The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Open accessAbstract
Significance: A hallmark of aging is chronic sterile inflammation, which is closely associated with frailty and age-related diseases. We found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory cytokines compared with nonsenescent cells. These cells provoked inflammation in adipose tissue and induced macrophage migration. The JAK pathway is activated in adipose tissue with aging, and the SASP can be suppressed by inhibiting the JAK pathway in senescent cells. JAK1/2 inhibitors reduced inflammation and alleviated frailty in aged mice. One possible mechanism contributing to reduced frailty is SASP inhibition. Our study points to the JAK pathway as a potential target for countering age-related dysfunction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Sncs can directly cause insulin resistance through release of SASP factors such as IL-6 and TNF-α (39, 40).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [39]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We showed that aged 3xTg-AD male mice in particular, exhibit elevated plasma levels of known SASP factors [65, 66], including IL-12, IL-10, IL-6, CXCL2, CXCL1, and G-CSF”
From Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients (2024) · cites this paper as [66]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“This concept is supported by a study of aged mice demonstrating that pharmacologic inhibition of the JAK pathway, which regulates the SASP in senescent preadipocytes and endothelial cells in vitro, suppresses markers of both adipose tissue and systemic inflammation and improved parameters of muscle strength, endurance, and coordination (39).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [39]
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, JAK inhibitors alleviated frailty in aged mice99.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [99]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Similarly, other inhibitors of proinflammatory signalling (e.g. JAK/STAT [124] and p38 [60]) and antibodies targeting IL-6 [125], IL-1 [126] and TNFa [127], might be potentially effective senomorphic drugs.”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [124]
In the citing paper
“Alternatively, it is possible to modulate individual components of the SASP by inhibiting Janus kinase (JAK) 1/2148 and JAK2/signal transducer and activator of transcription 3 (STAT3).149”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [148]
In the citing paper
“Similarly, the inhibition of pro-inflammatory JAK signalling in the same model was shown to attenuate pathogenesis by reducing the infiltration of monocytes to the lung130–132.”
From COVID-19 and cellular senescence (2023) · cites this paper as [131]
In the citing paper
“However, senomorphic treatment may require continuous administration and could potentially disrupt tissue homeostasis due to SASP blockade.”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [192]
In the citing paper
“In terms of alleviating age-related phenotypes, minimizing the SASP using Janus kinase/signal transducer and activator of transcription (JAK/STAT) inhibition is very similar to eliminating or reducing the burden of senescent cells genetically (e.g., using INK-ATTAC mice) or pharmacologically with senolytic agents [4, 11, 13, 60].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 4×
“(iii) p16positive senescent cells were the main cause of increased IL-6 expression in the stromal vascular fraction of adipose tissue digests from older progeroid mice (21).”
BackgroundMethodInfluentialSelf-citationPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · cited 1×
“IL-6, a major SASP component, signals through the JAK/ STAT pathway (61) and has been shown to be critical in stabilizing cellular senescence (62).”
Background
Cited by
Sorted by citations
Items 701–800 of 921
Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker
Ni, M., Peng, W., Wang, X., & Li, J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s504040 · Cited by 2
“16 Taken together, these findings suggest the possibility of targeting this pathway as a therapeutic option for age-related UC.”
