The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Gyrification from constrained cortical expansion
Open accessAbstract
Significance: The convolutions of the human brain are a symbol of its functional complexity and correlated with its information-processing capacity. Conversely, loss of folds is correlated with loss of function. But how did the outer surface of the brain, the layered cortex of neuronal gray matter, get its folds? Guided by prior experimental observations of the growth of the cortex relative to the underlying white matter, we argue that these folds arise due to a mechanical instability of a soft tissue that grows nonuniformly. Numerical simulations and physical mimics of the constrained growth of the cortex show how compressive mechanical forces sculpt it to form characteristic sulci and gyri, consistent with observations across species in both normal and pathological situations.
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Cites
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
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Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
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A tension-based theory of morphogenesis and compact wiring in the central nervous system
Essen, D. C. V. (1997) · Nature · doi:10.1038/385313a0 · Cited by 1,683
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Development and Evolution of the Human Neocortex
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Cited by
On the growth and form of cortical convolutions
Tallinen, T., Chung, J. Y., Rousseau, F., Girard, N., Lefèvre, J., & Mahadevan, L. (2016) · Nature Physics · doi:10.1038/nphys3632 · Cited by 579
Self-citationCerebral cortex expansion and folding: what have we learned?
Fernández, V., Llinares‐Benadero, C., & Borrell, V. (2016) · The EMBO Journal · doi:10.15252/embj.201593701 · Cited by 361
Programmed and self-organized flow of information during morphogenesis
Collinet, C., & Lecuit, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00318-6 · Cited by 322
The Genetics of Primary Microcephaly
Jayaraman, D., Bae, B.-I., & Walsh, C. A. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021441 · Cited by 285
Deconstructing cortical folding: genetic, cellular and mechanical determinants
Llinares-Benadero, C., & Borrell, V. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0112-2 · Cited by 243
Metadata
- Authors
- Tallinen, T., Chung, J. Y., Biggins, J. S., & Mahadevan, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-18
- Volume
- 111
- Issue
- 35
- Pages
- 12667-12672
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2121893022
- Cited by
- 422
- References
- 35
- FWCI
- 37.79
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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