Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Regulatory T Cells and Immune Tolerance

Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,357 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090 · see citing works

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,754 · see citing works

Th17 and regulatory T cells in mediating and restraining inflammation

Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039 · see citing works

Transient expression of FOXP3 in human activated nonregulatory CD4 ⁺ T cells

Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011 · see citing works

FOXP3: Of Mice and Men

Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921 · see citing works

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

Valencia, X., Stephens, G. L., Goldbach‐Mansky, R. T., Wilson, M., Shevach, E. M., & Lipsky, P. E. (2006) · Blood · doi:10.1182/blood-2005-11-4567 · Cited by 782 · see citing works

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Gavin, M. A., Torgerson, T. R., Houston, E., DeRoos, P. C., Ho, W., Stray‐Pedersen, A., Ocheltree, E., Greenberg, P. D., Ochs, H. D., & Rudensky, A. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509484103 · Cited by 779 · see citing works

Phenotypical and functional specialization of FOXP3+ regulatory T cells

Campbell, D. J., & Koch, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2916 · Cited by 773 · see citing works

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I. (2008) · Blood · doi:10.1182/blood-2008-01-133967 · Cited by 735 · see citing works

Stability of the Regulatory T Cell Lineage in Vivo

Rubtsov, Y. P., Niec, R. E., Josefowicz, S., Li, L., Darce, J., Mathis, D., Benoist, C., & Rudensky, A. Y. (2010) · Science · doi:10.1126/science.1191996 · Cited by 730 · see citing works

Development and Maintenance of Regulatory T cells

Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 728 · see citing works

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T., & Sakaguchi, S. (2007) · Nature · doi:10.1038/nature05673 · Cited by 692 · see citing works

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

Miyao, T., Floess, S., Setoguchi, R., Luche, H., Fehling, H. J., Waldmann, H., Huehn, J., & Hori, S. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.012 · Cited by 612 · see citing works

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

Oldenhove, G., Bouladoux, N. J., Wohlfert, E. A., Hall, J. A., Chou, D. B., dos Santos, L. M., O’Brien, S., Blank, R. B., Lamb, E. W., Natarajan, S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.001 · Cited by 578 · see citing works

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

Nie, H., Zheng, Y., Li, R., Guo, T. B., He, D., Fang, L., Liu, X., Xiao, L., Chen, X. X., Wan, B., et al. (2013) · Nature Medicine · doi:10.1038/nm.3085 · Cited by 516 · see citing works

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

Feuerer, M., Hill, J. A., Mathis, D. J., & Benoist, C. O. (2009) · Nature Immunology · doi:10.1038/ni.1760 · Cited by 507 · see citing works

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

Wang, Y., Su, M. A., & Wan, Y. Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.012 · Cited by 461 · see citing works

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Rudra, D., DeRoos, P. C., Chaudhry, A., Niec, R. E., Arvey, A. J., Samstein, R. M., Leslie, C. S., Shaffer, S. A., Goodlett, D. R., & Rudensky, A. Y. (2012) · Nature Immunology · doi:10.1038/ni.2402 · Cited by 431 · see citing works

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410 · see citing works

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

van Loosdregt, J., Vercoulen, Y., Guichelaar, T., Gent, Y. Y. J., Beekman, J. M., van Beekum, O., Brenkman, A. B., Hijnen, D., Mutis, T., Kalkhoven, E., et al. (2009) · Blood · doi:10.1182/blood-2009-02-207118 · Cited by 389 · see citing works

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works

Death without caspases, caspases without death

Abraham, M. C., & Shaham, S. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.03.002 · Cited by 302 · see citing works

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Chen, Z., Barbi, J. J., Bu, S., Yang, H., Li, Z., Gao, Y., Jinasena, D., Fu, J. L., Lin, F., Chen, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.006 · Cited by 300 · see citing works

