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Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
Open accessAbstract
Significance: Muscle insulin resistance is a major factor in the pathogenesis of type 2 diabetes, but the underlying cellular mechanisms are yet unclear. This study found that muscle diacylglycerol content was temporally associated with protein kinase Cθ activation and impairment of insulin signaling in human skeletal muscle. A similar relationship between muscle diacylglycerol content and protein kinase Cθ activation was observed in insulin-resistant obese and type 2 diabetic individuals. In contrast, we observed no relationship between other putative mediators of muscle insulin resistance including ceramides, acylcarnitines, or circulating adipocytokines. These data support the hypothesis that diacylglycerol activation of protein kinase Cθ and subsequent impairment of insulin signaling plays a major role in the pathogenesis of muscle insulin resistance in humans.
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“Lipotoxicity is characterized by the accumulation of lipid metabolites (ceramides and diacylglycerol) that interfere with insulin signaling, thus impairing insulin action (26,28).”
From Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity (2018) · cites this paper as [28]
In the citing paper
“Similar to IKK and JNK pathways, it induces serine or threonine phosphorylation or IR or IRS-1, resulting in impairment of insulin signaling [80,81].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [80]
In the citing paper
“PKCθ is predominantly expressed in skeletal muscle and endothelium and is activated by increased DAG content in muscles, via elevated plasma fatty acid infusion in humans [80] or palmitate treatment in myocytes [64].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [80]
In the citing paper
“Szendroedi et al. (2014) showed a strong relationship between muscle DAG content, PKCθ translocation and muscle insulin resistance in obese and type 2 diabetic patients, whereas no correlation with muscle ceramide content and muscle insulin resistance was seen in these subjects.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Szendroedi et al., 2014
In the citing paper
“These findings have been replicated in animal studies (rodents and rats), further expanding our understanding of the defect involving insulin signaling and action (Griffin et al., 1999; Shulman, 2014; Szendroedi et al., 2014).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Szendroedi et al., 2014
In the citing paper
“In particular, an overabundance of SFA (e.g., Palmitate) can induce IR through the accumulation of lipid derivatives including DAGs, ceramides and long chain acyl-CoAs in the cytosol, which in turn can interfere with IRS1-PKB signalling [113,114,115,116,117,118].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [113]
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Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Self-citationMechanisms for Insulin Resistance: Common Threads and Missing Links
Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294
Self-citationKoves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Self-citationItani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
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Items 101–200 of 417
von Loeffelholz, C., Coldewey, S. M., & Birkenfeld, A. L. (2021) · Cells · doi:10.3390/cells10071822 · Cited by 70
Mechanism by which arylamine N -acetyltransferase 1 ablation causes insulin resistance in mice
Camporez, J. P., Wang, Y., Faarkrog, K., Chukijrungroat, N., Petersen, K. F., & Shulman, G. I. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716990115 · Cited by 67
Self-citationCho, M. E., Hansen, J. L., Peters, C. B., Cheung, A. K., Greene, T., & Sauer, B. C. (2019) · Kidney International · doi:10.1016/j.kint.2019.04.029 · Cited by 66
Goedeke, L., Peng, L., Montalvo-Romeral, V., Butrico, G. M., Dufour, S., Zhang, X.-M., Perry, R. J., Cline, G. W., Kievit, P., Chng, K., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0284 · Cited by 63
Self-citationIntramyocellular lipid droplets and insulin sensitivity, the human perspective
Gemmink, A., Goodpaster, B. H., Schrauwen, P., & Hesselink, M. K. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.010 · Cited by 62
Scheel, A. K., Espelage, L., & Chadt, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094759 · Cited by 68
