Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol: Abstinence across drugs
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Unified theories of addiction are challenged by differing drug-seeking behaviors and neurobiological adaptations across drug classes, particularly for narcotics and psychostimulants. We previously showed that protracted abstinence to opiates leads to despair behavior and social withdrawal in mice, and we identified a transcriptional signature in the extended amygdala that was also present in animals abstinent from nicotine, Δ9-tetrahydrocannabinol (THC) and alcohol. Here we examined whether protracted abstinence to these four drugs would also share common behavioral features, and eventually differ from abstinence to the prototypic psychostimulant cocaine. We found similar reduced social recognition, increased motor stereotypies and increased anxiety with relevant c-fos response alterations in morphine, nicotine, THC and alcohol abstinent mice. Protracted abstinence to cocaine, however, led to strikingly distinct, mostly opposing adaptations at all levels, including behavioral responses, neuronal activation and gene expression. Together, these data further document the existence of common hallmarks for protracted abstinence to opiates, nicotine, THC and alcohol that develop within motivation/emotion brain circuits. In our model, however, these do not apply to cocaine, supporting the notion of unique mechanisms in psychostimulant abuse.
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Withdrawal from drugs of abuse often results in social isolation and general impairments in sociability.
“Withdrawal from drugs of abuse often results in social isolation and general impairments in sociability [140].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [140]
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Self-citationKetamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in micePreprint
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- Authors
- Becker, J. A. J., Kieffer, B. L., & Le Merrer, J.
- Affiliations
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Médecine Translationelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U-964, CNRS UMR-7104; Université de Strasbourg; France
- Corresponding author
- Becker, Jérôme A.J.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2016-04-28
- Volume
- 22
- Issue
- 5
- Pages
- 1205-1217
- ISSN
- 1355-6215 (ISSN-L)
- PMC
- PMC5085894
- OpenAlex
- W2344104685
- Cited by
- 77
- References
- 85
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 12 · 2019: 11 · 2018: 7 · 2017: 6 · 2016: 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Centre National de la Recherche Scientifique
- Institut National de la Santé et de la Recherche Médicale
- Université de Strasbourg (16658, 005010)
- Institut de Recherches Scientifiques sur les Boissons (IREB)
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cocaine, morphine, nicotine, tetrahydrocannabinol, alcohol, psychostimulants, opiates, social recognition, social withdrawal, anxiety, motor stereotypies, c-fos, extended amygdala, gene expression
- MeSH terms
- Ethanol, Amygdala, Analgesics, Opioid, Animals, Anxiety, Behavior, Animal, Brain, Central Nervous System Depressants, Cocaine, Emotions, Male, Morphine, Motivation, Nicotine, Social Behavior, Stereotyped Behavior, Substance Withdrawal Syndrome, Dronabinol, Proto-Oncogene Proteins c-fos, Nicotinic Agonists, Dopamine Uptake Inhibitors, Mice, Drug-Seeking Behavior, Cannabinoid Receptor Agonists, Alcohol Abstinence
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