Senescence and oral cancer: From mechanisms to therapeutic opportunities
Yang, Z. R., Guo, L., & Wang, B. (2025) · Translational dental research. · doi:10.1016/j.tdr.2025.100034 · Cited by 3
Wong, J., Qudrat, A., Mosabbir, A. A., & Truong, K. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_5 · Cited by 2
Boulet, N., Briot, A., Jargaud, V., Estève, D., Rémaury, A., Belles, C., Viana, P., Fontaine, J., Murphy, L., Déon, C., et al. (2023) · Aging Cell · doi:10.1111/acel.13776 · Cited by 1
Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseases
Buffard, T., & Ferbeyre, G. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_4 · Cited by 2
Senomorphic, senolytic, and rejuvenation therapies
Zhu, X. Y., & Lerman, L. O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00025-1 · Cited by 2
Zhang, H., Yeware, A. M., Lee, S., & Zhan, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.753465 · Cited by 4
Khosla, S., Monroe, D. G., & Farr, J. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00011-0 · Cited by 2
Proteome network analysis of skeletal muscle in lignan-enriched nutmeg extract-fed aged mice
Lee, J., Kang, H., Ban, G.-T., Kim, B. K., Lee, J., Hwang, H., Yoo, H.-S., Cho, K., & Choi, J. (2023) · Journal of Analytical Science & Technology · doi:10.1186/s40543-023-00377-2 · Cited by 2
“2016), and aged mice fed ruxolitinib (INCB18424) for 10 weeks increases hanging duration and grip strength (Xu et al. 2015).”
BackgroundObesity and Aging. General Aspects
Dyleva, Y. A., Belik, E. V., & Gruzdeva, O. V. (2023) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813923030020 · Cited by 2
Čepelak, I., & Dodig, S. (2019) · Rad Hrvatske akademije znanosti i umjetnosti Medicinske znanosti · doi:10.21857/moxpjhglzm · Cited by 2
Age-related modifications of macrophages influenced by “inflammageing” in graft vs. host disease
Hong, Y., Wan, B., & Li, X. (2020) · Biocell · doi:10.32604/biocell.2020.08887 · Cited by 2
“Notably, increased infiltration of macrophages in inflammageing state regulate many disease development (MaesoDíaz et al., 2019; Noble et al., 2019; Xu et al., 2015).”
BackgroundModifications du tissu adipeux au cours du vieillissement
Tropis, C., Catenacci, M., Valet, P., & Dray, C. (2021) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2021.01.010 · Cited by 2
Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells
Chen, Y.-L., & Rudolph, K. L. (2020) · Haematologica · doi:10.3324/haematol.2020.271205 · Cited by 3
Impaired JAK-STAT Pathway Signaling in Leukocytes of Frail ElderlyPreprint
Samson, L. D., Engelfriet, P. M., Verschuren, W. M. M., Picavet, H. S. J., Ferreira, J. A., de Zeeuw‐Brouwer, M., Buisman, A., & Boots, A. M. H. (2021) · Research Square · doi:10.21203/rs.3.rs-970801/v1 · Cited by 2
Nadeem, J., Parveen, A., & Kim, S. Y. (2023) · Preprints.org · doi:10.20944/preprints202309.1932.v1 · Cited by 1
Age effect on mesenchymal stem cell properties: a concise review
Chen, C., Bin, X., Huang, Y., Ng, T. K., & Cheung, H. S. (2022) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2022.12.101 · Cited by 1
Protein kinase modulation for anti-aging intervention
Muñoz, M. F., Argüelles, S., Ayala, A., & Marotta, F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00011-4 · Cited by 1
Obesity and Aging: General Aspects
Dyleva, Y. A., Belik, E. V., & Gruzdeva, O. V. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093023020102 · Cited by 1
Redox state of aging skin: A double-edged sword in wound healing
Chen, Q., Sophabmixay, A., Albertson, T., Ghasb, G., Terzian, A., Yan, L., Young, L. H., & Barsotti, R. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.008 · Cited by 1
New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target
Légaré, C., Berglund, J. A., Duchesne, É., & Dumont, N. A. (2024) · BioEssays · doi:10.1002/bies.202400216 · Cited by 1
“JAK inhibitors reduced the expression of SASP (e.g., IL-6, IL-8, and CXCL1) in senescent human primary preadipocytes and HUVEC [68].”
CNPY2 modulates senescence-associated secretory phenotype in tendon stem/progenitor cells
Xu, G., & Wang, Y. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102706 · Cited by 1
Yang, L., Wang, Y., & Zuo, Y. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-024-03760-0 · Cited by 1
“JAK inhibitors have shown effective - ness in treating BP patients and improving frailty in aged mice [12–14].”