Skeletal muscle and MASLD: Mechanistic and clinical insights
Marjot, T., Armstrong, M. J., & Stine, J. G. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000711 · Cited by 76
Lipidomics—Reshaping the Analysis and Perception of Type 2 Diabetes
Markgraf, D. F., Al‐Hasani, H., & Lehr, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111841 · Cited by 64
The lifecycle of skeletal muscle mitochondria in obesity
Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews · doi:10.1111/obr.13164 · Cited by 61
Changes in Cells Associated with Insulin Resistance
Szablewski, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042397 · Cited by 78
Akoumi, A., Haffar, T., Mousterji, M., Kiss, R. S., & Bousette, N. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.032 · Cited by 61
Castillo, Í. M. P., Argilés, J. M. A., Rueda, R., Ramírez, M., & Pedrosa, J. M. L. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09954-9 · Cited by 75
Tumor progression and the different faces of the PERK kinase
Pytel, D., Majsterek, I., & Diehl, J. A. (2015) · Oncogene · doi:10.1038/onc.2015.178 · Cited by 60
The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise
Pesta, D. H., & Roden, M. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0867-2 · Cited by 58
Self-citationOpposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess
Lundsgaard, A., Sjøberg, K. A., Høeg, L. D., Jeppesen, J. F., Jordy, A. B., Serup, A. K., Fritzen, A. M., Pilegaard, H., Myrmel, L. S., Madsen, L., et al. (2017) · Diabetes · doi:10.2337/db17-0046 · Cited by 61
Cheng, F., Han, L., Xiao, Y., Pan, C., Li, Y., Ge, X., Zhang, Y., Yan, S., & Wang, M. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01253 · Cited by 59
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Carrageta, D. F., Pereira, S., Ferreira, R. M., Monteiro, M. P., Oliveira, P. F., & Alves, M. G. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00866-y · Cited by 65
Identification of functional lipid metabolism biomarkers of brown adipose tissue aging
Gohlke, S., Zagoriy, V., Inostroza, A. C., Méret, M., Mancini, C., Japtok, L., Schumacher, F., Kuhlow, D., Graja, A., Stephanowitz, H., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.03.011 · Cited by 59
GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance
Kim, Y., Greimel, P., & Hirabayashi, Y. (2018) · iScience · doi:10.1016/j.isci.2018.10.001 · Cited by 61
Sánchez‐González, C., Nuevo‐Tapioles, C., Martín, J. C. H., Pereira, M. P., Sanz, S. S., de Molina, A. R., Cuezva, J. M., & Formentini, L. (2020) · The EMBO Journal · doi:10.15252/embj.2019103812 · Cited by 55
Apostolopoulou, M., Mastrototaro, L., Hartwig, S., Pesta, D. H., Straßburger, K., Filippo, E. D., Jeleník, T., Karusheva, Y., Gancheva, S., Markgraf, D. F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi9551 · Cited by 54
Self-citationLoza-Medrano, S., Baiza-Gutman, L. A., Manuel‐Apolinar, L., García-Macedo, R., Damasio‐Santana, L., Martínez-Mar, O. A., Sánchez-Becerra, M. C., Cruz, M., Ibáñez-Hernández, M. Á., & Díaz-Flores, M. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05136-4 · Cited by 51
The Diabetes Risk Phenotype of Young Women With Recent Gestational Diabetes
Rottenkolber, M., Ferrari, U., Holland, L., Aertsen, S., Kammer, N. N., Hetterich, H., Fugmann, M., Banning, F., Weise, M., Sacco, V., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3898 · Cited by 52
Diabetes and dyslipidemia: characterizing lipoprotein metabolism
TOMKIN, G. H., & Owens, D. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s115855 · Cited by 55
Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis
Kalavalapalli, S., Bril, F., Guingab, J., Vergara, A., Garrett, T. J., Sunny, N. E., & Cusi, K. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0007 · Cited by 51
Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions
Bandet, C. L., Mahfouz, R., Véret, J., Sotiropoulos, A., Poirier, M., Giussani, P., Campaña, M. B., Philippe, E., Błachnio-Zabielska, A. U., Ballaire, R., et al. (2018) · Diabetes · doi:10.2337/db17-0901 · Cited by 51
D’Souza, K., Mercer, A., Mawhinney, H., Pulinilkunnil, T., Udenigwe, C. C., & Kienesberger, P. C. (2020) · Nutrients · doi:10.3390/nu12020425 · Cited by 47
Wang, W., Yang, W., Dai, Y. M., Liu, J., & Chen, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08835 · Cited by 49
Whytock, K. L., & Goodpaster, B. H. (2025) · Circulation Research · doi:10.1161/circresaha.125.325532 · Cited by 57
