Cited by 1,129Reproductive tract infections researchGut microbiota and healthOral microbiology and periodontitis research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Temporal and spatial variation of the human microbiota during pregnancy

Open access

DiGiulio, Daniel B., Callahan, Benjamin J., McMurdie, Paul J., Costello, Elizabeth K., Lyell, Deirdre J., Robaczewska, Anna, Sun, Christine L., Goltsman, Daniela S. A., Wong, Ronald J., Shaw, Gary, Stevenson, David K., Holmes, Susan P., Relman, David A.·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1502875112PMC PMC4568272

Open this paper in CoChat — free account Open PDF

Abstract

Significance: The human indigenous microbial communities (microbiota) play critical roles in health and may be especially important for mother and fetus during pregnancy. Using a case-control cohort of 40 women, we characterized weekly variation in the vaginal, gut, and oral microbiota during and after pregnancy. Microbiota membership remained relatively stable at each body site during pregnancy. An altered vaginal microbial community was associated with preterm birth; this finding was corroborated by an analysis of samples from an additional cohort of nine women. We also discovered an abrupt change in the vaginal microbiota at delivery that persisted in some cases for at least 1 y. Our findings suggest that pregnancy outcomes might be predicted by features of the microbiota early in gestation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1502875112

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,942
Self-citation
Estimating the Number of Clusters in a Data Set Via the Gap Statistic
Tibshirani, R., Walther, G., & Hastie, T. (2001) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00293 · Cited by 6,205
Vaginal microbiome of reproductive-age women
Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Born Too Soon: The global epidemiology of 15 million preterm births
Blencowe, H. K., Cousens, S. N., Chou, D., Oestergaard, M. Z., Say, L., Moller, A., Kinney, M. V., Lawn, J. E., & the Born Too Soon Preterm Birth Action Group (see acknowledgement for full list) (2013) · Reproductive Health · doi:10.1186/1742-4755-10-s1-s2 · Cited by 2,214
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165
Preterm labor: One syndrome, many causes
Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Self-citation
Temporal Dynamics of the Human Vaginal Microbiota
Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J. M., Schütte, U. M. E., Zhong, X., Koenig, S. S. K., Fu, L., Ma, Z. S., Zhou, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003605 · Cited by 1,583

Show all 35 references

Sorted by citations

Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data
Davis, N. M., Proctor, D. M., Holmes, S. P., Relman, D. A., & Callahan, B. J. (2018) · Microbiome · doi:10.1186/s40168-018-0605-2 · Cited by 3,493
Self-citation
Exact sequence variants should replace operational taxonomic units in marker-gene data analysis
Callahan, B. J., McMurdie, P. J., & Holmes, S. (2017) · The ISME Journal · doi:10.1038/ismej.2017.119 · Cited by 3,253
Self-citation
The healthy human microbiome
Lloyd-Price, J., Abu-Ali, G., & Huttenhower, C. (2016) · Genome Medicine · doi:10.1186/s13073-016-0307-y · Cited by 1,891
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513
The Integrative Human Microbiome Project
The Integrative HMP (iHMP) Research Network Consortium, Proctor, L. M., Creasy, H. H., Fettweis, J. M., Lloyd-Price, J., Mahurkar, A., Zhou, W., Buck, G. A., Snyder, M. P., Strauss, J. F., et al. (2019) · Nature · doi:10.1038/s41586-019-1238-8 · Cited by 1,381
Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child
Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306
The vaginal microbiome and preterm birth
Fettweis, J. M., Serrano, M. G., Brooks, J. P., Edwards, D. J., Girerd, P. H., Parikh, H. I., Huang, B., Arodz, T. J., Edupuganti, L., Glascock, A. L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0450-2 · Cited by 983
Evidence that the endometrial microbiota has an effect on implantation success or failure
Moreno, I., Codoñer, F. M., Vilella, F., Valbuena, D., Martínez-Blanch, J. F., Jimenez-Almazán, J., Alonso, R., Alamá, P., Remohi, J., Sr., Pellicer, A., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.09.075 · Cited by 907
The Human Microbiome and Child Growth – First 1000 Days and Beyond
Robertson, R. C., Manges, A. R., Finlay, B. B., & Prendergast, A. J. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2018.09.008 · Cited by 793
The Vaginal Microenvironment: The Physiologic Role of Lactobacilli
Amabebe, E., & Anumba, D. O. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00181 · Cited by 785
Microbiome-wide association studies link dynamic microbial consortia to disease
Gilbert, J. A., Quinn, R. A., Debelius, J. W., Xu, Z. Z., Morton, J. T., Garg, N., Jansson, J. K., Dorrestein, P. C., & Knight, R. D. (2016) · Nature · doi:10.1038/nature18850 · Cited by 731
Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health
Chee, W. J. Y., Chew, S. Y., & Than, L. T. L. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01464-4 · Cited by 761
The Human Microbiome during Bacterial Vaginosis
Onderdonk, A. B., Delaney, M. L., & Fichorova, R. N. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00075-15 · Cited by 678
Our gut microbiome: The evolving inner self
Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017) · Cell · doi:10.1016/j.cell.2017.11.024 · Cited by 633
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel‐Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 647
The impact of the gut microbiota on the reproductive and metabolic endocrine system
Qi, X., Yun, C., Pang, Y., & Qiao, J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1894070 · Cited by 587
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development
Yockey, L. J., & Iwasaki, A. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.017 · Cited by 588
Menstruation: science and society
Critchley, H., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M. D., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 533
The vaginal microbiota, host defence and reproductive physiology
Smith, S. B., & Ravel, J. (2016) · The Journal of Physiology · doi:10.1113/jp271694 · Cited by 449
Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment
Marcos-Zambrano, L. J., Karađuzović-Hadžiabdić, K., Lončar-Turukalo, T., Przymus, P., Trajkovik, V., Aasmets, O., Berland, M., Gruca, A., Telalović, J. H., Hron, K., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.634511 · Cited by 447
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419
Self-citation
Lactobacilli Dominance and Vaginal pH: Why Is the Human Vaginal Microbiome Unique?
Miller, E. A., Beasley, D. E., Dunn, R. R., & Archie, E. A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01936 · Cited by 411
Towards a deeper understanding of the vaginal microbiota
France, M., Alizadeh, M. A., Brown, S. E., Ma, B., & Ravel, J. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01083-2 · Cited by 412
Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women
Callahan, B. J., DiGiulio, D. B., Goltsman, D. S. A., Sun, C. L., Costello, E. K., Jeganathan, P., Biggio, J. R., Wong, R. J., Druzin, M. L., Shaw, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705899114 · Cited by 391
Self-citation
Uterine Microbiota: Residents, Tourists, or Invaders?
Baker, J. M., Chase, D. M., & Herbst‐Kralovetz, M. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00208 · Cited by 400
The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk
Kindinger, L. M., Bennett, P. R., Lee, Y. S., Marchesi, J. R., Smith, A., Cacciatore, S., Holmes, E., Nicholson, J. K., Teoh, T. G., & MacIntyre, D. A. (2017) · Microbiome · doi:10.1186/s40168-016-0223-9 · Cited by 372
Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery
Elovitz, M. A., Gajer, P., Riis, V. M., Brown, A. G., Humphrys, M. S., Holm, J. B., & Ravel, J. (2019) · Nature Communications · doi:10.1038/s41467-019-09285-9 · Cited by 375
Modeling microbial abundances and dysbiosis with beta-binomial regression
Martin, B. D., Witten, D., & Willis, A. D. (2020) · The Annals of Applied Statistics · doi:10.1214/19-aoas1283 · Cited by 379
Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation
Chen, X., Li, P., Liu, M., Zheng, H., He, Y., Chen, M.-X., Tang, W., Yue, X., Huang, Y., Zhuang, L., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319101 · Cited by 367
The Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323
q2-longitudinal: Longitudinal and Paired-Sample Analyses of Microbiome Data
Bokulich, N. A., Dillon, M. R., Zhang, Y., Rideout, J. R., Bolyen, E. K., Li, H., Albert, P. S., & Caporaso, J. G. (2018) · mSystems · doi:10.1128/msystems.00219-18 · Cited by 331
Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing
Loesche, M. A., Gardner, S. E., Kalan, L., Horwinski, J., Zheng, Q., Hodkinson, B. P., Tyldsley, A. S., Franciscus, C. L., Hillis, S. L., Mehta, S. D., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.08.009 · Cited by 313
The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system
Heiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy
Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., Huang, B., Girerd, P. H., Bokhari, Y. A., Bradley, S. P., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0465-8 · Cited by 300
Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity
Anahtar, M. N., Gootenberg, D. B., Mitchell, C. M., & Kwon, D. S. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.01.013 · Cited by 302
Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin
Brown, R. G., Marchesi, J. R., Lee, Y. S., Smith, A., Lehne, B., Kindinger, L. M., Terzidou, V., Holmes, E., Nicholson, J. K., Bennett, P. R., et al. (2018) · BMC Medicine · doi:10.1186/s12916-017-0999-x · Cited by 295
The prenatal gut microbiome: are we colonized with bacteria in utero ?