The Role of Sirtuins in Cellular Senescence and the Development of Age-Associated Diseases
Markelov, V. A., Akhmadishina, L. Z., Кочетова, О. В., Эрдман, В. В., & Korytina, G. F. (2025) · Russian Journal of Genetics · doi:10.1134/s1022795425700152 · Cited by 1
“A specific SASP expression profile provides mechanisms for proinflammatory transformation of healthy adipose tissue under the influence of the conditioned medium of senescent cells [84].”
Bhandari, R., Liao, Y., & Ma, K. (2025) · Cancer · doi:10.1002/cncr.35977 · Cited by 2
“68,70 Gamma irradiation and genotoxic insults induce cellular senescence, 71,72 and thus radiation or chemotherapy may result in premature senescence in skeletal muscle and adipose tissue with an associated SASP, which leads to an accelerated aging - like presentation in CCSs.”
Schroll, M., Amar, Y., Krüger, P., Neuhaus, K., & Djabali, K. (2025) · Aging Cell · doi:10.1111/acel.70273 · Cited by 1
“Interestingly, JAK–STAT inhibition reduced systemic inflammation and improved physical function in aged mice (Xu et al. 2015).”
Gao, X., Ruzbarsky, J. J., Huard, M., Sajedi, S., Shyu, P. T., Xiao, Z., Force, B. S., White, S., Ayers, J. D., Wang, B., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108016 · Cited by 1
Mechanisms of aging in the cardiovascular system: challenges and opportunities
Zhao, X., Yang, X., Lin, Y., Lei, R., Ding, W., He, X.-Y., Cao, Y. J., Zhang, D., Liu, P., Liang, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1635736 · Cited by 4
Adipocytes as core drivers of skin aging and novel targets for regeneration
Wang, E., Xu, Z., Wang, Y., Wang, J., Jiang, Y., & Zhao, C. (2026) · Biogerontology · doi:10.1007/s10522-026-10413-4 · Cited by 2
“…cells and their SASP, elevated pro-inflammatory cytokine/chemokine expression, and engagement of stress-and inflammation-respon-sive signaling pathways such as NF-κB and JNK (e.g., JNK/p53-linked regulation of SASP in aged adipose tissue) (Wu et al. 2007; Xu et al. 2015a, b; Yang et al. 2018).”
InfluentialJAK1/STAT3 signalling in cortical bone development, growth and maintenance
Koh, N. Y. Y., Maes, C., & Sims, N. A. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120129 · Cited by 1
Zhu, M., Mu, H., Wang, B., Han, M., Ma, Z., Nie, X., Wang, T., Zhang, L., & Liang, F. (2026) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2026.100367 · Cited by 1
“However, it remains unclear whether JAK inhibitors exert direct antioxidant effects or indirectly mitigate oxidative damage by quenching upstream inflammatory signals [11].”
Zhou, R., Lin, X., Lin, J., Liao, Z., Ni, H., Lin, X., He, Q., & Ning, W. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103110 · Cited by 1
Gong, T., Jiang, W., Han, Y., Liu, Y., Zhuo, W., Li, S., Hu, Z., Zeng, Z., Yue, R., & Yang, M. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1779773 · Cited by 1
Santaniello, U., Rosset, F., Mastorino, L., Crespi, O., Quaglino, P., & Ribero, S. (2026) · Dermato · doi:10.3390/dermato6020018 · Cited by 1
Manni, E., Al‐kuraishy, H. M., Fawzy, M. N., & Batiha, G. E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05416-4 · Cited by 1
Schulz, N., van Wijnen, P., Wilhelmi, T., Müller‐Ladner, U., Lange, U., & Klemm, P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1835307 · Cited by 1
Cell senescence in chronic pain: An integrative perspective on cellular and neural mechanisms
Ma, L., Wang, Y., Wang, J., Li, Y., Hu, X., Zou, X., Zhang, D., Zhu, T., & Zhou, C. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106789 · Cited by 3
Small-Molecule Strategies for Polymyalgia Rheumatica and Giant Cell Arteritis in Older Adults
Kurdybacha, J., Kravets, O., Lekston, N., Kotyla, K., Gumkowska-Sroka, O., & Kotyla, P. (2026) · Molecules · doi:10.3390/molecules31132218
“Conventional non-selective immunosuppression, primarily based on long-term GC therapy, is associated with an increased risk of infectious and metabolic complications [6,7].”