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Fu, W., Ergün, A., Lu, T., Hill, J. A., Haxhinasto, S. A., Fassett, M. S., Gazit, R., Adoro, S., Glimcher, L. H., Chan, S. H., et al. (2012) · Nature Immunology · doi:10.1038/ni.2420 · Cited by 299 · see citing works

Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3

Du, J., Huang, C., Zhou, B., & Ziegler, S. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4785 · Cited by 234 · see citing works

Critical role of all - trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

Lu, L., Lan, Q., Li, Z., Zhou, X., Gu, J., Li, Q., Wang, J., Chen, M., Liu, Y., Shen, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408780111 · Cited by 225 · see citing works

Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice

Escande, C., Chini, C. C. S., Nin, V., Dykhouse, K. M., Novak, C. M., Levine, J. A., van Deursen, J., Gores, G. J., Chen, J., Lou, Z., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39319 · Cited by 186 · see citing works

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

Grinberg‐Bleyer, Y., Saadoun, D., Baeyens, A., Billiard, F., Goldstein, J. D., Grégoire, S., Martin, G. H., Elhage, R., Dérian, N., Carpentier, W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42945 · Cited by 167 · see citing works

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease

Li, B., Samanta, A., Song, X., Iacono, K. T., Brennan, P. J., Chatila, T. A., Roncador, G., Banham, A. H., Riley, J. L., Wang, Q., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm043 · Cited by 134 · see citing works

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

van Loosdregt, J., Brunen, D., Fleskens, V., Pals, C. E. G. M., Lam, E. W. ‐., & Coffer, P. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019047 · Cited by 116 · see citing works

PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

Li, Z., Lin, F., Zhuo, C., Deng, G., Chen, Z., Yin, S., Gao, Z., Piccioni, M., Tsun, A., Cai, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586651 · Cited by 110 · see citing works

Natural but Not Inducible Regulatory T Cells Require TNF-α Signaling for In Vivo Function

Housley, W. J., Adams, C. O., Nichols, F. C., Puddington, L., Lingenheld, E. G., Zhu, L. X., Rajan, T. V., & Clark, R. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003868 · Cited by 106 · see citing works

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway

Zhang, Q., Cui, F., Fang, L., Hong, J., Zheng, B. Q., & Zhang, J. Z. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs063 · Cited by 88 · see citing works

Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

Lan, Q., Zhou, X., Fan, H., Chen, M., Wang, J., Ryffel, B., Brand, D. D., Ramalingam, R., Kiela, P. R., Horwitz, D. A., et al. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs040 · Cited by 87 · see citing works

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

Sundararajan, R., Chen, G., Mukherjee, C., & White, E. (2005) · Oncogene · doi:10.1038/sj.onc.1208681 · Cited by 61 · see citing works

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

Gao, Y., Lin, F. F., Su, J., Gao, Z., Li, Y., Yang, J., Deng, Z., Liu, B., Tsun, A., & Li, B. (2011) · Genes and Immunity · doi:10.1038/gene.2011.77 · Cited by 44 · see citing works

Plasticity of Treg at infected sites

Wohlfert, E. A., & Belkaid, Y. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.11 · Cited by 37 · see citing works

The Foxp3 interactome: a network perspective of Treg cells

Hori, S. (2012) · Nature Immunology · doi:10.1038/ni.2424 · Cited by 30 · see citing works

Next-generation regulatory T cell therapy

Ferreira, L. M. R., Müller, Y. D., Bluestone, J. A., & Tang, Q. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0041-4 · Cited by 482 · see citing works

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

Meng, X., Liu, X., Guo, X., Jiang, S., Chen, T., Hu, Z., Liu, H., Bai, Y., Xue, M., Hu, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0756-0 · Cited by 303 · see citing works

Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms

Luo, Y., & Zheng, S. G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00604 · Cited by 288 · see citing works

Inflammatory osteolysis: A conspiracy against bone

Mbalaviele, G., Novack, D. V., Schett, G., & Teitelbaum, S. L. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93356 · Cited by 251 · see citing works

Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease

Zhao, R., Zhang, W. Y., Ma, C., Yaping, Z., Xiong, R., Wang, H., Chen, W., & Zheng, S. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.574967 · Cited by 196 · see citing works

FOXP3+ Treg Cells and Gender Bias in Autoimmune Diseases

Nie, J., Li, Y. Y., Zheng, S. G., Tsun, A., & Li, B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00493 · Cited by 153 · see citing works

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis

Zhou, Y., Cui, C., Ma, X., Luo, W., Zheng, S. G., & Qiu, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00391 · Cited by 150 · see citing works

CD4 + CD25 + regulatory T cells in tumor immunity

Chen, X., Du, Y., Lin, X., Qian, Y., Zhou, T., & Huang, Z. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.009 · Cited by 143 · see citing works

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 139 · see citing works

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

Cuadrado, E., van den Biggelaar, M., de Kivit, S., Chen, Y.-Y., Slot, M., Doubal, I., Meijer, A., van Lier, R. A. W., Borst, J., & Amsen, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.008 · Cited by 132 · see citing works

Regulatory T Cell Plasticity and Stability and Autoimmune Diseases

Qiu, R., Zhou, L., Ma, Y., Zhou, L., Liang, T., Shi, L., Long, J., & Yuan, D. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8721-0 · Cited by 128 · see citing works

Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease

Zhang, W., Liu, X., Zhu, Y., Liu, X., Gu, Y., Dai, X., & Li, B. (2021) · European Journal of Immunology · doi:10.1002/eji.202048794 · Cited by 127 · see citing works

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

Atretkhany, K. N., Mufazalov, I. A., Dunst, J., Kuchmiy, A. A., Gogoleva, V. S., Andruszewski, D., Drutskaya, M. S., Faustman, D. L., Schwabenland, M., Prinz, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807499115 · Cited by 109 · see citing works

IL-38: A New Player in Inflammatory Autoimmune Disorders

Xie, L., Huang, Z., Li, H., Liu, X., Zheng, S. G., & Su, W. (2019) · Biomolecules · doi:10.3390/biom9080345 · Cited by 109 · see citing works

Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond

Bittner, S., Hehlgans, T., & Feuerer, M. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.04.005 · Cited by 107 · see citing works

Insights into the biology and therapeutic implications of TNF and regulatory T cells

Salomon, B. L. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00639-6 · Cited by 106 · see citing works

Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity

Hu, W., Wang, Z.-M., Feng, Y., Schizas, M., Hoyos, B. E., van der Veeken, J., Verter, J. G., Bou-Puerto, R., & Rudensky, A. Y. (2021) · Nature Immunology · doi:10.1038/s41590-021-01001-4 · Cited by 92 · see citing works

Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39–CD73–Adenosine and IDO Signals

Huang, F., Chen, M., Chen, W., Gu, J., Yuan, J., Xue, Y., Dang, J., Su, W., Wang, J., Zadeh, H. H., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00068 · Cited by 95 · see citing works

All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling

Cai, W., Wang, J., Hu, M., Chen, X., Lu, Z., Bellanti, J. A., & Zheng, S. G. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1557-6 · Cited by 94 · see citing works

Distinct modes of TNF signaling through its two receptors in health and disease

Atretkhany, K. N., Gogoleva, V. S., Drutskaya, M. S., & Nedospasov, S. A. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mr0120-510r · Cited by 89 · see citing works

The progress and prospect of regulatory T cells in autoimmune diseases

Zhang, X., Olsen, N. J., & Zheng, S. G. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102461 · Cited by 86 · see citing works

Kidney Failure Associates With T Cell Exhaustion and Imbalanced Follicular Helper T Cells

Hartzell, S., Bin, S., Cantarelli, C., Haverly, M., Manrique, J., Angeletti, A., Manna, G. L., Murphy, B. T., Zhang, W., Levitsky, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583702 · Cited by 79 · see citing works

The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among U.S. adults with rheumatoid arthritis: results from NHANES 1999-2020

