Cited by 325Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

Open access

Schaeffer, Marie, Langlet, Fanny, Lafont, Chrystel, Molino, François, Hodson, David J., Roux, Thomas, Lamarque, Laurent, Verdié, Pascal, Bourrier, Emmanuel, Dehouck, Bénédicte, Banères, Jean-Louis, Martinez, Jean, Méry, Pierre-François, Marie, Jacky, Trinquet, Eric, Fehrentz, Jean-Alain, Prévot, Vincent, Mollard, Patrice·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1212137110PMC PMC3557016

Open this paper in CoChat — free account

Abstract

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1212137110

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034827 · Cited by 691

Show all 46 references

Sorted by citations

Items 201–300 of 324

Vascular and perivascular cell profiling reveals the molecular and cellular bases of blood-brain barrier heterogeneityPreprint
Pfau, S. J., Langen, U. H., Fisher, T. M., Prakash, I., Nagpurwala, F., Lozoya, R. A., Lee, W.-C. A., Wu, Z., & Gu, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.26.441465 · Cited by 13
The role of ghrelin/GHS-R1A signaling in nonalcohol drug addictions
Sustkova-Fiserova, M., Charalambous, C., Khryakova, A., Certilina, A., Lapka, M., & Šlamberová, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020761 · Cited by 12
Control of tuberal hypothalamic development and its implications in metabolic disorders
Placzek, M., Chinnaiya, K., Kim, D. W., & Blackshaw, S. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01036-1 · Cited by 12
Ghrelin system and GLP-1 as potential treatment targets for alcohol use disorder
Jerlhag, E. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.07.006 · Cited by 12
Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI
Tyagi, A., Wu, S.-Y., Kim, J.-W., Deshpande, R. P., Wu, K., Smith, E. C., Banna, G. L., & Watabe, K. (2025) · Nature Communications · doi:10.1038/s41467-025-60730-4 · Cited by 11
Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors
Piper, N. B. C., Whitfield, E. A., Stewart, G. D., Xu, X., & Furness, S. G. B. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115115 · Cited by 11
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
Nagi, K., & Habib, A. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109976 · Cited by 11
To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?
Tolle, V., du Montcel, C. T., Mattioni, J., Schéle, E., Viltart, O., & Dickson, S. L. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104045 · Cited by 11
Negative Feedback Loops and Hormonal Factors that Regulate GH Secretion
de Sousa, L. M. M., Vicente, V. V. D. A., & Donato, J. (2025) · Endocrinology · doi:10.1210/endocr/bqaf139 · Cited by 12
Effects of intracerebroventricular infusions of ghrelin on secretion of follicle-stimulating hormone in peripubertal female sheep
Wójcik-Gładysz, A., Wańkowska, M., Gajewska, A., Misztal, T., Zielińska-Górska, M. K., Szlis, M., & Polkowska, J. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16028 · Cited by 10
Impact of [d-Lys3]-GHRP-6 and feeding status on hypothalamic ghrelin-induced stress activation
Brockway, E. T., Krater, K. R., Selva, J. A., Wauson, S. E. R., & Currie, P. J. (2016) · Peptides · doi:10.1016/j.peptides.2016.03.013 · Cited by 10
Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice
Pierre, A., Schuerbeek, A. V., Allaoui, W., Laere, S. V., Singewald, N., Eeckhaut, A. V., Smolders, I. J., & Bundel, D. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14996 · Cited by 10
Chronic Social Defeat Stress Increases Brain Permeability to Ghrelin in Male Mice
Smith, A., MacAulay, B., Scheufen, J., Hudak, A., & Abizaid, A. B. (2024) · eNeuro · doi:10.1523/eneuro.0093-24.2024 · Cited by 10
The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis
Le, N., Sayers, S., Mata‐Pacheco, V., & Wagner, E. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.877647 · Cited by 10
The roles of anti-Müllerian hormone in breast cancer
Chen, X., Liu, S., Peng, X., & Zong, X. (2023) · Endocrine Related Cancer · doi:10.1530/erc-23-0060 · Cited by 10
Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update
Vargas, Y., Tron, A. E. C., Charli, J., Rodríguez-Rodríguez, A., Uribe, R. M., & Joseph‐Bravo, P. (2024) · Metabolites · doi:10.3390/metabo14060302 · Cited by 10
