CoChat
Sign Up
Cited by 16Developmental Biology and Gene RegulationMicroRNA in disease regulationCircadian rhythm and melatonin

Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development

Open access
Fishman, Elizabeth S., Han, Jisoo S., La Torre, Anna·2022·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2022.831750PMC PMC8847441
Open this paper in CoChat — free accountOpen PDF

Abstract

A broad repertoire of transcription factors and other genes display oscillatory patterns of expression, typically ranging from 30 min to 24 h. These oscillations are associated with a variety of biological processes, including the circadian cycle, somite segmentation, cell cycle, and metabolism. These rhythmic behaviors are often prompted by transcriptional feedback loops in which transcriptional activities are inhibited by their corresponding gene target products. Oscillatory transcriptional patterns have been proposed as a mechanism to drive biological clocks, the molecular machinery that transforms temporal information into accurate spatial patterning during development. Notably, several microRNAs (miRNAs) -small non-coding RNA molecules-have been recently shown to both exhibit rhythmic expression patterns and regulate oscillatory activities. Here, we discuss some of these new findings in the context of the developing retina. We propose that miRNA oscillations are a powerful mechanism to coordinate signaling pathways and gene expression, and that addressing the dynamic interplay between miRNA expression and their target genes could be key for a more complete understanding of many developmental processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fcell.2022.831750

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • MIR204 belongs to the group of recently characterised retinal-specific miRNAs regulating important processes in the retina including phototransduction cascade and development of RPE, neural retina, ciliary body, and lens.

    “The MIR204 belongs to the group of recently characterised retinal-specific miRNAs 20,21 regulating important processes in the retina including phototransduction cascade and development of RPE, neural retina, ciliary body, and lens.”

    From Confirmation of the <i>MIR204</i> n.37C&gt;T heterozygous variant as a cause of chorioretinal dystrophy variably associated with iris coloboma, early-onset cataracts and congenital glaucoma (2023) · cites this paper as [20]

    The 'miRNAs in the Developing Retina' table (page unavailable) lists miR-204 and associates it with retina and lens development. It does not identify miR-204 as retinal-specific or recently characterized, and it does not attribute phototransduction or development of the RPE and ciliary body specifically to miR-204. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 164

  1. Ait-Hmyed O. Felder-Schmittbuhl M.-P. Garcia-Garrido M. Beck S. Seide C. Sothilingam V. (2013). Mice Lacking Period 1 and Period 2 Circadian Clock Genes Exhibit Blue Cone Photoreceptor Defects. Eur. J. Neurosci. 37 (7), 1048– 1060. 10.1111/ejn.12103 23351077 · DOI
  2. Alexiades M. R. Cepko C. (1996). Quantitative Analysis of Proliferation and Cell Cycle Length During Development of the Rat Retina. Dev. Dyn. 205 (3), 293– 307. 10.1002/(sici)1097-0177(199603)205::3<293aid-aja9>3.0.co;2-d 8850565 · DOI
  3. Ambros V. Horvitz H. R. (1984). Heterochronic Mutants of the Nematode Caenorhabditis elegans. Science 226 (4673), 409– 416. 10.1126/science.6494891 6494891 · DOI · Paper page
  4. Ambros V. (2001). microRNAs. Cell 107 (7), 823– 826. 10.1016/s0092-8674(01)00616-x 11779458 · DOI
  5. Arora A. McKay G. J. Simpson D. A. C. (2007). Prediction and Verification of miRNA Expression in Human and Rat Retinas. Invest. Ophthalmol. Vis. Sci. 48 (9), 3962– 3967. 10.1167/iovs.06-1221 17724173 · DOI
  6. Baba K. Piano I. Lyuboslavsky P. Chrenek M. A. Sellers J. T. Zhang S. (2018). Removal of Clock Gene Bmal1 from the Retina Affects Retinal Development and Accelerates Cone Photoreceptor Degeneration During Aging. Proc. Natl. Acad. Sci. USA 115 (51), 13099– 13104. 10.1073/pnas.1808137115 30498030 PMC6305005 · DOI
  7. Baek J. H. Hatakeyama J. Sakamoto S. Ohtsuka T. Kageyama R. (2006). Persistent and High Levels of Hes1 Expression Regulate Boundary Formation in the Developing Central Nervous System. Development 133 (13), 2467– 2476. 10.1242/dev.02403 16728479 · DOI
  8. Barbato S. Marrocco E. Intartaglia D. Pizzo M. Asteriti S. Naso F. (2017). MiR-211 Is Essential for Adult Cone Photoreceptor Maintenance and Visual Function. Sci. Rep. 7 (1), 17004. 10.1038/s41598-017-17331-z 29209045 PMC5717140 · DOI
  9. Bartel D. P. (2009). MicroRNAs: Target Recognition and Regulatory Functions. Cell 136 (2), 215– 233. 10.1016/j.cell.2009.01.002 19167326 PMC3794896 · DOI · Paper page
  10. Ben-Moshe Z. Alon S. Mracek P. Faigenbloom L. Tovin A. Vatine G. D. (2014). The Light-Induced Transcriptome of the Zebrafish Pineal Gland Reveals Complex Regulation of the Circadian Clockwork by Light. Nucleic Acids Res. 42 (6), 3750– 3767. 10.1093/nar/gkt1359 24423866 PMC3973289 · DOI
