Genetically engineering Synechocystis sp. Pasteur Culture Collection 6803 for the sustainable production of the plant secondary metabolite p -coumaric acid
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p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates for the production of certain plant metabolites, including phenylpropanoids. Here, we produced p-coumaric acid in a strain of transgenic cyanobacterium Synechocystis sp. Pasteur Culture Collection 6803 (hereafter Synechocystis 6803). Whereas a strain of Synechocystis 6803 genetically engineered to express sam8, a tyrosine ammonia lyase gene from the actinomycete Saccharothrix espanaensis, accumulated little or no p-coumaric acid, a strain that both expressed sam8 and lacked slr1573, a native hypothetical gene shown here to encode a laccase that oxidizes polyphenols, produced ∼82.6 mg/L p-coumaric acid, which was readily purified from the growth medium.
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Xue et al. engineered Synechocystis sp. PCC 6803 by introducing the tyrosine ammonia lyase gene sam8 from Saccharothrix espanaensis and deleting the native slr1573 laccase-like gene, resulting in secretion of approximately 82.6 mg/L p-coumaric acid into the culture medium.
“Xue et al. engineered Synechocystis sp. PCC 6803 by introducing the tyrosine ammonia lyase gene sam8 from Saccharothrix espanaensis and deleting the native slr1573 laccase-like gene, resulting in secretion of approximately 82.6 mg/L p-coumaric acid into the culture medium [185].”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [185]
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Cites
Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria
Rippka, R., Stanier, R. Y., Deruelles, J., Herdman, M., & Waterbury, J. B. (1979) · Microbiology · doi:10.1099/00221287-111-1-1 · Cited by 7,606 · see citing works
Stress-Induced Phenylpropanoid Metabolism.
Dixon, R. A., & Paiva, N. L. (1995) · The Plant Cell · doi:10.1105/tpc.7.7.1085 · Cited by 3,815 · see citing works
Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
Kris‐Etherton, P. M., Hecker, K. D., Bonanome, A., Coval, S. M., Binkoski, A. E., Hilpert, K. F., Griel, A. E., & Etherton, T. D. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00995-0 · Cited by 2,544 · see citing works
Stress-Induced Phenylpropanoid Metabolism
Dixon, R. A., & Paiva, N. L. (1995) · The Plant Cell · doi:10.2307/3870059 · Cited by 2,200 · see citing works
The structure and function of fungal laccases
Thurston, C. F. (1994) · Microbiology · doi:10.1099/13500872-140-1-19 · Cited by 1,941 · see citing works
Childs, R. E., & Bardsley, W. G. (1975) · Biochemical Journal · doi:10.1042/bj1450093 · Cited by 895 · see citing works
Laccases: A Useful Group of Oxidoreductive Enzymes
Gianfreda, L., Xu, F., & Bollag, J. (1999) · Bioremediation Journal · doi:10.1080/10889869991219163 · Cited by 834 · see citing works
Laccases: structure, reactions, distribution
Claus, H. (2003) · Micron · doi:10.1016/j.micron.2003.10.029 · Cited by 737 · see citing works
Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
Alarcón‐de‐la‐Lastra, C., & Villegas, I. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500022 · Cited by 705 · see citing works
Fellay, R., Joachim Frey, A., & Krisch, H. M. (1987) · Gene · doi:10.1016/0378-1119(87)90041-2 · Cited by 684 · see citing works
[83] Conjugal transfer of DNA to cyanobacteria
Elhai, J., & Wölk, C. P. (1988) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(88)67086-8 · Cited by 568 · see citing works
Engineering cyanobacteria to generate high-value products
Ducat, D. C., Way, J. C., & Silver, P. A. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.12.003 · Cited by 507 · see citing works
CotA of Bacillus subtilis Is a Copper-Dependent Laccase
Hullo, M.-F., Moszer, I., Danchin, A., & Martin‐Verstraete, I. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5426-5430.2001 · Cited by 428 · see citing works
Bioavailability of Phenolic Compounds
Karakaya, S. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490886683 · Cited by 413 · see citing works
Phenylpropanoid metabolism and lignin biosynthesis: from weeds to trees
Douglas, C. J. (1996) · Trends in Plant Science · doi:10.1016/1360-1385(96)10019-4 · Cited by 398 · see citing works
Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health.
