The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Open accessAbstract
Significance: Studies examining paternal exposure to diverse environmental stimuli propose that epigenetic marks in germ cells, including small noncoding RNAs such as microRNA (miR), transmit experience-dependent information from parent to offspring. However, these nongenetic mechanisms of transgenerational inheritance are poorly understood, specifically how these germ-cell marks may act postfertilization to enact long-term changes in offspring behavior or physiology. In this study, through zygote microinjection of nine specific sperm miRs previously identified in our paternal stress mouse model, we demonstrate that sperm miRs function to reduce maternal mRNA stores in early zygotes, ultimately reprogramming gene expression in the offspring hypothalamus and recapitulating the offspring stress dysregulation phenotype.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This has almost exclusively been done in animal models, 63 , 64 , 65 , 66 with a few exceptions of studies in human cohorts. 67”
From Epigenetics and depression (2019) · cites this paper as [64]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Nonetheless, a few studies have shown environmentally driven changes of the epigenetic landscape in other ways, such as via histone modifications and long noncoding RNAs.”
From Epigenetics and depression (2019) · cites this paper as [64]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“and a mechanistic role for sperm microRNAs in the transgenerational transmission of stress reactivity to the offspring has also been demonstrated [70].”
The cited source says what the claim attributes to it.
In the citing paper
“They provide some compelling evidence for the transgenerational transmission and inheritance of environmentally acquired risk factors across generations via the germline [69], with epigenetic mechanisms strongly implicated [70].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Dweep, H., Sticht, C., Pandey, P., & Gretz, N. (2011) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2011.05.002 · Cited by 1,707
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421
Cited by
Sorted by citations
Items 301–400 of 755
Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring
Hernandez, R., Li, X., Shi, J., Dave, T. R., Zhou, T., Chen, Q., & Zhou, C. (2024) · JCI Insight · doi:10.1172/jci.insight.179291 · Cited by 23
Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs
Olmedo-Suárez, M. Á., Ramírez‐Díaz, I., Pérez-González, A., Molina-Herrera, A., Coral-García, M. Á., Lobato, S., Sarvari, P., Barreto, G., & Rubio, K. (2022) · Biomolecules · doi:10.3390/biom12040513 · Cited by 22
Champroux, A., Tang, Y., Dickson, D. A., Meng, A., Harrington, A. N., Liaw, L., Marzi, M. J., Nicassio, F., Schlaeger, T. M., & Feig, L. A. (2024) · Epigenetics · doi:10.1080/15592294.2024.2346694 · Cited by 25
Hehar, H., Ma, I. W. Y., & Mychasiuk, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-07784-7 · Cited by 22
Batchelor, V., & Pang, T. Y. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.04.010 · Cited by 23
Hoffmann, L. B., Li, B., Zhao, Q., Wei, W., Leighton, L. J., Bredy, T. W., Pang, T. Y., & Hannan, A. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02350-2 · Cited by 21
Liao, H., Da, L., Reisinger, S. N., Kleeman, E. A., van de Garde, N., Gubert, C., & Hannan, A. J. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.017 · Cited by 25
Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?
