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MicroRNA-223 coordinates cholesterol homeostasis
Abstract
Significance: Results from this study represent a breakthrough in our understanding of posttranscriptional control of cholesterol metabolism and how microRNAs (miRNAs) are at the heart of cholesterol regulatory circuitry and homeostasis. Although cells are adept at maintaining proper cholesterol levels, it was unknown how cells posttranscriptionally coordinate cholesterol uptake, efflux, and synthesis. MicroRNA-223 (miR-223) transcription and expression are maintained by cholesterol, and, as a feedback network, miR-223 inhibits cholesterol biosynthesis and uptake and increases cholesterol efflux. This study clearly demonstrates the extensive role that miRNAs play in coordinating metabolic adaptation to disease and general homeostasis. This work highlights a unique regulatory control point for cholesterol homeostasis and illustrates how important the study of miRNAs is to the greater understanding of dyslipidemia and cardiovascular disease.
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The promotive effect of miR-223 on Abca1 relies on the inhibition of Sp3.
“Previous studies have indicated that the promotive effect of miR-223 on Abca1 relies on the inhibition of Sp3 [38, 39].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [39]
miR-223 has a critical role in lipid metabolism and inflammation in vitro.
“These studies collectively affirm the critical role of miR-223 in lipid metabolism and inflammation in vitro.”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [39]
miR-223 exerts control over cellular cholesterol levels by directly inhibiting genes involved in cholesterol biosynthesis and uptake in hepatocytes and coronary artery endothelial cells.
“miR-223 exerts control over cellular cholesterol levels by directly inhibiting genes involved in cholesterol biosynthesis and uptake in hepatocytes and coronary artery endothelial cells [39, 60].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [39]
miR-223 stands out as one of the few miRNAs capable of indirectly activating Abca1, promoting lipid efflux.
“In contrast, miR-223 stands out as one of the few miRNAs capable of indirectly activating Abca1, promoting lipid efflux.”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [39]
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Cites
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144
Ramírez, C. M., Rotllan, N., Vlassov, A. V., Dávalos, A., Li, M., Goedeke, L., Aranda, J. F., Cirera-Salinas, D., Araldi, E., Salerno, A., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300626 · Cited by 217
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Sorted by citations
Annema, W., & von Eckardstein, A. (2016) · Translational Research · doi:10.1016/j.trsl.2016.02.008 · Cited by 94
Dluzen, D. F., Noren Hooten, N., & Evans, M. K. (2017) · WIREs RNA · doi:10.1002/wrna.1385 · Cited by 31
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Metadata
- Authors
- Vickers, K. C., Landstreet, S. R., Levin, M. G., Shoucri, B. M., Toth, C. L., Taylor, R. C., Palmisano, B. T., Tabet, F., Cui, H. L., Rye, K.-A., Sethupathy, P., & Remaley, A. T.
- Affiliations
- National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892;
- Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232;
- Lipid Research Group, The Heart Research Institute, Newtown, NSW 2042, Australia;
- Lipoproteins and Atherosclerosis, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; and
- Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-09-22
- Volume
- 111
- Issue
- 40
- Pages
- 14518-14523
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 253
- References
- 2
- Language
- en
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