Zhou, E., Wu, J. H., Zhou, X., & Yin, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1309835 · Cited by 76 · see citing works

Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children

Chen, M., Kuo, H., Lee, Y., Chi, H., Li, S. C., Lee, H., & Yang, K. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632890 · Cited by 75 · see citing works

The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

Yang, J. C., Wei, P., Barbi, J. J., Huang, Q., Yang, E., Bai, Y., Nie, J., Gao, Y., Tao, J., Lu, Y., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050308 · Cited by 70 · see citing works

Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

Merkley, S. D., Chock, C. J., Yang, X. O., Harris, J., & Castillo, E. F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02914 · Cited by 67 · see citing works

Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells

Luo, Y., Xue, Y., Wang, J., Dang, J., Fang, Q., Huang, G., Olsen, N. J., & Zheng, S. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.066 · Cited by 66 · see citing works

The effect of icariin on immunity and its potential application.

Shen, R., & Wang, J. (2018) · Europe PMC (PubMed Central) · Cited by 66 · see citing works

IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function

Skartsis, N., Peng, Y., Ferreira, L. M. R., Nguyen, V. Q., Ronin, É., Müller, Y. D., Vincenti, F. G., & Tang, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.783282 · Cited by 65 · see citing works

Pentraxin 3: A promising therapeutic target for autoimmune diseases

Wu, Q., Cao, F., Tao, J., Li, X., Zheng, S. G., & Pan, H. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102584 · Cited by 65 · see citing works

The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.

Xu, Y., Melo-Cardenas, J., Zhang, Y., Gau, I., Wei, J.-C., Montauti, E., Zhang, Y., Gao, B., Jin, H.-L., Sun, Z.-L., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.121887 · Cited by 60 · see citing works

TGF-β-Induced CD8+CD103+ Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells

Zhong, H., Liu, Y., Xu, Z., Liang, P., Yang, H., Zhang, X., Zhao, J. J., Chen, J., Fu, S., Tang, Y., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00035 · Cited by 59 · see citing works

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

Li, Y., Strick‐Marchand, H., Lim, A. I., Ren, J., Masse‐Ranson, G., Li, D., Jouvion, G., Rogge, L., Lucas, S., Li, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01570-9 · Cited by 58 · see citing works

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis

Massey, J., Plant, D., Hyrich, K. L., Morgan, A. W., Wilson, A. G., Spiliopoulou, A., Colombo, M., McKeigue, P., Isaacs, J. D., Cordell, H. J., et al. (2018) · The Pharmacogenomics Journal · doi:10.1038/s41397-018-0040-6 · Cited by 54 · see citing works

Improving the Efficacy of Regulatory T Cell Therapy

Baeten, P., Zeebroeck, L. V., Kleinewietfeld, M., Hellings, N., & Broux, B. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08866-1 · Cited by 52 · see citing works

IL-21 induces pyroptosis of Treg cells via Akt–mTOR–NLRP3–caspase 1 axis in eosinophilic chronic rhinosinusitis

Chang, L., Wu, H., Huang, W., Li, Y., Chen, Y., Li, X., Yao, Z., Chen, X., Lai, X., Zheng, R., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.04.013 · Cited by 50 · see citing works

Intratumoral FoxP3 expression is associated with angiogenesis and prognosis in malignant canine mammary tumors

Carvalho, M. I., Pires, I. C. R., Prada, J., Gregório, H., Lobo, L., & QUEIROGA, F. L. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.06.006 · Cited by 49 · see citing works

Ring finger protein 31–mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function

Zhu, F., Yi, G., Liu, X., Zhu, F., Zhao, A., Wang, A., Zhu, R., Chen, Z., Zhao, B., Fang, S., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005802 · Cited by 49 · see citing works

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska‐Stolarska, M., & McInnes, I. B. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13098 · Cited by 44 · see citing works

Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells

Chen, Y., Colello, J., Jarjour, W. N., & Zheng, S. G. (2019) · Cells · doi:10.3390/cells8020188 · Cited by 44 · see citing works

Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments

Korn, T., & Muschaweckh, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02634 · Cited by 42 · see citing works

IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis

Basho, K., Zoldan, K., Schultheiß, M., Bettinger, D., Globig, A.-M., Bengsch, B., Neumann‐Haefelin, C., Klocperk, A., Warnatz, K., Hofmann, M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.012 · Cited by 42 · see citing works

Mechanisms of TREG cell adaptation to inflammation

Alvarez, F., Al-Aubodah, T.-A., Yang, Y. H., & Piccirillo, C. A. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1mr0120-196r · Cited by 40 · see citing works

Erratum: Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemia via suppression of Th1 and Th17 cells and enhancement of CD4+Foxp3+ regulatory T cells differentiation.

Zhao, J., Chen, J., Huang, F., Wang, J., Su, W., Zhou, J., Qi, Q., Cao, F., Sun, B., Liu, Z., et al. (2019) · Europe PMC (PubMed Central) · Cited by 39 · see citing works

Current status and perspectives of regulatory T cell-based therapy

Qu, G., Chen, J., Li, Y., Yuan, Y., Liang, R., & Li, B. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.05.005 · Cited by 39 · see citing works

Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington's disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways

Elbaz, E. M., Helmy, H. S., El-Sahar, A. E., Saad, M. A., & Sayed, R. H. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104548 · Cited by 38 · see citing works

Different T cell related immunological profiles in COVID-19 patients compared to healthy controls

Khesht, A. M. S., Karpisheh, V., Saeed, B. Q., Zekiy, A. O., Yapanto, L. M., Nabi‐Afjadi, M., Aksoun, M., Esfahani, M. N., Aghakhani, F., Movahed, M., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107828 · Cited by 37 · see citing works

Tregs in Autoimmunity: Insights Into Intrinsic Brake Mechanism Driving Pathogenesis and Immune Homeostasis

Bednar, K. J., Lee, J. H., & Ort, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932485 · Cited by 36 · see citing works

T cell activation and deficits in T regulatory cells are associated with major depressive disorder and severity of depression

Rachayon, M., Jirakran, K., Sodsai, P., Sughondhabirom, A., & Maes, M. H. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-61865-y · Cited by 34 · see citing works

Mechanisms of Dysregulated Humoral and Cellular Immunity by SARS-CoV-2

Taefehshokr, N., Taefehshokr, S., & Heit, B. (2020) · Pathogens · doi:10.3390/pathogens9121027 · Cited by 27 · see citing works

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Bai, J., Ding, B., & Li, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844931 · Cited by 34 · see citing works

Mesenchymal stromal cells attenuate multiple sclerosis via IDO-dependent increasing the suppressive proportion of CD5+ IL-10+ B cells.

Li, H., Deng, Y., Liang, J., Huang, F., Qiu, W., Zhang, M., Long, Y., Hu, X., Lu, Z., Liu, W., et al. (2019) · PubMed Central · Cited by 33 · see citing works

Immunoregulatory Cells in Myasthenia Gravis

Wu, Y., Luo, J., & Garden, O. A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.593431 · Cited by 33 · see citing works

Association of the systemic immune-inflammation index with all-cause and cardiovascular mortality in individuals with rheumatoid arthritis

Yin, X., Zhang, Y., Zou, J., & Yang, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-66152-4 · Cited by 32 · see citing works

Inflammatory factor-mediated miR-155/SOCS1 signaling axis leads to Treg impairment in systemic lupus erythematosus

Yu, J., Mei, J., Zuo, D., Zhang, M., Yu, S., Li, F., Wang, J., Bi, D., Ma, S., Wang, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113013 · Cited by 32 · see citing works

The Dynamic Role of FOXP3+ Tregs and Their Potential Therapeutic Applications During SARS-CoV-2 Infection