Gilardi, F., Augsburger, M. P., & Thomas, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00702 · Cited by 22
Liang, K., Yao, L., Wang, S., Zheng, L., Zhang, Q., Ge, Y., Chen, L., Cheng, X., Ma, R., Li, C., et al. (2021) · Aging Cell · doi:10.1111/acel.13508 · Cited by 23
Veronica, C.-S., Ivan, G.-M., & Francisco, G.-G. (2022) · Evolution; international journal of organic evolution · doi:10.1111/evo.14613 · Cited by 20
Sperm RNA-mediated epigenetic inheritance in mammals: challenges and opportunities
Chen, Q. (2022) · Reproduction Fertility and Development · doi:10.1071/rd22218 · Cited by 25
Environmental and Genetic Traffic in the Journey from Sperm to Offspring
Sengupta, P., Dutta, S., Liew, F. F., Dhawan, V., Das, B., Mottola, F., Sláma, P., Rocco, L., & Roychoudhury, S. (2023) · Biomolecules · doi:10.3390/biom13121759 · Cited by 25
Epigenetic mechanisms linking early-life adversities and mental health
Cánepa, E. T., & Berardino, B. G. (2024) · Biochemical Journal · doi:10.1042/bcj20230306 · Cited by 22
Korgan, A. C., O’Leary, M. E., Bauer, J., Fortier, A., Weaver, I. C. G., & Perrot, T. S. (2016) · eNeuro · doi:10.1523/eneuro.0231-16.2016 · Cited by 22
Variant Histone H2afv reprograms DNA methylation during early zebrafish development
Madakashira, B. P., Corbett, L., Zhang, C., Paoli, P. P., Casement, J., Mann, J., Sadler, K. C., & Mann, D. A. (2017) · Epigenetics · doi:10.1080/15592294.2017.1359382 · Cited by 22
Genome and stress-reaction in animals and humans
Dyuzhikova, N. A., & Даев, Е. В. (2018) · Ecological genetics · doi:10.17816/ecogen1614-26 · Cited by 22
Adrian‐Kalchhauser, I., Walser, J., Schwaiger, M., & Burkhardt‐Holm, P. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1132-2 · Cited by 22
Inter- and transgenerational inheritance of behavioral phenotypes
Jawaid, A., & Mansuy, I. M. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.12.004 · Cited by 21
Ryan, C. P., & Kuzawa, C. W. (2020) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21828 · Cited by 21
Proximate causes and consequences of intergenerational influences of salient sensory experience
Aoued, H. S., Sannigrahi, S., Hunter, S. C., Doshi, N. K., Sathi, Z. S., Chan, A. W. S., Walum, H., & Dias, B. G. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12638 · Cited by 18
Rathod, R. S., Ferguson, C., Seth, A., Baratta, A. M., Plasil, S. L., & Homanics, G. E. (2020) · Brain Sciences · doi:10.3390/brainsci10090658 · Cited by 21
Merino, O., Risopatrón, J., Valdebenito, I., Figueroa, E., & Farías, J. G. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12729 · Cited by 26
An epigenetic resolution of the lek paradox
Bonilla, M. M., Zeh, J. A., & Zeh, D. W. (2016) · BioEssays · doi:10.1002/bies.201500176 · Cited by 20
Pataia, V., Papacleovoulou, G., Nikolova, V., Samuelsson, A., Chambers, S., Jansen, E. H. J. M., Taylor, P. D., Poston, L., & Williamson, C. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0095-0 · Cited by 21
Champagne, F. A. (2019) · Functional Ecology · doi:10.1111/1365-2435.13411 · Cited by 23
Environmental epigenetics: new horizons in redefining biological and health outcomes
Faraji, J., & Metz, G. A. S. (2026) · Environment International · doi:10.1016/j.envint.2026.110072 · Cited by 22
Brass, K. E., Herndon, N., Gardner, S. A., Grindstaff, J. L., & Polly Campbell, A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104806 · Cited by 19
Luu, I., Ikert, H., & Craig, P. M. (2020) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2020.108918 · Cited by 21
Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the “Germ Plasm”
Lev, I., & Rechavi, O. (2020) · iScience · doi:10.1016/j.isci.2020.101831 · Cited by 18
Varela, R. B., Cararo, J. H., Tye, S. J., Carvalho, A. F., Valvassori, S. S., Fries, G. R., & Quevedo, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104579 · Cited by 21
Korgan, A. C., Foxx, C. L., Hashmi, H., Sago, S. A., Stamper, C. E., Heinze, J. D., O’Leary, M. E., King, J. L., Perrot, T. S., Lowry, C. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14095-z · Cited by 21
The molecular basis for sex differences in depression susceptibility
Issler, O., & Nestler, E. J. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.019 · Cited by 19
Yaw, A. M., Prosser, R. A., Jones, P. C., Garcia, B. J., Jacobson, D., & Glass, J. D. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.043 · Cited by 19
Transgenerational consequences of maternal immune activation
Pollak, D. D., & Weber‐Stadlbauer, U. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.06.006 · Cited by 20
