Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

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Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

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GTPase Networks in Membrane Traffic

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The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor

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Social stress: From rodents to primates

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Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

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A Central Role for GRB10 in Regulation of Islet Function in Man

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Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

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The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

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Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo

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Mice with a Disruption of the Imprinted <i>Grb10</i> Gene Exhibit Altered Body Composition, Glucose Homeostasis, and Insulin Signaling during Postnatal Life

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Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1

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Grb10 Inhibits Insulin-stimulated Insulin Receptor Substrate (IRS)-Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Disrupting the Association of IRS-1/IRS-2 with the Insulin Receptor

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Interaction of the Grb10 Adapter Protein with the Raf1 and MEK1 Kinases

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mGrb10 Interacts with Nedd4

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Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis

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Maternally-inherited Grb10 reduces placental size and efficiency

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Role for the Adaptor Protein Grb10 in the Activation of Akt

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A mono‐allelic bivalent chromatin domain controls tissue‐specific imprinting at Grb10

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Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression

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Grb10 Identified as a Potential Regulator of Growth Hormone (GH) Signaling by Cloning of GH Receptor Target Proteins

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GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling

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Regulation of insulin and type 1 insulin‐like growth factor signaling and action by the G rb10/14 and SH 2 B 1/ B 2 adaptor proteins

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Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades

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Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation

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Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

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Dual Ablation of Grb10 and Grb14 in Mice Reveals Their Combined Role in Regulation of Insulin Signaling and Glucose Homeostasis

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Structural Basis for Dimerization of the Grb10 Src Homology 2 Domain

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CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation

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Negative Regulation of Insulin-Stimulated Mitogen-Activated Protein Kinase Signaling By Grb10

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Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup

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Role of DNA Methylation and Histone H3 Lysine 27 Methylation in Tissue-Specific Imprinting of Mouse Grb10

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FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

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Nonallelic Transcriptional Roles of CTCF and Cohesins at Imprinted Loci

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Grb10 regulates the development of fiber number in skeletal muscle

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Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis

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Grb10 exceeding the boundaries of a common signaling adapter

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Grb10 is a dual regulator of receptor tyrosine kinase signaling

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The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling

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Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10

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Mitogenic roles of Gab1 and Grb10 as direct cellular partners in the regulation of MAP kinase signaling

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Phosphorylation of Grb10 Regulates Its Interaction with 14-3-3

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Type 2 Diabetes Mellitus in a Non-Obese Mouse Model Induced by Meg1/Grb10 Overexpression

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Grb10 interacts with Bim L and inhibits apoptosis

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Histone Acetylome-wide Association Study of Autism Spectrum Disorder

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The genome-wide mutational landscape of pituitary adenomas

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Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank

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Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

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Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children

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Quantifying the contribution of Neanderthal introgression to the heritability of complex traits

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Epigenetic changes in the developing brain: Effects on behavior

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HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

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Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain

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The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting

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Systemic sclerosis pathogenesis: contribution of recent advances in genetics

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Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes

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Role of genomic imprinting in mammalian development

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miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles

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The Intergenerational Impacts of Paternal Diet on DNA Methylation and Offspring Phenotypes in Sheep

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Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex

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GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

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Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expressionPreprint

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Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood

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Screening of potential biomarkers in peripheral blood of patients with depression based on weighted gene co-expression network analysis and machine learning algorithms

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RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway

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Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development

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Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder

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Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration

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Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells

Schrott, R., Greeson, K. W., King, D. E., Crow, K. M. S., Easley, C. A., & Murphy, S. K. (2022) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2022.2073292 · Cited by 24 · see citing works

Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

SanMiguel, J. M., Abramowitz, L. K., & Bartolomei, M. S. (2018) · Development · doi:10.1242/dev.160622 · Cited by 24 · see citing works

Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach

Schmidt, S., Haase, M., Best, L., Groth, M., Lindner, J., Witte, O. W., Kaleta, C., & Frahm, C. (2022) · Cells · doi:10.3390/cells11233864 · Cited by 20 · see citing works

In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression

Bouschet, T., Dubois, E., Reynès, C., Kota, S. K., Rialle, S., Maupetit‐Mehouas, S., Pezet, M. G., Digarcher, A. L., Nidelet, S., Demolombe, V., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw102 · Cited by 20 · see citing works

Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver: A Focus on Genomic Imprinting by Tissue and Sex

Morgan, R. K., Wang, K., Svoboda, L. K., Rygiel, C. A., Lalancette, C., Cavalcante, R. G., Bartolomei, M. S., Prasasya, R. D., Neier, K. E., Perera, B. P. U., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14074 · Cited by 19 · see citing works

Translational control by heme-regulated elF2α kinase during erythropoiesis

Chen, J.-J., & Zhang, S. (2022) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000704 · Cited by 19 · see citing works

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart

Prickett, A. R., Montibus, B., Barkas, N., Amante, S. M., Franco, M. M., Cowley, M., Puszyk, W. M., Shannon, M. F., Irving, M. D., Madon-Simon, M., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.676543 · Cited by 16 · see citing works

