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The IRF Family Transcription Factors in Immunity and Oncogenesis

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A comprehensive pathway map of epidermal growth factor receptor signaling

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

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Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPβ.

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Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord

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Body-mass Index and Health

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Nimotuzumab for COVID-19: Case Series

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Mechanism of herpesvirus protein kinase UL13 in immune escape and viral replication

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Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages

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Role of mitogens in normal and pathological liver regeneration

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Different Master Regulators Define Proximal and Distal Gastric Cancer: Insights into Prognosis and Opportunities for Targeted Therapy

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Baicalin promotes the survival of flaps by downregulating the JAK2-STAT3 signaling pathway

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Performance of D-dimer to lymphocyte ratio in predicting the mortality of COVID-19 patients

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MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma

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The Impact of Inflammation on Cognitive Impairment in Chronic Kidney Disease Patients

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Breaking the oncostatin M feed‐forward loop to suppress metastasis and therapy failure

Smigiel, J. M., Parvani, J. G., Tamagno, I., Polak, K. L., & Jackson, M. W. (2018) · The Journal of Pathology · doi:10.1002/path.5063 · Cited by 8

Cell-specific regulation of insulin action and hepatic fibrosis by CEACAM1

Aldroubi, B., Najjar, J. A., Youssef, T., Rizk, C., Abuamreh, B. A. M., Aramouni, K., Ghadieh, H. E., & Najjar, S. M. (2024) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2024.48 · Cited by 8

TGF-β and IL-6 family signalling crosstalk: an integrated model

Khatibi, S., Babon, J. J., Wagner, J., Manton, J. H., Tan, C. W., Zhu, H., Wormald, S., & Burgess, A. W. (2017) · Growth Factors · doi:10.1080/08977194.2017.1363746 · Cited by 7

Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway

Vidal, V., Gutierrez, O., Talamillo, A., Velásquez, C., & Fernández-Luna, J. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-95753-6 · Cited by 6

TLR4-Mediated Recognition of Mouse Polyomavirus Promotes Cancer-Associated Fibroblast-Like Phenotype and Cell Invasiveness

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Prophylactic and Therapeutic Effect of Kynurenine for Experimental Autoimmune Encephalomyelitis (EAE) Disease

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Distinct clinical profiles and patient outcomes in aCML and CNL

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IL6 Supports Development of an Immunosuppressive Microenvironment and Resistance to Therapy in Glioblastoma

Young, J. S., Cho, N. W., Lucas, C. G., Najem, H., Mirchia, K., Chen, W., Tamaki, C. M., Congivaram, H., Seo, K., Zakimi, N., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-2922 · Cited by 9

Overexpression of Bcl‐2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4‐nitroquinoline 1‐oxide‐induced murine oral cancer model

Ortega, A., Gonçalves, V. D. P., Guimarães, M. R., Rossa, C., & Spolidório, L. C. (2016) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12413 · Cited by 6

A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway

Zhang, B., Li, B., Xie, Y., Chang, S., Xu, Z., Hu, H., Chen, G., Zhang, T., He, J., Wu, X., et al. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023014 · Cited by 6

Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression

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Current Mechanobiological Pathways and Therapies Driving Spinal Health

Kumar, R., Sporn, K., Kaur, H., Khanna, A., Paladugu, P., Zaman, N., & Tavakkoli, A. (2025) · Bioengineering · doi:10.3390/bioengineering12080886 · Cited by 6

Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases

Zhou, T., Yang, Z., Ni, B., Zhou, H. Q., Zhou, Y., Xu, H., Lin, X., Lin, S., Wei, Y. Z., He, C., et al. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.12.44 · Cited by 5

Alkaline Treatment Enhances the Anti-Inflammatory and Reparative Potential of Dentin Matrix Proteins in Inflamed Pulp

Jia, P., Li, J., Wu, J., Li, X., Mao, S., Wang, S., & Dong, Y. (2025) · Journal of Endodontics · doi:10.1016/j.joen.2025.06.002 · Cited by 5

A Molecular Analysis of Cytokine Content across Extracellular Vesicles, Secretions, and Intracellular Space from Different Site-Specific Adipose-Derived Stem Cells

Santos, J., Dalla, P. V., & MILTHORPE, B. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010397 · Cited by 5

Wound fluid enhances cancer cell proliferation via activation of STAT3 signal pathway in vitro

