The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Quantification of HIV-1 latency reversal in resting CD4 + T cells from patients on suppressive antiretroviral therapy
Open accessAbstract
Significance: A pool of latently infected resting CD4 + T cells in patients on antiretroviral therapy is a major barrier to a cure for HIV-1. Clinical trials are underway to assess whether small molecules can “kick” HIV-1 out of latency, but the potency of such latency reversing agents has not been evaluated at the level of single proviruses. Using a unique quantitative system, we found that the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid), which is being investigated clinically, did not induce unspliced cellular viral RNA or lead to virion production from the large majority of proviruses in resting CD4 + T cells. Our results demonstrate that more potent interventions will likely be necessary to reduce the size of the latent reservoir.
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Cites
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., & Richman, D. D. (1997) · Science · doi:10.1126/science.278.5341.1291 · Cited by 2,186
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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050
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Cited by
International AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Self-citationResearch priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Deeks, S. G., Archin, N., Cannon, P., Collins, S., Jones, R. B., de Jong, M. A. W. P., Lambotte, O., Lamplough, R., Ndung’u, T., Sugarman, J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01590-5 · Cited by 377
Clonally expanded CD4 + T cells can produce infectious HIV-1 in vivo
Simonetti, F. R., Sobolewski, M. D., Fyne, E., Shao, W., Spindler, J., Hattori, J., Anderson, E. M., Watters, S. A., Hill, S., Wu, X., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522675113 · Cited by 372
Self-citationPollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S.-H., Karandish, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.008 · Cited by 370
Darcis, G., Kula, A., Bouchat, S., Fujinaga, K., Corazza, F., Ait-Ammar, A., Delacourt, N., Melard, A., Kabeya, K., Vanhulle, C., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005063 · Cited by 281
Metadata
- Authors
- Cillo, A. R., Sobolewski, M. D., Bosch, R. J., Fyne, E., Piatak, M., Coffin, J. M., & Mellors, J. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-31
- Volume
- 111
- Issue
- 19
- Pages
- 7078-7083
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964173449
- Cited by
- 232
- References
- 5
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cillo, A. R., Sobolewski, M. D., Bosch, R. J., Fyne, E., Piatak, M., Coffin, J. M., & Mellors, J. W. (2014). Quantification of HIV-1 latency reversal in resting CD4 + T cells from patients on suppressive antiretroviral therapy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1402873111
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
