Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation

Cole, Steven W.; Capitanio, John P.; Chun, Katie; Arevalo, Jesusa M. G.; Ma, Jeffrey; Cacioppo, John T.

doi:10.1073/pnas.1514249112

Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation

Significance Perceived social isolation (PSI) (loneliness) is linked to increased risk of chronic disease and mortality, and previous research has implicated up-regulated inflammation and down-regulated antiviral gene expression (the conserved transcriptional response to adversity; CTRA) as a pot…