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Cited by 39Tryptophan and brain disordersSuicide and Self-Harm StudiesDeath Anxiety and Social Exclusion

Association between baseline pro-inflammatory cytokines and brain activation during social exclusion in patients with vulnerability to suicide and depressive disorder

Conejero, I, Jaussent, I., Cazals, A., Thouvenot, E., Mura, T., Le Bars, E., Guillaume, S., Squalli, S. +2 more·2019·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2018.09.041
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Abstract

Background Neuroimaging studies suggest that social distress and suicidal vulnerability share common cerebral bases. Moreover, increased peripheral inflammatory activity is involved in both social distress and suicidal behavior.Objective To evaluate, in suicidal and non-suicidal individuals, the association between the activation of specific cerebral regions (anterior cingulate, insula and orbitofrontal cortex) during experimental social exclusion and the baseline blood levels of the pro-inflammatory cytokines interleukin-6 (IL-6), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) and of the anti-inflammatory cytokine interleukin-2 (IL-2).Methods In total, 101 euthymic women were recruited: 42 suicide attempters (SA), 40 affective controls (AC), and 19 healthy controls (HC). During functional MRI (fMRI), they performed the Cyberball game, a validated social exclusion task. Blood levels of IL-1β, IL-6, TNF-α and IL-2 were measured prior to fMRI. The activation of insula, orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) during the explicit social exclusion (ESE) vs social inclusion (INC) conditions of the Cyberball game was analyzed in function of the baseline cytokine levels.Results IL-1β was negatively associated with right OFC activation (p = 0.01) in ESE vs. INC, whereas IL-2 was positively associated with activation of the right ACC (p = 0.02), insula (p = 0.002) and OFC (p = 0.004) in ESE vs. INC. These associations remained significant after controlling for group, indicating that they were independent of the suicidal status.Conclusion Baseline IL-1β and IL-2 blood levels are differentially associated with cerebral activation involved in the perception of social exclusion, independently of suicidal behavior. Our results may help to better understand the role of basal inflammation in social distress and its link with mood disorder pathophysiology.

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  • IL-1β negatively correlates, whereas IL-2 positively correlates, with OFC activation during experimental social exclusion.

    “IL-1β negatively correlates, whereas IL-2 positively correlates, with OFC activation during experimental social exclusion (204), a known trigger of suicidal ideation and behavior.”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [204]

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Authors
Conejero, I., Jaussent, I., Cazals, A., Thouvenot, E., Mura, T., Le Bars, E., Guillaume, S., Squalli, S., Courtet, P., & Olié, E.
Affiliations
  • Inserm (FR)
  • Université de Montpellier (FR)
Corresponding author
Conejero, I
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2019-01
Volume
99
Pages
236-242
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2018.09.041
OpenAlex
W2895151537
Cited by
39
References
51
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 3
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
National Agency for Research ANR MNPS 2009 “VASCO” and Institut Servier
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
Keywords
social exclusion, depressive disorders, inflammatory cytokines, IL-1β, interleukin-2, interleukin-6, TNF-α, brain activation, orbitofrontal cortex, anterior cingulate cortex, insula, Cyberball game, social distress, suicide attempters
MeSH terms
Adult, Cerebral Cortex, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Inflammation, Interleukin-2, Magnetic Resonance Imaging, Middle Aged, Social Behavior, Psychological Distance, Suicide, Suicide, Attempted, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Prefrontal Cortex, Interleukin-1beta, Suicidal Ideation

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