Zhan, X., Jiang, X. X., Dai, X., & Li, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.916411 · Cited by 32 · see citing works

Corrigendum: Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children

Chen, M., Kuo, H., Lee, Y., Chi, H., Li, S. C., Lee, H., & Yang, K. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.722582 · Cited by 31 · see citing works

Foxp3 Instability Helps tTregs Distinguish Self and Non-self

Zhang, Z., & Zhou, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02226 · Cited by 30 · see citing works

One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity

Sambucci, M., Gargano, F., Guerrera, G., Battistini, L., & Borsellino, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02947 · Cited by 31 · see citing works

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Lim, S. P., Costantini, B., Mian, S. A., Abellan, P. P., Gandhi, S., Martínez‐Llordella, M., Lozano, J. J., Reis, R. A. D., Povoleri, G. A. M., Mourikis, T. P., et al. (2020) · Blood · doi:10.1182/blood.2019001347 · Cited by 30 · see citing works

Next steps in regulatory T cells: Biology and clinical application

Zou, C., Li, P., Li, B., Sparwasser, T. D., & Yuan, J. (2026) · Cell · doi:10.1016/j.cell.2025.11.035 · Cited by 29 · see citing works

CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis

Johnson, G. S., Rajendran, P., & Dashwood, R. H. (2020) · Cancer Science · doi:10.1111/cas.14579 · Cited by 28 · see citing works

Gene‐disease associations identify a connectome with shared molecular pathways in human cholangiopathies

Luo, Z., Jegga, A. G., & Bezerra, J. A. (2017) · Hepatology · doi:10.1002/hep.29504 · Cited by 27 · see citing works

Prospects of the Use of Cell Therapy to Induce Immune Tolerance

Wang, Z., Liu, X., Cao, F., Bellanti, J. A., Zhou, J., & Zheng, S. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00792 · Cited by 27 · see citing works

Neuroinflammation: Extinguishing a blaze of T cells

Benallegue, N., Kébir, H., & Alvarez, J. I. (2022) · Immunological Reviews · doi:10.1111/imr.13122 · Cited by 25 · see citing works

Heterogeneity and Stability in Foxp3+ Regulatory T Cells

Min, B. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2017.0027 · Cited by 24 · see citing works

Type 2 inflammation suppression by T-regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis

Chang, L., Wang, Z., Li, S., Chen, X., Li, X., Zhao, J. J., Lai, X., Huang, J., Wu, X., Huang, Z., et al. (2020) · Clinical Science · doi:10.1042/cs20190388 · Cited by 24 · see citing works

Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis.

Zhang, X., Huang, F., Chen, Y., Qian, X., & Zheng, S. G. (2016) · PubMed Central · Cited by 23 · see citing works

A protocol to develop T helper and Treg cells in vivo

Chen, W., Xu, Z., Zheng, Y., Wang, J., Qian, W., Olsen, N. J., Brand, D. D., Lin, J., & Zheng, S. G. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.116 · Cited by 22 · see citing works

Stromal cells from perinatal and adult sources modulate the inflammatory immune response in vitro by decreasing Th1 cell proliferation and cytokine secretion

Khoury, O., Atala, A., & Murphy, S. V. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0123 · Cited by 22 · see citing works

Thymus-derived Foxp3+ regulatory T cells upregulate RORγt expression under inflammatory conditions

Yang, J., Zou, M., Pezoldt, J., Zhou, X., & Huehn, J. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1706-x · Cited by 20 · see citing works

Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer

Gunnarsson, U., Strigård, K., Edin, S., Gkekas, I., Mustonen, H. K., Kaprio, T., Böckelman, C., Hagström, J., Palmqvist, R., & Haglund, C. H. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02336-6 · Cited by 19 · see citing works

Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells

Browning, L. M., Miller, C., Kuczma, M., Pietrzak, M., Jing, Y., Rempała, G. A., Muranski, P. J., Ignatowicz, L., & Kraj, P. J. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108219 · Cited by 19 · see citing works

