Authors
- Chiang, J. J., Cole, S. W., Bower, J. E., Irwin, M. R., Taylor, S. E., Arevalo, J., & Fuligni, A. J.
- Affiliations
- Northwestern University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Chiang, Jessica J.
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 103
- Pages
- 147-155
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC8447850
- OpenAlex
- W2907096392
- Cited by
- 44
- References
- 81
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 1
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California Institute for Mexico and the United States
- National Heart, Lung, and Blood Institute (F32-HL134276)
- American Psychological Association
- National Institute on Drug Abuse (R01-DA032922)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24-HD041022, P30-AG028748, U24AG047867, P30-AG017265, R01-HD062547)
- Biotechnology and Biological Sciences Research Council (ES/M00919X/1)
- National Institute on Aging (R01-AG051944, R01-AG052655, R01-AG056424)
- Universiteit Stellenbosch
- University of California, Los Angeles
- National Cancer Institute (R01-CA160245, R01-CA207130, R01-CA203930)
- Economic and Social Research Council
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- interpersonal stress, sleep duration, late adolescence, gene expression, NF-κB signaling, inflammation, antiviral genes, major life events, perceived stress, sleep efficiency, peripheral blood mononuclear cells, immune response
- MeSH terms
- Adolescent, Female, Gene Expression Regulation, Humans, Inflammation, Sleep Initiation and Maintenance Disorders, Leukocytes, Leukocytes, Mononuclear, Male, Sleep, Stress, Psychological, Body Mass Index, NF-kappa B, Interferon Regulatory Factors, Genome-Wide Association Study, Young Adult, Actigraphy, Self Report
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