  11. Berber P. Grassmann F. Kiel C. Weber B. H. F. (2017). An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology. Mol. Diagn. Ther. 21 (1), 31– 43. 10.1007/s40291-016-0234-z 27658786 PMC5250647 · DOI
  12. Bernardos R. L. Lentz S. I. Wolfe M. S. Raymond P. A. (2005). Notch-Delta Signaling Is Required for Spatial Patterning and Müller Glia Differentiation in the Zebrafish Retina. Developmental Biol. 278 (2), 381– 395. 10.1016/j.ydbio.2004.11.018 15680358 · DOI
  13. Besharse J. C. Iuvone P. M. (1983). Circadian Clock in Xenopus Eye Controlling Retinal Serotonin N-Acetyltransferase. Nature 305 (5930), 133– 135. 10.1038/305133a0 6888555 · DOI
  14. Bhattacharyya S. N. Habermacher R. Martine U. Closs E. I. Filipowicz W. (2006). Stress-induced Reversal of microRNA Repression and mRNA P-Body Localization in Human Cells. Cold Spring Harbor Symposia Quantitative Biol. 71, 513– 521. 10.1101/sqb.2006.71.038 17381334 · DOI
  15. Birney E. Birney E. Stamatoyannopoulos J. A. Dutta A. Guigó R. Gingeras T. R. (2007). Identification and Analysis of Functional Elements in 1% of the Human Genome by the ENCODE Pilot Project. Nature 447 (7146), 799– 816. 10.1038/nature05874 17571346 PMC2212820 · DOI · Paper page
  16. Bonev B. Pisco A. Papalopulu N. (2011). MicroRNA-9 Reveals Regional Diversity of Neural Progenitors Along the Anterior-Posterior Axis. Developmental Cel. 20 (1), 19– 32. 10.1016/j.devcel.2010.11.018 PMC3361082 21238922 · DOI
  17. Bonev B. Stanley P. Papalopulu N. (2012). MicroRNA-9 Modulates Hes1 Ultradian Oscillations by Forming a Double-Negative Feedback Loop. Cel. Rep. 2 (1), 10– 18. 10.1016/j.celrep.2012.05.017 PMC4103481 22840391 · DOI
  18. Borenstein E. Ruppin E. (2006). Direct Evolution of Genetic Robustness in microRNA. Proc. Natl. Acad. Sci. 103 (17), 6593– 6598. 10.1073/pnas.0510600103 16608911 PMC1458928 · DOI
  19. Bosze B. Moon M.-S. Kageyama R. Brown N. L. (2020). Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance. J. Neurosci. 40 (7), 1501– 1513. 10.1523/JNEUROSCI.2327-19.2020 31949107 PMC7044741 · DOI
  20. Bray S. J. (2016). Notch Signalling in Context. Nat. Rev. Mol. Cel. Biol. 17 (11), 722– 735. 10.1038/nrm.2016.94 27507209 · DOI · Paper page
  21. Bueno M. J. Malumbres M. (2011). MicroRNAs and the Cell Cycle. Biochim. Biophys. Acta (Bba) - Mol. Basis Dis. 1812 (5), 592– 601. 10.1016/j.bbadis.2011.02.002 21315819 · DOI
  22. Bushati N. Cohen S. M. (2007). microRNA Functions. Annu. Rev. Cel. Dev. Biol. 23, 175– 205. 10.1146/annurev.cellbio.23.090506.123406 17506695 · DOI · Paper page
  23. Busskamp V. Krol J. Nelidova D. Daum J. Szikra T. Tsuda B. (2014). miRNAs 182 and 183 Are Necessary to Maintain Adult Cone Photoreceptor Outer Segments and Visual Function. Neuron 83 (3), 586– 600. 10.1016/j.neuron.2014.06.020 25002228 · DOI
  24. Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. (2005). The Transcriptional Landscape of the Mammalian Genome. Science 309 (5740), 1559– 1563. 10.1126/science.1112014 16141072 · DOI
  25. Cepko C. (2014). Intrinsically Different Retinal Progenitor Cells Produce Specific Types of Progeny. Nat. Rev. Neurosci. 15 (9), 615– 627. 10.1038/nrn3767 25096185 · DOI
  26. Chekulaeva M. Filipowicz W. (2009). Mechanisms of miRNA-Mediated post-transcriptional Regulation in Animal Cells. Curr. Opin. Cel. Biol. 21 (3), 452– 460. 10.1016/j.ceb.2009.04.009 19450959 · DOI · Paper page
  27. Chen X. Emerson M. M. (2021). Notch Signaling Represses Cone Photoreceptor Formation Through the Regulation of Retinal Progenitor Cell States. Sci. Rep. 11 (1), 14525. 10.1038/s41598-021-93692-w 34267251 PMC8282820 · DOI
  28. Cheng H.-Y. M. Papp J. W. Varlamova O. Dziema H. Russell B. Curfman J. P. (2007). microRNA Modulation of Circadian-Clock Period and Entrainment. Neuron 54 (5), 813– 829. 10.1016/j.neuron.2007.05.017 17553428 PMC2590749 · DOI
  29. Chu-Tan J. A. Rutar M. Saxena K. Aggio-Bruce R. Essex R. W. Valter K. (2018). MicroRNA-124 Dysregulation Is Associated with Retinal Inflammation and Photoreceptor Death in the Degenerating Retina. Invest. Ophthalmol. Vis. Sci. 59 (10), 4094– 4105. 10.1167/iovs.18-24623 30098196 PMC11647551 · DOI
  30. Clark B. S. Stein-O’Brien G. L. Shiau F. Cannon G. H. Davis-Marcisak E. Sherman T. (2019). Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification. Neuron 102 (6), 1111– 1126. 10.1016/j.neuron.2019.04.010 31128945 PMC6768831 · DOI
  31. Conner C. Ackerman K. M. Lahne M. Hobgood J. S. Hyde D. R. (2014). Repressing Notch Signaling and Expressing TNF Are Sufficient to Mimic Retinal Regeneration by Inducing Muller Glial Proliferation to Generate Committed Progenitor Cells. J. Neurosci. 34 (43), 14403– 14419. 10.1523/JNEUROSCI.0498-14.2014 25339752 PMC4205560 · DOI
  32. Conte I. Carrella S. Avellino R. Karali M. Marco-Ferreres R. Bovolenta P. (2010). miR-204 Is Required for Lens and Retinal Development via Meis2 Targeting. Proc. Natl. Acad. Sci. 107 (35), 15491– 15496. 10.1073/pnas.0914785107 20713703 PMC2932609 · DOI · Paper page
