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Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex
Open accessAbstract
Significance: Using 3D culture of human ES cells, we show new self-organizing aspects of human corticogenesis: spontaneous development of intracortical polarity, curving morphology, and complex zone separations. Moreover, this culture generates species-specific progenitors, outer radial glia, which are abundantly present in the human, but not mouse, neocortex. Our study suggests an unexpectedly wide range of self-organizing events that are driven by internal programs in human neocortex development.
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“The production of radial glial cells, intermediate progenitors, and deep- and superficial-layer neurons in an ordered temporal fashion has been reported by studies using all of the protocols currently in use2,3,5,25.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [3]
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“Both of these protocols generated organoids containing a dorsalized neuroepithelium that reproduced certain aspects of cortical development, both structurally and in terms of cell behaviour.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [3]
In the citing paper
“Interestingly, the developmental timing of cortical neurogenesis appears to be conserved in vitro and has been demonstrated with both suspension and adherent differentiation methods2,3,5,39.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [3]
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Cites
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S.-I., Muguruma, K., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1310 · Cited by 2,055
Self-citationNeuronal subtype specification in the cerebral cortex
Molyneaux, B. J., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2151 · Cited by 1,704
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522
Self-citationSelf-formation of optic cups and storable stratified neural retina from human ESCs
Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447
Self-citationNeurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Development of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977
Kostović, I., & RAKIC, P. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902970309 · Cited by 912
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830
Research works printed but not linked: 2
- SA Bayer, J Altman Atlas of Human Central Nervous System Development, Volume 3: The Human Brain During the Second Trimester (CRC Press, Boca Raton, FL, 2005).
- SA Bayer, J Altman Atlas of Human Central Nervous System Development, Volume 2: The Human Brain During the Third Trimester (CRC Press, Boca Raton, FL, 2004).
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Limame, R., Limame, R., Piumatti, M., Piumatti, M., Iwata, R., Zaratin, M., Herpoel, A., Bilheu, A., van Benthem, H., Herpoel, A., et al. (2026) · Developmental Cell · doi:10.1101/2023.09.25.559314 · Cited by 3
Kim, E., Kim, Y. H., Hong, S.-J., Kim, I. S., Lee, J. H., Yoo, J.-Y., Kim, J., Yoo, K., Kim, J., Choi, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.01.615952 · Cited by 2
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Wu, Q., Manser, C., Suetsugu, T., Yoshida, R., Sakaguchi, H., Nabeshima, Y.-I., Kiyonari, H., Perez‐Carrasco, R., & Matsuzaki, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.23.677958 · Cited by 2
Self-citationHerrema, K. E., Kharitonova, E. K., Bogatova, D., Wilson, M. N., Martin, E. A., Chung, C., Puppo, F., Klorfeld-Auslender, S., Boucher, P. O., Tsai, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.20.695690 · Cited by 2
Mary Jane Hogue (1883–1962): A pioneer in human brain tissue culture
Zottoli, S. J., & Seyfarth, E. (2018) · Journal of the History of the Neurosciences · doi:10.1080/0964704x.2018.1468967 · Cited by 1
Cerebral organoids: a promising model in cellular technologies
Шнайдер, Т. А. (2018) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj18.344 · Cited by 1
In Vitro Niches for the Culture of Pluripotent Stem Cells
Ueki, M., & Ito, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65534-4 · Cited by 1
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Eşiyok, N., Tynianskaia, L., & Heide, M. (2023) · BIOspektrum · doi:10.1007/s12268-023-1903-1 · Cited by 1
Approaches in vivo and in vitro for solving the vascularization issue of brain organoids
Li, T. (2025) · Highlights in Science Engineering and Technology · doi:10.54097/vhxbb234 · Cited by 1
Bertacchi, M., Maharaux, G., & Studer, M. (2025) · BIO-PROTOCOL · doi:10.21769/bioprotoc.5354 · Cited by 1
Research insights and clinical opportunities of functional organoid-based platforms
Huang, Y., Shen, W., Li, K., Zhang, Y., Lv, Q., Wang, C., Mao, W., & Zhao, A. (2025) · Bio-Design and Manufacturing · doi:10.1631/bdm.2400519 · Cited by 1
Li, T., Mo, F., Qi, J., Li, C., Li, X., Zhang, J., Lu, Y., Yao, C., Zhang, L., Hu, B., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf125 · Cited by 1
Organizers in a dish: Modeling human CNS morphogenesis