Promises and Pitfalls of Next-Generation Treg Adoptive Immunotherapy

Christofi, P., Pantazi, C., Psatha, N., Sakellari, I., Yannaki, E., & Παπαδοπούλου, Α. (2023) · Cancers · doi:10.3390/cancers15245877 · Cited by 17 · see citing works

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development

Satooka, H., Nakamura, Y., & Hirata, T. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103590 · Cited by 17 · see citing works

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization

Ciudad, M., Ouandji, S., Lamarthée, B., Cladière, C., Ghesquière, T., Nivet, M., Thébault, M., Boidot, R., Soudry‐Faure, A., Chevrier, S., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.282859 · Cited by 15 · see citing works

Bone Morphogenetic Proteins Shape Treg Cells

Kraj, P. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865546 · Cited by 15 · see citing works

Immune factors associated with the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer

Kim, R., Kawai, A., Wakisaka, M., Sawada, S., Shimoyama, M., Yasuda, N., Hidaka, M., Morita, Y., Ohtani, S., Ito, M., et al. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100927 · Cited by 14 · see citing works

Interleukin‐2‐induced skin inflammation

Sommer, C., Cohen, J. N., Dehmel, S., Neuhaus, V., Schaudien, D., Braun, A. C., Sewald, K., & Rosenblum, M. D. (2024) · European Journal of Immunology · doi:10.1002/eji.202350580 · Cited by 14 · see citing works

The Comparison of Inflammation-Based Prognostic Scores in Patients With Extrahepatic Bile Duct Cancer After Pancreaticoduodenectomy

Fujiwara, Y., Haruki, K., Shiba, H., Hamura, R., Shirai, Y., Furukawa, K., Gocho, T., & Yanaga, K. K. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2019.01.033 · Cited by 14 · see citing works

Advances on the role of the deleted in breast cancer (DBC1) in cancer and autoimmune diseases

Fang, Q., Bellanti, J. A., & Zheng, S. G. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0320-086r · Cited by 14 · see citing works

Stromal senescence contributes to age-related increases in cancer

Ye, J., Melam, A., & Stewart, S. A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00840-9 · Cited by 14 · see citing works

A short course of tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in the presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts

Iglesias, M., Khalifian, S., Oh, B. C., Zhang, Y., Miller, D., Beck, S. E., Brandacher, G., & Raimondi, G. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16456 · Cited by 12 · see citing works

Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells

Hsiung, S., Moro, A., Ban, Y. J., Chen, X., Savio, A. S., Hernandez, R., & Malek, T. R. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000099 · Cited by 12 · see citing works

Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics

Mikulak, J., Terzoli, S., Marzano, P., Cazzetta, V., Martiniello, G., Piazza, R., Viano, M. E., Vitobello, D., Portuesi, R., Grizzi, F., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07557-5 · Cited by 11 · see citing works

Pharmacological Inhibition of Caspase-8 Suppresses Inflammation-Induced Angiogenesis in the Cornea

Tian, Y., Li, H., Liu, X., Xie, L., Huang, Z., Li, W., Li, Z., Pan, Y. J., Chen, X., & Su, W. (2020) · Biomolecules · doi:10.3390/biom10020210 · Cited by 11 · see citing works

A protocol for isolation and culture of mesenchymal stem cells from human gingival tissue.

Zhang, X., Zeng, D., Huang, F., & Wang, J. (2019) · PubMed Central · Cited by 11 · see citing works

SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

Wang, Y., Wang, J., Xiao, Y., Hu, X., Zheng, S., Fu, J., Zhang, L., Gan, Y., Liang, X.-M., & Li, D. W. (2023) · Aging · doi:10.18632/aging.205001 · Cited by 10 · see citing works

Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage

Geng, S., Zhong, Y., Zhou, X., Zhao, G., Xie, X., Pei, Y., Hu, L., Zhang, H., Shi, Y., & Wang, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00663 · Cited by 10 · see citing works