Roles of Ghrelin and Leptin in Body Mass Regulation under Food Restriction Based on the AMPK Pathway in the Red-Backed Vole, Eothenomys miletus, from Kunming and Dali Regions
Liu, Y., Jia, T., Ren, Y., Wang, Z., & Zhu, W. (2022) · Animals · doi:10.3390/ani12233333 · Cited by 9
Intracerebroventricular injection of ghrelin decreases wheel running activity in rats
Miyatake, Y., Shiuchi, T., Mawatari, K., Toda, S., Taniguchi, Y., Futami, A., Sato, F., Kuroda, M., Sebe, M., Tsutsumi, R., et al. (2016) · Peptides · doi:10.1016/j.peptides.2016.11.005 · Cited by 8
Regulation of Body Weight and Metabolism by Tanycyte-Derived Neurogenesis in Young Adult Mice
Blackshaw, S., Lee, D. A., Pak, T. K., & Yoo, S. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-41603-8_5 · Cited by 8
Nutritionally induced tanycytic plasticity in the hypothalamus of adult ewes
Prezotto, L. D., Thorson, J. F., Prévot, V., Redmer, D. A., & Grazul‐Bilska, A. T. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106438 · Cited by 8
Ghrelin hormone a new molecular modulator between obesity and glomerular damage
Ibrahim, M., Khalife, L., Abdellatif, R., & Faour, W. H. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08866-8 · Cited by 8
Experimental biology can inform our understanding of food insecurity
Wilbrecht, L., Lin, W. C., Callahan, K., Melissa Bateson, B., Myers, K. P., & Ross, R. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246215 · Cited by 7
Programming the Brain from the Womb: Maternal Obesity Perturbs the Hypothalamic Blood-Brain Barrier
Duquenne, M., Dehouck, B., & Prévot, V. (2016) · Endocrinology · doi:10.1210/en.2016-1262 · Cited by 8
Hormones and Neuropeptide Receptor Heteromers in the Ventral Tegmental Area. Targets for the Treatment of Loss of Control of Food Intake and Substance Use Disorders
Ferré, S. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0109-x · Cited by 7
Novel insights into the spatial and temporal complexity of hypothalamic organization through precision methods allowing nanoscale resolution
Alpár, A., & Harkany, T. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12815 · Cited by 8
Obesity induced by Borna disease virus in rats: key roles of hypothalamic fast-acting neurotransmitters and inflammatory infiltrates
Gosztonyi, G., Ludwig, H., Bode, L., Kao, M., Sell, M., Petrusz, P., & Halász, B. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02063-0 · Cited by 7
Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction
Aguggia, J. P., Fernández, G., Cassano, D., Mustafá, E. R., Rodríguez, S., Cantel, S., Fehrentz, J., Raingo, J., Schiöth, H. B., Habib, A. M., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae160 · Cited by 6
Pancreatic amylin dynamically reconfigures distributed brain networks governing appetite regulation in mice
Gezginer, I., Mazzini, G., Foll, C. L., Kindler, D., Lutz, T. A., & Razansky, D. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102313 · Cited by 7
The Pattern of GH Action in the Mouse Brain
Menezes, F., Wasinski, F., de Souza, G. O., Nunes, A. P., Bernardes, E. S., dos Santos, S. N., da Silva, F. F. A., Peroni, C. N., Oliveira, J. E., Kopchick, J. J., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae057 · Cited by 6
Constitutive accessibility of circulating proteins to hippocampal neurons in physiologically normal rats
Hamasaki, S., Mukuda, T., Koyama, Y., Nakane, H., & Kaidoh, T. (2020) · Brain and Behavior · doi:10.1002/brb3.1544 · Cited by 5
Therapeutic potential of GHSR-1A antagonism in alcohol dependence, a review
Gupta, S., Mukhopadhyay, S., & Mitra, A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120316 · Cited by 6
Metabolic Stress Impairs Pericyte Response to Optogenetic Stimulation in Pancreatic Islets
Michau, A., Lafont, C., Bargi‐Souza, P., Kemkem, Y., Guillou, A., Ravier, M. A., Bertrand, G., Varrault, A., Fiordelisio, T., Hodson, D. J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.918733 · Cited by 7
The Melanocortin Signal System of the Hypothalamus and Its Functional State in Type 2 Diabetes Mellitus and Metabolic Syndrome
Shpakov, A. O., & Derkach, K. V. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0426-y · Cited by 6
Functional expression of P2 purinoceptors in a primary neuroglial cell culture of the rat arcuate nucleus
Pollatzek, E., Hitzel, N., Ott, D., Raisl, K., Reuter, B., & Gerstberger, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.009 · Cited by 6