Miller, G., Sanchez, D. J. L.-D., Martínez, J. G., Justin, A. W., Lancaster, M. A., & Guglielmi, L. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.01.003 · Cited by 2
Baggiani, M., Desbats, M. A., Naef, V., Giacich, M., Galatolo, D., Mero, S., Zampieri, S., Cappello, V., Valentino, A., Salviati, L., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08476-9 · Cited by 2
Modeling pediatric low-grade glioma heterogeneity using human forebrain organoids
Leva, G., Santomaso, L., Gianesello, M., Patrizi, S. T., Ress, F., Cocchini, F., Antonacci, C., Gianno, F., Abballe, L., Lago, C., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02612-x · Cited by 1
Ishan, M., JImenez-Macias, J. L., & Read, R. D. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1803705 · Cited by 1
Disease modelling with in vitro vascularised organoids
Kan, C., Liu, L., & Sugimura, R. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052769 · Cited by 1
Beyene, S., Thunemann, M., Campbell, N. B., Kharitonova, E. K., Klorfeld-Auslender, S., Mortazavi, F., & Zeldich, E. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1874430 · Cited by 2
Organoid Culture: Applications in Development and Cancer
Cañadas, I., & Barbie, D. A. (2016) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-45397-2_3 · Cited by 1
Ferdaos, N., & Mason, J. O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812636-3.00008-0 · Cited by 1
Bhaduri, A., Andrews, M. G., & Kriegstein, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00029-1 · Cited by 1
Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification
Holmes, D. B., & Heine, V. M. (2017) · Journal of Visualized Experiments · doi:10.3791/56888-v · Cited by 1
Fan, W., Xudong, C., Yizheng, S., Wu, S., Wang, H., Suresh, K. S., Krishnan, S., Ramalingam, M., & Deng, J. (2022) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2022.2991 · Cited by 1
Kaur, K. K., Allahbadia, G., & Singh, M. (2021) · Journal of Biomedical Engineering and Medical Imaging · doi:10.14738/jbemi.86.11266 · Cited by 1
Chang, X., Gu, M., & Tchieu, J. H. (2022) · Cells · doi:10.3390/cells11030460 · Cited by 1
The Brain Organoid Technology: Diversity of Protocols and Challenges
Popatansov, A. (2022) · Biomedical engineering · doi:10.5772/intechopen.105733 · Cited by 1
iPS cell technologies toward overcoming neurological diseases
Kimura, T., & Muguruma, K. (2022) · Folia Pharmacologica Japonica · doi:10.1254/fpj.22084 · Cited by 1
Filan, C. E., Charles, S., Costa, P. C., Cheng, B., Lu, H., & Robles, F. E. (2023) · Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues · doi:10.1117/12.2650755 · Cited by 1
Organoids As a Tool to Fuel Basic Medical Research
Zhang, Y. (2023) · Journal of Complementary Medicine & Alternative Healthcare · doi:10.19080/jcmah.2023.11.555823 · Cited by 1
Telencephalic organoids as model systems to study cortical development and diseases
Yang, W. S., Kiral, F. R., & Park, I. (2024) · Organoid · doi:10.51335/organoid.2024.4.e1 · Cited by 1
Chimeric brain organoids capture human genetic diversity
Bhaduri, A. (2024) · Nature · doi:10.1038/d41586-024-01648-7 · Cited by 1
Functional Exploration of Epilepsy Genes in Patient-Derived Cells
Varela, M. C., Samarasinghe, R. A., & Parent, J. M. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0042 · Cited by 1
Research progress of brain organoids in the field of diabetes
Su, Y., Liu, A., Chen, H., Chen, Q., Zhao, B., Gao, R., Zhang, K., Peng, T., Zhang, Z., Ouyang, C., et al. (2024) · Molecular Brain · doi:10.1186/s13041-024-01123-4 · Cited by 1
Stem Cell-Derived Neural Organoids: From the Origin to Next Generation
Sakaguchi, H., & Takata, N. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_6 · Cited by 1
Self-citationPathway to independence: perspectives on the future
Birtele, M., Cerise, M., Djenoune, L., Kale, G., Maniou, E., Prahl, L. S., Schuster, K., & Villeneuve, C. (2024) · Development · doi:10.1242/dev.204366 · Cited by 1
Generating Mini-Organs in Culture
Koike, H., & Takebe, T. (2016) · Current Pathobiology Reports · doi:10.1007/s40139-016-0101-y · Cited by 1
Uncovering cell biology in the third dimension
Robertson, G. L., Romero-Morales, A. I., Lippmann, E. S., & Gama, V. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-04-0211 · Cited by 1
Induced pluripotent stem cells as models of human neurodevelopmental disorders
Jourdon, A., Mariani, J., Scuderi, S., Amiri, A., Wu, F., Yuen, E. Y., Abyzov, A. S., & Vaccarino, F. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814409-1.00005-7 · Cited by 1
Cerebral Organoids: A Model of Brain Development
Sukhinich, K. K., & Aleksandrova, M. A. (2020) · Russian Journal of Developmental Biology · doi:10.1134/s1062360420040074 · Cited by 1
Use of iPSC-derived brain organoids to study human brain evolution
Reiner, O., Sapir, T., & Parichha, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822231-7.00012-6 · Cited by 1
Siddiqui, S. S., Aboshamat, K., Loganathan, S., & Siddiqui, Z. K. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-78101-9_4 · Cited by 1