Ex vivo expansion of regulatory T cells from long-term Belatacept-treated kidney transplant patients restores their phenotype and suppressive function but not their FOXP3 TSDR demethylation status

Cortés-Hernández, A. K., Alvarez-Salazar, E. K., Arteaga-Cruz, S., Alberú, J., & Soldevila, G. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104044 · Cited by 10 · see citing works

A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b Induced Mesenchymal Transition of Intestinal Epithelial Cells

Chen, B., Dong, W., Shao, T., Miao, X., Guo, Y., Liu, X., & Feng, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.697614 · Cited by 10 · see citing works

Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines

Cortés-Hernández, A., Alvarez-Salazar, E. K., Arteaga-Cruz, S., Rosas-Cortina, K., Linares, N., Gómez, J. M. A., & Soldevila, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686530 · Cited by 10 · see citing works

IL-38 A New Player in Inflammatory Autoimmune Disorders

Xie, L., Huang, Z., Li, H., Liu, X., Zheng, S. G., & Su, W. (2020) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pamb.1.2020.3 · Cited by 10 · see citing works

Revisiting Tregs in cancer and beyond: immunological control and therapeutic potential

Zheng, L., Wu, D., Xie, H., & Zhao, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1581093 · Cited by 16 · see citing works

Separating the wheat from the chaff: Making sense of Treg heterogeneity for better adoptive cellular therapy

Opstelten, R., & Amsen, D. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.03.002 · Cited by 9 · see citing works

Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells

Yang, J., Zou, M., Chu, X., Floess, S., Li, Y., Delacher, M., & Huehn, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.991671 · Cited by 9 · see citing works

T cell activation via the CD40 ligand and transferrin receptor and deficits in T regulatory cells are associated with major depressive disorder and severity of depressionPreprint

Rachayon, M., Jirakran, K., Sodsai, P., Sughondhabirom, A., & Maes, M. (2023) · medRxiv · doi:10.1101/2023.05.03.23289312 · Cited by 9 · see citing works

Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

Huang, Q., Tian, N., Zhang, J., Song, S., Cheng, H., Liu, X., Zhang, W., Ye, Y., Du, Y., Dai, X., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci178079 · Cited by 8 · see citing works

Cannabinoids in Autoimmune and Rheumatic Diseases

Navarini, L., Margiotta, D. P. E., Afflitto, G. G., & Afeltra, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814307-0.00038-4 · Cited by 7 · see citing works

Confirmation of the Prognostic Value of Foxp3+ Cells in Canine Mammary Tumors

Parisi, F., Millanta, F., Nicastro, M., Vannozzi, I., & Poli, A. (2023) · Animals · doi:10.3390/ani13030505 · Cited by 6 · see citing works

181 The role of nuclear IL-37 in regulating FOXP3 expression and Treg cell stability

Osborne, D., Domenico, J. M., Vaddi, P. K., Zhai, Z., Dinarello, C. A., & Fujita, M. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.03.182

Original Article Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation

Gao, Z., Gao, Y., Li, Z., Chen, Z., Lu, D., Tsun, A., & Li, B. (2012)

Inducible protein degradation reveals inflammation-dependent function of the T reg cell lineage–defining transcription factor Foxp3

Jäger, C., Dimitrova, P. D., Sun, Q., Tennebroek, J., Marchiori, E., Jaritz, M., Rauschmeier, R., Estivill, G., Obenauf, A. C., Busslinger, M., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adr7057 · Cited by 19 · see citing works

DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions

Satoh, K., Yamashita-Kanemaru, Y., Abe, F., Murata, R., Nakamura-Shinya, Y., Kanemaru, K., Muratani, M., Veillette, A., Goto, M., Ito, M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021309118 · Cited by 44 · see citing works

A Degrading View of Regulatory T Cells

Laurence, A. D. J., Belkaid, Y., & O’Shea, J. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.017 · Cited by 14 · see citing works