Neuropeptide oxytocin facilitates its own brain-to-periphery uptake
Rajamannar, P., Blechman, J., Raz, O., & Levkowitz, G. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115491 · Cited by 5
Glycemic control: Tanycytes march to the beat of the suprachiasmatic drummer
Imbernón, M., Dehouck, B., & Prévot, V. (2022) · Current Biology · doi:10.1016/j.cub.2022.01.038 · Cited by 5
Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity
Dali, R., & Langlet, F. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114917 · Cited by 5
Omental transplantation for neuroendocrinological disorders.
Rafael, H. (2015) · PubMed · Cited by 6
Cells Co-Expressing Luteinising Hormone and Thyroid-Stimulating Hormone Are Present in the Ovine Pituitary Pars Distalis but Not the Pars Tuberalis: Implications for the Control of Endogenous Circannual Rhythms of Prolactin
Hodson, D. J., Townsend, J. S., & Tortonese, D. J. (2013) · Neuroendocrinology · doi:10.1159/000350790 · Cited by 5
Neurovascular plasticity as a modulator of hypothalamic function
Chen, B., Furtado, J., & Schneeberger, M. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09982-5 · Cited by 6
Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Song, J. W., Lee, K.-H., Seong, H., Shin, D., & Shon, W.-J. (2023) · BMC Biology · doi:10.1186/s12915-023-01723-x · Cited by 4
Cooperative tanycytes fuel the neuronal tank
Haddad-Tóvolli, R., & Claret, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153279 · Cited by 4
Effects of the consumption of algal biomass versus protein concentrate on postprandial satiety and metabolism
Wu, J. Y., Tso, R., Yong, Y. N., Lim, S. P. S., Wheeler, T., Nag, A., Cheng, L., Talukder, M. M. R., Huffman, L. M., Quek, S. Y., et al. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100436 · Cited by 4
Plasticité de la barrière hémato-hypothalamique
Dehouck, B., Prévot, V., & Langlet, F. (2014) · médecine/sciences · doi:10.1051/medsci/20143006010 · Cited by 4
Central Ghrelin Receptors and Food Intake
Perelló, M., & Raingo, J. (2014) · The Receptors · doi:10.1007/978-1-4939-0823-3_5 · Cited by 4
Le tanycyte, une cellule clé de l’interface hémato-hypothalamique
Langlet, F. (2014) · Biologie Aujourd hui · doi:10.1051/jbio/2014025 · Cited by 3
Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Poelman, R., May, M. V. L., Schéle, E., Stoltenborg, I., & Dickson, S. L. (2025) · Endocrinology · doi:10.1210/endocr/bqae166 · Cited by 3
Tanycytes hypothalamiques, barrière hématoencéphalique et rôle dans la régulation de l’homéostasie énergétique
Florent, V., Baroncini, M., & Prévot, V. (2016) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2016.10.001 · Cited by 3
The big, bad obesity pandemic
Regestein, Q. R. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001050 · Cited by 3
What’s the occasion? Phasic dopamine signaling and interoception
Roitman, M. F., & McCutcheon, J. E. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103074 · Cited by 3
New routes to the neuroendocrine hypothalamus: the extracellular space
Nicolas, J. C., Huwart, S. J. P., Ziemens, D., Freire-Agulleiro, Ó., Lee, T. H.-Y., Mattot, V., & Quarta, C. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf197 · Cited by 2
Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits
Zhu, W., Libert, C., & Vanderhaeghen, T. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00416-6 · Cited by 2
Critical issues in practice development: localism and public health reforms.
Regan, P. (2011) · PubMed · Cited by 2
Pseudospatial transcriptional gradient analysis of hypothalamic ependymal cells: towards a new tanycyte classificationPreprint
Brunner, M., Lopez-Rodriguez, D., Messina, A., Thorens, B., Santoni, F. A., & Langlet, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.06.547914 · Cited by 1
Hormones and the Regulation of Neuronal Voltage-Sensing Ion Channels
Lyons, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00011-0 · Cited by 1
GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments
Wang, H., Wu, C., Landrock, D., Nevarez, A., Liu, S., Thalacker‐Mercer, A. E., Zhang, Y., Baum, J., Kim, S.-J., Xue, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01922-0 · Cited by 1
Brain Nutrient Sensing: A Unifying Framework
Blouet, C., & Schwartz, G. J. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042324-100329 · Cited by 3
