The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes
Open accessAbstract
Significance: Early detection of cancer positively impacts diagnosis and treatment, ultimately improving patient survival. Using fluorescence imaging offers the promise of safe, noninvasive detection with excellent resolution and guides surgical removal of tumors to improve patient outcomes. However, the success of current optical probes is limited due to high background from tissue autofluorescence, poor penetration depth, and inherently low signal stability. Here, we engineered M13 bacteriophage to stabilize single-walled carbon nanotubes for selective, targeted imaging of ovarian tumors. These nanoprobes fluoresce at longer near-infrared wavelengths than current probes, thereby improving noninvasive detection of small, deep tumors and guidance for surgical removal of submillimeter tumors. This material-based approach may be attractive to guide surgical interventions where deep tissue molecular imaging is informative.
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Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958
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He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
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Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Metadata
- Authors
- Ghosh, D., Bagley, A. F., Na, Y. J., Birrer, M. J., Bhatia, S. N., & Belcher, A. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-09-11
- Volume
- 111
- Issue
- 38
- Pages
- 13948-13953
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965003174
- Cited by
- 251
- References
- 1
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Ghosh, D., Bagley, A. F., Na, Y. J., Birrer, M. J., Bhatia, S. N., & Belcher, A. M. (2014). Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1400821111
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