Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Open accessAbstract
Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning and found that BLA-projecting ACC (ACC→BLA) neurons preferentially encode socially derived aversive cue information. Inhibition of ACC→BLA alters real-time amygdala representation of the aversive cue during observational conditioning. Selective inhibition of the ACC→BLA projection impaired acquisition, but not expression, of observational fear conditioning. We show that information derived from observation about the aversive value of the cue is transmitted from the ACC to the BLA and that this routing of information is critically instructive for observational fear conditioning. VIDEO ABSTRACT.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Projections from the anterior cingulate cortex and insula to the basolateral amygdala have been implicated in social transfer of fear.
“Projections from the ACC and insula to the BLA have been implicated in this form of emotional contagion.”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [102]
Inhibition of anterior cingulate cortex-to-nucleus accumbens core projections did not influence the social transfer of fear, which was reduced by inhibition of anterior cingulate cortex-to-basolateral amygdala projections.
“Surprisingly this same manipulation did not influence the social transfer of fear, which was reduced by inhibition of ACC-to-BLA projections, as previously demonstrated [102].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [102]
Inhibition of anterior cingulate cortex projections to the basolateral amygdala prevents the acquisition of fear, as assessed by freezing, in observer mice.
“Specifically, there is an increase in ACC activity in voles exposed to a stressed partner [93] and inhibition of ACC projections to the BLA prevents the acquisition of fear, as assessed by freezing, in observer mice [98,102,103].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [102]
Prior investigations in rodents and primates have provided evidence for neurons that encode information about other individuals, demonstrating changes in activity when animals observe another's appetitive or aversive experiences.
“Prior investigations in rodents and primates, for example, have provided evidence for the presence of neurons that encode information about other individuals, demonstrating changes in activity when the animals observe another’s appetitive or aversive experiences 1–11.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Empathy: its ultimate and proximate bases
Preston, S. D., & de Waal, F. B. M. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000018 · Cited by 4,126 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Imitation of Facial and Manual Gestures by Human Neonates
Meltzoff, A. N., & Moore, M. (1977) · Science · doi:10.1126/science.198.4312.75 · Cited by 3,277 · see citing works
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360 · see citing works
Context-dependent computation by recurrent dynamics in prefrontal cortex
Mante, V., Sussillo, D., Shenoy, K. V., & Newsome, W. T. (2013) · Nature · doi:10.1038/nature12742 · Cited by 1,807 · see citing works
Neural population dynamics during reaching
Churchland, M. M., Cunningham, J. P., Kaufman, M. T., Foster, J. D., Nuyujukian, P., Ryu, S. I., & Shenoy, K. V. (2012) · Nature · doi:10.1038/nature11129 · Cited by 1,636 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Self-citationAmygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works
Self-citationPrefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Dimensionality reduction for large-scale neural recordings
Cunningham, J. P., & Yu, B. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3776 · Cited by 1,219 · see citing works
Truccolo, W., Eden, U. T., Fellows, M. R., Donoghue, J. P., & Brown, E. N. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00697.2004 · Cited by 1,063 · see citing works
Self-citationAllman, J. M., Hakeem, A. Y., Erwin, J. M., Nimchinsky, E. A., & Hof, P. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03476.x · Cited by 903 · see citing works
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692 · see citing works
Molecular detection of pheromone signals in mammals: from genes to behaviour
Dulac, C. G., & Torello, A. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1140 · Cited by 662 · see citing works
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Jeon, D., Kim, S., Chetana, M., Jo, D., Ruley, H. E., Lin, S.-Y., Rabah, D., Kinet, J.-P., & Shin, H.-S. (2010) · Nature Neuroscience · doi:10.1038/nn.2504 · Cited by 651 · see citing works
The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
Apps, M. A. J., Rushworth, M. F. S., & Chang, S. W. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.018 · Cited by 559 · cited 2× · see citing works
“…conditioning (Bissie`re et al., 2008; Buchanan and Powell, 1982; Steenland et al., 2012), the ACC is a large structure and different anatomical portions of the ACC may have different functions (Allman et al., 2001; Apps et al., 2016; Bussey et al., 1996; Devinsky et al., 1995; Jones et al., 2005).”
