Cited by 195Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesNeuroscience and Neuropharmacology Research

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Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss

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Wang, Lei, Chiang, Hsueh-Cheng, Wu, Wenjuan, Liang, Bin, Xie, Zuolei, Yao, Xinsheng, Ma, Weiwei, Du, Shuwen, Zhong, Yi·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1208011109PMC PMC3478595

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Abstract

Current understanding of amyloid-β (Aβ) metabolism and toxicity provides an extensive list of potential targets for developing drugs for treating Alzheimer’s disease. We took two independent approaches, including synaptic-plasticity–based analysis and behavioral screening of synthetic compounds, for identifying single compounds that are capable of rescuing the Aβ-induced memory loss in both transgenic fruit fly and transgenic mouse models. Two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Aβ oligomers-induced activation of the epidermal growth factor receptor (EGFR). Such surprising converging outcomes from two parallel approaches lead us to conclude that EGFR is a preferred target for treating Aβ-induced memory loss.

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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
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Epidermal growth factor receptor mutations in lung cancer
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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
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Authors: Wang, L., Chiang, H.-C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S., & Zhong, Y.
Affiliations: Tsinghua University (CN)
Cold Spring Harbor Laboratory (US)
Tsinghua Shenzhen International Graduate School (CN)
Hainan Normal University (CN)
JoeKai Biotech, LLC, Beijing 100084, China; and
Division of Life Science and Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;
ORCID: Wang, Lei
Chiang, Hsueh-Cheng
Wu, Wenjuan
Ma, Weiwei
Zhong, Yi
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-09-27
Volume: 109
Issue: 41
Pages: 16743-16748
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1208011109
PMC: PMC3478595
OpenAlex: W2091619946
Cited by: 190
References: 45
Citations by year: 2026: 9 · 2025: 16 · 2024: 21 · 2023: 25 · 2022: 14 · 2021: 18 · 2020: 13 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 6 · 2012: 2
FWCI: 7.07
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: epidermal growth factor receptor, amyloid-beta, Alzheimer's disease, memory loss, amyloid-beta oligomers, synaptic plasticity, behavioral screening, synthetic compounds, drug repurposing, transgenic mouse model
MeSH terms: Erlotinib Hydrochloride, Gefitinib, Animals, Chlorocebus aethiops, Drosophila, Drug Evaluation, Preclinical, Humans, Memantine, Memory, Memory Disorders, Mice, Transgenic, Peptide Fragments, Quinazolines, Blotting, Western, Molecular Structure, Amyloid beta-Peptides, Maze Learning, COS Cells, Drosophila Proteins, Animals, Genetically Modified, Protein Kinase Inhibitors, Mice, ErbB Receptors

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Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss

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