The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling
Open accessAbstract
Significance: A mechanistic understanding of how calcium phosphate (CaP) minerals contribute to osteogenic commitment of stem cells and bone tissue formation is a necessary requirement for developing efficient CaP-based synthetic matrices to treat bone defects. This study unravels a previously unknown mechanism, phosphate-ATP-adenosine metabolic signaling, by which the CaP-rich mineral environment in bone tissues promotes osteogenic differentiation of human mesenchymal stem cells. In addition to a mechanical perspective on how biomaterials can influence stem cell differentiation through metabolic pathways, this discovery opens up new avenues for treating critical bone defects and bone metabolic disorders.
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Cites
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Cited by
Materials as stem cell regulators
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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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Metadata
- Authors
- Shih, Y.-R. V., Hwang, Y., Phadke, A., Kang, H., Hwang, N. S., Caro, E. J., Nguyen, S., Siu, M., Theodorakis, E. A., Gianneschi, N. C., Vecchio, K. S., Chien, S., Lee, O. K., & Varghese, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-06
- Volume
- 111
- Issue
- 3
- Pages
- 990-995
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041048532
- Cited by
- 356
- References
- 54
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shih, Y.-R. V., Hwang, Y., Phadke, A., Kang, H., Hwang, N. S., Caro, E. J., Nguyen, S., Siu, M., Theodorakis, E. A., Gianneschi, N. C., Vecchio, K. S., Chien, S., Lee, O. K., & Varghese, S. (2014). Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1321717111
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