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Regional, Directional, and Age-Dependent Properties of the Brain Undergoing Large Deformation

Prange, Michael T., Margulies, Susan S.·2002·Journal of Biomechanical Engineering
DOI 10.1115/1.1449907
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Abstract

The large strain mechanical properties of adult porcine gray and white matter brain tissues were measured in shear and confirmed in compression. Consistent with local neuroarchitecture, gray matter showed the least amount of anisotropy, and corpus callosum exhibited the greatest degree of anisotropy. Mean regional properties were significantly distinct, demonstrating that brain tissue is inhomogeneous. Fresh adult human brain tissue properties were slightly stiffer than adult porcine properties but considerably less stiff than the human autopsy data in the literature. Mixed porcine gray/white matter samples were obtained from animals at “infant” and “toddler” stages of neurological development, and shear properties compared to those in the adult. Only the infant properties were significantly different (stiffer) from the adult.

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Metadata

Authors
Prange, M. T., & Margulies, S. S.
Venue
Journal of Biomechanical Engineering
Publisher
ASME International
Published
2002-03-29
Volume
124
Issue
2
Pages
244-252
ISSN
  • 0148-0731 (ISSN-L)
  • 1528-8951
DOI
10.1115/1.1449907
OpenAlex
W1963892608
Cited by
635
References
2
FWCI
8.05
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Regional, Directional, and Age-Dependent Properties of the Brain Undergoing Large Deformation. https://app.cochat.ai/papers/10.1115/1.1449907
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Prange, M. T., & Margulies, S. S. (2002). Regional, Directional, and Age-Dependent Properties of the Brain Undergoing Large Deformation. Journal of Biomechanical Engineering. https://doi.org/10.1115/1.1449907

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