Walker, R. W., Clemente, J. C., Peter, I., & Loos, R. J. F. (2017) · Pediatric Obesity · doi:10.1111/ijpo.12217 · Cited by 310
The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls
Ata, B., Yıldız, Ş., Türkgeldi, E., Pérez‐Brocal, V., Dinleyici, E. Ç., Moyá, A., & Urman, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-39700-6 · Cited by 294
The T helper type 17/regulatory T cell paradigm in pregnancy
Figueiredo, A. S., & Schumacher, A. (2016) · Immunology · doi:10.1111/imm.12595 · Cited by 292
The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis
Prince, A., Ma, J., Kannan, P. S., Alvarez, M., Gisslen, T. A., Harris, R. A., Sweeney, E. L., Knox, C. L., Lambers, D. S., Jobe, A. H., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.01.193 · Cited by 282
Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls
Stewart, C. J., Embleton, N. D., Marrs, E. C. L., Smith, D. P., Fofanova, T. Y., Nelson, A., Skeath, T., Perry, J. D., Petrosino, J. F., Berrington, J. E., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0295-1 · Cited by 276
Early pregnancy vaginal microbiome trends and preterm birth
Stout, M. J., Zhou, Y., Wylie, K. M., Tarr, P. I., Macones, G. A., & Tuuli, M. G. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.05.030 · Cited by 269
The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions
Mitra, A., MacIntyre, D. A., Ntritsos, G., Smith, A., Tsilidis, K. K., Marchesi, J. R., Bennett, P. R., Moscicki, A., & Kyrgiou, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15856-y · Cited by 263
Changes in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM)
Ferrocino, I., Ponzo, V., Gambino, R., Zarovska, A., Leone, F., Monzeglio, C., Goitre, I., Rosato, R., Romano, A., Grassi, G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30735-9 · Cited by 257
Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy
Nuriel‐Ohayon, M., Neuman, H., Oren, Z., Belogolovski, A., Barsheshet, Y., Bloch, N., Uzan-Yulzari, A., Lahav, R., Peretz, A., Frishman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.075 · Cited by 255
Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases
Lewis, F. M. T., Bernstein, K. T., & Aral, S. O. (2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001932 · Cited by 248
A microbial perspective of human developmental biology
Charbonneau, M. R., Blanton, L. V., DiGiulio, D. B., Relman, D. A., Lebrilla, C. B., Mills, D. A., & Gordon, J. I. (2016) · Nature · doi:10.1038/nature18845 · Cited by 251
Self-citation
Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva
Doan, T. A., Akileswaran, L., Andersen, D., Johnson, B. A., Ko, N., Shrestha, A., Shestopalov, V. I., Lee, C. S., Lee, A., & Gelder, R. N. V. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19803 · Cited by 252
Maternal vertical transmission affecting early-life microbiota development
Wang, S., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.07.010 · Cited by 243
Ecological dynamics of the vaginal microbiome in relation to health and disease
Greenbaum, S., Greenbaum, G., Moran‐Gilad, J., & Weintraub, A. Y. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.11.1089 · Cited by 258
Cervicovaginal microbiota, women's health, and reproductive outcomes
Kroon, S. J., Ravel, J., & Huston, W. M. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.06.036 · Cited by 246
Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants
Gregory, K. E., Samuel, B. S., Houghteling, P. D., Shan, G., Ausubel, F. M., Sadreyev, R. I., & Walker, W. A. (2016) · Microbiome · doi:10.1186/s40168-016-0214-x · Cited by 244
Gut microbial diversity is associated with lower arterial stiffness in women
Menni, C., Lin, C., Cecelja, M., Mangino, M., Matey-Hernandez, M. L., Keehn, L., Mohney, R. P., Steves, C. J., Spector, T. D., Kuo, C., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy226 · Cited by 240
Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential
Hasain, Z., Mokhtar, N. M., Kamaruddin, N. A., Ismail, N. A. M., Razalli, N. H., Gnanou, J. V., & Ali, R. A. R. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00188 · Cited by 242
Group B Streptococcus and the Vaginal Microbiota