Fennell, K. A., Busby, R. G. G., Li, S., Bodden, C., Stanger, S. J., Nixon, B., Short, A. K., Hannan, A. J., & Pang, T. Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-72560-z · Cited by 19
Beversdorf, D. Q., Shah, A., Jhin, A., Noel‐MacDonnell, J., Hecht, P. M., Ferguson, B. J., Bruce, D., Tilley, M. R., & Talebizadeh, Z. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.668577 · Cited by 19
Deciphering the RNA universe in sperm in its role as a vertical information carrier
Kretschmer, M., & Gapp, K. (2022) · Current Zoology · doi:10.1093/eep/dvac011 · Cited by 19
Oluwayiose, O. A., Houle, E., Whitcomb, B. W., Suvorov, A., Rahil, T., Sites, C. K., Krawetz, S. A., Visconti, P. E., & Pilsner, J. R. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121529 · Cited by 19
Neuroepigenetic mechanisms underlying fear extinction: emerging concepts
Marshall, P. R., & Bredy, T. W. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5084-4 · Cited by 18
Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†
McCarthy, D. M., & Bhide, P. G. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab116 · Cited by 17
A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline
Zhu, Q., Stöger, R. J., & Alberio, R. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00024 · Cited by 21
Nichols, A. R., Rundle, A., Factor-Litvak, P. R., Insel, B. J., Hoepner, L., Rauh, V., Perera, F. P., & Widen, E. M. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000412 · Cited by 17
Yin, X., Anwar, A., Wang, Y., Hu, H., Liang, G., & Zhang, C. (2021) · Frontiers of Medicine · doi:10.1007/s11684-021-0885-y · Cited by 17
Li, H., Wan, X., Zhao, J., Liang, X., Dai, Y., & Li, H. (2022) · Translational research · doi:10.1016/j.trsl.2022.12.006 · Cited by 18
Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter
Golding, M. C. (2023) · Birth Defects Research · doi:10.1002/bdr2.2215 · Cited by 17
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Wu, D., Zhang, K., Guan, K., Khan, F. A., Pandupuspitasari, N. S., Negara, W., Sun, F., & Huang, C. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03713-6 · Cited by 20
Lei, J., Nie, Q. H., & Chen, D. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy050 · Cited by 17
Silva, W. T. A. F., Otto, S. P., & Immler, S. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009581 · Cited by 18
Olovnikov, A. M. (2022) · Biosystems · doi:10.1016/j.biosystems.2022.104706 · Cited by 17
Nonprotein-coding RNAs in Fetal Alcohol Spectrum Disorders
Mahnke, A. H., Salem, N. A., Tseng, A. M., Chung, D. D., & Miranda, R. C. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.024 · Cited by 17
Central Neuroepigenetic Regulation of the Hypothalamic–Pituitary–Adrenal Axis
Dick, A. L. W., & Provençal, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.006 · Cited by 17
Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway
Kaltsas, A., Papaharitou, S., Dimitriadis, F., Chrisofos, M., & Sofikitis, N. (2026) · Biomedicines · doi:10.3390/biomedicines14020259 · Cited by 18
Cardinal role of the environment in stress induced changes across life stages and generations
Pang, T. Y., Yaeger, J. D. W., Summers, C. H., & Mitra, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.012 · Cited by 17
Small Non-Coding RNAs in Male Reproduction
Olotu, O., Ahmedani, A., & Kotaja, N. (2023) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1779726 · Cited by 17
Inheritance of Cytosine Methylation
Tillo, D., Mukherjee, S., & Vinson, C. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25350 · Cited by 16
miRNAs may change rapidly with thoughts: The Relaxation Response after myocardial infarction
Lin, C. D., Gola, E., Brocca, A., Rubino, G., Marinova, M., Brugnolo, L., Plebani, M., Iliceto, S., & Tona, F. (2018) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2018.03.009 · Cited by 17
Akinjo, O. O., Gant, T. W., & Marczylo, E. L. (2018) · Toxicology Research · doi:10.1039/c7tx00314e · Cited by 17
Differences in small noncoding RNAs profile between bull X and Y sperm
Zhou, H., Liu, J., Sun, W., Ding, R., Li, X., Shangguan, A., Zhou, Y., Worku, T., Hao, X., Khan, F. A., et al. (2020) · PeerJ · doi:10.7717/peerj.9822 · Cited by 18
Zaidan, H., Galiani, D., & Gaisler‐Salomon, I. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01220-1 · Cited by 19
Parental obesity programs pancreatic cancer development in offspring
da Cruz, R. S., Clarke, J., Curi, A. C. P., Al-Yawar, A., Lu, J., Baird, A., Cruz, M. I., Kallakury, B., & de Assis, S. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0016 · Cited by 15