  33. Damiani D. Alexander J. J. O'Rourke J. R. McManus M. Jadhav A. P. Cepko C. L. (2008). Dicer Inactivation Leads to Progressive Functional and Structural Degeneration of the Mouse Retina. J. Neurosci. 28 (19), 4878– 4887. 10.1523/JNEUROSCI.0828-08.2008 18463241 PMC3325486 · DOI
  34. Dantas da Costa e Silva M. E. Polina E. R. Crispim D. Sbruzzi R. C. Lavinsky D. Mallmann F. (2019). Plasma Levels of miR-29b and miR-200b in Type 2 Diabetic Retinopathy. J. Cel. Mol. Med. 23 (2), 1280– 1287. 10.1111/jcmm.14030 PMC6349208 30467971 · DOI
  35. Davis E. S. Voss G. Miesfeld J. B. Zarate‐Sanchez J. Voss S. R. Glaser T. (2021). The Rax Homeobox Gene Is Mutated in the Eyeless Axolotl, Ambystoma mexicanum. Developmental Dyn. 250 (6), 807– 821. 10.1002/dvdy.246 PMC8907009 32864847 · DOI
  36. Davis N. Mor E. Ashery-Padan R. (2011). Roles for Dicer1 in the Patterning and Differentiation of the Optic Cup Neuroepithelium. Development 138 (1), 127– 138. 10.1242/dev.053637 21138975 · DOI
  37. Decembrini S. Andreazzoli M. Barsacchi G. Cremisi F. (2008). Dicer Inactivation Causes Heterochronic Retinogenesis in Xenopus laevis. Int. J. Dev. Biol. 52 (8), 1099– 1103. 10.1387/ijdb.082646sd 18956342 · DOI
  38. Decembrini S. Bressan D. Vignali R. Pitto L. Mariotti S. Rainaldi G. (2009). MicroRNAs Couple Cell Fate and Developmental Timing in Retina. Pnas 106 (50), 21179– 21184. 10.1073/pnas.0909167106 19965369 PMC2781736 · DOI
  39. Dennis D. J. Han S. Schuurmans C. (2019). bHLH Transcription Factors in Neural Development, Disease, and Reprogramming. Brain Res. 1705, 48– 65. 10.1016/j.brainres.2018.03.013 29544733 · DOI
  40. Deo M. Yu J.-Y. Chung K.-H. Tippens M. Turner D. L. (2006). Detection of Mammalian microRNA Expression by In Situ Hybridization with RNA Oligonucleotides. Dev. Dyn. 235 (9), 2538– 2548. 10.1002/dvdy.20847 16736490 · DOI
  41. Dexheimer P. J. Cochella L. (2020). MicroRNAs: From Mechanism to Organism. Front. Cel. Dev. Biol. 8, 409. 10.3389/fcell.2020.00409 PMC7283388 32582699 · DOI
  42. Dexter J. S. (1914). The Analysis of a Case of Continuous Variation in Drosophila by a Study of its Linkage Relations. The Am. Naturalist 48 (576), 712– 758. 10.1086/279446 · DOI
  43. Dixit R. Tachibana N. Touahri Y. Zinyk D. Logan C. Schuurmans C. (2014). Gene Expression Is Dynamically Regulated in Retinal Progenitor Cells Prior to and During Overt Cellular Differentiation. Gene Expr. Patterns 14 (1), 42– 54. 10.1016/j.gep.2013.10.003 24148613 · DOI
  44. Dorsky R. I. Rapaport D. H. Harris W. A. (1995). Xotch Inhibits Cell Differentiation in the Xenopus Retina. Neuron 14 (3), 487– 496. 10.1016/0896-6273(95)90305-4 7695895 · DOI
  45. Doyle S. E. Grace M. S. McIvor W. Menaker M. (2002). Circadian Rhythms of Dopamine in Mouse Retina: The Role of Melatonin. Vis. Neurosci. 19 (5), 593– 601. 10.1017/s0952523802195058 12507326 · DOI
  46. Ertekin S. Yıldırım O. Dinç E. Ayaz L. Fidancı S. B. Tamer L. (2014). Evaluation of Circulating miRNAs in Wet Age-Related Macular Degeneration. Mol. Vis. 20, 1057– 1066. http://www.molvis.org/molvis/v20/1057/. 25221421 PMC4113960
  47. Eulalio A. Huntzinger E. Izaurralde E. (2008). Getting to the Root of miRNA-Mediated Gene Silencing. Cell 132 (1), 9– 14. 10.1016/j.cell.2007.12.024 18191211 · DOI
  48. Fairchild C. L. A. Cheema S. K. Wong J. Hino K. Simó S. La Torre A. (2021). Author Correction: Let-7 Regulates Cell Cycle Dynamics in the Developing Cerebral Cortex and Retina. Sci. Rep. 11 (1), 2872. 10.1038/s41598-021-82224-1 33510314 PMC7844291 · DOI
  49. Fairchild C. L. A. Cheema S. K. Wong J. Hino K. Simó S. La Torre A. (2019). Let-7 Regulates Cell Cycle Dynamics in the Developing Cerebral Cortex and Retina. Sci. Rep. 9 (1), 15336. 10.1038/s41598-019-51703-x 31653921 PMC6814839 · DOI
  50. Fishman E. S. Louie M. Miltner A. M. Cheema S. K. Wong J. Schlaeger N. M. (2021). MicroRNA Signatures of the Developing Primate Fovea. Front. Cel. Dev. Biol. 9, 654385. 10.3389/fcell.2021.654385 PMC8060505 33898453 · DOI
  51. Fogerty J. Stepanyan R. Cianciolo L. T. Tooke B. P. Perkins B. D. (2019). Genomic Non-redundancy of the Mir-183/96/182 Cluster and its Requirement for Hair Cell Maintenance. Sci. Rep. 9 (1), 10302. 10.1038/s41598-019-46593-y 31311951 PMC6635406 · DOI
  52. Friedman R. C. Farh K. K.-H. Burge C. B. Bartel D. P. (2009). Most Mammalian mRNAs Are Conserved Targets of microRNAs. Genome Res. 19 (1), 92– 105. 10.1101/gr.082701.108 18955434 PMC2612969 · DOI · Paper page
  53. Furukawa T. Mukherjee S. Bao Z.-Z. Morrow E. M. Cepko C. L. (2000). Rax, Hes1, and Notch1 Promote the Formation of Müller Glia by Postnatal Retinal Progenitor Cells. Neuron 26 (2), 383– 394. 10.1016/s0896-6273(00)81171-x 10839357 · DOI
  54. Gao F. Zhang Y.-F. Zhang Z.-P. Fu L.-A. Cao X.-L. Zhang Y.-Z. (2017). miR-342-5p Regulates Neural Stem Cell Proliferation and Differentiation Downstream to Notch Signaling in Mice. Stem Cel. Rep. 8 (4), 1032– 1045. 10.1016/j.stemcr.2017.02.017 PMC5390133 28344005 · DOI
  55. Gao L. Jiang B. Lei D. Zhou X. Yuan H. (2016a). Expression Profiling of microRNAs in Optineurin (E50K) Mutant Transgenic Mice. Biomed. Rep. 4 (2), 193– 196. 10.3892/br.2015.565 26893837 PMC4734194 · DOI
