The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
Open accessAbstract
To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.
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“Peripherally produced ghrelin exerts its appetite-inducing effects centrally after passing through the BBB [112, 302-304].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [302]
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Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828
Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034827 · Cited by 691
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Pratlong, M. (2014) · theses.fr (ABES) · doi:10.70675/02dafa47zd1cfz49e6z86a9zb57e2f9d693f
Espinosa-Carrasco, G. (2016) · theses.fr (ABES) · doi:10.70675/f4c31cbcz110ez48dbza3eaz9a7512ef00fe
Perrin‐Terrin, A. (2018) · theses.fr (ABES) · doi:10.70675/e19e922bz4ab1z4df2z8e00z839db7c46630
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Barbotin, A. (2019) · theses.fr (ABES) · doi:10.70675/5c3c5015z53bcz4871zbeeezb7ea08d90009
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Chevillard, P. (2022) · theses.fr (ABES) · doi:10.70675/6d5212ddzd1fcz4605z9e7az0c9212990874
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Mattioni, J. (2024) · theses.fr (ABES) · doi:10.70675/e375f801z0fd1z4fc6z9d73zc74380dd25f4
Dalvi, P. S., Kelly, O., Grady, L., Carris, N., Sullivan, J., & Liu, H. (2026) · Cureus · doi:10.7759/cureus.112030
Brain barriers as checkpoints in endocrine regulation of body homeostasis
Kang, D. Y., Lee, M. J., Kim, S. C., Park, S., An, J. H., Pyo, C. H., Kim, Y., Jeong, J., Park, Y., Yeo, M., et al. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261444202
Geysen, S., Brands, A. M. A., Schultz, H., Koenig, J., Tittgemeyer, M., & Peters, J. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1330
Martínez‐Corral, I., Monaco, N., Brierley, D. I., & Imbernón, M. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70636
Extracellular vesicles: Multi-source regulatory mechanisms in hippocampal homeostasis
Liu, Q., & Guo, L. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107015
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Jee, Y. H., Tsuo, K., Parsa, S., Argentieri, M. A., Isaac, S., Elliott, A., Walters, R. K., Padhi, E. M., Kiernan, E., Lichtenstein, L., et al. (2026) · medRxiv · doi:10.64898/2026.10.06.26364311
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Nampoothiri, S. S., Fernandois, D., Journiac, N., Delahaye, F., Mbouamboua, Y., Sauvé, F., Couralet, M., Gallet, S., Mroueh, N., Aponte, M. L. S., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01635-4
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Giovanini, L., Cornejo, M. P., Gómez, I., Wanionok, N. E., Francesco, P. N. D., Heredia, F., Castrogiovanni, D. C., Urrutia, L., Falasco, G., Cantel, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2615145123
Baenas, I., Camacho‐Barcia, L., Granero, R., Tamarit, S., Tovar, S. A., Sánchez, I., Diéguez, C., du Montcel, C. T., Gorwood, P. A. P. M., Ehrlich, S., et al. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10096-9
Metadata
- Authors
- Schaeffer, M., Langlet, F., Lafont, C., Molino, F., Hodson, D. J., Roux, T., Lamarque, L., Verdié, P., Bourrier, E., Dehouck, B., Banères, J.-L., Martinez, J., Méry, P.-F., Marie, J., Trinquet, E., Fehrentz, J.-A., Prévot, V., & Mollard, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Cisbio (France) (FR)
- Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5247, Institut des Biomolécules Max Mousseron, Faculty of Pharmacy, Universities of Montpellier 1 and 2, F-34093 Montpellier Cedex 5, France; and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-01-07
- Volume
- 110
- Issue
- 4
- Pages
- 1512-1517
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3557016
- OpenAlex
- W2152571442
- Semantic Scholar
- 95d156475087f3165a661ace77280d02caabbebe
- Cited by
- 325
- References
- 46
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 25 · 2023: 17 · 2022: 28 · 2021: 25 · 2020: 28 · 2019: 19 · 2018: 26 · 2017: 28 · 2016: 25 · 2015: 28 · 2014: 26 · 2013: 14
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ghrelin, hypothalamus, arcuate nucleus, blood-brain barrier, fenestrated capillaries, feeding behavior, energy homeostasis, neuropeptide binding
- MeSH terms
- Animals, Appetite Regulation, Blood-Brain Barrier, Capillary Permeability, Eating, Fasting, Hypothalamus, Male, Median Eminence, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neurons, Microscopy, Fluorescence, Multiphoton, Mice, Ghrelin
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