Cited by 325Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology Research

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Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

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Schaeffer, Marie, Langlet, Fanny, Lafont, Chrystel, Molino, François, Hodson, David J., Roux, Thomas, Lamarque, Laurent, Verdié, Pascal, Bourrier, Emmanuel, Dehouck, Bénédicte, Banères, Jean-Louis, Martinez, Jean, Méry, Pierre-François, Marie, Jacky, Trinquet, Eric, Fehrentz, Jean-Alain, Prévot, Vincent, Mollard, Patrice·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1212137110PMC PMC3557016

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Abstract

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.

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Authors: Schaeffer, M., Langlet, F., Lafont, C., Molino, F., Hodson, D. J., Roux, T., Lamarque, L., Verdié, P., Bourrier, E., Dehouck, B., Banères, J.-L., Martinez, J., Méry, P.-F., Marie, J., Trinquet, E., Fehrentz, J.-A., Prévot, V., & Mollard, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Cisbio (France) (FR)
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5247, Institut des Biomolécules Max Mousseron, Faculty of Pharmacy, Universities of Montpellier 1 and 2, F-34093 Montpellier Cedex 5, France; and
ORCID: Schaeffer, Marie
Langlet, Fanny
Molino, François
Hodson, David J.
Roux, Thomas
Lamarque, Laurent
Verdié, Pascal
Bourrier, Emmanuel
Banères, Jean-Louis
Méry, Pierre-François
Trinquet, Eric
Fehrentz, Jean-Alain
Prévot, Vincent
Mollard, Patrice
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-01-07
Volume: 110
Issue: 4
Pages: 1512-1517
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1212137110
PMC: PMC3557016
OpenAlex: W2152571442
Semantic Scholar: 95d156475087f3165a661ace77280d02caabbebe
Cited by: 325
References: 46
Citations by year: 2026: 13 · 2025: 22 · 2024: 25 · 2023: 17 · 2022: 28 · 2021: 25 · 2020: 28 · 2019: 19 · 2018: 26 · 2017: 28 · 2016: 25 · 2015: 28 · 2014: 26 · 2013: 14
FWCI: 16.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ghrelin, hypothalamus, arcuate nucleus, blood-brain barrier, fenestrated capillaries, feeding behavior, energy homeostasis, neuropeptide binding
MeSH terms: Animals, Appetite Regulation, Blood-Brain Barrier, Capillary Permeability, Eating, Fasting, Hypothalamus, Male, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neurons, Microscopy, Fluorescence, Multiphoton, Mice, Ghrelin

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Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

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