  56. Gao Q. Zhou L. Yang S.-Y. Cao J.-M. (2016b). A Novel Role of microRNA 17-5p in the Modulation of Circadian Rhythm. Sci. Rep. 6, 30070. 10.1038/srep30070 27440219 PMC4954982 · DOI
  57. Georgi S. A. Reh T. A. (2011). Dicer Is Required for the Maintenance of Notch Signaling and Gliogenic Competence During Mouse Retinal Development. Devel. Neurobio. 71 (12), 1153– 1169. 10.1002/dneu.20899 PMC5373852 21542136 · DOI
  58. Georgi S. A. Reh T. A. (2010). Dicer Is Required for the Transition from Early to Late Progenitor State in the Developing Mouse Retina. J. Neurosci. 30 (11), 4048– 4061. 10.1523/JNEUROSCI.4982-09.2010 20237275 PMC2853880 · DOI
  59. Gérard C. Lemaigre F. Gonze D. (2019). Modeling the Dynamics of Let-7-Coupled Gene Regulatory Networks Linking Cell Proliferation to Malignant Transformation. Front. Physiol. 10, 848. 10.3389/fphys.2019.00848 31354514 PMC6637753 · DOI
  60. Glaser T. Jepeal L. Edwards J. G. Young S. R. Favor J. Maas R. L. (1994). PAX6 Gene Dosage Effect in a Family with Congenital Cataracts, Aniridia, Anophthalmia and central Nervous System Defects. Nat. Genet. 7 (4), 463– 471. 10.1038/ng0894-463 7951315 · DOI
  61. Glaser T. Walton D. S. Maas R. L. (1992). Genomic Structure, Evolutionary Conservation and Aniridia Mutations in the Human PAX6 Gene. Nat. Genet. 2 (3), 232– 239. 10.1038/ng1192-232 1345175 · DOI
  62. Goodfellow M. Phillips N. E. Manning C. Galla T. Papalopulu N. (2014). microRNA Input into a Neural Ultradian Oscillator Controls Emergence and Timing of Alternative Cell States. Nat. Commun. 5, 3399. 10.1038/ncomms4399 24595054 PMC3959193 · DOI
  63. Ha M. Kim V. N. (2014). Regulation of microRNA Biogenesis. Nat. Rev. Mol. Cel. Biol. 15 (8), 509– 524. 10.1038/nrm3838 25027649 · DOI · Paper page
  64. Hackler L. Jr. Wan J. Swaroop A. Qian J. Zack D. J. (2010). MicroRNA Profile of the Developing Mouse Retina. Invest. Ophthalmol. Vis. Sci. 51 (4), 1823– 1831. 10.1167/iovs.09-4657 19933188 PMC2868396 · DOI
  65. Hirata H. Yoshiura S. Ohtsuka T. Bessho Y. Harada T. Yoshikawa K. (2002). Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop. Science 298 (5594), 840– 843. 10.1126/science.1074560 12399594 · DOI
  66. Hwang H.-W. Wentzel E. A. Mendell J. T. (2007). A Hexanucleotide Element Directs microRNA Nuclear Import. Science 315 (5808), 97– 100. 10.1126/science.1136235 17204650 · DOI
  67. Iida A. Shinoe T. Baba Y. Mano H. Watanabe S. (2011). Dicer Plays Essential Roles for Retinal Development by Regulation of Survival and Differentiation. Invest. Ophthalmol. Vis. Sci. 52 (6), 3008– 3017. 10.1167/iovs.10-6428 21273552 · DOI
  68. Imayoshi I. Isomura A. Harima Y. Kawaguchi K. Kori H. Miyachi H. (2013). Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors. Science 342 (6163), 1203– 1208. 10.1126/science.1242366 24179156 · DOI
  69. Indrieri A. Carrella S. Romano A. Spaziano A. Marrocco E. Fernandez‐Vizarra E. (2019). miR‐181a/b Downregulation Exerts a Protective Action on Mitochondrial Disease Models. EMBO Mol. Med. 11 (5), e8734. 10.15252/emmm.201708734 30979712 PMC6505685 · DOI
  70. Intartaglia D. Giamundo G. Conte I. (2020). The Impact of miRNAs in Health and Disease of Retinal Pigment Epithelium. Front. Cel Dev. Biol. 8, 589985. 10.3389/fcell.2020.589985 PMC7844312 33520981 · DOI
  71. Inui M. Martello G. Piccolo S. (2010). MicroRNA Control of Signal Transduction. Nat. Rev. Mol. Cel Biol 11 (4), 252– 263. 10.1038/nrm2868 20216554 · DOI
  72. Jadhav A. P. Cho S.-H. Cepko C. L. (2006). Notch Activity Permits Retinal Cells to Progress through Multiple Progenitor States and Acquire a Stem Cell Property. Proc. Natl. Acad. Sci. 103 (50), 18998– 19003. 10.1073/pnas.0608155103 17148603 PMC1682012 · DOI
  73. Jarriault S. Brou C. Logeat F. Schroeter E. H. Kopan R. Israel A. (1995). Signalling Downstream of Activated Mammalian Notch. Nature 377 (6547), 355– 358. 10.1038/377355a0 7566092 · DOI
  74. Johnson S. M. Grosshans H. Shingara J. Byrom M. Jarvis R. Cheng A. (2005). RAS Is Regulated by the Let-7 microRNA Family. Cell 120 (5), 635– 647. 10.1016/j.cell.2005.01.014 15766527 · DOI
  75. Kapranov P. Cawley S. E. Drenkow J. Bekiranov S. Strausberg R. L. Fodor S. P. A. (2002). Large-scale Transcriptional Activity in Chromosomes 21 and 22. Science 296 (5569), 916– 919. 10.1126/science.1068597 11988577 · DOI
  76. Karali M. Peluso I. Gennarino V. A. Bilio M. Verde R. Lago G. (2010). miRNeye: A microRNA Expression Atlas of the Mouse Eye. BMC Genomics 11, 715. 10.1186/1471-2164-11-715 21171988 PMC3018480 · DOI
  77. Karali M. Persico M. Mutarelli M. Carissimo A. Pizzo M. Singh Marwah V. (2016). High-resolution Analysis of the Human Retina miRNome Reveals isomiR Variations and Novel microRNAs. Nucleic Acids Res. 44 (4), 1525– 1540. 10.1093/nar/gkw039 26819412 PMC4770244 · DOI
  78. Kaufman M. L. Park K. U. Goodson N. B. Chew S. Bersie S. Jones K. L. (2019). Transcriptional Profiling of Murine Retinas Undergoing Semi-synchronous Cone Photoreceptor Differentiation. Developmental Biol. 453 (2), 155– 167. 10.1016/j.ydbio.2019.05.016 PMC7722777 31163126 · DOI