Boeshore, K. L., Lee, C., & Freed, W. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823882-0.00006-0 · Cited by 1
Current progress in brain organoid technology
Wei, P. A. N. G., YanTong, L. I. U., & Xiang, Y. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0278 · Cited by 1
Modeling Schizophrenia In Vitro: Challenges and Insights on Studying Brain Cells
Brandão‐Teles, C., Zuccoli, G. S., Smith, B. J., Vieira, G. M., & Crunfli, F. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-97182-3_3 · Cited by 1
Brain Organoids as a Model to Study Zika Virus and SARS-CoV-2 Infections
Krenn, V., Higa, L. M., & Garcez, P. P. (2022) · Neuromethods · doi:10.1007/978-1-0716-2720-4_10 · Cited by 1
Yaqing, W. A. N. G., Tao, T., & Qin, J. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0027 · Cited by 1
Cerebral Organoids in Developmental Neuroscience
Forero, A., & Cappello, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_179 · Cited by 1
Parekh, Y., Dagar, E., Haider, K. H., & Bokara, K. K. (2022) · Springer eBooks · doi:10.1007/978-981-19-2655-6_38 · Cited by 1
Three-dimensional human axon tracts derived from cerebral organoidsPreprint
Cullen, D. K., Struzyna, L. A., Jgamadze, D., Gordián-Vélez, W. J., Lim, J., Wofford, K. L., Browne, K. D., & Chen, H. I. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/253369 · Cited by 1
From Neural Stem Cells (NSC) to Glioblastoma (GBM): A Natural History of GBM Recapitulated in VitroPreprint
Almengló, C., Caamaño, P., Fraga, M., Devesa, J., Costoya, J. A., & Arce, V. M. (2020) · Preprints.org · doi:10.20944/preprints202008.0637.v1
Fischer, J., Peters, J., Namba, T., Huttner, W. Β., & Heide, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.01.322792 · Cited by 1
Yıldırım, M., Delepine, C., Feldman, D., Pham, V. A., Chou, S., Ip, J. P. K., Nott, A., Tsai, L., Ming, G., So, P. T. C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.28.482282 · Cited by 1
The biology of schizophrenia as a neurodevelopmental disorder
van Berlekom, A. B. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1269 · Cited by 1
Singh, J., Daniels, N. J., Pirozzi, F., Wynshaw-Boris, A. J., Lopez-Gonzalez, R., & Padgett, R. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.29.520610 · Cited by 1
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Lim, B., Djekidel, M. N., Matsui, Y., Jung, S., Yuan, Z., Wang, X., Yang, X., Shirinifard, A., Pan, H., Wang, F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.04.539457 · Cited by 1
Chiola, S., Yang, J., Ullah, H. M. A., Napan, K. L., Huang, Q., Gamboa, N. T., Youssef, O. A., Colman, H., Cheshier, S. H., & Shcheglovitov, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.11.540229 · Cited by 1
Bury, L. A. D., Fu, S., & Wynshaw-Boris, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.17.545314 · Cited by 1
Scuderi, S., Jourdon, A., & Vaccarino, F. M. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch20 · Cited by 1
Ramani, A., Pasquini, G., Gerkau, N. J., Altinisk, N., Vinchure, O. S., Gabriel, E., Rothenaigner, I., Lin, S., Mariappan, A., Rathinam, D., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4627469 · Cited by 1
Colinet, M., Chiver, I., Bonafina, A., Masset, G., Almansa, D., Valentin, E. D., Twizere, J., Nguyen, L., & Espuny-Camacho, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.16.589036 · Cited by 1
Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer NeurogenesisPreprint
Nguyen, C. V., Martija, A. A., Nano, P. R., Soto, J., Jaklic, D. C., Mil, J., White, R., Martín, J. M., Rana, D., Geschwind, D. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.25.650717 · Cited by 1
Intravital Multimodal Imaging of Human Cortical Organoids for Chronic Stroke Treatment in MicePreprint
Wang, J., Qiao, G., Tan, H., Li, M. J., Wang, K., Xu, J., Janowski, M., Tian-ming Fu, B., Walczak, P., & Liang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.05.663297 · Cited by 1
Turkalj, E. M., Kuljanishvili, M., Kang, G., Liu, I., Ghent, C. M., Soriano, C. W., Keyhanvar, N., Brody, D., Oldham, M., & Vissers, C. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.13.664555 · Cited by 1
Human whole-epigenome modelling for clinical applications with PleiadesPreprint
Niki, P., Nalmpantis, C., Ganbat, J.-O., Byrne, D., Kathail, P., Fang, C., Wong, A., Karailiev, A., Babikir, H. A., Jhutty, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.16.665231 · Cited by 3
Modeling interregional propagation of α-synuclein in human striatal–midbrain assembloidsPreprint
Nishimura, K., Amimoto, N., Sato, Y., Morishima, M., Sakaibara, M., Haratake, A., Nakano, M., Kaneko, N., Yamamoto, H., Hirano‐Iwata, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.11.723670 · Cited by 1
Vértesy, Á., Najm, R., Doleschall, B., Isaev, S. V., Zabolocki, M., Novatchkova, M., Burkard, T. R., Ziegler, C., Krautberger, S., Li, C. V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.01.755792 · Cited by 1
Human Stem Cell Models of Neurodevelopmental Disorders
Kirwan, P., & Livesey, F. J. (2015) · Wiley eBooks · doi:10.1002/9781118524947.ch10
[Biologic treatments for hereditary diseases].