Scherzad, A., Gehrke, T. E., Meyer, T. J., Ickrath, P., Bregenzer, M., Eiter, R., Hagen, R., Kleinsasser, N. H., & Hackenberg, S. (2019) · Oncology Reports · doi:10.3892/or.2019.7047 · Cited by 5

Patient Characteristics Influence Activated Signal Transducer and Activator of Transcription 3 (STAT3) Levels in Primary Breast Cancer—Impact on Prognosis

Nilsson, L. H., Sandén, E., Khazaei, S., Tryggvadottir, H., Nodin, B., Jirström, K., Borgquist, S., Isaksson, K., & Jernström, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01278 · Cited by 5

Cross-talk between Janus kinase-signal transducer and activator of transcription pathway and transforming growth factor beta pathways and increased collagen1A1 production in uterine leiomyoma cells

Malik, M., Britten, J., DeAngelis, A., & Catherino, W. H. (2020) · F&S Science · doi:10.1016/j.xfss.2020.07.005 · Cited by 4

Hepatitis C virus modified sE2 F442NYT as an antigen in candidate vaccine facilitates human immune cell activation

Haga, Y., Meyer, K., Sung, M. M. H., Reagan, E. K., Weissman, D., & Ray, R. (2023) · Journal of Virology · doi:10.1128/jvi.01809-23 · Cited by 5

Regulatory mechanisms underlying interleukin‐6 expression in murine brown adipocytes

Fu, X., Murakami, M., Hashimoto, O., Matsui, T., & Funaba, M. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3915 · Cited by 5

Tocilizumab, a Potent Interleukin-6 Receptor Inhibitor, Decreases Bone Resorption and Increases the Rate of Bacterial Infection After Tooth Extraction in Rats

Rodrigues, M. I. D. Q., Martins, J. O. D. L., Silva, P. G. D. B., Júnior, A. E. C. F., Verde, M. E. Q. L., Sousa, F. B., Mota, M. R. L., & Alves, A. P. N. N. (2020) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2020.08.012 · Cited by 5

Advanced glycation end products (AGEs) impair the intestinal epithelial barrier via STAT3 activation mediated by macrophages

Qiang, X., Shumin, L., Lv, Y., Wang, X., Zhang, H., & Zhan, J. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114966 · Cited by 5

The Significance of STAT3 in Colonic Diseases: A Comprehensive Study of Pathological Roles and Therapeutic Implications

Ahmed, A. T., Oghenemaro, E. F., Hjazi, A., Jain, V. D., Ahmad, I., Roopashree, R., Soothwal, P. K., Goswami, M., Zwamel, A. H., & Kdhim, K. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01816-0 · Cited by 4

In Silico Discovery of SARS-CoV-2 Main Protease Inhibitors Using Docking, Molecular Dynamics, and Fragment Molecular Orbital Calculations

Ishikawa, T., Matsumoto, K., Hamada, T., Koze, H., Baba, M., Okamoto, M., & Sudoh, M. (2025) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c07920 · Cited by 4

Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents

Xu, J., Kim, H.-J., Dong, J., Chen, H., Xu, J., Ma, R., Zhou, M., Wang, T., Shen, Q., & Zhou, J. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114229 · Cited by 4

Inhibiting JAK1, not NF-κB, reverses the effect of pro-inflammatory cytokines on engineered human ligament function

Avey, A. M., Devos, F., Roberts, A. G., Essawy, E. S. E., & Baar, K. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.12.007 · Cited by 4

Body Mass Index and Colorectal Cancer

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Fibroblast EGFR signaling mediates ricin toxin-induced acute lung injury via EGR1/CXCL1 axis

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Interleukin-6 induces upregulation of BNIP3 in cardiomyocytes to protect against myocardial ischemia/reperfusion injury

Wu, J., Li, Z., Wang, Y., Hu, H. Q., & Ma, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115473 · Cited by 3

Impaired PTEN Expression in T Cells Drives Resistance to Treg-Mediated Immune Regulation in Multiple Sclerosis

Schlöder, J., Trinschek, B., Luessi, F., & Jonuleit, H. (2025) · Cells · doi:10.3390/cells14181445 · Cited by 3

STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice

Chi-Wei, L., Wu, H.-F., Yen, H.-J., Lun-De, L., Mao, W.-C., Chang, H., Chen, Y., Lin, C.-H., Li, C.-T., & Lin, H.-C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05638-2 · Cited by 3