  79. Ko G. Y. P. (2020). Circadian Regulation in the Retina: From Molecules to Network. Eur. J. Neurosci. 51 (1), 194– 216. 10.1111/ejn.14185 30270466 PMC6441387 · DOI
  80. Kozomara A. Griffiths-Jones S. (2011). miRBase: Integrating microRNA Annotation and Deep-Sequencing Data. Nucleic Acids Res. 39, D152– D157. 10.1093/nar/gkq1027 21037258 PMC3013655 · DOI · Paper page
  81. Krol J. Busskamp V. Markiewicz I. Stadler M. B. Ribi S. Richter J. (2010). Characterizing Light-Regulated Retinal microRNAs Reveals Rapid Turnover as a Common Property of Neuronal microRNAs. Cell 141 (4), 618– 631. 10.1016/j.cell.2010.03.039 20478254 · DOI · Paper page
  82. La Torre A. Georgi S. Reh T. A. (2013). Conserved microRNA Pathway Regulates Developmental Timing of Retinal Neurogenesis. Proc. Natl. Acad. Sci. 110 (26), E2362– E2370. 10.1073/pnas.1301837110 23754433 PMC3696811 · DOI
  83. Lagos-Quintana M. Rauhut R. Meyer J. Borkhardt A. Tuschl T. (2003). New microRNAs from Mouse and Human. RNA 9 (2), 175– 179. 10.1261/rna.2146903 12554859 PMC1370382 · DOI · Paper page
  84. Lagos-Quintana M. Rauhut R. Yalcin A. Meyer J. Lendeckel W. Tuschl T. (2002). Identification of Tissue-specific microRNAs from Mouse. Curr. Biol. 12 (9), 735– 739. 10.1016/s0960-9822(02)00809-6 12007417 · DOI · Paper page
  85. Lauderdale J. D. Wilensky J. S. Oliver E. R. Walton D. S. Glaser T. (2000). 3' Deletions Cause Aniridia by Preventing PAX6 Gene Expression. Proc. Natl. Acad. Sci. 97 (25), 13755– 13759. 10.1073/pnas.240398797 11087823 PMC17648 · DOI
  86. LaVail M. M. Ward P. A. (1978). Studies on the Hormonal Control of Circadian Outer Segment Disc Shedding in the Rat Retina. Invest. Ophthalmol. Vis. Sci. 17 (12), 1189– 1193. https://iovs.arvojournals.org/article.aspx?articleid=2158737. 721391
  87. Lee R. C. Ambros V. (2001). An Extensive Class of Small RNAs in Caenorhabditis elegans. Science 294 (5543), 862– 864. 10.1126/science.1065329 11679672 · DOI · Paper page
  88. Lee R. C. Feinbaum R. L. Ambros V. (1993). The C. elegans Heterochronic Gene Lin-4 Encodes Small RNAs with Antisense Complementarity to Lin-14. Cell 75 (5), 843– 854. 10.1016/0092-8674(93)90529-y 8252621 · DOI · Paper page
  89. Lee Y. S. Dutta A. (2007). The Tumor Suppressor microRNA Let-7 Represses the HMGA2 Oncogene. Genes Dev. 21 (9), 1025– 1030. 10.1101/gad.1540407 17437991 PMC1855228 · DOI
  90. Leucht C. Stigloher C. Wizenmann A. Klafke R. Folchert A. Bally-Cuif L. (2008). MicroRNA-9 Directs Late Organizer Activity of the Midbrain-Hindbrain Boundary. Nat. Neurosci. 11 (6), 641– 648. 10.1038/nn.2115 18454145 · DOI · Paper page
  91. Lewis B. P. Shih I.-h. Jones-Rhoades M. W. Bartel D. P. Burge C. B. (2003). Prediction of Mammalian microRNA Targets. Cell 115 (7), 787– 798. 10.1016/s0092-8674(03)01018-3 14697198 · DOI · Paper page
  92. Liu Q. Novak M. K. Pepin R. M. Eich T. Hu W. (2021). microRNA-Mediated Regulation of microRNA Machinery Controls Cell Fate Decisions. Elife 10. 10.7554/eLife.72289 PMC8504967 34596044 · DOI
  93. Loscher C. J. Hokamp K. Kenna P. F. Ivens A. C. Humphries P. Palfi A. (2007). Altered Retinal microRNA Expression Profile in a Mouse Model of Retinitis Pigmentosa. Genome Biol. 8 (11), R248. 10.1186/gb-2007-8-11-r248 18034880 PMC2258196 · DOI
  94. Louvi A. Artavanis-Tsakonas S. (2006). Notch Signalling in Vertebrate Neural Development. Nat. Rev. Neurosci. 7 (2), 93– 102. 10.1038/nrn1847 16429119 · DOI
  95. Lowrey P. L. Takahashi J. S. (2004). Mammalian Circadian Biology: Elucidating Genome-wide Levels of Temporal Organization. Annu. Rev. Genom. Hum. Genet. 5, 407– 441. 10.1146/annurev.genom.5.061903.175925 PMC3770722 15485355 · DOI · Paper page
  96. Lumayag S. Haldin C. E. Corbett N. J. Wahlin K. J. Cowan C. Turturro S. (2013). Inactivation of the microRNA-183/96/182 Cluster Results in Syndromic Retinal Degeneration. Proc. Natl. Acad. Sci. 110 (6), E507– E516. 10.1073/pnas.1212655110 23341629 PMC3568372 · DOI
  97. Maeda A. Tsujiya S. Higashide T. Toida K. Todo T. Ueyama T. (2006). Circadian Intraocular Pressure Rhythm Is Generated by Clock Genes. Invest. Ophthalmol. Vis. Sci. 47 (9), 4050– 4052. 10.1167/iovs.06-0183 16936122 · DOI
  98. Makarev E. Spence J. R. Del Rio-Tsonis K. Tsonis P. A. (2006). Identification of microRNAs and Other Small RNAs from the Adult Newt Eye. Mol. Vis. 12, 1386– 1391. http://www.molvis.org/molvis/v12/a156/. 17149364
  99. Malumbres M. Barbacid M. (2001). To Cycle or Not to Cycle: A Critical Decision in Cancer. Nat. Rev. Cancer 1 (3), 222– 231. 10.1038/35106065 11902577 · DOI
  100. Masamizu Y. Ohtsuka T. Takashima Y. Nagahara H. Takenaka Y. Yoshikawa K. (2006). Real-time Imaging of the Somite Segmentation Clock: Revelation of Unstable Oscillators in the Individual Presomitic Mesoderm Cells. Proc. Natl. Acad. Sci. 103 (5), 1313– 1318. 10.1073/pnas.0508658103 16432209 PMC1345707 · DOI
  101. Mattick J. S. Makunin I. V. (2006). Non-coding RNA. Hum. Mol. Genet. 15, R17– R29. 10.1093/hmg/ddl046 16651366 · DOI
  102. Mercer T. R. Mattick J. S. (2013). Understanding the Regulatory and Transcriptional Complexity of the Genome Through Structure. Genome Res. 23 (7), 1081– 1088. 10.1101/gr.156612.113 23817049 PMC3698501 · DOI