Rosen, G. H., Randis, T. M., Desai, P. V., Sapra, K. J., Ma, B., Gajer, P., Humphrys, M. S., Ravel, J., Gelber, S. E., & Ratner, A. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix395 · Cited by 232
Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease
Stewart, C. J., Embleton, N. D., Marrs, E. C. L., Smith, D. P., Nelson, A., Abdulkadir, B., Skeath, T., Petrosino, J. F., Perry, J. D., Berrington, J. E., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0216-8 · Cited by 222
Identification and evaluation of the microbiome in the female and male reproductive tracts
Koedooder, R., Mackens, S., Budding, A. E., Fares, D. A., Blockeel, C., Laven, J. S. E., & Schoenmakers, S. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy048 · Cited by 211
Endometrial microbiota—new player in town
Moreno, I., & Franasiak, J. M. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.034 · Cited by 203
Effects of Rare Microbiome Taxa Filtering on Statistical Analysis
Cao, Q., Sun, X., Rajesh, K., Chalasani, N., Gelow, K., Katz, B. P., Shah, V. H., Sanyal, A. J., & Smirnova, E. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.607325 · Cited by 211
Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth
Freitas, A. C., Bocking, A. D., Hill, J. E., & Money, D. (2018) · Microbiome · doi:10.1186/s40168-018-0502-8 · Cited by 199
The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction
Al‐Nasiry, S., Ambrosino, E., Schlaepfer, M., Morré, S. A., Wieten, L., Voncken, J. W., Spinelli, M., Mueller, M., & Kramer, B. W. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00378 · Cited by 204
Vaginal microbiome: normalcy vs dysbiosis
Saraf, V. S., Sheikh, S. A., Ahmad, A., Gillevet, P. M., Bokhari, H., & Javed, S. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02414-3 · Cited by 216
Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility
Proctor, D. M., Dangana, T., Sexton, D. J., Fukuda, C., Yelin, R. D., Stanley, M., Bell, P. B., Baskaran, S., Deming, C., Chen, Q., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01383-w · Cited by 198
Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease
Codagnone, M. G., Spichak, S., O’Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.014 · Cited by 198
The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women
Freitas, A. C., Chaban, B. L., Bocking, A. D., Rocco, M., Yang, S., Hill, J. E., Money, D., Hemmingsen, S. M., Reid, G., Dumonceaux, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07790-9 · Cited by 198
Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case–control study
Tabatabaei, N., Eren, A. M., Barreiro, L. B., Yotova, V., Dumaine, A., Allard, C., & Fraser, W. D. (2018) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15299 · Cited by 201
Translocation of vaginal microbiota is involved in impairment and protection of uterine health
Wang, J., Li, Z., Ma, X., Du, L., Jia, Z., Cui, X., Yu, L., Yang, J., Xiao, L., Zhang, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24516-8 · Cited by 197
Risk factors for spontaneous preterm delivery
Cobo, T., Kacerovský, M., & Jacobsson, B. (2020) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13184 · Cited by 217
Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage
Kindinger, L. M., MacIntyre, D. A., Lee, Y. S., Marchesi, J. R., Smith, A., McDonald, J. A. K., Terzidou, V., Cook, J. R., Lees, C., Israfil‐Bayli, F., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1026 · Cited by 199
The pathophysiology of intrahepatic cholestasis of pregnancy
Dixon, P. H., & Williamson, C. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.12.008 · Cited by 198
Evidence that intra-amniotic infections are often the result of an ascending invasion – a molecular microbiological study
Romero, R. J., Gomez‐Lopez, N., Winters, A. D., Jung, E., Shaman, M., Bieda, J., Panaitescu, B., Pacora, P., Erez, O., Greenberg, J. M., et al. (2019) · Journal of Perinatal Medicine · doi:10.1515/jpm-2019-0297 · Cited by 195
The global health impact of vaginal dysbiosis
van de Wijgert, J. H. H. M., & Jespers, V. (2017) · Research in Microbiology · doi:10.1016/j.resmic.2017.02.003 · Cited by 199
New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?