Long-range connectivity defines behavioral specificity of amygdala neurons
Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522 · cited 2× · see citing works
“…about the aversive cue is transmitted from the ACC to the BLA during observational conditioning, we used an intersectional viral strategy (Senn et al., 2014) to express channelrhodopsin-2 (ChR2) in ACC neurons that monosynaptically project to the BLA (Figures 4A and 4B) (Burgos-Robles et…”
Reicher, S. D. (1996) · European Journal of Social Psychology · doi:10.1002/(sici)1099-0992(199601)26:1 · Cited by 429 · see citing works
Evidence for mirror systems in emotions
Bastiaansen, J. A., Thioux, M., & Keysers, C. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0058 · Cited by 414 · see citing works
Divergent routing of positive and negative information from the amygdala during memory retrieval
Beyeler, A., Namburi, P., Glober, G. F., Simonnet, C., Calhoon, G. G., Conyers, G. F., Luck, R., Wildes, C. P., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.004 · Cited by 412 · see citing works
Self-citationDecoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh, E. H., Matthews, G. A., Allsop, S. A., Presbrey, K. N., Leppla, C. A., Wichmann, R., Neve, R., Wildes, C. P., & Tye, K. M. (2015) · Cell · doi:10.1016/j.cell.2015.01.003 · Cited by 402 · see citing works
Self-citationEstimating a State-Space Model from Point Process Observations
Smith, A. C., & Brown, E. N. (2003) · Neural Computation · doi:10.1162/089976603765202622 · Cited by 395 · see citing works
Self-citationStress, social behavior, and resilience: Insights from rodents
Beery, A. K., & Kaufer, D. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.004 · Cited by 373 · see citing works
Learning fears by observing others: the neural systems of social fear transmission
Olsson, A., Nearing, K. I., & Phelps, E. A. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm005 · Cited by 349 · see citing works
Neuronal reference frames for social decisions in primate frontal cortex
Chang, S. W. C., Gariépy, J.-F., & Platt, M. L. (2013) · Nature Neuroscience · doi:10.1038/nn.3287 · Cited by 336 · cited 1× · see citing works
“…non-human primates, and humans, the anterior cingulate cortex (ACC) and the amygdala have been implicated in observational fear learning and social cognition (Adolphs et al., 1994; Chang et al., 2013, 2015; Haroush and Williams, 2015; Jeon et al., 2010; Kim et al., 2012; Olsson et al., 2007).”
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Burgos-Robles, A., Kimchi, E. Y., Izadmehr, E. M., Porzenheim, M. J., Ramos-Guasp, W. A., Nieh, E. H., Felix-Ortiz, A. C., Namburi, P., Leppla, C. A., Presbrey, K. N., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4553 · Cited by 318 · see citing works
Self-citationMechanisms involved in the observational conditioning of fear.
Mineka, S., & Cook, M. (1993) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.122.1.23 · Cited by 317 · see citing works
Molecular organization of vomeronasal chemoreception
Isogai, Y., Si, S., Pont-Lezica, L., Tan, T., Kapoor, V., Murthy, V. N., & Dulac, C. (2011) · Nature · doi:10.1038/nature10437 · Cited by 317 · see citing works
Emotional reactions of rats to the pain of others.
Church, R. M. (1959) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0043531 · Cited by 285 · see citing works
Rodent empathy and affective neuroscience
Panksepp, J. B., & Lahvis, G. P. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.05.013 · Cited by 224 · see citing works
Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice
Warren, B. L., Vialou, V. F., Iñiguez, S. D., Alcantara, L. F., Wright, K. N., Feng, J., Kennedy, P. J., LaPlant, Q., Shen, L., Nestler, E. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.006 · Cited by 222 · see citing works
Social Transmission of Fear in Rats: The Role of 22-kHz Ultrasonic Distress Vocalization
Kim, E. J., Kim, E. S., Covey, E., & Kim, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015077 · Cited by 216 · see citing works
Empathy is moderated by genetic background in mice
Chen, Q., Panksepp, J. B., & Lahvis, G. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004387 · Cited by 211 · see citing works
Neuronal Prediction of Opponent’s Behavior during Cooperative Social Interchange in Primates
Haroush, K., & Williams, Z. M. (2015) · Cell · doi:10.1016/j.cell.2015.01.045 · Cited by 210 · see citing works
Experience modulates vicarious freezing in rats: a model for empathy
Atsak, P., Orre, M., Bakker, P., Cerliani, L., Roozendaal, B., Gazzola, V., Moita, M., & Keysers, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021855 · Cited by 193 · see citing works
Neural Dynamics of Reaching following Incorrect or Absent Motor Preparation
Ames, K. C., Ryu, S. I., & Shenoy, K. V. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.003 · Cited by 170 · see citing works
Oxytocin enhances observational fear in mice
Pisansky, M. T., Hanson, L. R., Gottesman, I. I., & Gewirtz, J. C. (2017) · Nature Communications · doi:10.1038/s41467-017-02279-5 · Cited by 167 · see citing works
A demonstration of observational learning in rats using a bidirectional control.
Heyes, C., & Gr, D. (1990) · PubMed · Cited by 166 · see citing works
Cingulate cortex: Its role in Pavlovian conditioning.
