The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Astrocytes contribute to gamma oscillations and recognition memory
Open accessAbstract
Significance: Astrocytes are well placed to modulate neural activity. However, the functions typically attributed to astrocytes are associated with a temporal dimension significantly slower than the timescale of synaptic transmission of neurons. Consequently, it has been assumed that astrocytes do not play a major role in modulating fast neural network dynamics known to underlie cognitive behavior. By creating a transgenic mouse in which vesicular release from astrocytes can be reversibly blocked, we found that astrocytes are necessary for novel object recognition behavior and to maintain functional gamma oscillations both in vitro and in awake-behaving animals. Our findings reveal an unexpected role for astrocytes in neural information processing and cognition.
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Cites
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MethodThe novel object recognition memory: neurobiology, test procedure, and its modifications
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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
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Astrocyte function from information processing to cognition and cognitive impairment
Santello, M., Toni, N., & Volterra, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0325-8 · Cited by 737
Voytek, B., & Knight, R. T. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.016 · Cited by 556
Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies
Kozai, T. D. Y., Jaquins-Gerstl, A. S., Vazquez, A. L., Michael, A. C., & Cui, X. T. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500256e · Cited by 622
Human astrocytes: structure and functions in the healthy brain
Vasile, F., Dossi, E., & Rouach, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1383-5 · Cited by 428
Metadata
- Authors
- Lee, H. S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Piña-Crespo, J. C., Roberts, A. J., Verma, I. M., Sejnowski, T. J., & Heinemann, S. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-07-28
- Volume
- 111
- Issue
- 32
- Pages
- E3343-52
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1995101735
- Cited by
- 259
- References
- 61
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, H. S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Piña-Crespo, J. C., Roberts, A. J., Verma, I. M., Sejnowski, T. J., & Heinemann, S. F. (2014). Astrocytes contribute to gamma oscillations and recognition memory. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1410893111
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