  103. Miyata T. (2008). Development of Three-Dimensional Architecture of the Neuroepithelium: Role of Pseudostratification and Cellular ‘community'. Dev. Growth Differ. 50 (Suppl. 1), S105– S112. 10.1111/j.1440-169X.2007.00980.x 18070110 · DOI
  104. Moss E. G. Lee R. C. Ambros V. (1997). The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the Lin-4 RNA. Cell 88 (5), 637– 646. 10.1016/s0092-8674(00)81906-6 9054503 · DOI · Paper page
  105. Mu G. Liu H. Zhou F. Xu X. Jiang H. Wang Y. (2010). Correlation of Overexpression of HMGA1 and HMGA2 with Poor Tumor Differentiation, Invasion, and Proliferation Associated with Let-7 Down-Regulation in Retinoblastomas. Hum. Pathol. 41 (4), 493– 502. 10.1016/j.humpath.2009.08.022 20004941 · DOI
  106. Nelson B. R. Hartman B. H. Georgi S. A. Lan M. S. Reh T. A. (2007). Transient Inactivation of Notch Signaling Synchronizes Differentiation of Neural Progenitor Cells. Developmental Biol. 304 (2), 479– 498. 10.1016/j.ydbio.2007.01.001 PMC1979095 17280659 · DOI
  107. Nelson B. R. Ueki Y. Reardon S. Karl M. O. Georgi S. Hartman B. H. (2011). Genome-Wide Analysis of Müller Glial Differentiation Reveals a Requirement for Notch Signaling in Postmitotic Cells to Maintain the Glial Fate. PLoS One 6 (8), e22817. 10.1371/journal.pone.0022817 21829655 PMC3149061 · DOI
  108. Norbury C. Nurse P. (1992). Animal Cell Cycles and Their Control. Annu. Rev. Biochem. 61, 441– 468. 10.1146/annurev.bi.61.070192.002301 1497317 · DOI
  109. Norden C. Young S. Link B. A. Harris W. A. (2009). Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina. Cell 138 (6), 1195– 1208. 10.1016/j.cell.2009.06.032 19766571 PMC2791877 · DOI
  110. Ohana R. Weiman-Kelman B. Raviv S. Tamm E. Pasmanik-Chor M. Rinon A. (2015). MicroRNAs of the RPE Are Essential for RPE Differentiation and Photoreceptor Maturation. Development 142 (14), 2487– 2498. 10.1242/dev.121533 26062936 · DOI
  111. Ohtsuka T. Ishibashi M. Gradwohl G. Nakanishi S. Guillemot F. Kageyama R. (1999). Hes1 and Hes5 as Notch Effectors in Mammalian Neuronal Differentiation. EMBO J. 18 (8), 2196– 2207. 10.1093/emboj/18.8.2196 10205173 PMC1171303 · DOI · Paper page
  112. Pasquinelli A. E. Reinhart B. J. Slack F. Martindale M. Q. Kuroda M. I. Maller B. (2000). Conservation of the Sequence and Temporal Expression of Let-7 Heterochronic Regulatory RNA. Nature 408 (6808), 86– 89. 10.1038/35040556 11081512 · DOI
  113. Patterson M. Gaeta X. Loo K. Edwards M. Smale S. Cinkornpumin J. (2014). let-7 miRNAs Can Act Through Notch to Regulate Human Gliogenesis. Stem Cel. Rep. 3 (5), 758– 773. 10.1016/j.stemcr.2014.08.015 PMC4235151 25316189 · DOI · Paper page
  114. Peskova L. Jurcikova D. Vanova T. Krivanek J. Capandova M. Sramkova Z. (2020). miR-183/96/182 Cluster Is an Important Morphogenetic Factor Targeting PAX6 Expression in Differentiating Human Retinal Organoids. Stem Cells 38, 1557– 1567. 10.1002/stem.3272 32875669 · DOI
  115. Pierfelice T. Alberi L. Gaiano N. (2011). Notch in the Vertebrate Nervous System: An Old Dog with New Tricks. Neuron 69 (5), 840– 855. 10.1016/j.neuron.2011.02.031 21382546 · DOI
  116. Pinter R. Hindges R. (2010). Perturbations of microRNA Function in Mouse Dicer Mutants Produce Retinal Defects and Lead to Aberrant Axon Pathfinding at the Optic Chiasm. PLoS One 5 (4), e10021. 10.1371/journal.pone.0010021 20386732 PMC2850387 · DOI
  117. Qiu R. Liu K. Liu Y. Mo W. Flynt A. S. Patton J. G. (2009). The Role of miR-124a in Early Development of the Xenopus Eye. Mech. Development 126 (10), 804– 816. 10.1016/j.mod.2009.08.002 PMC4445405 19703558 · DOI
  118. Ramachandran R. Fausett B. V. Goldman D. (2010). Ascl1a Regulates Müller Glia Dedifferentiation and Retinal Regeneration Through a Lin-28-dependent, Let-7 microRNA Signalling Pathway. Nat. Cel. Biol. 12 (11), 1101– 1107. 10.1038/ncb2115 PMC2972404 20935637 · DOI
  119. Reinhart B. J. Slack F. J. Basson M. Pasquinelli A. E. Bettinger J. C. Rougvie A. E. (2000). The 21-nucleotide Let-7 RNA Regulates Developmental Timing in Caenorhabditis elegans. Nature 403 (6772), 901– 906. 10.1038/35002607 10706289 · DOI
  120. Riesenberg A. N. Liu Z. Kopan R. Brown N. L. (2009). Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina. J. Neurosci. 29 (41), 12865– 12877. 10.1523/JNEUROSCI.3382-09.2009 19828801 PMC2788434 · DOI
  121. Roese-Koerner B. Stappert L. Berger T. Braun N. C. Veltel M. Jungverdorben J. (2016). Reciprocal Regulation between Bifunctional miR-9/9∗ and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation. Stem Cel. Rep. 7 (2), 207– 219. 10.1016/j.stemcr.2016.06.008 PMC4982985 27426040 · DOI
  122. Roese-Koerner B. Stappert L. Brüstle O. (2017). Notch/Hes Signaling and miR-9 Engage in Complex Feedback Interactions Controlling Neural Progenitor Cell Proliferation and Differentiation. Neurogenesis 4 (1), e1313647. 10.1080/23262133.2017.1313647 28573150 PMC5443189 · DOI · Paper page