Buchanan, S. L., & Powell, D. A. (1982) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077925 · Cited by 164 · see citing works
Topography of projections from the medial prefrontal cortex to the amygdala in the rat
Cassell, M. D., & Wright, D. J. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90237-6 · Cited by 161 · see citing works
Observational learning in chimpanzees and children studied through ‘ghost’ conditions
Hopper, L. M., Lambeth, S. P., Schapiro, S. J., & Whiten, A. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2007.1542 · Cited by 158 · see citing works
Neural mechanisms of social decision-making in the primate amygdala
Chang, S. W. C., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514761112 · Cited by 157 · cited 1× · see citing works
“…non-human primates, and humans, the anterior cingulate cortex (ACC) and the amygdala have been implicated in observational fear learning and social cognition (Adolphs et al., 1994; Chang et al., 2013, 2015; Haroush and Williams, 2015; Jeon et al., 2010; Kim et al., 2012; Olsson et al., 2007).”
Dynamic Analyses of Information Encoding in Neural Ensembles
Barbieri, R., Frank, L. M., Nguyen, D. P., Quirk, M. C., Solo, V., Wilson, M. A., & Brown, E. N. (2004) · Neural Computation · doi:10.1162/089976604322742038 · Cited by 154 · see citing works
Self-citationThe Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning
Bissière, S., Plachta, N., Hoyer, D., McAllister, K. H., Olpe, H.-R., Grace, A. A., & Cryan, J. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.022 · Cited by 151 · see citing works
Maren, S. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00281.x · Cited by 139 · see citing works
Hultman, R. C., Mague, S. D., Li, Q., Katz, B. M., Michel, N., Lin, L., Wang, J., David, L. K., Blount, C., Chandy, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.038 · Cited by 137 · see citing works
Jones, B. F., Groenewegen, H. J., & Witter, M. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.063 · Cited by 135 · see citing works
Fear conditioning by-proxy: Social transmission of fear during memory retrieval
Bruchey, A. K., Jones, C. E., & Monfils, M.-H. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.047 · Cited by 128 · see citing works
Bussey, T. J., Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)81107-2 · Cited by 126 · see citing works
Analysis of Between-Trial and Within-Trial Neural Spiking Dynamics
Czanner, G., Eden, U. T., Wirth, S., Yanike, M., SUZUKI, W. A., & Brown, E. N. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00343.2007 · Cited by 121 · see citing works
Self-citationLateralization of observational fear learning at the cortical but not thalamic level in mice
Kim, S., Mátyás, F., Lee, S., Acsády, L., & Shin, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213903109 · Cited by 101 · see citing works
An intra-amygdala circuit specifically regulates social fear learning
Twining, R. C., Vantrease, J. E., Love, S., Padival, M., & Rosenkranz, J. A. (2017) · Nature Neuroscience · doi:10.1038/nn.4481 · Cited by 93 · cited 3× · see citing works
“…fear learning; the ability to learn about novel stimuli in the environment that are predictive of aversive consequences without directly experiencing them (Bruchey et al., 2010; Guzma´n et al., 2009; Jeon et al., 2010; Kim et al., 2012; Twining et al., 2017; Yusufishaq and Rosenkranz, 2013).”
Empathic Fear Responses in Mice Are Triggered by Recognition of a Shared Experience
Sanders, J., Mayford, M., & Jeste, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074609 · Cited by 90 · cited 1× · see citing works
“Prior experience with punishments from an imperceptible source may equip animals with the added advantage of not only being able to identify predictive cues, but to also avoid the source of the aversive event (Masuda and Aou, 2009; Mineka and Cook, 1993; Sanders et al., 2013).”
Silence resulting from the cessation of movement signals danger
Pereira, A. G., Cruz, A., Lima, S. Q., & Moita, M. A. (2012) · Current Biology · doi:10.1016/j.cub.2012.06.015 · Cited by 88 · see citing works
Fear and affiliation in domesticated male rats.
Taylor, G. T. (1981) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077817 · Cited by 86 · see citing works
Social modeling of conditioned fear in mice by non-fearful conspecifics
Guzmán, Y. F., Tronson, N. C., Guedea, A., Huh, K. H., Gao, C., & Radulovic, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.024 · Cited by 85 · see citing works
Post-weaning social isolation impairs observational fear conditioning
Yusufishaq, S., & Rosenkranz, J. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.050 · Cited by 80 · see citing works
Steenland, H. W., Li, X., & Zhuo, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5566-11.2012 · Cited by 55 · see citing works
Sensitization of fear learning to mild unconditional stimuli in male and female rats.
