A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
Open accessAbstract
Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with >1,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. Here, we report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for the fastest video-rate imaging in the second NIR window with ∼50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. In addition, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.
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Tail fluorescence emission sometimes allows high-contrast imaging with current organic SWIR fluorophores.
“This tail fluorescence emission sometimes allows high-contrast imaging with current organic SWIR fluorophores.29,34,96,219,220”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [220]
The Results section, “Deep lymph node imaging with CH-4T complexes” (page unavailable), reports high-contrast NIR-II imaging with the organic CH-4T–protein fluorophore, including a signal-to-background ratio of approximately 13 for deep lymph nodes. The paper does not identify tail fluorescence emission as the reason for that contrast; it describes CH-4T as a dye whose emission peaks in the NIR-II window. (LLM, conf=0.84)
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Cites
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287 · see citing works
Self-citationDeep optical imaging of tissue using the second and third near-infrared spectral windows
Sordillo, L. A., Pu, Y., Pratavieira, S., Budansky, Y., & Alfano, R. R. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.5.056004 · Cited by 407 · see citing works
Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386 · see citing works
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Research works printed but not linked: 36
- Hong G.. Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window. Nat. Commun. 5, 4206 (2014). 24947309
- Antaris A. L.. A small-molecule dye for NIR-II imaging. Nat. Mater. 15, 235– 242 (2016). 26595119
- Hong G.. Through-skull fluorescence imaging of the brain in a new near-infrared window. Nat. Photonics 8, 723– 730 (2014). 27642366 PMC5026222
- Hong G.. Multifunctional in vivo vascular imaging using near-infrared II fluorescence. Nat. Med. 18, 1841– 1846 (2012). 23160236 PMC3595196
- Yi H.. M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors. Nano Lett. 12, 1176– 1183 (2012). 22268625 PMC3905603
- Dang X.. Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer. Proc. Natl Acad. Sci. USA 113, 5179– 5184 (2016). 27114520 PMC4868435
- Hong G.. Near-Infrared II fluorescence for imaging hindlimb vessel regeneration with dynamic tissue perfusion measurement. Circ. Cardiovasc. Imaging 7, 517– 525 (2014). 24657826 PMC4079035
- Sun Y.. Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II optical imaging. Chem. Sci. 7, 6203– 6207 (2016). PMC6024204 30034761
- Hof M., Hutterer R. & Fidler V. Fluorescence Spectroscopy in Biology: advanced Methods and Their Applications to Membranes, Proteins, DNA, and Cells Springer (2005).
- Umezawa K., Nakamura Y., Makino H., Citterio D. & Suzuki K. Bright, color-tunable fluorescent dyes in the visible-near-infrared region. J. Am. Chem. Soc. 130, 1550– 1551 (2008). 18193873
- Diao S.. Fluorescence imaging in vivo at wavelengths beyond 1500 nm. Angew. Chem. Int. Ed. 54, 14758– 14762 (2015). 26460151
- Chen J.. Direct water-phase synthesis of lead sulfide quantum dots encapsulated by β-lactoglobulin for in vivo second near infrared window imaging with reduced toxicity. Chem. Commun. 52, 4025– 4028 (2016). 26888668
- Kong Y.. Highly fluorescent ribonuclease-A-encapsulated lead sulfide quantum dots for ultrasensitive fluorescence in vivo imaging in the second near-infrared window. Chem. Mater. 28, 3041– 3050 (2016). 27212793 PMC4869608
- Bhasikuttan A. C., Mohanty J., Nau W. M. & Pal H. Efficient fluorescence enhancement and cooperative binding of an organic dye in a supra-biomolecular host-protein assembly. Angew. Chem. Int. Ed. 46, 4120– 4122 (2007). 17443829
- Ifft J. B. Sedimentation equilibrium of proteins in density gradients. Biophys. Chem. 5, 137– 157 (1976). 9163
- Hutteman M.. Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer. Am. J. Obstet. Gynecol. 206, 89.e1–5 (2012). 21963099 PMC3246078
- Bardhan N. M., Ghosh D. & Belcher A. M. Carbon nanotubes as in vivo bacterial probes. Nat. Commun. 5, 4918 (2014). 25230005 PMC4349414
- Iverson N. M.. In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes. Nat. Nanotechnol. 8, 873– 880 (2013). 24185942 PMC4066962
- Yi H. J.. M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors. Nano Lett. 12, 1176– 1183 (2012). 22268625 PMC3905603