  123. Ryan D. G. Oliveira-Fernandes M. Lavker R. M. (2006). MicroRNAs of the Mammalian Eye Display Distinct and Overlapping Tissue Specificity. Mol. Vis. 12, 1175– 1184. http://www.molvis.org/molvis/v12/a134/. 17102797
  124. Sage J. Ventura A. (2011). miR Than Meets the Eye: Figure 1. Genes Dev. 25 (16), 1663– 1667. 10.1101/gad.17454011 21852531 PMC3165930 · DOI
  125. Sahu A. Devi S. Jui J. Goldman D. (2021). Notch Signaling via Hey1 and Id2b Regulates Müller Glia's Regenerative Response to Retinal Injury. Glia 69 (12), 2882– 2898. 10.1002/glia.24075 34415582 PMC8502208 · DOI
  126. Sampson V. B. Rong N. H. Han J. Yang Q. Aris V. Soteropoulos P. (2007). MicroRNA Let-7a Down-Regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma Cells. Cancer Res. 67 (20), 9762– 9770. 10.1158/0008-5472.CAN-07-2462 17942906 · DOI
  127. Sangoram A. M. Saez L. Antoch M. P. Gekakis N. Staknis D. Whiteley A. (1998). Mammalian Circadian Autoregulatory Loop. Neuron 21 (5), 1101– 1113. 10.1016/s0896-6273(00)80627-3 9856465 · DOI
  128. Sauer F. C. (1935). Mitosis in the Neural Tube. J. Comp. Neurol. 62 (2), 377– 405. 10.1002/cne.900620207 · DOI
  129. Shimojo H. Isomura A. Ohtsuka T. Kori H. Miyachi H. Kageyama R. (2016). Oscillatory Control of Delta-like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis. Genes Dev. 30 (1), 102– 116. 10.1101/gad.270785.115 26728556 PMC4701973 · DOI
  130. Shimojo H. Ohtsuka T. Kageyama R. (2008). Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors. Neuron 58 (1), 52– 64. 10.1016/j.neuron.2008.02.014 18400163 · DOI
  131. Shu P. Wu C. Ruan X. Liu W. Hou L. Fu H. (2019). Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental Cel. 49 (5), 764– 785. 10.1016/j.devcel.2019.04.017 31080058 · DOI
  132. Smit-McBride Z. Nguyen A. T. Yu A. K. Modjtahedi S. P. Hunter A. A. Rashid S. (2020). Unique Molecular Signatures of microRNAs in Ocular Fluids and Plasma in Diabetic Retinopathy. PLoS One 15 (7), e0235541. 10.1371/journal.pone.0235541 32692745 PMC7373301 · DOI
  133. Sridhar A. Hoshino A. Finkbeiner C. R. Chitsazan A. Dai L. Haugan A. K. (2020). Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures. Cel. Rep. 30 (5), 1644– 1659. 10.1016/j.celrep.2020.01.007 PMC7901645 32023475 · DOI
  134. Storch K.-F. Paz C. Signorovitch J. Raviola E. Pawlyk B. Li T. (2007). Intrinsic Circadian Clock of the Mammalian Retina: Importance for Retinal Processing of Visual Information. Cell 130 (4), 730– 741. 10.1016/j.cell.2007.06.045 17719549 PMC2040024 · DOI · Paper page
  135. Sundermeier T. R. Sakami S. Sahu B. Howell S. J. Gao S. Dong Z. (2017). MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J. Biol. Chem. 292 (8), 3366– 3378. 10.1074/jbc.M116.770024 28104803 PMC5336169 · DOI
  136. Tan S.-L. Ohtsuka T. González A. Kageyama R. (2012). MicroRNA9 Regulates Neural Stem Cell Differentiation by Controlling Hes1 Expression Dynamics in the Developing Brain. Genes Cells 17 (12), 952– 961. 10.1111/gtc.12009 23134481 · DOI
  137. Taylor S. M. Alvarez-Delfin K. Saade C. J. Thomas J. L. Thummel R. Fadool J. M. (2015). The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration through Delta-Notch Signaling. Invest. Ophthalmol. Vis. Sci. 56 (12), 7496– 7515. 10.1167/iovs.15-17616 26580854 PMC4654396 · DOI
  138. Taylor S. M. Giuffre E. Moseley P. Hitchcock P. F. (2019). The MicroRNA, miR-18a, Regulates NeuroD and Photoreceptor Differentiation in the Retina of Zebrafish. Develop Neurobiol. 79 (2), 202– 219. 10.1002/dneu.22666 PMC6351175 30615274 · DOI
  139. Thomas E. D. Timms A. E. Giles S. Harkins-Perry S. Lyu P. Hoang T. (2021). Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-specific Cis-Regulatory Elements and Mechanisms of Non-coding Genetic Disease Risk. bioRxiv 2007, 2031– 454254. 10.1101/2021.07.31.454254 · DOI
  140. Tomita K. Ishibashi M. Nakahara K. Ang S.-L. Nakanishi S. Guillemot F. (1996). Mammalian Hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis. Neuron 16 (4), 723– 734. 10.1016/s0896-6273(00)80093-8 8607991 · DOI
  141. Tosini G. Pozdeyev N. Sakamoto K. Iuvone P. M. (2008). The Circadian Clock System in the Mammalian Retina. Bioessays 30 (7), 624– 633. 10.1002/bies.20777 18536031 PMC2505342 · DOI
  142. Villarreal G. Jr. Oh D.-J. Kang M. H. Rhee D. J. (2011). Coordinated Regulation of Extracellular Matrix Synthesis by the microRNA-29 Family in the Trabecular Meshwork. Invest. Ophthalmol. Vis. Sci. 52 (6), 3391– 3397. 10.1167/iovs.10-6165 21330653 PMC3109034 · DOI
  143. Walker J. C. Harland R. M. (2009). microRNA-24a Is Required to Repress Apoptosis in the Developing Neural Retina. Genes Dev. 23 (9), 1046– 1051. 10.1101/gad.1777709 19372388 PMC2682950 · DOI
  144. Wang Q. Navitskaya S. Chakravarthy H. Huang C. Kady N. Lydic T. A. (2016). Dual Anti-inflammatory and Anti-angiogenic Action of miR-15a in Diabetic Retinopathy. EBioMedicine 11, 138– 150. 10.1016/j.ebiom.2016.08.013 27531575 PMC5049929 · DOI
  145. Weston M. D. Pierce M. L. Rocha-Sanchez S. Beisel K. W. Soukup G. A. (2006). MicroRNA Gene Expression in the Mouse Inner Ear. Brain Res. 1111 (1), 95– 104. 10.1016/j.brainres.2006.07.006 16904081 · DOI
