Cited by 999Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

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Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

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Kadoshima, Taisuke, Sakaguchi, Hideya, Nakano, Tokushige, Soen, Mika, Ando, Satoshi, Eiraku, Mototsugu, Sasai, Yoshiki·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1315710110PMC PMC3864329

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Abstract

Significance: Using 3D culture of human ES cells, we show new self-organizing aspects of human corticogenesis: spontaneous development of intracortical polarity, curving morphology, and complex zone separations. Moreover, this culture generates species-specific progenitors, outer radial glia, which are abundantly present in the human, but not mouse, neocortex. Our study suggests an unexpectedly wide range of self-organizing events that are driven by internal programs in human neocortex development.

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Authors: Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y.
Affiliations: Kyoto University (JP)
Laboratory of Organogenesis and Neurogenesis and
RIKEN (JP)
ORCID: Sakaguchi, Hideya
Ando, Satoshi
Eiraku, Mototsugu
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-11-25
Volume: 110
Issue: 50
Pages: 20284-20289
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1315710110
PMC: PMC3864329
OpenAlex: W2051785391
Cited by: 999
References: 33
Citations by year: 2026: 62 · 2025: 99 · 2024: 90 · 2023: 84 · 2022: 122 · 2021: 113 · 2020: 113 · 2019: 94 · 2018: 66 · 2017: 66 · 2016: 44 · 2015: 30 · 2014: 16
FWCI: 11.13
Type: journal article
Language: en
Update notices: correction (2014-04-29)
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science (24680037)
Japan Science and Technology Agency
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: human embryonic stem cells, self-organization, axial polarity, subplate, cortical plate, outer subventricular zone, outer radial glia, 3D cell culture, cortical morphogenesis
MeSH terms: Amides, Collagen, Drug Combinations, Humans, Laminin, Neuroglia, Proteoglycans, Pyridines, Species Specificity, Cell Polarity, Cell Culture Techniques, Neocortex, Organogenesis, Embryonic Stem Cells

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Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

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