Gestational arsenic exposure and paternal intergenerational epigenetic inheritance
Nohara, K., Suzuki, T., & Okamura, K. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115319 · Cited by 16
Li, X., Wang, M., Liu, S., Chen, X., Qiao, Y., Yang, X., Yao, J., & Wu, S. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.07.002 · Cited by 16
Preconception paternal mental disorders and child health: Mechanisms and interventions
Tan, X., Luo, J., Ding, X., & Li, H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104976 · Cited by 16
Cinquina, V., Keimpema, E., Pollak, D. D., & Harkany, T. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13320 · Cited by 16
Patterns of expression of sperm and seminal plasma microRNAs in boar semen
Kasimanickam, V. R., Buhr, M. M., & Kasimanickam, R. K. (2018) · Theriogenology · doi:10.1016/j.theriogenology.2018.10.021 · Cited by 15
Koabel, J., McNivens, M., McKee, P. C., Pautassi, R. M., Bordner, K. A., & Nizhnikov, M. E. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.01.009 · Cited by 12
Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders
Escher, J., Yan, W., Rissman, E. F., Wang, H. V., Hernández, A., & Corces, V. G. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05304-1 · Cited by 15
Hime, G. R., Stonehouse, S. L., & Pang, T. Y. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.711 · Cited by 13
Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera
Watson, O. T., Buchmann, G., Young, P. E., Lo, K., Remnant, E. J., Yagound, B., Shambrook, M., Hill, A. F., Oldroyd, B. P., & Ashe, A. (2022) · BMC Genomics · doi:10.1186/s12864-022-08478-9 · Cited by 15
Paternal transmission of early life traumatization through epigenetics: Do fathers play a role?
Rowold, E. D., Schulze, L. N., der Auwera, S. V., & Grabe, H. J. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.011 · Cited by 16
Transgenerational Impact of Environmental Change
Morgan, H. L., & Watkins, A. J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-23633-5_4 · Cited by 15
Qin, H., Qu, P., Hu, H., Cao, W., Liu, H., Zhang, Y., Zhao, J., Fatima, N., & Liu, E. (2021) · Zygote · doi:10.1017/s0967199420000805 · Cited by 15
Zhang, S., Li, X., Wang, Z., Liu, Y., Gao, Y., Tan, L., Liu, E., Zhou, Q., Xu, C., Wang, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01811-3 · Cited by 15
Lim, M. Y.-T., & Bernier, N. J. (2022) · Journal of Experimental Biology · doi:10.1242/jeb.244715 · Cited by 14
Rahia Mashoodh, A., Habrylo, I. B., Gudsnuk, K. M., & Champagne, F. A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105357 · Cited by 15
Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm
Tuulari, J. J., Bourgery, M., Iversen, J. F., Koefoed, T. G., Ahonen, A., Ahmedani, A., Kataja, E.-L., Karlsson, L., Barrès, R., Karlsson, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-024-02872-3 · Cited by 14
Insights into the roles of sperm in animal cloning
Qu, P., Wang, Y., Zhang, C., & Liu, E. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01599-6 · Cited by 14
Sex-specific transgenerational effects of morphine exposure on reward and affective behaviors
Brynildsen, J. K., Sanchez, V., Yohn, N. L., Carpenter, M. D., & Blendy, J. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112842 · Cited by 14
DNA Methylation in Ovarian Cancer Susceptibility
Reid, B. M., & Fridley, B. L. (2020) · Cancers · doi:10.3390/cancers13010108 · Cited by 13
Harnessing male germline epigenomics for the genetic improvement in cattle
Wang, X. Q., Li, W., Feng, X., Li, J., Liu, G. E., Fang, L., & Yu, Y. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00874-9 · Cited by 15
Molecular and Epigenetic Mechanisms Underlying Cognitive and Adaptive Responses to Stress
Trollope, A. F., Mifsud, K. R., Saunderson, E. A., & Reul, J. M. H. M. (2017) · Epigenomes · doi:10.3390/epigenomes1030017 · Cited by 13
Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs
Solich, J., Kuśmider, M., Faron-Górecka, A., Pabian, P., & Dziedzicka-Wasylewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249469 · Cited by 13
Skerrett-Byrne, D. A., Pépin, A.-S., Laurent, K., Beckers, J., Schneider, R., de Angelis, M. H., & Teperino, R. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70261 · Cited by 18
Chu, M.-C., Wu, H.-F., Lee, C. J., Chung, Y.-J., Chi, H., Chen, P. S., & Lin, H. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00835-w · Cited by 14
Developmental origins of adult diseases
Mo, J., Liu, X., Huang, Y., He, R., Zhang, Y., & Huang, H. (2022) · Medical Review · doi:10.1515/mr-2022-0027 · Cited by 14
Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?
Leggio, L., Paternò, G., Cavallaro, F., Falcone, M., Vivarelli, S., Manna, C., Calogero, A. E., Cannarella, R., & Iraci, N. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04962-w · Cited by 16
Sperm long non-coding RNAs as markers for ram fertility
Hitit, M., Kaya, A., & Memili, E. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1337939 · Cited by 13
A novel miRNA analysis framework to analyze differential biological networks
Bansal, A., Singh, T. R., & Chauhan, R. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-14973-x · Cited by 14
Maciel, E., & Mansuy, I. M. (2019) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2019.356 · Cited by 13
Kong, Q.-Q., Tian, X., Wang, J., Yuan, H.-J., Ning, S.-F., Luo, M., & Tan, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87060-x · Cited by 13
Sperm signatures of fertility and freezability
Hitit, M., & Memili, E. (2022) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2022.107147 · Cited by 13
Perturbation of epigenetic processes by doxorubicin in the mouse testis
Akinjo, O. O., Gant, T. W., & Marczylo, E. L. (2016) · Toxicology Research · doi:10.1039/c6tx00078a · Cited by 13
Small RNA Sequencing: A Technique for miRNA Profiling
Pantaleão, L. C., & Ozanne, S. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_21 · Cited by 13
The specificity of sperm-mediated paternal effects in threespine sticklebacks
Chen, E., Zielinski, C., Deno, J., Singh, R., Bell, A. M., & Hellmann, J. K. (2021) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-021-03001-8 · Cited by 13
Leader, J. E., Mínguez‐Alarcón, L., Williams, P. L., Ford, J. B., Dadd, R., Chagnon, O., Bellinger, D. C., Oken, E., Calafat, A. M., Hauser, R. B., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108337 · Cited by 12
Fischer, V., Kretschmer, M., Germain, P., Kaur, J., Barrenechea, S. M., Pelczar, P., Schürmann, D., Schär, P., & Gapp, K. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02684-z · Cited by 13
Parental preconception stress in zebrafish induces long-lasting anxiety in offspring
Yeramilli, V. A., Rizek, C. A. S., Graham, J. A., Taylor, C., Cheddadi, R., Patterson, S., Watts, S. A., & Martin, C. A. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114477 · Cited by 12
Hamilton, M., Russell, S. J., Swanson, G., Krawetz, S. A., Menezes, K., Moskovtsev, S. I., & Librach, C. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-60586-6 · Cited by 12
The paternal contribution to shaping the health of future generations
Casciaro, C., Hamada, H., Bloise, E., & Matthews, S. G. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.10.007 · Cited by 13
Hocher, B., Lu, Y.-P., Reichetzeder, C., Zhang, X., Tsuprykov, O., Rahnenführer, J., Xie, L. H., Li, J., Hu, L., Krämer, B. K., et al. (2021) · Diabetologia · doi:10.1007/s00125-022-05700-x · Cited by 12
Metadata
- Authors
- Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-10-19
- Volume
- 112
- Issue
- 44
- Pages
- 13699-13704
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4640733
- OpenAlex
- W1949928978
- Cited by
- 751
- References
- 48
- Citations by year
- 2026: 50 · 2025: 40 · 2024: 54 · 2023: 74 · 2022: 69 · 2021: 70 · 2020: 81 · 2019: 67 · 2018: 107 · 2017: 72 · 2016: 61 · 2015: 3
- FWCI
- 35.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Mental Health (MH073030, MH091258, MH087597, MH099910, MH104184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- sperm microRNA, paternal stress, chronic stress, hypothalamic-pituitary-adrenal axis, zygote microinjection, blood-brain barrier permeability, extracellular matrix, collagen, maternal mRNA degradation, SIRT1, chromatin remodeling, germ cells, single-cell transcriptomics
- MeSH terms
- Animals, Hypothalamo-Hypophyseal System, Male, Mice, Inbred C57BL, Spermatozoa, Stress, Physiological, Paternal Exposure, MicroRNAs, Epigenesis, Genetic, Mice, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review