Ballestri, S., Nascimbeni, F., Romagnoli, D., Baldelli, E., Targher, G., & Lonardo, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030355 · Cited by 48
CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance
Summers, S. A., & Goodpaster, B. H. (2016) · The Journal of Physiology · doi:10.1113/jp271676 · Cited by 48
Li, A., Liu, Q., Li, Q., Liu, B., Yang, Y., & Zhang, N. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.07.039 · Cited by 49
Fiorenza, M., Onslev, J., Henríquez‐Olguín, C., Persson, K. W., Hesselager, S. A., Jensen, T. E., Wojtaszewski, J. F. P., Hostrup, M., & Bangsbo, J. (2024) · Science Advances · doi:10.1126/sciadv.adq4461 · Cited by 58
Verdú, E., Homs, J., & Boadas‐Vaello, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182413333 · Cited by 57
Effect of metformin on bioactive lipid metabolism in insulin-resistant muscle
Zabielski, P., Chacińska, M., Charkiewicz, K., Baranowski, M., Górski, J., & Błachnio-Zabielska, A. U. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0381 · Cited by 46
Tanaka, M., Okada, H., Hashimoto, Y., Kumagai, M., Nishimura, H., Oda, Y., & Fukui, M. (2019) · Liver International · doi:10.1111/liv.14253 · Cited by 44
Abulizi, A., Perry, R. J., Camporez, J. P. G., Jurczak, M. J., Petersen, K. F., Aspichueta, P., & Shulman, G. I. (2017) · The FASEB Journal · doi:10.1096/fj.201700001r · Cited by 41
Self-citationProlonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men
Bak, A. M., Vendelbo, M. H., Christensen, B., Viggers, R., Bibby, B. M., Rungby, J., Jørgensen, J. O. L., Møller, N., & Jessen, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200817 · Cited by 42
Kurauti, M. A., Soares, G. M., Marmentini, C., Bronczek, G. A., Branco, R. C. S., & Boschero, A. C. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.010 · Cited by 47
Sugimoto, M., Shimizu, Y., Zhao, S., Ukon, N., Nishijima, K., Wakabayashi, M., Yoshioka, T., Higashino, K., Numata, Y., Okuda, T., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.019 · Cited by 42
Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
Song, J. D., Alves, T. C., Befroy, D. E., Perry, R. J., Mason, G. F., Zhang, X., Munk, A., Zhang, Y., Zhang, D., Cline, G. W., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.008 · Cited by 40
Self-citationDietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle
Sarabhai, T., Koliaki, C. C., Mastrototaro, L., KAHL, S., Pesta, D. H., Apostolopoulou, M., Wolkersdorfer, M. F., Bönner, A. C., Bobrov, P., Markgraf, D. F., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05596-z · Cited by 42
Self-citationFrankó, A., Merkel, D., Kovářová, M., Hoene, M., Jaghutriz, B. A., Heni, M., Königsrainer, A., Papan, C., Lehr, S., Häring, H., et al. (2018) · Nutrients · doi:10.3390/nu10091314 · Cited by 41
Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis
Muniz‐Santos, R., Costa, G. L. A., de Almeida, M. A. P., Moraes-de-Souza, I., Brito, M. A. D. S. M., Silva, A. R., & Gonçalves-de-Albuquerque, C. F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224335 · Cited by 43
Montgomery, M. K., Brown, S. H. J., Mitchell, T. W., Coster, A. C. F., Cooney, G. J., & Turner, N. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14214-1 · Cited by 41
Mthembu, S. X. H., Mazibuko-Mbeje, S. E., Ziqubu, K., Nyawo, T. A., Obonye, N., Nyambuya, T. M., Nkambule, B. B., Silvestri, S., Tiano, L., Muller, C. J. F., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120467 · Cited by 42
Guariglia, M., Saba, F., Rosso, C., & Bugianesi, E. (2023) · Nutrients · doi:10.3390/nu15245053 · Cited by 41
Imierska, M., Kurianiuk, A., & Błachnio-Zabielska, A. U. (2020) · Biomolecules · doi:10.3390/biom10121665 · Cited by 44
Johannsen, N. M., Swift, D. L., Lavie, C. J., Earnest, C. P., Blair, S. N., & Church, T. S. (2016) · Sports Medicine · doi:10.1007/s40279-016-0548-3 · Cited by 39
Lyu, K., Zhang, D., Song, J. D., Li, X., Perry, R. J., Samuel, V. T., & Shulman, G. I. (2021) · JCI Insight · doi:10.1172/jci.insight.139946 · Cited by 38
Self-citationXiao, N., Yang, L., Yang, Y., Liu, L., Li, J., Liu, B., Liu, K., Qi, L., & Li, P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00043 · Cited by 38
Handy, R. M., & Holloway, G. P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1151389 · Cited by 38
“Within skeletal muscle, DAGs have been demonstrated to activate PKC-θ and PKC-ε in both human and rodent models (Itani et al., 2002; Yu et al., 2002; Szendroedi et al., 2014; Lee et al., 2017).”
