The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The dynamic role of genetics on cortical patterning during childhood and adolescence
Open accessAbstract
Significance: Quantitative genetic studies have established that evolutionarily novel regions of the cerebral cortex have high heritability within human populations. Longitudinal imaging studies have demonstrated that the cerebral cortex is highly dynamic in childhood. In the current study, we examine how genetic effects on cortical thickness change longitudinally over childhood and adolescence using a large genetically informative imaging sample. We find rapid changes in genetic effects in early childhood, with stabilization in late adolescence. The areas with the greatest changes include evolutionarily novel regions. These findings have implications for future molecular genetic studies of imaging endophenotypes and further our sparse understanding of how genes help to shape the brain after birth.
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“the heritability of tract-based FA in neonates149, 150 and in 9- and 12-year-olds151 is relatively low”
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Metadata
- Authors
- Schmitt, J. E., Neale, M. C., Fassassi, B., Perez, J., Lenroot, R. K., Wells, E. M., & Giedd, J. N.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- Virginia Commonwealth University (US)
- National Institutes of Health (US)
- UNSW Sydney (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-21
- Volume
- 111
- Issue
- 18
- Pages
- 6774-6779
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4020057
- OpenAlex
- W2089810490
- Cited by
- 103
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 3 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 6
- FWCI
- 19.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-20030, T32MH020030)
- National Institute of Biomedical Imaging and Bioengineering (EB-004311, T32EB004311)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- cortical thickness, heritability, brain development, childhood, adolescence, temporal pole, inferior parietal lobule, frontal cortex, longitudinal MRI, twins and siblings, latent growth curve models
- MeSH terms
- Adolescent, Cerebral Cortex, Child, Female, Frontal Lobe, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Organ Size, Parietal Lobe, Prospective Studies, Temporal Lobe, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation, Body Patterning, Siblings, Young Adult, Neuroimaging
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