Poulos, A. M., Zhuravka, I., Long, V., Gannam, C., & Fanselow, M. S. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000033 · Cited by 49 · see citing works
Altruistic behavior in the albino rat
Greene, J. T. (1969) · Psychonomic Science · doi:10.3758/bf03336420 · Cited by 41 · see citing works
Social Transmission of Avoidance Behavior under Situational Change in Learned and Unlearned Rats
Masuda, A., & Aou, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006794 · Cited by 33 · see citing works
Behavioral and Neurophysiological Analyses of Dynamic Learning Processes
SUZUKI, W. A., & Brown, E. N. (2005) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582305280030 · Cited by 32 · see citing works
Self-citationState-Space Algorithms for Estimating Spike Rate Functions
Smith, A. C., Scalon, J. D., Wirth, S., Yanike, M., SUZUKI, W. A., & Brown, E. N. (2009) · Computational Intelligence and Neuroscience · doi:10.1155/2010/426539 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 487 · see citing works
“This interesting observational form of social transmission depends on anterior cingulate input to amygdala (Allsop et al. 2018).”
BackgroundCorrelated neural activity and encoding of behavior across brains of socially interacting animals
Kingsbury, L., Huang, S., Wang, J., Gu, K., Golshani, P., Wu, Y. E., & Hong, W. (2019) · Cell · doi:10.1016/j.cell.2019.05.022 · Cited by 380 · see citing works
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
Smith, M. L., Asada, N., & Malenka, R. C. (2021) · Science · doi:10.1126/science.abe3040 · Cited by 368 · see citing works
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346 · see citing works
“For the purposes of this review, we will focus on rodent PL and IL, although recent work has implicated dACC in observational threat pathways, which may be relevant to PTSD from witnessed trauma [25].”
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
Guo, B., Chen, J., Chen, Q., Ren, K., Feng, D., Mao, H., Yao, H., Yang, J., Liu, H., Liu, Y., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0445-9 · Cited by 287 · see citing works
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273 · see citing works
Self-citationThe neural and computational systems of social learning
Olsson, A., Knapska, E., & Lindström, B. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0276-4 · Cited by 267 · see citing works
Neural Circuit Motifs in Valence Processing
Tye, K. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.001 · Cited by 247 · see citing works
Self-citationPrefrontal–amygdala circuits in social decision-making
Gangopadhyay, P., Chawla, M., Monte, O. D., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00738-9 · Cited by 247 · see citing works
Brain circuits for pain and its treatment
Lindsay, N. M., Chen, C., Gilam, G., Mackey, S., & Scherrer, G. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7360 · Cited by 234 · see citing works
Emotional Mirror Neurons in the Rat’s Anterior Cingulate Cortex
Carrillo, M., Han, Y., Migliorati, F., Liu, M., Gazzola, V., & Keysers, C. (2019) · Current Biology · doi:10.1016/j.cub.2019.03.024 · Cited by 229 · see citing works
Is There a ‘Social’ Brain? Implementations and Algorithms
Lockwood, P. L., Apps, M. A. J., & Chang, S. W. C. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.06.011 · Cited by 202 · see citing works
The mouse prefrontal cortex: Unity in diversity
Le Merre, P., Ährlund-Richter, S., & Carlén, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.035 · Cited by 207 · see citing works
Viewpoints: Approaches to defining and investigating fear
Mobbs, D., Adolphs, R., Fanselow, M. S., Barrett, L. F., LeDoux, J. E., Ressler, K., & Tye, K. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0456-6 · Cited by 202 · see citing works
Self-citationA Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex
Xu, H., Liu, L., Tian, Y., Wang, J., Li, J., Zheng, J., Zhao, H., He, M., Xu, T.-L., Duan, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.026 · Cited by 181 · see citing works
Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response
Jhang, J., Lee, H., Kang, M. S., Lee, H.-S., Park, H., & Han, J. (2018) · Nature Communications · doi:10.1038/s41467-018-05090-y · Cited by 172 · see citing works
Cortical ensembles orchestrate social competition through hypothalamic outputs
Padilla-Coreano, N., Batra, K., Patarino, M., Chen, Z., Rock, R. R., Zhang, R., Hausmann, S. B., Weddington, J., Patel, R. R., Zhang, Y. E., et al. (2022) · Nature · doi:10.1038/s41586-022-04507-5 · Cited by 157 · see citing works
Self-citationNeural control of affiliative touch in prosocial interaction
Wu, Y. E., Dang, J., Kingsbury, L., Zhang, M., Sun, F., Hu, R. K., & Hong, W. (2021) · Nature · doi:10.1038/s41586-021-03962-w · Cited by 153 · see citing works