BackgroundRole of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors
Collao, N., Farup, J., & Lisio, M. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00009 · Cited by 39
Insulin resistance in glomerular podocytes: Potential mechanisms of induction
Rogacka, D. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109005 · Cited by 38
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
Daemen, S., van Polanen, N., & Hesselink, M. K. C. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.167015 · Cited by 39
Bilet, L., Phielix, E., van de Weijer, T., Gemmink, A., Bosma, M., Moonen‐Kornips, E., Jörgensen, J. A., Schaart, G., Zhang, D., Meijer, K., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05128-1 · Cited by 37
Self-citationVieira‐Lara, M. A., Dommerholt, M. B., Zhang, W., Blankestijn, M., Wolters, J. C., Abegaz, F., Gerding, A., van der Veen, Y. T., van Dijk, T. H., van Os, R. P., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01082-5 · Cited by 39
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Mocciaro, G., & Gastaldelli, A. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2021_573 · Cited by 37
NOD1: An Interface Between Innate Immunity and Insulin Resistance
RIVERS, S. L., Klip, A., & Giacca, A. (2019) · Endocrinology · doi:10.1210/en.2018-01061 · Cited by 36
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis
Massart, J., & Zierath, J. R. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.06.003 · Cited by 35
Fernández-Verdejo, R., Bajpeyi, S., Ravussin, E., & Galgani, J. E. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00126.2018 · Cited by 34
Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective
Engin, A. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_5 · Cited by 37
Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications
Tashkandi, A. J. A., Gorman, A., Mathers, E. M., Carney, G., Yacoub, A., Setyaningsih, W. A. W., Kuburas, R., & Margariti, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073016 · Cited by 35
Defining lipid mediators of insulin resistance: controversies and challenges
Metcalfe, L. K., Smith, G. C., & Turner, N. A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0023 · Cited by 35
Vorotnikov, A. V., Stafeev, I., Menshikov, M. Y., Shestakova, M. V., & Parfyonova, Y. V. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919110099 · Cited by 34
Fritsch, M., Koliaki, C., Livingstone, R., Phielix, E., Bierwagen, A., Meisinger, M., Jelenik, T., Strassburger, K., Zimmermann, S., Brockmann, K., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.107599 · Cited by 33
Self-citationBatova, A., Altomare, D., Creek, K. E., Naviaux, R. K., Wang, L., Li, K., Green, E., Williams, R. T., Naviaux, J. C., Diccianni, M. B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172632 · Cited by 33
Tanaka, M., Okada, H., Hashimoto, Y., Kumagai, M., Nishimura, H., Oda, Y., & Fukui, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.07.021 · Cited by 33
Organ Crosstalk and the Modulation of Insulin Signaling
Romero, A., & Eckel, J. (2021) · Cells · doi:10.3390/cells10082082 · Cited by 34
Gaeini, Z., Bahadoran, Z., & Mirmiran, P. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac071 · Cited by 34