The role of tanycytes in the regulation of energy balance
Martínez-Martínez, S., Iglesias, C., Diéguez, C., Rasika, S., Schwaninger, M., Prévot, V., & Nogueiras, R. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-10010-9 · Cited by 1
Ghrelin Increases Glutamate Release at the Perforant Path‐Dentate Gyrus Granule Cell Synapses by Cross‐Activating Dopamine D 1 Receptors
Oraegbuna, C. S., Hasler, W. A., Chen, X., & Lei, S. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70130 · Cited by 1
Serum biomarkers of postanoxic encephalopathy in relation to ghrelin treatment. A secondary analysis of the GRECO trial
Omes, Q. P. M., Nutma, S., Beishuizen, A., et al. (2026) · Resuscitation · doi:10.1016/j.resuscitation.2026.110980 · Cited by 1
Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities
Mekki, Y. M., Park, J., Alzaareer, Z., Hussain, Z., Gulzar, A., Elzouki, A. Y. A., Güemes, A., & Zughaier, S. M. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-01876-w · Cited by 1
Neurobiological mechanisms of second-generation antipsychotic-induced obesity: Interactions between ghrelin signaling and neurotransmitter systems
Zogovic, N. S., Despotović, A., Misirkic-Marjanovic, M., Vucicevic, L. M., & Janjetović, K. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111959 · Cited by 1
Analysis of a cell niche with proliferative potential at the roof of the aqueduct of Sylvius
Martínez-Mendoza, M. L., Rodríguez-Arzate, C. A., Gómez-González, G. B., Kirchhoff, F., & Martínez‐Torres, A. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.11.004 · Cited by 1
Endocrine Disturbances in Anorexia Nervosa
Sjögren, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-16691-4_31 · Cited by 1
The Connection Between the Appetite-Regulatory Peptides Ghrelin and GLP-1 and Alcohol Use Disorder
Jerlhag, E. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_8 · Cited by 2
Development of a Ghrelin Deacylase to Attenuate Drug Reward and Associated Effects of Methamphetamine
Stewart, M. J., Wei, H., Chandar, N. B., Zheng, F., & Zhan, C. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00391 · Cited by 1
Food Intake, Circuitry, and Energy Metabolism
Yeo, G. S. H. (2016) · Wiley eBooks · doi:10.1002/9781118760369.ch16 · Cited by 1
Acute changes in systemic glycaemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasisPreprint
Bakker, W., Salinas, C. G., Imbernón, M., Chao, D. H. M., Hassouna, R., Morel, C., Martin, C., Gangarossa, G., Denis, R., Castel, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.11.198341 · Cited by 1
Dinner for Two: Digging into how Ghrelin and Endocannabinoid Systems Interact in the Ventral Tegmental Area to Regulate Non-Homeostatic Feeding
Edwards, A. (2020) · doi:10.22215/etd/2020-14020 · Cited by 1
Circadian Entry of Glucose into the Arcuate Nucleus Determines the Rhythm in Blood GlycemiaPreprint
Rodríguez-Cortés, B., Hurtado‐Alvarado, G., Martínez-Gómez, R., Mercado, L. L., Prager‐Khoutorsky, M., & Buijs, R. M. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3929031 · Cited by 1
Estudio de los circuitos neuronales involucrados y del rol modulador de ghrelina en los aspectos hedónicos del apetito
Valdivia, L. S. (2015) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/48904
Acylation state determines the action of ghrelin on energy and glucose metabolism
Heppner, K. M. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
Understanding the mechanisms underlying the neuroprotective role of calorie restriction in Parkinson’s Disease
Bayliss, J. A. (2017) · Figshare · doi:10.4225/03/58b8c4bc41e03
Dynamic Control of Neural Reproductive Centers by Endothelial Cells
Vanacker, C., Sharif, A., & Prévot, V. (2015) · CRC Press eBooks · doi:10.1201/b18028-5 · Cited by 1
Electrophysiology of the Appetite‐Regulating Circuits of the Hypothalamus
Sabatier, N., Menzies, J. R. W., & Leng, G. (2016) · doi:10.1002/9781118839317.ch8
Fluid/Mineral Balance: The Circumventricular Organs☆
Fry, M., & Ferguson, A. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02762-0
Review Article Omental transplantation for neuroendocrinological disorders
Rafael, H. (2015)
Gastrointestinal Hormones and the Control of Food Intake and Energy Metabolism
PAGE, L. C., Miller, M. D., D’Alessio, D. D., & Tong, J. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_3