A Multi-Brain Framework for Social Interaction
Kingsbury, L., & Hong, W. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.008 · Cited by 145 · see citing works
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation
Lee, C. R., Chen, A., & Tye, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.02.028 · Cited by 138 · see citing works
Self-citationSocial circuits and their dysfunction in autism spectrum disorder
Sato, M., Nakai, N., Fujima, S., Choe, K. Y., & Takumi, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02201-0 · Cited by 142 · see citing works
Malézieux, M., Klein, A. S., & Gogolla, N. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-103314 · Cited by 131 · see citing works
Emotional contagion and prosocial behavior in rodents
Keysers, C., Knapska, E., Moita, M. A. P., & Gazzola, V. (2022) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2022.05.005 · Cited by 123 · see citing works
Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization
Bian, X.-L., Qin, C., Cai, C.-Y., Zhou, Y., Tao, Y., Lin, Y., Wu, H., Chang, L., Luo, C., & Zhu, D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2739-18.2019 · Cited by 126 · see citing works
Understanding others: Emotion recognition in humans and other animals
Ferretti, V., & Papaleo, F. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12544 · Cited by 128 · see citing works
Hippocampal-amygdala memory circuits govern experience-dependent observational fear
Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K., & Kitamura, T. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.019 · Cited by 117 · see citing works
Valence coding in amygdala circuits
Pignatelli, M., & Beyeler, A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.010 · Cited by 120 · see citing works
Self-citationNeural Basis of Observational Fear Learning: A Potential Model of Affective Empathy
Keum, S., & Shin, H.-S. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.013 · Cited by 104 · see citing works
A neural manifold view of the brain
Perich, M. G., Narain, D., & Gallego, J. Á. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02031-z · Cited by 104 · see citing works
Specialized medial prefrontal–amygdala coordination in other-regarding decision preference
Monte, O. D., Chu, C.-C. J., Fagan, N. A., & Chang, S. W. C. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0593-y · Cited by 99 · see citing works
Dopamine tunes prefrontal outputs to orchestrate aversive processing
Weele, C. M. V., Siciliano, C. A., & Tye, K. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.044 · Cited by 89 · see citing works
Self-citationEmotional contagion in nonhuman animals: A review
Pérez‐Manrique, A., & Gomila, A. (2021) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1560 · Cited by 90 · see citing works
Harm to Others Acts as a Negative Reinforcer in Rats
Hernandez-Lallement, J., Attah, A. T., Soyman, E., Pinhal, C. M., Gazzola, V., & Keysers, C. (2020) · Current Biology · doi:10.1016/j.cub.2020.01.017 · Cited by 90 · see citing works
Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
Huda, R., Sipe, G. O., Breton‐Provencher, V., Cruz, K. G., Pho, G. N., Adam, E. M., Gunter, L. M., Sullins, A., Wickersham, I. R., & Sur, M. (2020) · Nature Communications · doi:10.1038/s41467-020-19772-z · Cited by 83 · see citing works
Neural mechanisms necessary for empathy-related phenomena across species
Paradiso, E., Gazzola, V., & Keysers, C. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.02.005 · Cited by 78 · see citing works
Expressions of emotions across species
Zych, A. D., & Gogolla, N. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.01.003 · Cited by 77 · see citing works
Amygdala connectivity and implications for social cognition and disorders
Meisner, O. C., Nair, A. R., & Chang, S. W. C. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823493-8.00017-1 · Cited by 79 · see citing works
Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice
Scheggia, D., Greca, F. L., Maltese, F., Chiacchierini, G., Italia, M., Molent, C., Bernardi, F., Coccia, G., Carrano, N., Zianni, E., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01179-2 · Cited by 76 · see citing works
Gao, S.-H., Shen, L., Wen, H., Zhao, Y., Chen, P., & Ruan, H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104862 · Cited by 72 · see citing works
Levels of naturalism in social neuroscience research
Fan, S., Monte, O. D., & Chang, S. W. C. (2021) · iScience · doi:10.1016/j.isci.2021.102702 · Cited by 71 · see citing works
Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
Linking Social Cognition to Learning and Memory
Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69 · see citing works
Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis
Beyeler, A., & Dabrowska, J. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-815134-1.00003-9 · Cited by 65 · see citing works
Self-citationCortical regulation of helping behaviour towards others in pain
Zhang, M., Wu, Y. E., Jiang, M., & Hong, W. (2024) · Nature · doi:10.1038/s41586-023-06973-x · Cited by 69 · see citing works
Basile, B. M., Schafroth, J. L., Karaskiewicz, C. L., Chang, S. W. C., & Murray, E. A. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000677 · Cited by 68 · see citing works
Sakaguchi, T., Iwasaki, S., Okada, M., Okamoto, K., & Ikegaya, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-05894-y · Cited by 63 · see citing works
Conserved features of anterior cingulate networks support observational learning across species
Burgos-Robles, A., Gothard, K. M., Monfils, M., Morozov, A., & Vicentic, A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.009 · Cited by 60 · see citing works
Self-citationDynamic influences on the neural encoding of social valence
Padilla-Coreano, N., Tye, K. M., & Zelikowsky, M. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00609-1 · Cited by 57 · see citing works
Self-citationObservational fear behavior in rodents as a model for empathy
Kim, A., Keum, S., & Shin, H. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12521 · Cited by 60 · see citing works
Bidirectional cingulate-dependent danger information transfer across rats
Han, Y., Bruls, R., Soyman, E., Thomas, R. M., Pentaraki, V., Jelinek, N., Heinemans, M., Bassez, I., Verschooren, S., Pruis, I., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000524 · Cited by 59 · see citing works
Frontal neurons driving competitive behaviour and ecology of social groups
Li, S. W., Zeliger, O., Strahs, L., Báez-Mendoza, R., Johnson, L. M., Wojciechowski, A. M., & Williams, Z. M. (2022) · Nature · doi:10.1038/s41586-021-04000-5 · Cited by 60 · see citing works
Social neuroscience of disgust
Kavaliers, M., Ossenkopp, K., & Choleris, E. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12508 · Cited by 58 · see citing works
Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock
Schneider, K. N., Sciarillo, X. A., Nudelman, J. L., Cheer, J. F., & Roesch, M. R. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.039 · Cited by 55 · see citing works
Monte, O. D., Fan, S., Fagan, N. A., Chu, C.-C. J., Zhou, M. B., Putnam, P. T., Nair, A. R., & Chang, S. W. C. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.013 · Cited by 55 · see citing works
Li, L., Yuan, W., He, Z., Wang, L., Jing, X.-Y., Zhang, J., Yang, Y., Guo, Q., Zhang, X., Cai, W., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.238 · Cited by 55 · see citing works
Biological mechanisms for observational learning
Carcea, I., & Froemke, R. C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.11.008 · Cited by 53 · see citing works
Sakurai, T., & Gamo, N. J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.007 · Cited by 49 · see citing works
Kim, S.-W., Kim, M., Baek, J., Latchoumane, C.-F. V., Gangadharan, G., Yoon, Y., Kim, D., Lee, J. H., & Shin, H. (2022) · Neuron · doi:10.1016/j.neuron.2022.11.001 · Cited by 50 · see citing works
The role of pain modulation pathway and related brain regions in pain
Yao, D., Chen, Y., & Chen, G. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0037 · Cited by 51 · see citing works
Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits
Xu, S., Jiang, M., Liu, X., Sun, Y., Yang, L., Yang, Q., & Bai, Z. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.768294 · Cited by 47 · see citing works
Kuniishi, H., Yamada, D., Wada, K., Yamada, M., & Sekiguchi, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0837-3 · Cited by 47 · see citing works
Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex
Fernández-León, J. A., Engelke, D. S., Aquino-Miranda, G., Goodson, A., Rasheed, M. N., & Monte, F. H. D. (2021) · eLife · doi:10.7554/elife.74950 · Cited by 45 · see citing works
Sexually dimorphic control of affective state processing and empathic behaviors
Fang, S., Luo, Z.-Y., Wei, Z., Qin, Y., Zheng, J., Zhang, H., Jin, J., Li, J., Miao, C., Yang, S., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.02.001 · Cited by 45 · see citing works
Similar levels of emotional contagion in male and female rats
Han, Y., Sichterman, B., Carrillo, M., Gazzola, V., & Keysers, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-59680-2 · Cited by 44 · see citing works
Affective empathy and prosocial behavior in rodents
Kim, S.-W., Kim, M., & Shin, H. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.05.002 · Cited by 44 · see citing works
A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code
Yuan, Z., Qi, Z., Wang, R., Cui, Y., An, S., Wu, G., Feng, Q., Lin, R., Dai, R., Li, A., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.022 · Cited by 45 · see citing works
