Cited by 329Circadian rhythm and melatoninSleep and Work-Related FatigueAdvanced Proteomics Techniques and Applications

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Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

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Mauvoisin, Daniel, Wang, Jingkui, Jouffe, Céline, Martin, Eva, Atger, Florian, Waridel, Patrice, Quadroni, Manfredo, Gachon, Frédéric, Naef, Felix·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1314066111PMC PMC3890886

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Abstract

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known about the accumulation patterns of proteins. Here, we quantified temporal profiles in the murine hepatic proteome under physiological light-dark conditions using stable isotope labeling by amino acids quantitative MS. Our analysis identified over 5,000 proteins, of which several hundred showed robust diurnal oscillations with peak phases enriched in the morning and during the night and related to core hepatic physiological functions. Combined mathematical modeling of temporal protein and mRNA profiles indicated that proteins accumulate with reduced amplitudes and significant delays, consistent with protein half-life data. Moreover, a group comprising about one-half of the rhythmic proteins showed no corresponding rhythmic mRNAs, indicating significant translational or posttranslational diurnal control. Such rhythms were highly enriched in secreted proteins accumulating tightly during the night. Also, these rhythms persisted in clock-deficient animals subjected to rhythmic feeding, suggesting that food-related entrainment signals influence rhythms in circulating plasma factors.

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Authors: Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F.
Affiliations: University of Lausanne (CH)
SIB Swiss Institute of Bioinformatics (CH)
Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland;
The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland; and
ORCID: Mauvoisin, Daniel
Wang, Jingkui
Jouffe, Céline
Atger, Florian
Waridel, Patrice
Quadroni, Manfredo
Gachon, Frédéric
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-12-16
Volume: 111
Issue: 1
Pages: 167-172
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1314066111
PMC: PMC3890886
OpenAlex: W2027410128
Cited by: 329
References: 58
Citations by year: 2026: 11 · 2025: 18 · 2024: 19 · 2023: 23 · 2022: 24 · 2021: 32 · 2020: 34 · 2019: 30 · 2018: 32 · 2017: 28 · 2016: 28 · 2015: 26 · 2014: 21 · 2013: 1
FWCI: 13.68
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: other-oa
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (130714)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: circadian clock, diurnal cycle, liver proteome, protein half-life, translational regulation, post-translational regulation, secreted proteins, light-dark cycle, mouse liver
MeSH terms: Albumins, alpha 1-Antitrypsin, Animals, Circadian Rhythm, Gene Expression Regulation, Liver, Male, Mice, Inbred C57BL, Models, Theoretical, Plasma, Protein Processing, Post-Translational, RNA, Messenger, Mass Spectrometry, Mice, Knockout, Proteome, Mice, Cryptochromes, Circadian Clocks

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Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

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