Bhavya, R., & Sandur, R. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2695165 · Cited by 1
“Additionally, JAK inhibitors function as senomorphics by suppressing the JAK/ STAT pathway, reducing the production of inflammatory mediators and supporting tissue and immune homeostasis without eliminating senescent cells (Campisi, 2013; Xu et al., 2015).”
Cellular senescence and aging: molecular mechanisms and convergent pathways
Piritore, F. C., Braggio, M., Minoia, A., Bolognin, S., Cominacini, M., Trabetti, E., Bombieri, C., Romanelli, M. G., Carbonare, L. D., & Valenti, M. T. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06317-8 · Cited by 1
“Some prominent examples are JAK inhibitors, metformin, and rapamycin analogs, which are currently being actively studied for their potential in modulating SASP across both preclinical and clinical research environments [252, 272–274] .”
TRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence
Kandhaya‐Pillai, R., Kim, H. Y., Belhadj, J., Sidorova, J. M., Tchkonia, T., Kirkland, J. L., & Oshima, J. (2026) · iScience · doi:10.1016/j.isci.2026.116770 · Cited by 1
Self-citationYao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1
Cellular senescence and inflammageing: from mechanisms to senotherapeutic interventions
Chmielewski, P. P. (2026) · Biogerontology · doi:10.1007/s10522-026-10477-2 · Cited by 2
“JAK inhibitors, including ruxolitinib and barici-tinib, attenuate signalling downstream of SASP-asso-ciated cytokines and reduce inflammatory activity without directly removing senescent cells (Xu et al. 2015).”
Xu, Z., Guo, J., Liu, Z., Yu, J., Yuan, R., Min, Y., Wei, Z., & Peng, X. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103270 · Cited by 1
Progenitor Cells from the Adult Heart
Ellison, G. M., & Lewis, F. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-56106-6_2 · Cited by 1
The Links Between Osteoporosis and Sarcopenia in Women
Blümel, J. E., Arteaga, E., Vallejo, M. S., & Chea, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-13936-0_26 · Cited by 1
Potential Applications of Aptamers for Targeting Senescent Cells
Leonardi, A., Pacifico, F., & Crescenzi, E. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_10 · Cited by 1
Immunesenescence and Compromised Removal of Senescent Cells: Implications for Health in Old Age
Hazeldine, J., & Lord, J. M. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-87532-9_3 · Cited by 1
Cell senescence is a cause of frailty
Wan, T., Miwa, S., & von Zglinicki, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00013-4 · Cited by 1
Thompson, P. J., & Bhushan, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00008-0 · Cited by 1
A geroscience approach for osteosarcopenia: Autophagy and senescence as therapeutic targets
Cordero, N. P., Schoenlein, P. V., Fulzele, S., & Hill, W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820088-9.00031-7 · Cited by 1
Palmer, A. K., & Kirkland, J. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00012-8 · Cited by 1
Self-citationSuppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?