Korkina, L. G. (2007) · PubMed · Cited by 388 · see citing works
Plant-derived phenolic antioxidants
Duthie, G. G., & Crozier, A. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200002000-00007 · Cited by 260 · see citing works
Elhai, J., & Wölk, C. P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07539.x · Cited by 224 · see citing works
THE CONJUGATION SYSTEM OF F, THE FERTILITY FACTOR OF ESCHERICHIA COLI
Ippen-Ihler, K., & Minkley, E. G. (1986) · Annual Review of Genetics · doi:10.1146/annurev.ge.20.120186.003113 · Cited by 217 · see citing works
Metabolic engineering of for the synthesis of the wine-related antioxidant resveratrol
BECKER, J., Armstrong, G. O., VANDERMERWE, M., Lambrechts, M. G., Vivier, M. A., & Pretorius, I. S. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00157-0 · Cited by 213 · see citing works
Katsuyama, Y., Funa, N., Miyahisa, I., & Horinouchi, S. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.004 · Cited by 203 · see citing works
Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
Lin, Y., & Yan, Y. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-42 · Cited by 173 · see citing works
Biosynthesis and biotechnological production of flavanones: current state and perspectives
Fowler, Z. L., & Koffas, M. A. G. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2039-z · Cited by 169 · see citing works
Choi, O., Wu, C., Kang, S. Y., Ahn, J. S., Uhm, T.-B., & Hong, Y. (2011) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-011-0954-3 · Cited by 103 · see citing works
Ng, W.-O., Zentella, R., Wang, Y., Taylor, J., & Pakrasi, H. B. (2000) · Archives of Microbiology · doi:10.1007/s002030000164 · Cited by 78 · see citing works
He, Q., & Vermaas, W. F. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5830 · Cited by 67 · see citing works
Self-citationAntimicrobial Dihydrofolate Reductase Inhibitors - Achievements and Future Options: Review
Then, R. L. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.1.3 · Cited by 66 · see citing works
[13] Conjugal transfer of plasmids to cyanobacteria
Thiel, T., & Wölk, C. P. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)53056-7 · Cited by 52 · see citing works
Xue, Y., Zhang, Y., Grace, S. C., & He, Q. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0113-5 · Cited by 49 · see citing works
Self-citationGescher, A. J. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.supplement-1.3 · Cited by 47 · see citing works
Antibiotic resistance versus small molecules, the chemical evolution
LEE, V. J., & Hecker, S. J. (1999) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199911)19:6 · Cited by 46 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Lee KH (1999) Novel antitumor agents from higher plants. Med Res Rev 19(6):569-596.
Cited by
Sorted by citations
Systems and Photosystems: Cellular Limits of Autotrophic Productivity in Cyanobacteria
Burnap, R. L. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00001 · Cited by 422 · see citing works
Aresta, M., Dibenedetto, A., & Quaranta, E. (2016) · Journal of Catalysis · doi:10.1016/j.jcat.2016.04.003 · Cited by 346 · see citing works
Metabolic engineering of cyanobacteria for the synthesis of commodity products
Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.03.009 · Cited by 273 · see citing works
Jendresen, C. B., Stahlhut, S. G., Li, M., Gaspar, P., Siedler, S., Förster, J., Maury, J., Borodina, I., & Nielsen, A. T. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00405-15 · Cited by 200 · see citing works
Mondo, A. D., Smerilli, A., Ambrosino, L., Albini, A., Noonan, D. M., Sansone, C., & Brunet, C. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1874284 · Cited by 144 · see citing works
Lan, E. I., Chuang, D. S., Shen, C. R., Lee, A. M., Ro, S. Y., & Liao, J. C. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.08.002 · Cited by 111 · see citing works
Lin, W., Tan, S., Hsiang, C., Sung, P.-K., & Ng, I. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121932 · Cited by 108 · see citing works
Cyanobacterial chassis engineering for enhancing production of biofuels and chemicals
Gao, X., Sun, T., Pei, G., Chen, L., & Zhang, W. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7374-2 · Cited by 106 · see citing works
Pi, E., Qu, L., Hu, J., Huang, Y., Qiu, L., Lü, H., Jiang, B., Liu, C., Peng, T., Zhao, Y., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.051961 · Cited by 92 · see citing works
Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production
Lai, M. J., & Lan, E. I. (2015) · Metabolites · doi:10.3390/metabo5040636 · Cited by 90 · see citing works
Brey, L. M. F., Włodarczyk, A., Thøfner, J. F. B., Burow, M., Crocoll, C., Nielsen, I., Nielsen, A. J., & Jensen, P. E. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.11.002 · Cited by 84 · see citing works
Ten years of algal biofuel and bioproducts: gains and pains
Chen, H., Li, T., & Wang, Q. (2019) · Planta · doi:10.1007/s00425-018-3066-8 · Cited by 83 · see citing works
Ng, A. H., Berla, B. M., & Pakrasi, H. B. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.01349-15 · Cited by 83 · see citing works
Shen, Y., Niu, F.-X., Yan, Z.-B., Fong, L. S., Huang, Y., & Liu, J.-Z. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00407 · Cited by 63 · see citing works
Cyanobacteria as Photosynthetic Biocatalysts: A Systems Biology Perspective
Gudmundsson, S., & Nogales, J. (2014) · Molecular BioSystems · doi:10.1039/c4mb00335g · Cited by 61 · see citing works
Cyanobacteria as Cell Factories to Produce Plant Secondary Metabolites
Xue, Y., & He, Q. (2015) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00057 · Cited by 57 · see citing works
Self-citationProduction of C3 platform chemicals from CO 2 by genetically engineered cyanobacteria
Wang, Y., Tao, F., Ni, J., Li, C., & Xu, P. (2015) · Green Chemistry · doi:10.1039/c5gc00129c · Cited by 53 · see citing works
Genetic, Genomics, and Responses to Stresses in Cyanobacteria: Biotechnological Implications
Cassier‐Chauvat, C., Blanc-Garin, V., & Chauvat, F. (2021) · Genes · doi:10.3390/genes12040500 · Cited by 47 · see citing works
Jin, H., Wang, Y., Idoine, A., & Bhaya, D. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01662 · Cited by 46 · see citing works
Fang, L., Ge, H., Huang, X., Liu, Y., Lu, M., Wang, J., Chen, W., Xu, W., & Wang, Y. (2016) · Molecular Plant · doi:10.1016/j.molp.2016.08.006 · Cited by 38 · see citing works
Ni, J., Tao, F., Wang, Y., Yao, F., & Xu, P. (2016) · Green Chemistry · doi:10.1039/c6gc00317f · Cited by 37 · see citing works
Gowthami, A., Marjuk, M. S., Santhanam, P., Ramasamy, T., Muralisankar, T., & Perumal, P. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.144024 · Cited by 37 · see citing works
Sanger, K., Zór, K., Jendresen, C. B., Heiskanen, A. R., Amato, L., Nielsen, A. T., & Boisen, A. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.06.184 · Cited by 36 · see citing works
Nomura, T., Ogita, S., & Kato, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-31566-4 · Cited by 34 · see citing works
Ge, H., Fang, L., Huang, X., Wang, J., Chen, W., Liu, Y., Zhang, Y., Wang, X., Xu, W., He, Q., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.068080 · Cited by 33 · see citing works
Self-citationCui, P., Zhong, W., Qin, Y., Tao, F., Wang, W., & Zhan, J. (2020) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-020-02325-5 · Cited by 31 · see citing works
Gao, E., Kyere-Yeboah, K., Wu, J., & Qiu, H. (2021) · Algal Research · doi:10.1016/j.algal.2020.102180 · Cited by 31 · see citing works
Wu, P., Hu, T., Sun, L., & Fan, J. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145974 · Cited by 29 · see citing works
Plant Flavonoid Production in Bacteria and Yeasts
Isogai, S., Tominaga, M., Kondo, A., & Ishii, J. (2022) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2022.880694 · Cited by 25 · see citing works
Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways
Vavitsas, K., Rue, E. Ø., Stefánsdóttir, L. K., Gnanasekaran, T., Blennow, A., Crocoll, C., Guðmundsson, S., & Jensen, P. E. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0757-y · Cited by 25 · see citing works
Textile Dye Decolorizing Synechococcus PCC7942 Engineered With CotA Laccase
Liang, Y., Hou, J., Liu, Y., Luo, Y., Tang, J., Cheng, J. J., & Daroch, M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00095 · Cited by 24 · see citing works
Building an Inducible T7 RNA Polymerase/T7 Promoter Circuit in Synechocystis sp. PCC6803
Jin, H., Lindblad, P. C., & Bhaya, D. (2019) · ACS Synthetic Biology · doi:10.1021/acssynbio.8b00515 · Cited by 23 · see citing works
Kukil, K., & Lindberg, P. (2022) · Microbial Cell Factories · doi:10.1186/s12934-021-01735-8 · Cited by 22 · see citing works
Advances in the Biotechnological Potential of Brazilian Marine Microalgae and Cyanobacteria