The Role of Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Dorsomedial Hypothalamus (DMH) and Ventral Premammilary Nucleus (PMV) In Energy Homeostasis in Mice
Hyland, L. (2017) · doi:10.22215/etd/2017-12229
Estudio de los efectos de la ghrelina sobre los circuitos neuronales del tallo encefálico
Cornejo, M. P. (2019) · doi:10.35537/10915/73341
Estudio de los mecanismos que median el ingreso de la ghrelina plasmática al cerebro
Uriarte, M. (2020) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/90225
Genome-wide association and transcriptome analysis reveals serum ghrelin to be linked with GFRALPreprint
Wittekind, D. A., Scholz, M. R., Kratzsch, J., Löffler, M., Horn, K., Kirsten, H., Witte, A. V., Villringer, A., & Kluge, M. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2009.11549
Estudios del rol modulador de ghrelina sobre la actividad neuroendocrina: circuitos neuronales implicados en la activación de las neuronas CRF hipofisiotrópicas
Cabral, A. (2014) · doi:10.35537/10915/34495
Faculty Opinions recommendation of Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.
Rodgers, R., & Hummitzsch, K. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733232135.793546087
Faculty Opinions recommendation of Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.
Selvanesan, B. C., & Chappell, N. R. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733232135.793546184
Efeitos de citocinas e fatores de crescimento sobre neurônios hipotalâmicos: estudo do fator de necrose tumoral-, interleucina-6, interleucina IL-1, hormônio do crescimento e fator de crescimento semelhante à insulina.
Chaves, F. M. (2021) · doi:10.11606/t.42.2021.tde-14012022-173310
Endocrine Disturbances in Anorexia Nervosa
Sjögren, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-67929-3_31-1
Estudio neuroanatómico y funcional de las neuronas del hipotálamo lateral que expresan el receptor de secretagogos de la hormona de crecimiento
Barrile, F. (2023) · doi:10.35537/10915/159462
Einfluss von Lebensmittelfotos mit unterschiedlicher Makronährstoff-Zusammensetzung auf die Serum-Ghrelin-Konzentration
Rademacher, J. (2024) · doi:10.53846/goediss-10271
New Perspectives in Eating Disorders
Monteleone, A. M., Sala, L., Gorwood, P. A. P. M., Treasure, J. L., & Monteleone, P. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009067287.006
The Effects of Ghrelin on Spike Activity of the Suprachiasmatic Nucleus Neurones of the Rat
Inyushkin, A. N., Sharafutdinova, A. Y., Inyushkin, A. A., & Inyushkin, A. A. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024030189
Ghrelin Regulates Food Intake in the Ventral Tegmental Area During Chronic Psychosocial Stress
Smith, A. (2024) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2024-16006
The Effects of Ghrelin on Spike Activity of the Suprachiasmatic Nucleus Neurones of the Rat
Inyushkin, A. N., Sharafutdinova, A. Y., Михайловна, И. Е., & Inyushkin, A. A. (2024) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813924060088
Neuroglia in eating disorders (obesity, Prader-Willi syndrome and anorexia nervosa)
Corrêa‐da‐Silva, F., & Yi, C. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00019-3
Tanycyte-mediated synapse pruning shapes hypothalamic circuits controlling metabolismPreprint
Dali, R., Kolotuev, I., Rodríguez, D. L., Gavini, C. K., Déglise, T., & Langlet, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.14.688419
Modulación de los canales de calcio presinápticos por variantes de receptores acoplados a proteína G humanos: "el receptor opioide mu y el receptor de ghrelina"
Soto, E. J. L. (2015) · doi:10.35537/10915/44545
Additional file 4 of Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Song, J. W., Lee, K.-H., Seong, H., Shin, D.-M., & Shon, W.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26636019
Additional file 1 of Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Song, J. W., Lee, K.-H., Seong, H., Shin, D.-M., & Shon, W.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26636010
Additional file 3 of Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Song, J. W., Lee, K.-H., Seong, H., Shin, D.-M., & Shon, W.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26636016
Additional file 2 of Taste receptor type 1 member 3 enables western diet-induced anxiety in mice
Song, J. W., Lee, K.-H., Seong, H., Shin, D.-M., & Shon, W.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26636013