  146. Wienholds E. Kloosterman W. P. Miska E. Alvarez-Saavedra E. Berezikov E. de Bruijn E. (2005). MicroRNA Expression in Zebrafish Embryonic Development. Science 309 (5732), 310– 311. 10.1126/science.1114519 15919954 · DOI · Paper page
  147. Wohl S. G. Hooper M. J. Reh T. A. (2019). MicroRNAs miR-25, Let-7 and miR-124 Regulate the Neurogenic Potential of Müller Glia in Mice. Development 146 (17). 10.1242/dev.179556 PMC6765125 31383796 · DOI
  148. Wohl S. G. Jorstad N. L. Levine E. M. Reh T. A. (2017). Müller Glial microRNAs Are Required for the Maintenance of Glial Homeostasis and Retinal Architecture. Nat. Commun. 8 (1), 1603. 10.1038/s41467-017-01624-y 29150673 PMC5693933 · DOI
  149. Wohl S. G. Reh T. A. (2016b). miR-124-9-9* Potentiates Ascl1-Induced Reprogramming of Cultured Müller Glia. Glia 64 (5), 743– 762. 10.1002/glia.22958 26732729 PMC5303620 · DOI
  150. Wohl S. G. Reh T. A. (2016a). The microRNA Expression Profile of Mouse Müller Glia In Vivo and In Vitro. Sci. Rep. 6, 35423. 10.1038/srep35423 27739496 PMC5064377 · DOI
  151. Wu Y.-C. Chen C.-H. Mercer A. Sokol N. S. (2012). Let-7-complex microRNAs Regulate the Temporal Identity of Drosophila Mushroom Body Neurons via Chinmo. Developmental Cel. 23 (1), 202– 209. 10.1016/j.devcel.2012.05.013 PMC3401410 22814608 · DOI
  152. Wuarin J. Falvey E. Lavery D. Talbot D. Schmidt E. Ossipow V. (1992). The Role of the Transcriptional Activator Protein DBP in Circadian Liver Gene Expression. J. Cel. Sci. Suppl. 1992, 123– 127. 10.1242/jcs.1992.supplement_16.15 1297647 · DOI
  153. Xia X. Ahmad I. (2016). let-7 microRNA Regulates Neurogliogenesis in the Mammalian Retina Through Hmga2. Developmental Biol. 410 (1), 70– 85. 10.1016/j.ydbio.2015.12.010 26698218 · DOI
  154. Xu S. Witmer P. D. Lumayag S. Kovacs B. Valle D. (2007). MicroRNA (miRNA) Transcriptome of Mouse Retina and Identification of a Sensory Organ-specific miRNA Cluster. J. Biol. Chem. 282 (34), 25053– 25066. 10.1074/jbc.M700501200 17597072 · DOI
  155. Yan Y. Salazar T. E. Dominguez J. M. 2nd Nguyen D. V. Li Calzi S. Bhatwadekar A. D. (2013). Dicer Expression Exhibits a Tissue-specific Diurnal Pattern that Is Lost During Aging and in Diabetes. PLoS One 8 (11), e80029. 10.1371/journal.pone.0080029 24244599 PMC3820540 · DOI
  156. Yang M. Lee J.-E. Padgett R. W. Edery I. (2008). Circadian Regulation of a Limited Set of Conserved microRNAs in Drosophila. BMC Genomics 9, 83. 10.1186/1471-2164-9-83 18284684 PMC2263044 · DOI
  157. Yang Y. Mei Q. (2015). miRNA Signature Identification of Retinoblastoma and the Correlations Between Differentially Expressed miRNAs During Retinoblastoma Progression. Mol. Vis. 21, 1307– 1317. http://www.molvis.org/molvis/v21/1307/. 26730174 PMC4688417
  158. Yaron O. Farhy C. Marquardt T. Applebury M. Ashery-Padan R. (2006). Notch1 Functions to Suppress Cone-Photoreceptor Fate Specification in the Developing Mouse Retina. Development 133 (7), 1367– 1378. 10.1242/dev.02311 16510501 · DOI
  159. Yu Z. Wang L. Wang C. Ju X. Wang M. Chen K. (2013). Cyclin D1 Induction of Dicer Governs microRNA Processing and Expression in Breast Cancer. Nat. Commun. 4, 2812. 10.1038/ncomms3812 24287487 PMC3874416 · DOI
  160. Zhao C. Sun G. Li S. Lang M.-F. Yang S. Li W. (2010). MicroRNA Let-7b Regulates Neural Stem Cell Proliferation and Differentiation by Targeting Nuclear Receptor TLX Signaling. Proc. Natl. Acad. Sci. USA 107 (5), 1876– 1881. 10.1073/pnas.0908750107 20133835 PMC2836616 · DOI
  161. Zhou L. Miller C. Miraglia L. J. Romero A. Mure L. S. Panda S. (2021). A Genome-wide microRNA Screen Identifies the microRNA-183/96/182 Cluster as a Modulator of Circadian Rhythms. Proc. Natl. Acad. Sci. USA 118 (1), e2020454118. 10.1073/pnas.2020454118 33443164 PMC7817116 · DOI
  162. Zhu Q. Sun W. Okano K. Chen Y. Zhang N. Maeda T. (2011). Sponge Transgenic Mouse Model Reveals Important Roles for the microRNA-183 (miR-183)/96/182 Cluster in Postmitotic Photoreceptors of the Retina. J. Biol. Chem. 286 (36), 31749– 31760. 10.1074/jbc.M111.259028 21768104 PMC3173082 · DOI
  163. Zuzic M. Rojo Arias J. E. Wohl S. G. Busskamp V. (2019). Retinal miRNA Functions in Health and Disease. Genes 10 (5), 377. 10.3390/genes10050377 PMC6562649 31108959 · DOI
  164. Zylka M. J. Shearman L. P. Levine J. D. Jin X. Weaver D. R. Reppert S. M. (1998). Molecular Analysis of Mammalian Timeless. Neuron 21 (5), 1115– 1122. 10.1016/s0896-6273(00)80628-5 9856466 · DOI

Cited by

Sorted by citations

Authors
Fishman, E. S., Han, J. S., & La Torre, A.
Affiliations
University of California, Davis (US)
ORCID
Han, Jisoo S.
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2022-02-02
Volume
10
Pages
831750-831750
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2022.831750
PMC
PMC8847441
OpenAlex
W4210642197
Cited by
16
References
7
Citations by year
2026: 5 · 2025: 2 · 2024: 4 · 2023: 5
FWCI
0.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
retinal development, transcriptional feedback loop, circadian clock, biological clock, gene expression rhythms, small RNA, temporal patterning

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review