Oliveira, D. T. D., Costa, A. A. F. D., Costa, F. F., Rocha Filho, G. N. D., & Nascimento, L. A. S. D. (2020) · Molecules · doi:10.3390/molecules25122908 · Cited by 21 · see citing works
Yang, G., Zhang, Y., Lee, N. K., Cozad, M. A., Kearney, S. E., Luesch, H., & Ding, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-12244-3 · Cited by 20 · see citing works
Self-citationChanges in polyphenol compounds and barley laccase expression during the malting process
Tomková, L., PSOTA, V., SACHAMBULA, L., Leišová‐Svobodová, L., Mikyška, A., & Kučera, L. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7116 · Cited by 18 · see citing works
Zhang, Z., Lebleu, M., Osprey, M., Kerr, C., & Courtot, E. (2017) · Environmental Geochemistry and Health · doi:10.1007/s10653-017-0002-y · Cited by 18 · see citing works
Potential of Producing Flavonoids Using Cyanobacteria as a Sustainable Chassis
Jin, H., Wang, Y., Zhao, P., Wang, L., Zhang, S., Meng, D., Yang, Q., Cheong, L.-Z., Bi, Y., & Fu, Y. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04632 · Cited by 17 · see citing works
Phenylpropanoids for the control of fungal diseases of postharvest fruit
Sun, Y., Wang, X., Huang, Z., Zhao, X., Qiao, L., Wu, C., Xue, Z., & Kou, X. (2025) · Plant Molecular Biology · doi:10.1007/s11103-025-01568-8 · Cited by 17 · see citing works
Gao, L., Ge, H., Huang, X., Liu, K., Zhang, Y., Xu, W., & Wang, Y. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.044800 · Cited by 17 · see citing works
Self-citationIntegrated Product Recovery Will Boost Industrial Cyanobacterial Processes
van den Berg, C., Eppink, M. H. M., & Wijffels, R. H. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.11.006 · Cited by 15 · see citing works
Synechocystis: A model system for expanding the study of cyanobacterial circadian rhythms
Zhao, C., Xu, Y. Q., Wang, B., & Johnson, C. H. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1085959 · Cited by 13 · see citing works
An introduction to microbial cell factories for production of biomolecules
Gohil, N., Bhattacharjee, G., & Singh, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821477-0.00021-0 · Cited by 13 · see citing works
Ranade, S., Zhang, Y., Kaplan, M., Majeed, W., & He, Q. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01484 · Cited by 11 · see citing works
Self-citationPhotoresponse Mechanism in Cyanobacteria: Key Factor in Photoautotrophic Chassis
Zhan, J., & Wang, Q. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0854-3_4 · Cited by 11 · see citing works
Recombinant protein synthesis and isolation of human interferon alpha-2 in cyanobacteria
Majhi, B. K., & Melis, A. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130664 · Cited by 10 · see citing works
Engineering cyanobacteria for the production of aromatic natural products
Gu, F., Li, C., Zheng, H., & Ni, J. (2024) · Blue Biotechnology · doi:10.1186/s44315-024-00002-w · Cited by 9 · see citing works
Tantong, S., Incharoensakdi, A., Sirikantaramas, S., & Lindblad, P. C. (2016) · Protein Expression and Purification · doi:10.1016/j.pep.2016.01.020 · Cited by 9 · see citing works
Deciphering proteolysis pathways for the error‐prone DNA polymerase in cyanobacteria
Jin, H., Kim, R. G., & Bhaya, D. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.14911 · Cited by 9 · see citing works
Harnessing Solar‐Powered Oxic N 2 ‐fixing Cyanobacteria for the BioNitrogen Economy
Young, J. S., Gu, L., Gibbons, W. R., & Zhou, R. (2021) · doi:10.1002/9783527824908.ch13 · Cited by 9 · see citing works
Morelli, L., Centorbi, F. A., Ilchenko, O. O., Jendresen, C. B., Demarchi, D., Nielsen, A. T., Zór, K., & Boisen, A. (2019) · The Analyst · doi:10.1039/c8an02128g · Cited by 8 · see citing works
Xiao, Z., Huang, C., Ge, H., Wang, Y., Duan, X., Wang, G., Zheng, L., Dong, J., Huang, X., Zhang, Y., et al. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100440 · Cited by 7 · see citing works
Self-citationReprogramming Metabolic Networks and Manipulating Circadian Clocks for Biotechnological Applications
Wang, B., Young, J. D., & Xu, Y. Q. (2021) · Springer eBooks · doi:10.1007/978-3-030-72158-9_14 · Cited by 7 · see citing works
Current progress of p-coumaric acid production using bioengineering technologies
Zhang, R., Shah, A. A., Wang, B., & Gong, C. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107109 · Cited by 6 · see citing works
Influence of Solubility of Ethanol Extracts in Artemia salina Tests
dos Santos, H. D., de Oliveira, F. F., & de Oliveira, R. A. (2017) · Revista Virtual de Química · doi:10.21577/1984-6835.20170089 · Cited by 6 · see citing works
Jin, H., Wang, Y., Fu, Y., & Bhaya, D. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15750 · Cited by 6 · see citing works
Interfacing solar energy with bacterial metabolism for sustainable chemical synthesis
Trotter, C. L., Clouston, K., Steele, J. F. C., Marlow, L., & Wallace, S. C. (2026) · Nature Reviews Clean Technology · doi:10.1038/s44359-025-00141-2 · Cited by 5 · see citing works
Tantong, S., Nuengchamnong, N., Kumphune, S., Incharoensakdi, A., Lindblad, P. C., & Sirikantaramas, S. (2017) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/s13562-017-0416-8 · Cited by 4 · see citing works
Metabolism of microalgae and metabolic engineering for biomaterial applications
de Morais, M. G., Cassuriaga, A. P. A., Cruz, C. G., Moraes, L., & Costa, J. A. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96142-4.00010-5 · Cited by 3 · see citing works
Generation of Synechocystis sp. PCC 6803 mutant with enhanced laccase-like activity
Hurtado-McCormick, V., Commault, A. S., Herdean, A., Price, S., Pernice, M., & Ralph, P. J. (2022) · Bioresource Technology Reports · doi:10.1016/j.biteb.2022.101266 · Cited by 3 · see citing works
Shi, Z., & Wang, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15558-1.00013-8 · Cited by 2 · see citing works
Carbon capture, storage, and utilization in cyanobacteria
Majhi, B. K. (2026) · Carbon Resources Conversion · doi:10.1016/j.crcon.2025.100388 · Cited by 2 · see citing works
Ge, H., Fang, L., Huang, X., Wang, J., Chen, W., Liu, Y., Zhang, Y., Wang, X., Xu, W., He, Q., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m117.068080 · Cited by 2 · see citing works
Self-citationXue, Y., & He, Q. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0854-3_11 · Cited by 2 · see citing works
Self-citationWalshe, J., & Saha, S. K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060638 · Cited by 1 · see citing works
“Xue et al. engineered Synechocystis sp. PCC 6803 by introducing the tyrosine ammonia lyase gene sam8 from Saccharothrix espanaensis and deleting the native slr1573 laccase-like gene, resulting in secretion of approximately 82.6 mg/L p-coumaric acid into the culture medium [185].”
InfluentialUse of Carbon Dioxide in Polymer Synthesis
Azim, A. A., Cordara, A., Battaglino, B., & Re, A. (2019) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-030-28638-5_1 · Cited by 1 · see citing works
Cyanobacteria as a photosynthetic factory for the production of natural and synthetic compounds
Xue, Y., White, R., & He, Q. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98391-4.00006-x · Cited by 1 · see citing works
Self-citationChen, A. Y., Ku, J. T., Tsai, T. P., Hung, J. J.-C., Hung, B. C., & Lan, E. I. (2023) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2023_218
Liu, X., Zhang, W., Wang, L., Li, R., Zhao, C., & Lü, X. (2026) · Life · doi:10.3390/life16060885
Commault, A. S., Barolo, L., Kopp, D., Hurtado-McCormick, V., Herdean, A., Ralph, P. J., & Pernice, M. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.136042
- Authors
- Xue, Y., Zhang, Y., Cheng, D., Daddy, S., & He, Q.
- Affiliations
- University of Arkansas at Little Rock (US)
- Shandong Academy of Agricultural Sciences (CN)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-09
- Volume
- 111
- Issue
- 26
- Pages
- 9449-9454
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4084433
- OpenAlex
- W2088141494
- Cited by
- 72
- References
- 31
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 11 · 2014: 2
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1120153)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- p-coumaric acid, phenylpropanoids, Synechocystis sp. PCC 6803, tyrosine ammonia-lyase, laccase, transgenic cyanobacteria, plant secondary metabolites, polyphenol oxidation
- MeSH terms
- Ammonia-Lyases, Chromatography, High Pressure Liquid, Coumaric Acids, Genetic Engineering, Plasmids, Propionates, Mass Spectrometry, Molecular Structure, DNA Primers, Gene Transfer Techniques, Bioreactors, Reverse Transcriptase Polymerase Chain Reaction, Synechocystis, Biosynthetic Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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