Molina, N. M., Sola‐Leyva, A., Sáez‐Lara, M. J., Plaza‐Díaz, J., Tubić-Pavlović, A., Romero, B., Clavero, A., Mozas‐Moreno, J., Fontes, J., & Altmäe, S. (2020) · Biomolecules · doi:10.3390/biom10040593 · Cited by 199
Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis
Grech, A. M., Collins, C. E., Holmes, A. J., Lal, R., Duncanson, K., Taylor, R., & Gordon, A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1897210 · Cited by 198
Review: Maternal health and the placental microbiome
Pelzer, E., Gómez-Arango, L. F., Barrett, H. L., & Nitert, M. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.003 · Cited by 199
Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function
Chu, D. M., Meyer, K. M., Prince, A., & Aagaard, K. M. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1241357 · Cited by 188
Microbiome and its relation to gestational diabetes
Cortez, R. V., Taddei, C. R., Sparvoli, L. G., Angelo, A. G. S., Padilha, M., Mattar, R., & Daher, S. (2018) · Endocrine · doi:10.1007/s12020-018-1813-z · Cited by 187
Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis
Barrientos‐Durán, A., Fuentes, A. P., de Salazar, A., Plaza‐Díaz, J., & García, F. (2020) · Nutrients · doi:10.3390/nu12020419 · Cited by 188
The developing gut microbiota and its consequences for health
Butel, M.-J., Waligora-Dupriet, A.-J., & Wydau-Dematteis, S. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000119 · Cited by 182
A citizen-science-enabled catalogue of the vaginal microbiome and associated factors
Lebeer, S., Ahannach, S., Gehrmann, T., Wittouck, S., Eilers, T., Oerlemans, E., Condori, S., Dillen, J., Spacova, I., Vander Donck, L., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01500-0 · Cited by 181
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 190
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
Ghaemi, M. S., DiGiulio, D. B., Contrepois, K., Callahan, B. J., Ngo, T. T. M., Lee‐McMullen, B., Lehallier, B., Robaczewska, A., McIlwain, D. R., Rosenberg‐Hasson, Y., et al. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty537 · Cited by 183
Self-citation
Chorioamnionitis and neonatal outcomes
Jain, V. G., Willis, K. A., Jobe, A. H., & Ambalavanan, N. (2021) · Pediatric Research · doi:10.1038/s41390-021-01633-0 · Cited by 181
Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes
Brown, R. G., Al‐Memar, M., Marchesi, J. R., Lee, Y. S., Smith, A., Chan, D., Lewis, H., Kindinger, L. M., Terzidou, V., Bourne, T., et al. (2018) · Translational research · doi:10.1016/j.trsl.2018.12.005 · Cited by 179
The Human Ureaplasma Species as Causative Agents of Chorioamnionitis
Sweeney, E. L., Dando, S. J., Kallapur, S. G., & Knox, C. L. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00091-16 · Cited by 179
Infections and Pregnancy: Effects on Maternal and Child Health
Kumar, M., Saadaoui, M., & Khodor, S. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.873253 · Cited by 173
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Zhou, X., Shen, X., Johnson, J. S., Spakowicz, D. J., Agnello, M., Zhou, W., Avina, M., Honkala, A. T., Chleilat, F., Chen, S. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.02.012 · Cited by 181
A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women
Wee, B. A., Thomas, M., Sweeney, E. L., Frentiu, F. D., Samios, M., Ravel, J., Gajer, P., Myers, G. S. A., Timms, P., ALLAN, J. A. B., et al. (2017) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12754 · Cited by 171
The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis
Guðnadóttir, U., Debelius, J. W., Du, J., Hugerth, L. W., Danielsson, H., Schuppe‐Koistinen, I., Fransson, E., & Brusselaers, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-12007-9 · Cited by 175
The pregnancy microbiome and preterm birth
Bayar, E., Bennett, P. R., Chan, D., Sykes, L., & MacIntyre, D. A. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00817-w · Cited by 164