- Diao S.. Chirality enriched (12,1) and (11,3) single-walled carbon nanotubes for biological imaging. J. Am. Chem. Soc. 134, 16971– 16974 (2012). 23033937
- Ghosh D.. Deep noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proc. Natl Acad. Sci. USA 111, 13948– 13953 (2014). 25214538 PMC4183329
- Tao Z. M.. Biological Imaging using nanoparticles of small organic molecules with fluorescence emission at wavelengths longer than 1000 nm. Angew. Chem. Int. Ed. 52, 13002– 13006 (2013). 24174264
- Hutteman M.. Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients. Breast Cancer Res. Treat. 127, 163– 170 (2011). 21360075 PMC3667709
- Desmettre T., Devoisselle J. M. & Mordon S. Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography. Surv. Ophthalmol. 45, 15– 27. 10946079
- Kirchher A.-M., Briel A. & Mader K. Stabilization of indocyanine green by encapsulation within micellar systems. Mol. Pharm. 6, 480– 491 (2009). 19228053
- Murphy J. E.. PbTe colloidal nanocrystals: synthesis, characterization, and multiple exciton generation. J. Am. Chem. Soc. 128, 3241– 3247 (2006). 16522105
- Hatami S.. Absolute photoluminescence quantum yields of IR26 and IR-emissive Cd1−xHgxTe and PbS quantum dots -method- and material-inherent challenges. Nanoscale 7, 133– 143 (2015). 25407424
- Benson R. C. & Kues H. A. Fluorescence properties of indocyanine green as related to angiography. Phys. Med. Biol. 23, 159– 163 (1978). 635011
- Mordon S., Devoisselle J. M., Soulie-Begu S. & Desmettre T. Indocyanine green: physicochemical factors affecting its fluorescence in vivo. Microvasc. Res. 55, 146– 152 (1998). 9521889
- Reja S. I., Khan I. A., Bhalla V. & Kumar M. A TICT based NIR-fluorescent probe for human serum albumin: a pre-clinical diagnosis in blood serum. Chem. Commun. 52, 1182– 1185 (2016). 26601767
- Cao C.. A twisted-intramolecular-charge-transfer (TICT) based ratiometric fluorescent thermometer with a mega-Stokes shift and a positive temperature coefficient. Chem. Commun. 50, 15811– 15814 (2014). 25372984
- Choi H. S.. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat. Biotechnol. 31, 148– 153 (2013). 23292608 PMC3568187
- Choi H. S.. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew. Chem. Int. Ed. 50, 6258– 6263 (2011). PMC3128676 21656624
- Senarathna J., Rege A., Li N. & Thakor N. V. Laser speckle contrast imaging: theory, instrumentation and applications. IEEE Rev. Biomed. Eng. 6, 99– 110 (2013). 23372086
- Sugiyama T., Araie M., Riva C. E., Schmetterer L. & Orgul S. Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 88, 723– 729 (2010). 19725814
- Hu S. & Wang L. V. Photoacoustic imaging and characterization of the microvasculature. J. Biomed. Opt. 15, 011101 (2010). 20210427 PMC2821418
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Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01682 · Cited by 215 · see citing works
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- Authors
- Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., Zhu, M., Cheng, K., Hong, X., Dai, H., & Cheng, Z.
- Affiliations
- Stanford University (US)
- Wuhan University (CN)
- Stanford Medicine (US)
- Corresponding author
- Hong, Xuechuan
- Dai, Hongjie
- Cheng, Zhen
- ORCID
- Venue
- Nature Communications
- Published
- 2017-05-19
- Volume
- 8
- Issue
- 1
- Pages
- 15269-15269
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5454457
- OpenAlex
- W2614165899
- Cited by
- 623
- References
- 3
- Citations by year
- 2026: 47 · 2025: 54 · 2024: 79 · 2023: 77 · 2022: 73 · 2021: 87 · 2020: 76 · 2019: 66 · 2018: 58 · 2017: 5
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Energy (DESC0008397)
- National Natural Science Foundation of China (21390402, 81573383, 2014DFB30020, 81373254, 2015DFA30440)
- Ministry of Education of the People's Republic of China (313040)
- Wuhan University
- Wuhan University School of Medicine
- National Science and Technology Major Project
- Office of Science (DESC0008397)
- Fundamental Research Funds for the Central Universities
- National Cancer Institute (U54CA119367, CA151459, U54CA151459, DE-SC0008397)
- National Institute of Neurological Disorders and Stroke (DP1NS105737)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- NIR-II fluorescence imaging, quantum yield enhancement, supramolecular self-assembly, deep tissue imaging, video-rate imaging, lymph node imaging
- MeSH terms
- Animals, Female, Fluorescence, Fluorescent Dyes, Ionophores, Lymph Nodes, Mice, Nude, Organic Chemicals, Quantum Theory, Semiconductors, Video Recording, Spectroscopy, Near-Infrared, Nanotubes, Carbon, Nanostructures, Mice, Optical Imaging
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