Differential roles of type I topoisomerases in regulating HPV pathogenesis

Vats, A., Templeton, C. W., & Laimins, L. A. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2526296123 · Cited by 3

The mechanism of wen jing tang in the treatment of endometriosis: Insights from network pharmacology and experimental validation

Hu, X., Guo, X., Dongxu, W., Yue, J., Zhang, J., & Wang, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39292 · Cited by 3

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Wei, X., Si, A., Zhao, S., Fu, Y., Li, J., Aishanjiang, K., Ma, Y., Yu, C. J., Yu, B., Cui, C., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00690-1 · Cited by 3

Immunization induces inflammation in the mouse heart during spaceflight

Veliz, A. L., Hughes, L., Carrillo, D., Pecaut, M. J., & Kearns‐Jonker, M. (2025) · BMC Genomics · doi:10.1186/s12864-025-11426-y · Cited by 4

Effects of Para-Toluenesulfonamide on Canine Melanoma Xenotransplants in a BALB/c Nude Mouse Model

Lin, C.-T., Lin, C., Wu, J.-T., Tsai, H.-P., Cheng, S.-Y., Liao, H.-J., Lin, T.-C., Wu, C.-H., Lin, Y.-C., Wang, J.-H., et al. (2022) · Animals · doi:10.3390/ani12172272 · Cited by 3

Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model

Wang, H., Sun, N., Sun, P., Zhang, H., Yin, W. H., Zheng, X., Fan, K., Sun, Y., & Li, H. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1455049 · Cited by 3

Methylation and Expression Status of SOCS1 and SOCS3 in Oral Lichen Planus

Yoshimura, K., Yada, N., Matsuo, K., Hikiji, H., Yoshiga, D., Habu, M., Sasaguri, M., & Tominaga, K. (2018) · Open Journal of Stomatology · doi:10.4236/ojst.2018.85016 · Cited by 3

Mycoplasma Faucium and Breast CancerPreprint

Митин, В., Tumanova, L., & Botnariuc, N. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/089128 · Cited by 3

Oncogenesis and autoimmunity as a result of mRNA COVID-19 vaccinationPreprint

Kyriakopoulos, A. M., Nigh, G., McCullough, P. A., & Seneff, S. (2024) · doi:10.22541/au.171387387.73158754/v1 · Cited by 3

High-Throughput De Novo Protein Design Yields Novel Immunomodulatory AgonistsPreprint

Abedi, M. H., Expòsit, M., Coventry, B., Mathew, D., Jain, S., Krishnakumar, A., Goreshnik, I., Gray-Gaillard, S. L., Lunn-Halbert, M. C., Yu, T.-Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.12.681920 · Cited by 5

The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition

Liu, Y., Yin, J., Lu, L., Pan, J., Shao, G., Xu, Y., Ji, G., & Xu, H. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00416-z · Cited by 3

Integrating network pharmacology and in vivo pharmacological validation to explore the gastroprotective mechanism of Sotetsuflavone against indomethacin-induced gastric ulcer in rats: Involvement of JAK2/STAT3 pathway

Tabaa, M. M. E., Harty, M. E. E., Mohsen, M. A., Rashad, E., Negm, W. A., elmorshedy, K., & Abu-Risha, S. E.-S. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109934 · Cited by 3

Human IL‐6‐Producing B Cells Promote the Differentiation of Monocytes Toward an Anti‐Inflammatory CD16⁺CD163⁺CD206⁺PD‐L1⁺ Phenotype in Tuberculosis

Bénard, A., Balboa, L., Caouaille, M., Ravon‐Katossky, L., Meunier, É., Fillatreau, S., Sasiain, M. D. C., Neyrolles, O., & Hudrisier, D. (2025) · European Journal of Immunology · doi:10.1002/eji.202451509 · Cited by 2

EGF activation of POMC gene transcription is mediated by STAT3

Gam, R., Sochodolsky, K., Balsalobre, A., Gauthier, Y., & Drouin, J. (2025) · Yearbook of pediatric endocrinology · doi:10.1530/ey.23.1.6 · Cited by 2

Transcriptomic Profiles of Splenic CD19+ B Cells in Mice Chronically Infected With the Larval Echinococcus granulosus

Xu, S., Guo, Y., Luo, T., Jiang, P., Yan, Z., He, Y., Fu, L.-L., Liu, H., Gao, Z., Wang, D., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.848458 · Cited by 2

Immunological mechanisms of increased susceptibility to COVID-19 disease and its severe course in patients with diabetes mellitus type 2 and obesity

Kp, Z., Tronko, M. D., & Комісаренко, С. В. (2023) · The Ukrainian Biochemical Journal · doi:10.15407/ubj95.02.005 · Cited by 2

Novel strategies for exploitation of milk glycoproteins for food ingredient applications

Feeney, S. (2019) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16178 · Cited by 2

Involvement of Bradykinin and Folate receptor in calming the SARS-COV2 cytokine storm: Lessons learnt from lung cancerPreprint

Gowda, P., & Sen, E. (2020) · doi:10.21203/rs.3.rs-23656/v1 · Cited by 2

Recent research advances in interleukin, microRNA and neuroendocrine tumor biomarkers (Review)

Guo, X., Yang, S., Cao, C., & Li, D. (2025) · Molecular and Clinical Oncology · doi:10.3892/mco.2025.2866 · Cited by 1

Anti-Neoplastic Activity of Estrogen Receptor Beta in Chemoresistant Triple-Negative Breast Cancer

Wang, X., Emch, M. J., Goetz, M. P., & Hawse, J. R. (2025) · Cancers · doi:10.3390/cancers17132132 · Cited by 2

Molecular basis of IFN-γ–induced STAT3 phosphorylation stimulated by Sendai virus C protein

Oda, K., Hatori, Y., Kodama, A., Uchiyama, S., Oda, T., Matoba, Y., Nakano, A., Ninomiya, K., Yoshidomi, S., & Sakaguchi, T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110744 · Cited by 1

Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive recovery following ischemic stroke

Nguyen, D. T., Mendoza, K., Hall, C., Tan, C., & Chauhan, A. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115562 · Cited by 1

Engineering pH-Responsive Dendrimer–STAT3 Inhibitor Conjugates for Intracellular Delivery

Sankara, C. S., Shanbhag, A. R., Díaz, D. R., Hodges, C. A., Li, C., Harrison, J. K., & Zhang, F. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01648 · Cited by 1

Lacosamide prevents cyclophosphamide-induced testicular dysfunction via inhibition of NF-κB/IL-6/STAT-3 and JNK1/Caspase-3 axes with AR and HO-1 preservation: in vivo and in silico evidence

Ali, M. R. A., Messiha, B. A. S., Abdel-Samea, A. S., Attya, M. E., & Mohyeldin, R. H. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-04994-7 · Cited by 1

Dietary Caloric Restriction Suppresses Endometriosis by Inhibiting STAT3 / ERK Pathways

Hosseinirad, H., An, H., Jeong, E. M., Juitt, L., Yoo, J., Kim, T. H., Shin, J., & Jeong, J.-W. (2026) · The FASEB Journal · doi:10.1096/fj.202503269r · Cited by 1

Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes

Setyaningsih, W. A. W., Naderi‐Meshkin, H., Yacoub, A., Cornelius, V. A., Silva, J. D., Fitriawan, A. S., Guduric‐Fuchs, J., Tashkandi, A. J. A., Kuburas, R., Zampetaki, A., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02696-4 · Cited by 1

The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies

Yang, T., Huo, S., & Wei, S. L. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103095 · Cited by 1

Rewiring Cellular Context as A Central Mechanism Governing Cancer Stem Cell Survival: Insights from ESC Comparisons

Ahmadi, Y., Far, B. E., & Abolhasani, S. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11217-2 · Cited by 1

Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor

Ferraz, E. R. A., Fernandes, A. S., de Amorim, Í. S. S., Felzenszwalb, I., & Mencalha, A. L. (2016) · Drug and Chemical Toxicology · doi:10.3109/01480545.2016.1167901 · Cited by 1

Consideration of Nebulized Lidocaine For Treatment of Covid19 Severity Via Targeting Neutrophil Extracellular Traps

Madhi, R. (2020) · Anaesthesia & Surgery Open Access Journal · doi:10.33552/asoaj.2020.02.000538 · Cited by 1

Diosmin induces mitochondrial-mediated apoptosis and anti-inflammatory effects in Hep-2 cells: an integrated in vitro and in silico analysis

Rajasekar, M., Kathiresan, S., Azhamuthu, T., Ravichandran, P., & Sivakumar, K. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03690-8 · Cited by 1

Role of NLRP3 in colitis and colitis associated colorectal cancer

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