Andraka, K., Kondrakiewicz, K., Rojek-Sito, K., Ziegart-Sadowska, K., Meyza, K. Z., Nikolaev, T., Hamed, A., Kursa, M. B., Wójcik, M., Danielewski, K., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.047 · Cited by 42 · see citing works
How Early Life Adversity Influences Defensive Circuitry
Murthy, S. S., & Gould, E. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.02.001 · Cited by 42 · see citing works
Brain-wide electrical dynamics encode individual appetitive social behavior
Mague, S. D., Talbot, A., Blount, C., Walder-Christensen, K. K., Duffney, L. J., Adamson, E., Bey, A. L., Ndubuizu, N., Thomas, G. E., Hughes, D. N., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.016 · Cited by 46 · see citing works
Valence processing in the PFC: Reconciling circuit-level and systems-level views
Coley, A. A., Padilla-Coreano, N., Patel, R. R., & Tye, K. M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.12.002 · Cited by 35 · see citing works
Self-citationSerotonin release in the habenula during emotional contagion promotes resilience
Mondoloni, S., Molina, P., Lecca, S., Wu, C.-H., Michel, L., Osypenko, D., Cachin, F., Flanigan, M. E., Congiu, M., Lalive, A. L., et al. (2024) · Science · doi:10.1126/science.adp3897 · Cited by 34 · see citing works
Deconstructing the neural circuit underlying social hierarchy in mice
Xin, Q., Zheng, D., Zhou, T., Xu, J., Ni, Z., & Hu, H. (2024) · Neuron · doi:10.1016/j.neuron.2024.11.007 · Cited by 39 · see citing works
Dopamine and Serotonin Are Both Required for Mate-Copying in Drosophila melanogaster
Monier, M., Nöbel, S., Danchin, É., & Isabel, G. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00334 · Cited by 33 · see citing works
Shared yet dissociable neural codes across eye gaze, valence and expectation
Pryluk, R., Shohat, Y., Morozov, A., Friedman, D., Taub, A. H., & Paz, R. (2020) · Nature · doi:10.1038/s41586-020-2740-8 · Cited by 35 · see citing works
Trask, S., Ferrara, N. C., Jasnow, A. M., & Kwapis, J. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.023 · Cited by 33 · see citing works
Lee, D. K., Li, S. W., Bounni, F., Friedman, G., Jamali, M., Strahs, L., Zeliger, O., Gabrieli, P., Stankovich, M. A., Demaree, J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00888-4 · Cited by 33 · see citing works
Li, M., Yang, X., Yang, J., Li, T., Cui, C., Peng, X., Lei, J., Ren, K., Ming, J., Zhang, P., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.026 · Cited by 33 · see citing works
Ferrara, N. C., Trask, S., & Rosenkranz, J. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.021 · Cited by 32 · see citing works
A prefrontal-thalamic circuit encodes social information for social recognition
Chen, Z., Han, Y., Ma, Z., Wang, X., Xu, S., Tang, Y. Y., Vyssotski, A. L., Si, B., & Zhan, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-45376-y · Cited by 35 · see citing works
A distinct cortical code for socially learned threat
Silverstein, S. E., O’Sullivan, R., Bukalo, O., Pati, D., Schaffer, J. A., Limoges, A., Zsembik, L. C. P., Yoshida, T., O’Malley, J. J., Paletzki, R. F., et al. (2024) · Nature · doi:10.1038/s41586-023-07008-1 · Cited by 34 · see citing works
The human social cognitive network contains multiple regions within the amygdala
Edmonds, D., Salvo, J. J., Anderson, N., Lakshman, M., Yang, Q.-H., Kay, K., Zelano, C., & Braga, R. M. (2024) · Science Advances · doi:10.1126/sciadv.adp0453 · Cited by 30 · see citing works
Neuronal Circuits for Social Decision-Making and Their Clinical Implications
Báez-Mendoza, R., Vázquez, Y., Mastrobattista, E. P., & Williams, Z. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.720294 · Cited by 32 · see citing works
Physiological synchrony predicts observational threat learning in humans
Pärnamets, P., Espinosa, L., & Olsson, A. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2779 · Cited by 33 · see citing works
Top2a promotes the development of social behavior via PRC2 and H3K27me3
Geng, Y., Zhang, T., Alonzo, I. G., Godar, S. C., Yates, C., Pluimer, B. R., Harrison, D. L., Nath, A. K., Yeh, J.-R. J., Drummond, I. A. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm7069 · Cited by 29 · see citing works
The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia
Lubejko, S. T., Graham, R., Livrizzi, G., Schaefer, R., Banghart, M. R., & Creed, M. C. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.1044686 · Cited by 31 · see citing works
Li, X., Shi, W., Chen, Q., Hao, S., Miao, H., Miao, Z., Xu, F., Bi, G., & Zhuo, M. (2023) · Communications Biology · doi:10.1038/s42003-023-05589-1 · Cited by 30 · see citing works
Prefrontal circuits guiding social preference: Implications in autism spectrum disorder
Fortier, A. V., Meisner, O. C., Nair, A. R., & Chang, S. W. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104803 · Cited by 30 · see citing works
