Stress, psychological resources, and HPA and inflammatory reactivity during late adolescence
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Psychosocial stress during childhood and adolescence is associated with alterations in the hypothalamic-pituitary-adrenal (HPA) axis and with heightened inflammation, both of which are implicated in poor health; however, factors that may protect against these effects relatively early in life are not well understood. Thus, we examined whether psychosocial resources protect against stress-related alterations in the HPA axis and heightened inflammation in a sample of 91 late adolescents. Participants completed measures of various stressors (major life events, daily interpersonal stress, early adversity), and psychosocial resources (mastery, optimism, self-esteem, and positive reappraisal). They also completed the Trier Social Stress Test and provided saliva and blood samples for the assessment of cortisol and interleukin-6 reactivity. Each of the stressors was associated with lower cortisol reactivity. Additionally, associations with major life events and daily stress were moderated by psychological resources, such that more life events and daily stress were associated with decreased HPA reactivity among adolescents with lower levels of psychological resources, but not among those with higher levels of psychological resources. This pattern of findings was observed only for cortisol reactivity and not for interleukin-6 reactivity. Findings suggest that psychological resources may counteract the effects of certain adversity-related decreases in cortisol reactivity.
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Other studies report no reliable link between self-esteem and systemic inflammation or only a significant correlation under certain contexts.
“However, other studies also report no reliable link between self-esteem and systemic inflammation (Chiang et al., 2019; Kim and Thomas, 2019) or only a significant correlation under certain contexts (Elliot and Chapman, 2016).”
From Social media use and systemic inflammation: The moderating role of self-esteem (2021) · cites this paper as Chiang et al., 2019
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“However, other studies also report no reliable link between self-esteem and systemic inflammation (Chiang et al., 2019; Kim and Thomas, 2019) or only a significant correlation under certain contexts (Elliot and Chapman, 2016).”
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- Authors
- Chiang, J. J., Ko, A., Bower, J. E., Taylor, S. E., Irwin, M. R., & Fuligni, A. J.
- Affiliations
- Northwestern University (US)
- Los Angeles County Department of Mental Health (US)
- University of California, Los Angeles (US)
- Corresponding author
- Chiang, Jessica J.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-08-06
- Volume
- 31
- Issue
- 02
- Pages
- 699-712
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC6363904
- OpenAlex
- W2887255759
- Cited by
- 44
- References
- 111
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Psychological Association
- National Institute on Aging (P30AG028748)
- National Heart, Lung, and Blood Institute (F32HL134276)
- National Institute of Child Health and Human Development (R01-HD062547)
- California Center for Population Research, University of California, Los Angeles (R24‐HD041022)
- Norman Cousins Center for Psychoneuroimmunology
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30-AG028748, R24HD041022, R01HD062547)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- psychosocial stress, hypothalamic-pituitary-adrenal axis, cortisol response, interleukin-6, inflammation, psychological resources, mastery, optimism, self-esteem, positive reappraisal, major life events, childhood adversity, late adolescence, Trier Social Stress Test, moderation
- MeSH terms
- Adolescent, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Inflammation, Male, Pituitary-Adrenal System, Saliva, Stress, Psychological, Interleukin-6, Young Adult
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