Yang, R., Kuang, M., Qiu, J., Yu, C., Sheng, G., & Zou, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1172323 · Cited by 32
Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO
Kwon, S. Y., Massey, K. A., Watson, M. A., Hussain, T., Volpe, G., Buckley, C. D., Nicolaou, A., & Badenhorst, P. W. (2020) · Life Science Alliance · doi:10.26508/lsa.201900356 · Cited by 39
Li, Z., Xu, K., Guo, Y., Ping, L., Gao, Y., Qiu, Y., Ni, J., Liu, Q., & Wang, Z. (2020) · Aging Cell · doi:10.1111/acel.13104 · Cited by 32
Steenberg, D. E., Hingst, J. R., Birk, J. B., Thorup, A., Kristensen, J. M., Sjøberg, K. A., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. P. (2020) · Diabetes · doi:10.2337/db19-1010 · Cited by 32
Peifer‐Weiß, L., Al‐Hasani, H., & Chadt, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031910 · Cited by 39
Davies, M. J., Lim, S. K., Slater, T., Goldney, J., Philis‐Tsimikas, A., Franco, D. R., Lamptey, R., Yates, T. E., Tankova, T. I., & Lingvay, I. (2026) · Nature Reviews Disease Primers · doi:10.1038/s41572-026-00687-w · Cited by 45
Triacylglycerol turnover in the failing heart
Carley, A. N., & Lewandowski, E. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.012 · Cited by 32
Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction
Liu, Y., Neumann, D., Glatz, J. F. C., & Luiken, J. J. F. P. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.06.002 · Cited by 36
Simon, M., Reinbeck, A. L., Wessel, C., Heindirk, J., Jeleník, T., Kaul, K., Arreguín-Cano, J. A., Strom, A., Blaut, M., Bäckhed, F., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010816 · Cited by 30
Self-citationIntramyocellular fat storage in metabolic diseases
Laurens, C., & Moro, C. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0045 · Cited by 31
Weber, K. S., Simon, M., Straßburger, K., Markgraf, D. F., Buyken, A. E., Szendroedi, J., Müssig, K., Roden, M., & GDS Group (2018) · Nutrients · doi:10.3390/nu10060774 · Cited by 31
Self-citationReassessing the Role of Diacylglycerols in Insulin Resistance
Jayasinghe, S. U., Tankeu, A. T., & Amati, F. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.06.005 · Cited by 31
Denhez, B., Rousseau, M., Spino, C., Dancosst, D.-A., Dumas, M.-È., Guay, A., Lizotte, F., & Geraldes, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-78376-1 · Cited by 40
Hartogh, D. J. D., Vlavcheski, F., Giacca, A., MacPherson, R. E. K., & Tsiani, E. (2022) · Cells · doi:10.3390/cells11010167 · Cited by 32
Gaspar, R. C., Lyu, K., Hubbard, B. T., Leitner, B. P., Luukkonen, P. K., Hirabara, S. M., Sakuma, I., Nasiri, A. R., Zhang, D., Kahn, M., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05838-8 · Cited by 28
Self-citationfor the GDS group, Apostolopoulou, M., Straßburger, K., Herder, C., Knebel, B., Kotzka, J., Szendroedi, J., & Roden, M. (2016) · Diabetologia · doi:10.1007/s00125-016-4038-9 · Cited by 29
Self-citationYang, R., Hu, C., Sun, W., Pan, Q., Shen, F., YANG, Z. K., Su, Q., Xu, G., & Fan, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11278-x · Cited by 29
Dysregulation of muscle glycogen synthase in recovery from exercise in type 2 diabetes.