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Kell, D. B., & Pretorius, E. (2015) · Integrative Biology · doi:10.1039/c5ib00158g · Cited by 170
Tracking network dynamics: A survey using graph distances
Donnat, C., & Holmes, S. (2018) · The Annals of Applied Statistics · doi:10.1214/18-aoas1176 · Cited by 179
Self-citation
Deciphering the effect of reproductive tract microbiota on human reproduction
Moreno, I., & Simón, C. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12249 · Cited by 164
Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy
Hantsoo, L., Jašarević, E., Criniti, S., McGeehan, B., Tanes, C., Sammel, M. D., Elovitz, M. A., Compher, C., Wu, G., & Epperson, C. N. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.11.005 · Cited by 156
Diet-Gut Microbiota Interactions and Gestational Diabetes Mellitus (GDM)
Ponzo, V., Fedele, D., Goitre, I., Leone, F., Lezo, A., Monzeglio, C., Finocchiaro, C., Ghigo, E., & Bo, S. (2019) · Nutrients · doi:10.3390/nu11020330 · Cited by 158
Oral microflora and pregnancy: a systematic review and meta-analysis
Jang, H., Patoine, A., Wu, T. T., Castillo, D. A., & Xiao, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-96495-1 · Cited by 165
Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women
Lv, L., Li, S., Li, S.-C., Zhong, Z.-C., Duan, H., Cheng, T., Li, H., He, W., Chen, M.-C., He, T., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00224 · Cited by 156
Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiomePreprint
Goltsman, D. S. A., Sun, C. L., Proctor, D. M., DiGiulio, D. B., Robaczewska, A., Thomas, B. C., Shaw, G. M., Stevenson, D. K., Holmes, S., Banfield, J. F., et al. (2018) · Genome Research · doi:10.1101/gr.236000.118 · Cited by 149
Self-citation
A Critical Review of the Bacterial Baptism Hypothesis and the Impact of Cesarean Delivery on the Infant Microbiome
Stinson, L. F., Payne, M. S., & Keelan, J. A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00135 · Cited by 154
Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes
Di Simone, N., Santamaria Ortiz, A., Specchia, M., Tersigni, C., Villa, P., Gasbarrini, A., Scambia, G., & D’Ippolito, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.528202 · Cited by 146

Authors: DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., Sun, C. L., Goltsman, D. S. A., Wong, R. J., Shaw, G., Stevenson, D. K., Holmes, S. P., & Relman, D. A.
Affiliations: March of Dimes (US)
ORCID: Callahan, Benjamin J.
McMurdie, Paul J.
Costello, Elizabeth K.
Lyell, Deirdre J.
Sun, Christine L.
Goltsman, Daniela S. A.
Wong, Ronald J.
Shaw, Gary
Stevenson, David K.
Holmes, Susan P.
Relman, David A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-08-17
Volume: 112
Issue: 35
Pages: 11060-11065
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1502875112
PMC: PMC4568272
OpenAlex: W1930591173
Cited by: 1,129
References: 35
Citations by year: 2026: 53 · 2025: 90 · 2024: 111 · 2023: 126 · 2022: 133 · 2021: 161 · 2020: 123 · 2019: 118 · 2018: 83 · 2017: 76 · 2016: 48 · 2015: 6
FWCI: 59.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: March of Dimes Foundation (Prematurity Research Center of Stanford University)
HHS | NIH | National Center for Advancing Translational Sciences (UL1 TR001085)
HHS | NIH | National Institute of General Medical Sciences (R01 GM086884)
NSF | MPS | Division of Mathematical Sciences (1162538)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: human microbiota, pregnancy, vaginal microbiota, preterm birth, Lactobacillus, Gardnerella, Ureaplasma, gut microbiota, saliva microbiota, community state types, microbial community dynamics, anaerobic bacteria, interpregnancy interval
MeSH terms: Female, Humans, Intestines, Periodontium, Pregnancy, Saliva, Vagina, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Temporal and spatial variation of the human microbiota during pregnancy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks