Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
Open accessAbstract
BACKGROUND: Relations among psychological stress, depression, social support, and interleukin‐6 (IL‐6, a proinflammatory cytokine) have been documented in humans and animals. Because elevated IL‐6 is associated with a poorer prognosis among ovarian cancer patients and has been implicated in the metastasis of ovarian cancer, the current study examined relations between psychosocial factors and IL‐6 among women with advanced‐stage ovarian cancer. METHODS: Sixty‐one ovarian cancer patients completed assessments of social support, distressed mood, and quality of life before surgery. Peripheral blood was drawn preoperatively, and the plasma was assayed for IL‐6. Ascites samples were also assayed for IL‐6 for a subset of patients. RESULTS: Both IL‐6 levels and distressed mood were elevated among patients. After statistically adjusting effects of age and disease stage, social attachment was associated with lower levels of IL‐6 in peripheral blood (P = 0.03), whereas poorer health‐related quality of life was associated with higher IL‐6 (P values ranged from 0.01 to 0.03 on different measures). This pattern of relations was also found in the ascites. Moreover, IL‐6 levels in peripheral blood plasma correlated significantly with IL‐6 in the ascites (P < 0.001), suggesting that peripheral IL‐6 reflects IL‐6 levels at the site of the tumor. CONCLUSIONS: Results suggest that social support may play a protective role with respect to IL‐6 elevations, and IL‐6 may be an independent marker of health‐related quality of life among ovarian cancer patients. Processes involving IL‐6 represent possible pathways by which behavioral factors may contribute to disease outcomes among women with ovarian cancer. Cancer 2005. © 2005 American Cancer Society.
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In ovarian cancer patients, more frequent use of instrumental support and greater perceptions of closeness and intimacy in personal relationships were associated with lower plasma IL-6.
“In ovarian cancer patients, the more frequent use of instrumental support and greater perceptions of closeness and intimacy in personal relationships were associated with lower plasma IL-6.”
From Close relationships, inflammation, and health (2010) · cites this paper as Costanzo et al., 2005
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- Authors
- Costanzo, E. S., Lutgendorf, S. K., Sood, A. K., Anderson, B., Sorosky, J., & Lubaroff, D. M.
- Affiliations
- University of Iowa (US)
- The University of Texas MD Anderson Cancer Center (US)
- Hartford Hospital (US)
- Corresponding author
- Lutgendorf, Susan K.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2005-06-13
- Volume
- 104
- Issue
- 2
- Pages
- 305-313
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2076308201
- Cited by
- 217
- References
- 57
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- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (T32AG000214, T32AG00214)
- National Cancer Institute (R21CA088293, R01CA1045-25, 1R21CA88293)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- interleukin-6, advanced ovarian cancer, psychosocial factors, social support, social attachment, health-related quality of life, depression, psychological stress, ascites, inflammatory cytokines, tumor microenvironment
- MeSH terms
- Ascitic Fluid, Depression, Female, Humans, Middle Aged, Ovarian Neoplasms, Psychology, Quality of Life, Social Support, Stress, Physiological, Interleukin-6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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