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Temporal and spatial variation of the human microbiota during pregnancy
Open accessAbstract
Significance: The human indigenous microbial communities (microbiota) play critical roles in health and may be especially important for mother and fetus during pregnancy. Using a case-control cohort of 40 women, we characterized weekly variation in the vaginal, gut, and oral microbiota during and after pregnancy. Microbiota membership remained relatively stable at each body site during pregnancy. An altered vaginal microbial community was associated with preterm birth; this finding was corroborated by an analysis of samples from an additional cohort of nine women. We also discovered an abrupt change in the vaginal microbiota at delivery that persisted in some cases for at least 1 y. Our findings suggest that pregnancy outcomes might be predicted by features of the microbiota early in gestation.
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“Women who went on to experience spontaneous PTB were less likely to exhibit a vaginal microbiota dominated by Lactobacillus crispatus, as previously reported in other populations59–62”
From The Integrative Human Microbiome Project (2019) · cites this paper as [59]
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Davis, N. M., Proctor, D. M., Holmes, S. P., Relman, D. A., & Callahan, B. J. (2018) · Microbiome · doi:10.1186/s40168-018-0605-2 · Cited by 3,493
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The Integrative Human Microbiome Project
The Integrative HMP (iHMP) Research Network Consortium, Proctor, L. M., Creasy, H. H., Fettweis, J. M., Lloyd-Price, J., Mahurkar, A., Zhou, W., Buck, G. A., Snyder, M. P., Strauss, J. F., et al. (2019) · Nature · doi:10.1038/s41586-019-1238-8 · Cited by 1,381
Metadata
- Authors
- DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., Sun, C. L., Goltsman, D. S. A., Wong, R. J., Shaw, G., Stevenson, D. K., Holmes, S. P., & Relman, D. A.
- Affiliations
- March of Dimes (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-08-17
- Volume
- 112
- Issue
- 35
- Pages
- 11060-11065
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4568272
- OpenAlex
- W1930591173
- Cited by
- 1,129
- References
- 35
- Citations by year
- 2026: 53 · 2025: 90 · 2024: 111 · 2023: 126 · 2022: 133 · 2021: 161 · 2020: 123 · 2019: 118 · 2018: 83 · 2017: 76 · 2016: 48 · 2015: 6
- FWCI
- 59.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation (Prematurity Research Center of Stanford University)
- HHS | NIH | National Center for Advancing Translational Sciences (UL1 TR001085)
- HHS | NIH | National Institute of General Medical Sciences (R01 GM086884)
- NSF | MPS | Division of Mathematical Sciences (1162538)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- human microbiota, pregnancy, vaginal microbiota, preterm birth, Lactobacillus, Gardnerella, Ureaplasma, gut microbiota, saliva microbiota, community state types, microbial community dynamics, anaerobic bacteria, interpregnancy interval
- MeSH terms
- Female, Humans, Intestines, Periodontium, Pregnancy, Saliva, Vagina, Microbiota
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