The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Neural mechanisms of social decision-making in the primate amygdala
Open accessAbstract
Significance: Making social decisions requires evaluation of benefits and costs to self and others. Long associated with emotion and vigilance, neurons in primate amygdala also signal reward and punishment as well as information about the faces and eyes of others. Here we show that neurons in the basolateral amygdala signal the value of rewards for self and others when monkeys make social decisions. These value-mirroring neurons reflected monkeys’ tendency to make prosocial decisions on a momentary as well as long-term basis. We also found that delivering the social peptide oxytocin into basolateral amygdala enhances both prosocial tendencies and attention to the recipients of prosocial decisions. Our findings endorse the amygdala as a critical neural nexus regulating social decisions.
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In the citing paper
“In nonhuman primates, exogenous inhaled oxytocin promotes social donation behavior 26 and focal infusion of oxytocin into the amygdala significantly increases prosocial decisions 7 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [7]
In the citing paper
“Individual differences in social preferences in nonhuman primates have been shown to be due in part to oxytocinergic regulation of amygdala-related neural circuits 6,7 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [7]
In the citing paper
“This result is consistent with studies in both nonhuman primates 7 and in human neuroimaging studies 16 suggesting that the amygdala represents how undesirable an outcome is.”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [7]
In the citing paper
“Moreover, we found evidence that social value distance is also encoded by neural responses in the ventral striatum and TPJ in prosocials, consistent with previous findings linking prosocial decisions with several hubs in the social brain network 7,36 , including the amygdala, ventral striatum and TPJ.”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [7]
In the citing paper
“This is consistent with studies showing that the amygdala plays a critical role in allocating attention to other people 7 and in integrating social information 42 and social emotions 13 into decision-making.”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [7]
Citations
Cites
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LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Rizzolatti, G., & Craighero, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144230 · Cited by 7,433
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Fehr, E., & Fischbacher, U. (2003) · Nature · doi:10.1038/nature02043 · Cited by 3,475 · cited 1×
“In humans, these behaviors involve perspective-taking, empathy, and theory of mind (1, 2), and the rudiments of these capacities appear to mediate complex social behavior in animals (3).”
BackgroundCattaneo, L., & Rizzolatti, G. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.41 · Cited by 3,137
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
Putting the Altruism Back into Altruism: The Evolution of Empathy
de Waal, F. B. M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093625 · Cited by 2,483 · cited 3×
“(F) Decision RTs (mean of session medians ± SEM) differed across decision types [F(3,1052) = 175.”
BackgroundProsocial Behavior: Multilevel Perspectives
Penner., L. A., Dovidio., J. F., Piliavin., J. A., & Schroeder., D. A. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070141 · Cited by 2,308
Research works printed but not linked: 1
- 10.2307/258391 · DOI
Cited by
Sorted by citations
The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
Apps, M. A. J., Rushworth, M. F. S., & Chang, S. W. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.018 · Cited by 559
“Past studies suggest dissociable roles for oxytocin, dopamine, and serotonin in influencing social behavior (Chang et al., 2015; Crockett et al., 2015).”
Self-citationRobert, P., Lanctôt, K., Agüera-Ortiz, L., Aalten, P., Brémond, F., Defrancesco, M., Hanon, C., David, R., Dubois, B., Dujardin, K., et al. (2018) · European psychiatry · doi:10.1016/j.eurpsy.2018.07.008 · Cited by 283
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop, S. A., Wichmann, R., Mills, F., Burgos-Robles, A., Chang, C.-J., Felix-Ortiz, A. C., Vienne, A., Beyeler, A., Izadmehr, E. M., Glober, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.004 · Cited by 288
“…non-human primates, and humans, the anterior cingulate cortex (ACC) and the amygdala have been implicated in observational fear learning and social cognition (Adolphs et al., 1994; Chang et al., 2013, 2015; Haroush and Williams, 2015; Jeon et al., 2010; Kim et al., 2012; Olsson et al., 2007).”
Prefrontal–amygdala circuits in social decision-making
Gangopadhyay, P., Chawla, M., Monte, O. D., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00738-9 · Cited by 266
Self-citationFreeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196
“Recent work using site-specific infusions of OT into the macaque brain has targeted the amygdala (81,83).”
Background
Metadata
- Authors
- Chang, S. W. C., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L.
- Affiliations
- Yale University (US)
- Duke University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-12-14
- Volume
- 112
- Issue
- 52
- Pages
- 16012-16017
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4702988
- OpenAlex
- W2217623521
- Cited by
- 157
- References
- 69
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 14 · 2023: 6 · 2022: 15 · 2021: 19 · 2020: 16 · 2019: 18 · 2018: 21 · 2017: 12 · 2016: 11
- FWCI
- 24.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Mental Health (R00-MH099093, R01-MH095894)
- DOD | Army Research Office (W81XWH-11-1-0584)
- Japan Society for the Promotion of Science (No number)
- HHS | NIH | National Institute of Environmental Health Sciences (K01-ES-025442)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social decision-making, amygdala, basolateral amygdala, oxytocin, dictator game, prosocial behavior, reward valuation, punishment, social preferences, neuromodulation, primate social behavior
- MeSH terms
- Animals, Choice Behavior, Cues, Decision Making, Humans, Macaca mulatta, Markov Chains, Models, Neurological, Monte Carlo Method, Neural Pathways, Neurons, Oxytocics, Oxytocin, Reward, Social Behavior, Basolateral Nuclear Complex
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