Yang, J., Xie, Y., & Chen, L. (2015) · PubMed
Migration Guidance of Human iPSC-derived Neurons by a Two-dimensional Patterning
Iida, S., Shimba, K., Tanaka, Y., Sakai, K., Kotani, K., & Jimbo, Y. (2016) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.136.1268
Rett Syndrome Modeling from Human Induced Pluripotent Stem Cells Using a Monolayer Culture System
Raquel, A., & Porteira, P. (2014)
Suga, H., & Ozone, C. (2017) · Springer eBooks · doi:10.1007/978-981-10-3768-9_3
Telencephalic Tissue Formation in 3D Stem Cell Culture
Kadoshima, T., Sakaguchi, H., & Eiraku, M. (2017) · Springer eBooks · doi:10.1007/978-981-10-3768-9_1
Self-citation6 Huntington’s Disease and Stem Cells
Ring, K. L., O’Brien, R., Zhang, N., & Ellerby, L. (2017) · CRC Press eBooks · doi:10.1201/9781315402185-7
Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy
Bury, L. A. D. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
Regeneration of Kidney From Human Reprogrammed Stem Cells
Little, M. H., & Osafune, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801734-0.00067-9
Engineering Organoid Systems to Model Health and Disease
Ankrum, J. A., Bartosh, T. J., Yin, X., Brown, A. J., Burand, A. J., & Boland, L. K. (2017) · Molecular and translational medicine · doi:10.1007/978-3-319-57153-9_10
Human Cerebral Organoids Reveal Secrets of Lissencephaly
Mukherjee, S. (2017) · Cell & Developmental Biology
Silva, Y. R. D. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2019.tde-10012019-111750
Relational Basis of the Organism's Self-organization A Philosophical Discussion
Karaca, Ç. (2019) · Open Research Exeter (University of Exeter)
Developing a neural implant to enable controlled alterations to brain architecture
Weir, N. (2019) · Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)
Developmental basis of Zika virus-induced neuropathology
Christian, K. M., Song, H., & Ming, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814409-1.00004-5
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Reiner, O., & Karzbrun, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00010-2
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Deleanu, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822230-0.00013-2
3D organotypic cell structures for drug development and Microorganism-Host interaction research
Zubareva, E. V., Nadezhdin, S. V., Nadezhdina, N. A., Belyaeva, V. S., Burda, Y. E., Avtina, T. V., Гудырев, О. С., Kolesnik, I. M., Kulikova, S. Y., & Mishenin, M. O. (2021) · Research Results in Pharmacology · doi:10.3897/rrpharmacology.7.62118
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Ni, P., & Chung, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85764-2.00011-9
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Metadata
- Authors
- Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y.
- Affiliations
- Kyoto University (JP)
- Laboratory of Organogenesis and Neurogenesis and
- RIKEN (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-11-25
- Volume
- 110
- Issue
- 50
- Pages
- 20284-20289
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3864329
- OpenAlex
- W2051785391
- Cited by
- 999
- References
- 33
- Citations by year
- 2026: 62 · 2025: 99 · 2024: 90 · 2023: 84 · 2022: 122 · 2021: 113 · 2020: 113 · 2019: 94 · 2018: 66 · 2017: 66 · 2016: 44 · 2015: 30 · 2014: 16
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-04-29)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (24680037)
- Japan Science and Technology Agency
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- human embryonic stem cells, self-organization, axial polarity, subplate, cortical plate, outer subventricular zone, outer radial glia, 3D cell culture, cortical morphogenesis
- MeSH terms
- Amides, Collagen, Drug Combinations, Humans, Laminin, Neuroglia, Proteoglycans, Pyridines, Species Specificity, Cell Polarity, Cell Culture Techniques, Neocortex, Organogenesis, Embryonic Stem Cells
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