Increased pregnancy losses following serial somatic cell nuclear transfer in goats

Yang, M., Périssé, I. V., Fan, Z., Regouski, M., Meyer‐Ficca, M. L., & Polejaeva, I. A. (2018) · Reproduction Fertility and Development · doi:10.1071/rd17323 · Cited by 16 · see citing works

Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues

Cohen, L., Halpern, A. R., Blosser, T. R., Che, Z. P., Pan, X., & Zhuang, X. (2026) · Cell · doi:10.1016/j.cell.2026.06.027 · Cited by 15 · see citing works

HRI protein kinase in cytoplasmic heme sensing and mitochondrial stress response: Relevance to hematological and mitochondrial diseases

Chen, J.-J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108494 · Cited by 15 · see citing works

Maternal GRB10 microdeletion is a novel cause of cystic placenta: Spectrum of genomic changes in the etiology of enlarged cystic placenta

Surti, U., Yatsenko, S. A., Hu, J., Bellissimo, D. B., Parks, W. T., & Hoffner, L. (2017) · Placenta · doi:10.1016/j.placenta.2017.05.018 · Cited by 14 · see citing works

Genetic dissection of the RNA polymerase II transcription cycle

Chou, S., Alexander, A. K., Rice, E. J., Choate, L. A., Cohen, P. E., & Danko, C. G. (2022) · eLife · doi:10.7554/elife.78458 · Cited by 13 · see citing works

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · BMC Biology · doi:10.1186/s12915-024-01926-w · Cited by 8 · see citing works

An NMF-based approach to discover overlooked differentially expressed gene regions from single-cell RNA-seq data

Matsumoto, H., Hayashi, T., Ozaki, H., Tsuyuzaki, K., Umeda, M., Iida, T., Nakamura, M., Okano, H., & Nikaido, I. (2019) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqz020 · Cited by 8 · see citing works

Methylation profile of SNRPN gene and its correlation with weight and chronological age

Carobin, N. V., Rubatino, F. V. M., de Freitas, M. L., de Oliveira, V. T., Pietra, R. X., Bosco, A., & Jehee, F. S. (2015) · Genetics and Molecular Research · doi:10.4238/2015.october.28.41 · Cited by 7 · see citing works

Quantifying Genomic Imprinting at Tissue and Cell Resolution in the Brain

Varrault, A., Dubois, E., Digarcher, A. L., & Bouschet, T. (2020) · Epigenomes · doi:10.3390/epigenomes4030021 · Cited by 7 · see citing works

High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells

Li, H., Gao, S., Huang, H., Liu, W., Huang, H., Liu, X., Gao, Y., Le, R., Kou, X., Zhao, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17185 · Cited by 7 · see citing works

Maternal uniparental disomy of chromosome 7: how chromosome 7-encoded imprinted genes contribute to the Silver–Russell phenotype

Begemann, M., Lengyel, A., Pinti, É., Kovács, Á. F., Fekete, G., Stratmann, S., Krause, J., Elbracht, M., Kraft, F., & Eggermann, T. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01867-3 · Cited by 6 · see citing works

Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells

Zhou, T. J., Ma, Y., Tang, J., Guo, F., Dong, M., & Wei, Q. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4336 · Cited by 6 · see citing works

Turbidity and temperature effects on growth and gene transcription of threatened juvenile Longfin Smelt (Spirinchus thaleichthys)

Biefel, F., Pasparakis, C., Cocherell, D. E., Hung, T., Carson, E. W., Fangue, N. A., Geist, J. P., Todgham, A. E., & Connon, R. E. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741296 · Cited by 4 · see citing works

Zfp57 Exerts Maternal and Sexually Dimorphic Effects on Genomic Imprinting

Xu, Z., Shi, J., Zhang, Y., Liu, Y., Zhao, J., Chen, Q., Song, C., Geng, S., Xie, W., Wu, F., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.784128 · Cited by 4 · see citing works

Frugal fat or munificent muscle: genomic imprinting and metabolism

Haig, D. (2014) · BMC Biology · doi:10.1186/s12915-014-0104-2 · Cited by 4 · see citing works

Epigenetic Mosaicism in Genomic Imprinting Disorders

Sazhenova, E. A., & Лебедев, И. Н. (2019) · Russian Journal of Genetics · doi:10.1134/s1022795419100119 · Cited by 4 · see citing works

Insights into tissue- and cell type-specific effects of Grb10 on pig skeletal muscle growth by multi-omics analysis

Li, M., Liu, H., Lu, T., Li, S., Zhou, X., Miao, H., Zhang, Y., Peng, C., Chen, K., He, J., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2910-7 · Cited by 3 · see citing works

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Casella, E., Depovere, J., Delger, C., Butynets, M., Antczak, P., Price, T. M., Jirtle, R. L., Murphy, S. K., Hoyo, C., & Soubry, A. (2025) · Aging · doi:10.18632/aging.206348 · Cited by 3 · see citing works

Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase

Guo, J., Zheng, J., Li, R., Yao, J., Zhang, H., Wang, X., & Zhang, C. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400099 · Cited by 3 · see citing works

Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring

Chen, H., Wang, T., Shao, J., Zhu, H., Chi-Zhang, Zhao, T., Xu, L., Wang, M., Li, J., Zhu, Q.-L., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.117994 · Cited by 3 · see citing works

Commercial ChIP-Seq Library Preparation Kits Performed Differently for Different Classes of Protein Targets

Simper, M., Coletta, L. D., Gaddis, S., Lin, K., Mikulec, C., Takata, T., Tomida, M., Zhang, D., Tang, D. G., Estecio, M. R., et al. (2022) · Journal of Biomolecular Techniques JBT · doi:10.7171/3fc1f5fe.7910785e · Cited by 2 · see citing works

Dopa decarboxylase is a genetic hub of parental control over offspring behaviorPreprint

Bonthuis, P. J., Steinwand, S., Huang, W.-C., Hörndli, C. S., Emery, J., Kravitz, S. N., Ferris, E., & Gregg, C. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.23.168195 · Cited by 2 · see citing works

Mom genes and dad genes: genomic imprinting in the regulation of social behaviors

O’Leary, E. M., & Bonthuis, P. J. (2025) · Epigenomics · doi:10.1080/17501911.2025.2491294 · Cited by 1 · see citing works

Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominancePreprint

Rienecker, K. D. A., Chavasse, A. T., Moorwood, K., Ward, A., & Isles, A. R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/493692 · Cited by 1 · see citing works

Effects of noncanonical genomic imprinting in monoaminergic pathways on the regulation of social behaviorsPreprint

O’Leary, E. M., Rahman, S. J., Tamas, A. L., Huang, T., Dweydari, M., Eggleston, R. L., Meling, D. D., & Bonthuis, P. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582619 · Cited by 1 · see citing works

Additional file 2 of RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway

Wei, Z., Xia, K., Zheng, D., Gong, C., & Guo, W. (2024) · Figshare · doi:10.6084/m9.figshare.24240257

Additional file 2 of Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · Figshare · doi:10.6084/m9.figshare.26727838

Additional file 1 of RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway

Wei, Z., Xia, K., Zheng, D., Gong, C., & Guo, W. (2023) · Figshare · doi:10.6084/m9.figshare.24240155

Additional file 1 of Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · Figshare · doi:10.6084/m9.figshare.26727835

Molecular mechanisms of pituitary adenoma tumorigenesis and invasiveness

Hage, M. P. (2018) · doi:10.70675/e786f91cz4e92z40a0z97eaz3959187a3007

Improved cryotolerance of bovine blastocysts by 1α,25-dihydroxyvitamin D3 supplementation during in vitro culture and post-thaw recovery

Lee, H.-K., Kim, D.-H., & Kwon, D. (2026) · Czech Journal of Animal Science · doi:10.17221/61/2026-cjas

Space weather fluctuations and epigenetic aging in an elderly male cohort from Massachusetts, USA

Zhai, T., Vieira, C. L. Z., Vokonas, P., Baccarelli, A., Nagel, Z. D., Schwartz, J. D., & Koutrakis, P. (2026) · npj Aging · doi:10.1038/s41514-026-00498-z

Parent-of-origin-dependent allelic regulation of social behaviors in mice by noncanonically imprinted monoamine synthesis genes

O’Leary, E. M., Eggleston, R. L., Meling, D. D., Usman, A.-F., Rahman, S. J., Tamas, A. L., Huang, T., Sands, M., Irudayaraj, J., & Bonthuis, P. J. (2026) · Genetics · doi:10.1093/genetics/iyag256

Decoding Parental Expression Patterns of Imprinted Genes: A Pathway to Regulate the Neuropsychiatric and Affective Disorders

Fu, Y., Zhang, Y., Wang, Z., Peng, G., Li, S., Miao, N., & Sun, T. (2026) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.6c00463

Investigating the role of the imprinted Grb10 gene in the regulation of maternal nutrient transfer.

Cowley, M. (2009) · The University of Bath Online Publications Store (The University of Bath)

Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression

Monk, D., Arnaúd, P., Frost, J. M., Hills, F. A., Stanier, P., Feil, R., & Moore, G. E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp248 · Cited by 87 · see citing works

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion

Blagitko, N. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.11.1587 · Cited by 177 · see citing works

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Garfield, A. S., Cowley, M., Smith, F. M., Moorwood, K., Stewart-Cox, J. E., Gilroy, K. E., Baker, S. L., Xia, J., Dalley, J. W., Hurst, L. D., et al. (2011) · Nature · doi:10.1038/nature09651 · Cited by 242 · see citing works

Characterisation of the imprinted genes in mouse, Grb10 and Dlk1

Madon-Simon, M. (2011) · The University of Bath Online Publications Store (The University of Bath)