Cited by 755Epigenetics and DNA MethylationBirth, Development, and HealthSperm and Testicular Function

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Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

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Rodgers, Ali B., Morgan, Christopher P., Leu, N. Adrian, Bale, Tracy L.·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1508347112PMC PMC4640733

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Abstract

Significance: Studies examining paternal exposure to diverse environmental stimuli propose that epigenetic marks in germ cells, including small noncoding RNAs such as microRNA (miR), transmit experience-dependent information from parent to offspring. However, these nongenetic mechanisms of transgenerational inheritance are poorly understood, specifically how these germ-cell marks may act postfertilization to enact long-term changes in offspring behavior or physiology. In this study, through zygote microinjection of nine specific sperm miRs previously identified in our paternal stress mouse model, we demonstrate that sperm miRs function to reduce maternal mRNA stores in early zygotes, ultimately reprogramming gene expression in the offspring hypothalamus and recapitulating the offspring stress dysregulation phenotype.

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Authors: Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L.
Affiliations: University of Pennsylvania (US)
ORCID: Morgan, Christopher P.
Bale, Tracy L.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-10-19
Volume: 112
Issue: 44
Pages: 13699-13704
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1508347112
PMC: PMC4640733
OpenAlex: W1949928978
Cited by: 751
References: 48
Citations by year: 2026: 50 · 2025: 40 · 2024: 54 · 2023: 74 · 2022: 69 · 2021: 70 · 2020: 81 · 2019: 67 · 2018: 107 · 2017: 72 · 2016: 61 · 2015: 3
FWCI: 35.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Institute of Mental Health (MH073030, MH091258, MH087597, MH099910, MH104184)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: sperm microRNA, paternal stress, chronic stress, hypothalamic-pituitary-adrenal axis, zygote microinjection, blood-brain barrier permeability, extracellular matrix, collagen, maternal mRNA degradation, SIRT1, chromatin remodeling, germ cells, single-cell transcriptomics
MeSH terms: Animals, Hypothalamo-Hypophyseal System, Male, Mice, Inbred C57BL, Spermatozoa, Stress, Physiological, Paternal Exposure, MicroRNAs, Epigenesis, Genetic, Mice, Transcriptome

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Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

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