The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Three-dimensional cell migration does not follow a random walk
Open accessAbstract
Significance: The motility of cells in the absence of gradients has long been described in terms of random walks. Most of what we know about eukaryotic cell migration has stemmed from well-controlled studies of cell migration on flat dishes. However, cells in vivo often move through 3D environments. Despite this difference, cell speed and persistence are typically extracted from fits using the same persistence random walk (PRW) model. This paper shows that the assumptions of the PRW model are erroneous for 3D cell migration. We introduce and validate a new model of 3D cell migration that takes into account cell heterogeneity and the anisotropic movements induced by local remodeling of the 3D matrix.
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Cell Migration: Integrating Signals from Front to Back
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Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
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Self-citationImmune cell migration in inflammation: present and future therapeutic targets
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A distinctive role for focal adhesion proteins in three-dimensional cell motility
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Self-citationEvolution of cellular morpho-phenotypes in cancer metastasis.
Wu, P.-H., Phillip, J. M., Khatau, S. B., Chen, W.-C., Stirman, J., Rosseel, S., Tschudi, K., Van Patten, J., Wong, M., Gupta, S., et al. (2015) · Scientific Reports · doi:10.1038/srep18437 · Cited by 117
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Metadata
- Authors
- Wu, P.-H., Giri, A., Sun, S. X., & Wirtz, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-04
- Volume
- 111
- Issue
- 11
- Pages
- 3949-3954
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035336687
- Cited by
- 324
- References
- 28
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, P.-H., Giri, A., Sun, S. X., & Wirtz, D. (2014). Three-dimensional cell migration does not follow a random walk. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1318967111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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