The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity
Open accessAbstract
Significance: A protein modification technology has been developed in this study to overcome current problems faced by protein therapy. After being individually encapsulated in a super-hydrophilic zwitterionic gel, a therapeutic protein showed exceptional stability and long in vivo circulation half-life. More importantly, no immune response against either the protein or the polymer was observed following repeated injections. This technology will benefit patients by reducing administration frequency and mitigating adverse reactions and could allow more immunogenic proteins to enter into human therapeutic or protective applications.
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Cites
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Self-citationStructural and immunologic characterization of bovine, horse, and rabbit serum albumins
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Cited by
Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation
Zhang, P., Sun, F., Liu, S., & Jiang, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.040 · Cited by 688
Self-citationEngineering protein-based therapeutics through structural and chemical design
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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation
Liu, Q., Chiu, A., Wang, L.-H., An, D., Zhong, M., Smink, A. M., de Haan, B. J., de Vos, P., Keane, K., Vegge, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13238-7 · Cited by 202
Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles
Souri, M., Soltani, M., Moradi Kashkooli, F., & Kiani Shahvandi, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.024 · Cited by 178
Metadata
- Authors
- Zhang, P., Sun, F., Tsao, C., Liu, S., Jain, P., Sinclair, A., Hung, H.-C., Bai, T., Wu, K., & Jiang, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-09-14
- Volume
- 112
- Issue
- 39
- Pages
- 12046-12051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2191594866
- Cited by
- 316
- References
- 34
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Zhang, P., Sun, F., Tsao, C., Liu, S., Jain, P., Sinclair, A., Hung, H.-C., Bai, T., Wu, K., & Jiang, S. (2015). Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1512465112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