Kietzman, H. W., & Gourley, S. L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105075 · Cited by 30 · see citing works
Dorsomedial prefrontal hypoexcitability underlies lost empathy in frontotemporal dementia
Phillips, H. L., Dai, H., Choi, S. Y., Jansen‐West, K. R., Zajicek, A. S., Daly, L., Petrucelli, L., Gao, F., & Yao, W. (2023) · Neuron · doi:10.1016/j.neuron.2022.12.027 · Cited by 29 · see citing works
Prefrontal-amygdala plasticity enabled by observational fear
Ito, W., & Morozov, A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0342-7 · Cited by 28 · see citing works
A dyad shows mutual changes during social buffering of conditioned fear responses in male rats
Kiyokawa, Y., Li, Y., & Takeuchi, Y. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.024 · Cited by 26 · see citing works
Neural mechanisms of comforting: Prosocial touch and stress buffering
Lim, K. Y., & Hong, W. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105391 · Cited by 29 · see citing works
Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats
Liu, L., Zhang, R., Chen, L., Zhao, H., Cai, J., Wang, J., Guo, D., Cui, Y., & Xing, G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.12.009 · Cited by 27 · see citing works
Hakamata, Y., Mizukami, S., Izawa, S., Moriguchi, Y., Hori, H., Kim, Y., Hanakawa, T., Inoue, Y., & Tagaya, H. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.11.008 · Cited by 27 · see citing works
Ability to share emotions of others as a foundation of social learning
Puścian, A., Bryksa, A., Kondrakiewicz, L., Kostecki, M., Winiarski, M. J., & Knapska, E. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.022 · Cited by 26 · see citing works
Covington, H. E., Newman, E. L., Leonard, M. Z., & Miczek, K. A. (2019) · F1000Research · doi:10.12688/f1000research.18883.1 · Cited by 26 · see citing works
Zheng, C., Huang, Y., Bo, B., Lei, W. I., Liang, Z., & Wang, Z. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00427-z · Cited by 25 · see citing works
Observational learning promotes hippocampal remote awake replay toward future reward locations
Mou, X., Pokhrel, A., Suresh, P., & Ji, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.12.005 · Cited by 25 · see citing works
Garwood, I. C., Major, A. J., Antonini, M., Correa, J., Lee, Y., Sahasrabudhe, A., Mahnke, M. K., Miller, E. K., Brown, E. N., & Anikeeva, P. (2023) · Science Advances · doi:10.1126/sciadv.adh0974 · Cited by 24 · see citing works
Self-citationRío, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 25 · see citing works
- Authors
- Allsop, S. A., Wichmann, R., Mills, F., Burgos-Robles, A., Chang, C.-J., Felix-Ortiz, A. C., Vienne, A., Beyeler, A., Izadmehr, E. M., Glober, G., Cum, M. I., Stergiadou, J., Anandalingam, K. K., Farris, K., Namburi, P., Leppla, C. A., Weddington, J. C., Nieh, E. H., Smith, A. C., Ba, D., Brown, E. N., & Tye, K. M.
- Affiliations
- Massachusetts Institute of Technology (US)
- University of Arizona (US)
- Harvard University (US)
- Corresponding author
- Tye, Kay M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 173
- Issue
- 6
- Pages
- 1329-1342.e18
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6345560
- OpenAlex
- W2799513798
- Cited by
- 288
- References
- 64
- Citations by year
- 2026: 26 · 2025: 30 · 2024: 42 · 2023: 37 · 2022: 33 · 2021: 43 · 2020: 28 · 2019: 26 · 2018: 23
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 395 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- JPB Foundation
- PIIF
- PNDRF
- JFDP
- Whitehall Foundation
- Klingenstein Foundation
- NARSAD Young Investigator Award
- Alfred P. Sloan Foundation
- New York Stem Cell Foundation
- McKnight Foundation
- Whitehead Career Development Chair
- NIMH (R01-MH102441-01)
- NIA (RF1-AG047661-01)
- NIH (DP2-DK-102256-01, DP1-AT009925, 1-R01-AG-050548-01, DP1-OD003646, R01-GM104948)
- Jeffrey and Nancy Halis Fellowship
- Henry E. Singleton Fund
- NLM
- Simons Center for the Social Brain
- Netherlands Organization for Scientific Research
- NARSAD
- Brain & Behavior Research Foundation
- National Research Service (5T32GM007484-38)
- Canadian Institutes of Health
- Swiss National Science Foundation
- NSF Graduate Research Fellowships (T32 GM007484)
- Training Program in the Neurobiology of Learning and Memory
- Singleton
- Leventhal
- Whitaker
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- observational learning, fear conditioning, anterior cingulate cortex, basolateral amygdala, social learning, mice
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Cerebral Cortex, Conditioning, Classical, Fear, Learning, Light, Male, Memory, Neural Pathways, Neurons, Prefrontal Cortex, Mice, Electrophysiological Phenomena, Optogenetics, Basolateral Nuclear Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