Authors: Schaeffer, M., Langlet, F., Lafont, C., Molino, F., Hodson, D. J., Roux, T., Lamarque, L., Verdié, P., Bourrier, E., Dehouck, B., Banères, J.-L., Martinez, J., Méry, P.-F., Marie, J., Trinquet, E., Fehrentz, J.-A., Prévot, V., & Mollard, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Cisbio (France) (FR)
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5247, Institut des Biomolécules Max Mousseron, Faculty of Pharmacy, Universities of Montpellier 1 and 2, F-34093 Montpellier Cedex 5, France; and
ORCID: Schaeffer, Marie
Langlet, Fanny
Molino, François
Hodson, David J.
Roux, Thomas
Lamarque, Laurent
Verdié, Pascal
Bourrier, Emmanuel
Banères, Jean-Louis
Méry, Pierre-François
Trinquet, Eric
Fehrentz, Jean-Alain
Prévot, Vincent
Mollard, Patrice
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-01-07
Volume: 110
Issue: 4
Pages: 1512-1517
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1212137110
PMC: PMC3557016
OpenAlex: W2152571442
Semantic Scholar: 95d156475087f3165a661ace77280d02caabbebe
Cited by: 325
References: 46
Citations by year: 2026: 13 · 2025: 22 · 2024: 25 · 2023: 17 · 2022: 28 · 2021: 25 · 2020: 28 · 2019: 19 · 2018: 26 · 2017: 28 · 2016: 25 · 2015: 28 · 2014: 26 · 2013: 14
FWCI: 16.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ghrelin, hypothalamus, arcuate nucleus, blood-brain barrier, fenestrated capillaries, feeding behavior, energy homeostasis, neuropeptide binding
MeSH terms: Animals, Appetite Regulation, Blood-Brain Barrier, Capillary Permeability, Eating, Fasting, Hypothalamus, Male, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neurons, Microscopy, Fluorescence, Multiphoton, Mice, Ghrelin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks