Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372

A ROCK inhibitor permits survival of dissociated human embryonic stem cells

Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S.-I., Muguruma, K., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1310 · Cited by 2,055

Neuronal subtype specification in the cerebral cortex

Molyneaux, B. J., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2151 · Cited by 1,704

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522

Self-formation of optic cups and storable stratified neural retina from human ESCs

Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447

Neurogenic radial glia in the outer subventricular zone of human neocortex

Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388

Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition

Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161

Development of the human cerebral cortex: Boulder Committee revisited

Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977

Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain

Kostović, I., & RAKIC, P. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902970309 · Cited by 912

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830

Next generation organoids for biomedical research and applications

Lou, Y., & Leung, A. W. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.10.005 · Cited by 138

Microglia increase inflammatory responses in iPSC-derived human BrainSpheres

Abreu, C. M., Gama, L., Krasemann, S., Chesnut, M., Odwin-Dacosta, S., Hogberg, H. T., Hartung, T., & Pamies, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02766 · Cited by 123

Self-Organized Synchronous Calcium Transients in a Cultured Human Neural Network Derived from Cerebral Organoids

Sakaguchi, H., Ozaki, Y., Ashida, T., Matsubara, T., Oishi, N., Kihara, S., & Takahashi, J. B. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.05.029 · Cited by 134

Engineering bone/cartilage organoids: strategy, progress, and application

Bai, L., Zhou, D., Li, G., Liu, J., Chen, X., & Su, J. (2024) · Bone Research · doi:10.1038/s41413-024-00376-y · Cited by 145

Neural Substrate Expansion for the Restoration of Brain Function

Chen, H.-C. I., Jgamadze, D., Serruya, M. D., Cullen, D. K., Wolf, J. A., & Smith, D. H. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00001 · Cited by 127

Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models

Buchsbaum, I. Y., & Cappello, S. (2019) · Development · doi:10.1242/dev.163766 · Cited by 132

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

Fleck, J. S., Sanchís-Calleja, F., He, Z., Santel, M., Boyle, M. J., Camp, J. G., & Treutlein, B. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.02.015 · Cited by 118

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

Mungenast, A. E., Siegert, S., & Tsai, L. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.11.010 · Cited by 136

Genetics and mechanisms leading to human cortical malformations

Romero, D. M., Bahi‐Buisson, N., & Francis, F. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.031 · Cited by 136

The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168870 · Cited by 123

Experimental models and tools to tackle glioblastoma

Robertson, F., Marqués‐Torrejón, M. Á., Morrison, G. M., & Pollard, S. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040386 · Cited by 127

Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

Tanaka, T., Yokoi, T., Tamalu, F., Watanabe, S., Nishina, S., & Azuma, N. (2015) · Scientific Reports · doi:10.1038/srep08344 · Cited by 122

Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras

Chen, H. I., Wolf, J. A., Blue, R., Song, M. M., Moreno, J. D., Ming, G., & Song, H. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.09.002 · Cited by 131

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund, I., Dougalis, A., Shakirzyanova, A., Gómez‐Budia, M., Pelkonen, A., Konttinen, H., Ohtonen, S., Fazaludeen, M. F., Koskuvi, M., Kuusisto, J., et al. (2021) · Cells · doi:10.3390/cells11010124 · Cited by 127

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

de Jong, J. O., Llapashtica, C., Genestine, M., Strauss, K. A., Provenzano, F. A., Sun, Y., Zhu, H., Cortese, G. P., Brundu, F. G., Brigatti, K. W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24358-4 · Cited by 130

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

Papamichail, L., Koch, L. S., Veerman, D., Broersen, K., & van der Meer, A. D. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1515340 · Cited by 120

Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease

Nickels, S., Modamio, J., Mendes-Pinheiro, B., Monzel, A. S., Betsou, F., & Schwamborn, J. C. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.101870 · Cited by 129

3D and organoid culture in research: physiology, hereditary genetic diseases and cancer

Suarez-Martinez, E., Suazo-Sanchez, I., Celis-Romero, M., & Carnero, A. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00775-w · Cited by 118

Brain Organoids: Human Neurodevelopment in a DishPreprint

Benito-Kwiecinski, S. K., & Lancaster, M. A. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035709 · Cited by 118

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities

Ming, G., Tang, H., & Song, H. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.014 · Cited by 121

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

Suzuki, I. K., & Vanderhaeghen, P. (2015) · Development · doi:10.1242/dev.120568 · Cited by 110

Human Cerebellar Organoids with functional Purkinje Cells

Atamian, A., Birtele, M., Hosseini, N., Nguyen, T., Seth, A., Dosso, A. D., Paul, S., Tedeschi, N., Taylor, R., Coba, M. P., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2023.11.013 · Cited by 104

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling

Kwak, T. H., Kang, J. H., Hali, S., Kim, J., Kim, K.-P., Park, C., Lee, J., Ryu, H. K., Na, J. E., Jo, J., et al. (2020) · Stem Cells · doi:10.1002/stem.3163 · Cited by 114

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

van den Ameele, J., Tiberi, L., Vanderhaeghen, P., & Espuny-Camacho, I. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.005 · Cited by 110

Probing human brain evolution and development in organoids

Giandomenico, S. L., & Lancaster, M. A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.01.001 · Cited by 111

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Passaro, A. P., & Stice, S. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.622137 · Cited by 120

3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

Velasco, S., Paulsen, B. D. S., & Arlotta, P. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050154 · Cited by 111

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model

Takagi, R., Ishimaru, J., Sugawara, A., Toyoshima, K.-E., Ishida, K., Ogawa, M., Sakakibara, K., Asakawa, K., Kashiwakura, A., Oshima, M., et al. (2016) · Science Advances · doi:10.1126/sciadv.1500887 · Cited by 107

Modeling and Targeting Alzheimer’s Disease With Organoids

Papaspyropoulos, A., Tsolaki, M., Foroglou, N., & Pantazaki, Α. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00396 · Cited by 107

Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

KITAHARA, T., Sakaguchi, H., Morizane, A., Kikuchi, T., Miyamoto, S., & Takahashi, J. B. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.016 · Cited by 116

Assembloid models of cell-cell interaction to study tissue and disease biology

Onesto, M. M., Kim, J.-I., & Pasca, S. P. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.09.017 · Cited by 107

3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery

Gao, G., Ahn, M., Cho, W.-W., Kim, B.-S., & Cho, D. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091373 · Cited by 112

Advances in microfluidic in vitro systems for neurological disease modeling

Holloway, P. M., Willaime‐Morawek, S., Siow, R. C. M., Barber, M., Owens, R. M., Sharma, A. D., Rowan, W. C., Hill, E. J., & Zagnoni, M. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24794 · Cited by 101

Three‐Dimensional Models of the Human Brain Development and Diseases

Jorfi, M., D’Avanzo, C., Kim, D. Y., & Irimia, D. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700723 · Cited by 106

Upgrading the Physiological Relevance of Human Brain Organoids

Dosso, A. D., Urenda, J., Nguyen, T. N., & Quadrato, G. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.029 · Cited by 106

How to make a hippocampal dentate gyrus granule neuron

Yu, D. X., Marchetto, M. C., & Gage, F. H. (2014) · Development · doi:10.1242/dev.096776 · Cited by 109

Tissue morphology influences the temporal program of human brain organoid development

Chiaradia, I., Imaz-Rosshandler, I., Nilges, B. S., Boulanger, J., Pellegrini, L., Das, R., Kashikar, N. D., & Lancaster, M. A. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.003 · Cited by 106

Mapping the Ethical Issues of Brain Organoid Research and Application

Sawai, T., Hayashi, Y., Niikawa, T., Shepherd, J., Thomas, E., Lee, T.-L., Erler, A., Watanabe, M., & Sakaguchi, H. (2021) · AJOB Neuroscience · doi:10.1080/21507740.2021.1896603 · Cited by 104

The Timing of Upper-Layer Neurogenesis Is Conferred by Sequential Derepression and Negative Feedback from Deep-Layer Neurons

Toma, K., Kumamoto, T., & Hanashima, C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2334-14.2014 · Cited by 102

Cell diversity in the human cerebral cortex: from the embryo to brain organoids

Arlotta, P., & Pașca, S. P. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.001 · Cited by 99

Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells

Penisson, M., Ladewig, J., Belvindrah, R., & Francis, F. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00381 · Cited by 97

Controllable fusion of human brain organoids using acoustofluidics

Ao, Z., Cai, H., Wu, Z., Ott, J., Wang, H., Mackie, K., & Guo, F. (2021) · Lab on a Chip · doi:10.1039/d0lc01141j · Cited by 104

Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes

Wang, Y., Chiola, S., Yang, G., Russell, C., Armstrong, C. J., Wu, Y., Spampanato, J. G., Tarboton, P., Ullah, H. M. A., Edgar, N. U., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33364-z · Cited by 104

Present and future of modeling human brain development in 3D organoids

Quadrato, G., & Arlotta, P. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.010 · Cited by 100

Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

Rai, M., Coleman, Z., Curley, M., Nityanandam, A., Platt, A., Robles‐Murguia, M., Jiao, J., Finkelstein, D., Wang, Y., Xu, B., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.005 · Cited by 95

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

Subramanian, L., Bershteyn, M., Paredes, M. F., & Kriegstein, A. R. (2017) · Nature Communications · doi:10.1038/ncomms14167 · Cited by 96

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

Xu, J.-C., Fan, J., Wang, X., Eacker, S. M., Kam, T., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0623 · Cited by 94

Multiscale 3D phenotyping of human cerebral organoids

Albanese, A., Swaney, J., Yun, D. H., Evans, N. B., Antonucci, J. M., Velasco, S., Sohn, C. H., Arlotta, P., Gehrke, L., & Chung, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-78130-7 · Cited by 92

Modeling human development in 3D culture

Ader, M., & Tanaka, E. M. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.013 · Cited by 89

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Rosebrock, D., Arora, S., Mutukula, N., Volkman, R., Gralinska, E., Balaskas, A., Aragonés Hernández, A., Buschow, R., Brändl, B., Müller, F.-J., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00929-5 · Cited by 89

The Application of Brain Organoids: From Neuronal Development to Neurological Diseases

Shou, Y., Liang, F., Xu, S., & Li, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.579659 · Cited by 87

Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges

Wang, D., Villenave, R., Stokar‐Regenscheit, N., & Clevers, H. C. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01317-y · Cited by 111

Innovations in 3D Tissue Models of Human Brain Physiology and Diseases

Lovett, M. L., Nieland, T. J. F., Dingle, Y. L., & Kaplan, D. L. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909146 · Cited by 87

Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly

Wang, L., Li, Z., Sievert, D., Smith, D. E. C., Mendes, M. I. S., Chen, D. Y., Stanley, V., Ghosh, S. G., Wang, Y., Kara, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17454-4 · Cited by 85

Microfluidics for Neuronal Cell and Circuit Engineering

Habibey, R., Arias, J. E. R., Striebel, J., & Busskamp, V. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00212 · Cited by 88

Advanced human developmental toxicity and teratogenicity assessment using human organoid models

Li, M., Gong, J., Gao, L., Zou, T., Kang, J., & Xu, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113429 · Cited by 84

Modeling psychiatric disorders with patient-derived iPSCs

Wen, Z., Christian, K. M., Song, H., & Ming, G.-L. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.11.003 · Cited by 84

Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease

Smits, L. M., & Schwamborn, J. C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00359 · Cited by 87

Application of Human Brain Organoids—Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental Diseases

Kim, S.-H., & Chang, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512528 · Cited by 96

Organoid bioprinting: from cells to functional tissues

Huang, M. S., Christakopoulos, F., Roth, J. G., & Heilshorn, S. C. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00268-0 · Cited by 99

Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule

Cao, S.-Y., Hu, Y. F., Chen, C. Y., Yuan, F., Xu, M., Li, Q., Fang, K.-H., Chen, Y., & Liu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-03519-w · Cited by 84

A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids

Fowler, J. L., Ang, L. T., & Loh, K. M. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.368 · Cited by 87

Invited Review: Epigenetics in neurodevelopment

Salinas, R. D., Connolly, D. R., & Song, H. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12608 · Cited by 90

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer’s Disease

Hernández, D., Rooney, L. A., Daniszewski, M., Gulluyan, L. M., Liang, H. H., Cook, A. L., Hewitt, A. W., & Pébay, A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10147-5 · Cited by 79

Human Brain Organoids and Consciousness

Niikawa, T., Hayashi, Y., Shepherd, J., & Sawai, T. (2022) · Neuroethics · doi:10.1007/s12152-022-09483-1 · Cited by 79

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

Brennand, K., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A. D., Belmonte, J. C. I., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.011 · Cited by 78

Robust production of uniform human cerebral organoids from pluripotent stem cells

Sivitilli, A., Gosio, J., Ghoshal, B., Evstratova, A., Trcka, D., Ghiasi, P., Hernández, J. J., Beaulieu, J., Wrana, J. L., & Attisano, L. (2020) · Life Science Alliance · doi:10.26508/lsa.202000707 · Cited by 85

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System

Christian, K. M., Song, H., & Ming, G. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-062231 · Cited by 79

Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets

Vértesy, Á., Eichmüller, O. L., Naas, J., Novatchkova, M., Esk, C., Balmaña, M., Ladstätter, S., Bock, C., von Haeseler, A., & Knoblich, J. A. (2022) · The EMBO Journal · doi:10.15252/embj.2022111118 · Cited by 70

Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues

Hong, Y. J., & Tae, J. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00400 · Cited by 78

Brain organoids as models to study human neocortex development and evolution

Heide, M., Huttner, W. Β., & Mora‐Bermúdez, F. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.06.006 · Cited by 77

Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease

Wu, Y., Chiu, F., Yeh, C.-S., & Kuo, H. (2019) · Open Biology · doi:10.1098/rsob.180177 · Cited by 78

Modeling neuropsychiatric disorders using human induced pluripotent stem cells

Wang, M., Zhang, L., & Gage, F. H. (2019) · Protein & Cell · doi:10.1007/s13238-019-0638-8 · Cited by 76

Six-month cultured cerebral organoids from human ES cells contain matured neural cells

Matsui, T. K., Matsubayashi, M., Sakaguchi, Y. M., Hayashi, R. K., Zheng, C., Sugie, K., Hasegawa, M., Nakagawa, T., & Mori, E. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.040 · Cited by 80

hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate

Ozair, M. Z., Kirst, C., van den Berg, B. L., Ruzo, A., Rito, T., & Brivanlou, A. H. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.024 · Cited by 74

Rigor and reproducibility in human brain organoid research: Where we are and where we need to go

Sandoval, S. O., Cappuccio, G., Kruth, K., Osenberg, S., Khalil, S. M., Méndez-Albelo, N. M., Padmanabhan, K., Wang, D., Niciu, M. J., Bhattacharyya, A., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.04.008 · Cited by 80

Organoid technology in cancer precision medicine

Xia, X., Li, F., He, J., Aji, R., & Gao, D. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.04.039 · Cited by 72

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

Kim, D.-S., Ross, P. J., Zaslavsky, K., & Ellis, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00109 · Cited by 70

Utilizing stem cells for three-dimensional neural tissue engineering

Knowlton, S. M., Cho, Y. K., Li, X. J., Khademhosseini, A., & Taşoğlu, S. (2016) · Biomaterials Science · doi:10.1039/c5bm00324e · Cited by 69

Genetic engineering in organoids

Teriyapirom, I., Batista-Rocha, A. S., & Koo, B.-K. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02029-z · Cited by 68

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 66

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

Srikanth, P., Lagomarsino, V. N., Muratore, C., Ryu, S. C., He, A., Taylor, W. M., Zhou, C. Q., Arellano, M., & Young‐Pearse, T. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0122-x · Cited by 69

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain

Yakoub, A. M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.249283 · Cited by 67

Organoid technologies meet genome engineering

Nie, J., & Hashino, E. (2017) · EMBO Reports · doi:10.15252/embr.201643732 · Cited by 69

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Nakamura, M., Shiozawa, S., Tsuboi, D., Amano, M., Watanabe, H., Maeda, S., Kimura, T., Yoshimatsu, S., Kisa, F., Karch, C. M. M., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.011 · Cited by 64

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

Tobon, A., Villa, C. E., Cheroni, C., Trattaro, S., Caporale, N., Conforti, P., Iennaco, R., Lachgar-Ruiz, M., Rigoli, M. T., de la Cruz, B. M., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.09.005 · Cited by 62

Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids

Tian, A., Muffat, J., & Li, Y. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0519-19.2019 · Cited by 68

Behavior and lineage progression of neural progenitors in the mammalian cortex

Lin, Y., Yang, J., Shen, Z., Ma, J., Simons, B. D., & Shi, S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.017 · Cited by 63

Brain organoids, consciousness, ethics and moral status

Jeziorski, J. J., Brandt, R., Evans, J. H., Campana, W. M., KALICHMAN, M. W., Thompson, E. T., Goldstein, L. S. B., Koch, C., & Muotri, A. R. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.020 · Cited by 71

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

Saglam‐Metiner, P., Devamoglu, U., Filiz, Y., Akbari, S., Beceren, G., Bağca, B. G., Yaldiz, B., Yanasik, S., Avcı, Ç. B., Erdal, E., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04547-1 · Cited by 69

Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

Toma, K., & Hanashima, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00274 · Cited by 74

Modeling the internet of things: a hybrid modeling approach using complex networks and agent-based models

Batool, K., & Niazi, M. A. (2017) · Complex Adaptive Systems Modeling · doi:10.1186/s40294-017-0043-1 · Cited by 64

Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids

Seiler, S. T., Mantalas, G. L., Selberg, J. A., Cordero, S. P., Torres-Montoya, S., Baudin, P. V., Ly, V. T., Amend, F., Tran, L., Hoffman, R. N., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20096-9 · Cited by 63

Dawn of the organoid era

Akkerman, N., & Defize, L. H. K. (2017) · BioEssays · doi:10.1002/bies.201600244 · Cited by 65

oRGs and mitotic somal translocation — a role in development and disease

Ostrem, B., Di Lullo, E., & Kriegstein, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.007 · Cited by 61

Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease

Dubey, S. K., Munnangi, S. R., Krishna, K. V., Saha, R. N., Singhvi, G., Agrawal, M., Ajazuddin, M., Saraf, S., Saraf, S., & Alexander, A. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00653-z · Cited by 64

Modelling neurodegenerative diseases with 3D brain organoids

Chang, Y., Kim, J., Park, H., Choi, H. G., & Kim, J. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12626 · Cited by 69

Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells

Sunamura, N., Iwashita, S., Enomoto, K., Kadoshima, T., & Isono, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-30025-4 · Cited by 62

Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus

Yi, S. A., Nam, K. H., Yun, J., Gim, D., Joe, D., Kim, Y. H., Kim, H., Han, J., & Lee, J. (2020) · Viruses · doi:10.3390/v12091004 · Cited by 65

Biofabrication of neural microphysiological systems using magnetic spheroid bioprinting

Bowser, D. A., & Moore, M. J. (2019) · Biofabrication · doi:10.1088/1758-5090/ab41b4 · Cited by 63

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K., & Sasai, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.051 · Cited by 692

Notice respecting certain phenomena of crystallization and polarization in decomposed glass

Brewster, D. (1861) · Journal of the Franklin Institute · doi:10.1016/0016-0032(61)90199-5

Self-organization of neural patterns and structures in 3D culture of stem cells

Sasai, Y. (2013) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2020888

Self-formation of layered neural structures in three-dimensional culture of ES cells

Eiraku, M., & Sasai, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.005 · Cited by 172