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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

Djuranovic, Sergej, Nahvi, Ali, Green, Rachel·2012·Science
DOI 10.1126/science.1215691PMC PMC3971879
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Abstract

Translation Block: MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene expression. Although whether gene activity is repressed by blocking translation of messenger RNA (mRNA) targets, or by promoting their deadenylation and then degradation, has been open to debate. Bazzini et al. (p. 233 , published online 15 March) and Djuranovic et al. (p. 237 ) looked at early points in the repression reaction in the zebrafish embryo or in Drosophila tissue culture cells, respectively, and found that translation was blocked before target mRNAs were significantly deadenylated and degraded. Thus, miRNAs appear to interfere with the initiation step of translation.

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  • miRNAs are excised from larger stem-loop-containing transcripts and incorporated into argonaute (Ago) proteins, generating functional entities capable of silencing target transcripts via translational repression and mRNA destabilization.

    “miRNAs are excised from larger stem-loop-containing transcripts and are subsequently incorporated into argonaute (Ago) proteins. This generates functional entities capable of silencing target transcripts via translational repression and mRNA destabilization (Bazzini et al., 2012; Djuranovic et al., 2012).”

    From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Djuranovic et al., 2012

  • Mature miRNAs bind to the 3′-untranslated region (UTR) sequence of target genes to form RNA-induced silencing complexes that influence protein synthesis by regulating gene transcription or degrading cytoplasmic messenger RNAs (mRNAs).

    “Mature miRNAs bind to the 3′-untranslated region (UTR) sequence of target genes to form RNA-induced silencing complexes that influence protein synthesis by regulating gene transcription or degrading cytoplasmic messenger RNAs (mRNAs)”

    From Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System (2020) · cites this paper as Djuranovic et al., 2012

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Research works printed but not linked: 29

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Metadata

Authors
Djuranovic, S., Nahvi, A., & Green, R.
Affiliations
Howard Hughes Medical Institute (HHMI) and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2012-04-13
Volume
336
Issue
6078
Pages
237-240
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1215691
PMC
PMC3971879
Cited by
811
References
1
Language
en

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