Pedersen, A. J. T., Hingst, J. R., Friedrichsen, M., Kristensen, J. M., Højlund, K., & Wojtaszewski, J. F. P. (2015) · Diabetologia · doi:10.1007/s00125-015-3582-z · Cited by 28
Zhong, J., Cheung, C. Y. Y., Su, X., Lee, C., Ru, Y., Fong, C. H.-Y., Liu, Y., Cheung, C., Lam, K. S. L., Cai, Z., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01677-4 · Cited by 28
Chen, Q., Rong, P., Zhu, S., Yang, X., Ouyang, Q., Wang, H. Y., & Chen, S. (2019) · Science Advances · doi:10.1126/sciadv.aav4116 · Cited by 27
Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia
Malínská, H., Hüttl, M., Miklánková, D., Trnovská, J., Zapletalová, I., Poruba, M., & Marková, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094527 · Cited by 28
Lipid Oxidation Assessed by Indirect Calorimetry Predicts Metabolic Syndrome and Type 2 Diabetes
Pujia, A., Mazza, E., Ferro, Y., Gazzaruso, C., Coppola, A., Doldo, P., Grembiale, R. D., Pujia, R., Romeo, S., & Montalcini, T. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00806 · Cited by 28
Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model
Seshadri, S., Naimisha, R., Prajapati, B., Mandaliya, D. K., Patel, S. J., Muggalla, C. S., Kapadia, B. B., Babu, P. P., Misra, P., & Saxena, U. (2019) · Scientific Reports · doi:10.1038/s41598-019-45369-8 · Cited by 27
Laurens, C., Badin, P.-M., Louche, K., Mairal, A., Tavernier, G., Marette, A., Tremblay, A., Weisnagel, S. J., Joanisse, D. R., Langin, D., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.004 · Cited by 27
Simon, M., Reinbeck, A. L., Wessel, C., Heindirk, J., Jeleník, T., Kaul, K., Arreguín-Cano, J. A., Strom, A., Blaut, M., Bäckhed, F., et al. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49908-x · Cited by 28
Self-citationLow-attenuation muscle is a predictor of diabetes mellitus: A population-based cohort study
Tanaka, M., Okada, H., Hashimoto, Y., Kumagai, M., Nishimura, H., & Fukui, M. (2020) · Nutrition · doi:10.1016/j.nut.2020.110752 · Cited by 27
Hou, G., Gao, Y. M., Poon, L. C., Ren, Y., Zeng, C., Wen, B., Syngelaki, A., Lin, L., Zi, J., Su, F., et al. (2022) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17297 · Cited by 27
Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome
Malínská, H., Hüttl, M., Oliyarnyk, O., Marková, I., Poruba, M., Rácová, Z., Kazdová, L., & Večeřa, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220377 · Cited by 25
Hulse, J. L., Habibi, J., Igbekele, A. E., Zhang, B., Li, J., Whaley‐Connell, A. T., Sowers, J. R., & Jia, G. (2022) · Endocrinology · doi:10.1210/endocr/bqac145 · Cited by 25
Tsilingiris, D., Natsi, A., Gavriilidis, E., Antoniadou, C., Eleftheriadou, I., Anastasiou, I. A., Tentolouris, A., Papadimitriou, E., Eftalitsidis, E., Kolovos, P., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.202451664 · Cited by 24
Metadata
- Authors
- Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., Shulman, G. I., & Roden, M.
- Affiliations
- Düsseldorf University Hospital (DE)
- Howard Hughes Medical Institute (US)
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany;
- Deutsches Diabetes-Zentrum e.V. (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-06-16
- Volume
- 111
- Issue
- 26
- Pages
- 9597-9602
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4084449
- OpenAlex
- W2055608265
- Cited by
- 415
- References
- 51
- Citations by year
- 2026: 36 · 2025: 30 · 2024: 26 · 2023: 18 · 2022: 32 · 2021: 36 · 2020: 47 · 2019: 46 · 2018: 46 · 2017: 38 · 2016: 32 · 2015: 24 · 2014: 3
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- European Foundation for the Study of Diabetes
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Gesundheit
- Novo Nordisk
- Novo Nordisk Fonden
- Novo Nordisk Foundation Center for Basic Metabolic Research
- National Institutes of Health (UL1TR000142)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01DK049230, R01 DK-49230, R24DK085638, P30DK045735)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- muscle insulin resistance, diacylglycerol, protein kinase C theta, lipid infusion, intramyocellular lipid, IRS-1 serine phosphorylation, Akt2 phosphorylation, obesity, type 2 diabetes, inflammation, adipokines, ceramide, acylcarnitines, skeletal muscle
- MeSH terms
- Protein Kinase C-theta, Analysis of Variance, Blood Chemical Analysis, Calorimetry, Indirect, Diabetes Mellitus, Type 2, Diglycerides, Enzyme Activation, Humans, Insulin Resistance, Isoenzymes, Muscles, Protein Kinase C, Glucose Clamp Technique
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