Roato, I., Visca, M., & Mussano, F. D. (2024) · Biomedicines · doi:10.3390/biomedicines12122811 · Cited by 1
Guo, S., Zhang, Y., Wang, Y., Guo, T., Zhu, J., Chang, L., Ling, W., Westover, K. D., Zhou, Z., & Wei, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159277 · Cited by 1
Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis
Sharma‐Oates, A., Dunne, N., Raza, K., Padyukov, L., Rivera, N., Mil, A. H. M. V. D. H., Pratt, A. G., Duggal, N. A., Jones, S. W., & Lord, J. M. (2025) · GeroScience · doi:10.1007/s11357-025-01508-w · Cited by 1
“…information as targeting the process could also deliver benefits in those with established disease, for example by suppressing the proinflammatory actions of senescent immune cells [14] with senomorphic drugs, or by reducing epigenetic age to reduce risk of other age-related diseases [15].”
Senescence and the Microenvironment
Rai, M. K., Yadav, P., Katailiha, A. S., Singh, A. K., & Yadav, S. K. (2025) · Springer eBooks · doi:10.1007/978-981-96-1041-9_3 · Cited by 1
Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities
Wong, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.884910 · Cited by 1
“…senescence-associate secretory phenotype (SASP) to delay age-related changes, improve tissue functions and subsequently increase health and life span were introduced and proven by many studies (Xu et al., 2015; Zhu et al., 2015, 2017; Chang et al., 2016; Fuhrmann-Stroissnigg et al., 2017).”
BackgroundLinked regulation of genome integrity and senescence-associated inflammation by p53Preprint
Miller, K. N., Li, B., Pierce-Hoffman, H. R., Patel, S., Lei, X., Rajesh, A., Teneche, M. G., Havas, A. P., Gandhi, A., Macip, C. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.20.567963 · Cited by 1
Koleva, L., & Harizanova, A. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-319-96397-6_31
Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease
Ridzuan, N., Widera, D., & Yahaya, B. H. (2019) · Stem cells in clinical applications · doi:10.1007/978-3-030-23421-8_8
Senescence-Associated Beta-Galactosidase Marker of Cellular Senescence
Dimri, M., & Dimri, G. P. (2019) · Reference Module in Biomedical Sciences · doi:10.1016/b978-0-12-801238-3.11446-1
Discovery of Senolytics and the Pathway to Early Phase Clinical Trials
Gerdes, E. O. W., Zhu, Y. Z., Tchkonia, T., & Kirkland, J. L. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_2
Self-citationMorris, B. J., Willcox, B. J., & Donlon, T. A. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_429-1
Engineering Ca2+-activated Control of Ras Family GTPases
Wong, J. (2019) · TSpace (University of Toronto)
Senotherapeutics: Experimental therapy of cellular senescence
Justice, J. N., Niedernhofer, L. J., & Orr, M. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00012-3
Cao, J., Li, J., Yang, X. L., Li, P., Yao, Z., Han, D., Ying, L., Wang, L., & Tian, J. (2020) · doi:10.21203/rs.3.rs-41767/v1
Subtelomere-Telomere Aging Theory
Libertini, G., Corbi, G., Conti, V., Shubernetskaya, O. S., & Ferrara, N. (2021) · Advances in studies of aging and health · doi:10.1007/978-3-030-73774-0_5
Characterization Of Age-Related Immune Features After Autologous NK Cell InfusionPreprint
Tang, X., Deng, B., Zang, A., He, X., Zhou, Y., Wang, D., Li, D., Zhang, X., Liu, Y., Yong-hua, X., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-511601/v1
Zhang, H., Castiglione, M. A., Zheng, L., & Zhan, H. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00241-2
Morris, B. J., Willcox, B. J., & Donlon, T. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_429
Kane, A. E., Bisset, E. S., & Howlett, S. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_356
Koleva, L., & Harizanova, A. (2018) · Reference series in phytochemistry · doi:10.1007/978-3-319-76887-8_31-1
Wang, Y., Che, L., Chen, X., He, Z., Song, D., Yuan, Y., & Liu, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1444778/v1
Faculty Opinions recommendation of Fisetin is a senotherapeutic that extends health and lifespan.
Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734139615.793563345
Takayanagi, H., & Terashima, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.729069932.793546383
Accelerated Lung Aging and Cellular Senescence in COPD
Barnes, P. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00058-5
Mason, R. S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733607913.793560955
She, J., & Wang, C.-Y. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733607913.793549270
Clinical translation of interventions that target ageing: towards a longevity dividend
Palmer, A. K., & Kirkland, J. L. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198701590.003.0168
Self-citationKane, A. E., Bisset, E. S., & Howlett, S. E. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_356-1
Clearance of senescent cells: potent anti-aging approach
Ferreira, J., & Deamer, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00002-1
Quiescencia y senescencia: enfoque traslacional al paciente oncológico y críticamente enfermo.
Moscoso, S. X. A., Montalvo-Villagómez, M., González, F. E. J., Páez, P. A. V., Montero, C. G. V., & Vélez-Páez, J. L. (2019) · Revista Ecuatoriana de Ciencia Tecnología e Innovación en Salud Pública · doi:10.31790/inspilip.v4i1.154
HD-PTP/PTPN23 hypomorphic mice display lipodystrophyPreprint
Davies, B. A., Payne, J. A., Martin, C. P., Schultz, D. F., Childs, B. G., Zhang, C., Jeganathan, K. B., Sturmlechner, I., White, T. A., de Bruin, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.02.502401
“Food intake, activity and metabolic rate were measured using a Comprehensive Lab Animal Monitoring System (CLAMS) as described in [90].”
MethodSelf-citationAn Overview of the Role of Senescence in Cancer
Al-Janabi, I. I. (2022) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v3i.77
Preclinical evaluation of senescence-based strategies to improve cancer therapy
Estepa‐Fernández, A. (2022) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/188845
Cellular senescence as a pathogenic factor and potential therapeutic target in osteoporosis
Larrea, L. P., Rodríguez, M. D. B., Naves‐Díaz, M., & Alonso, C. G. (2023) · Revista de Osteoporosis y Metabolismo Mineral · doi:10.20960/revosteoporosmetabminer.00013 · Cited by 1
Stem cell aging: role of signaling pathways and microRNAs
Muthusami, S., Mohan, M., Krishnamoorthy, S., Palaniyandi, K., Kumaran, R., Dharmarajan, A., Ramachandran, I., & Bhaskaran, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18800-8.00026-5
Farr, J. N., & Chandra, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00017-7
Cellular Senescence and Lung Diseases: From COPD to Fibrosis
Yadav, V., Bharadwaj, P., & Maruthi, M. (2025) · Springer eBooks · doi:10.1007/978-981-96-1041-9_11
Cellular Senescence and Cancer
Moar, K., Kakde, G. S., & Maurya, P. K. (2025) · Springer eBooks · doi:10.1007/978-981-96-1041-9_10
Libertini, G., Corbi, G., Shubernetskaya, O. S., Komici, K., & Ferrara, N. (2024) · Advances in studies of aging and health · doi:10.1007/978-3-031-84877-3_8
Iwasaki, K., Carapeto, P., Abarca, C., Hela, F., Sanjines, S., Pena, S., Le, S. M., Pan, H., Cahill, C., Midha, A. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.07.648438
“The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is one of the known regulators of cytokine production [8, 9], and its inhibition has been shown to downregulate SASP secretion in adipose tissue [10].”
Self-citationGrimaldi, F., Memoli, M., Avilia, S., Russo, R., Scalia, G., Visconti, R., Errichiello, S., Izzo, B., & Pane, F. (2025) · Annals of Hematology · doi:10.1007/s00277-025-06404-z
“JAK2 -driven hemopoiesis re-expanded once the patient achieved CR, showing the ability of JAK2 -mutated HSC to survive under stress conditions as ones given by chemother - apy, and as highlighted in several MPN disease models [ 45, 46 ].”
Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction
Jean-Baptiste, Q. (2024) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/2f5r-h13w
Bilder, G. E., & Brown-O’Hara, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-84831-5_10
Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines
Naigeon, M., Bitoun, S., Dugage, M. R., de Oliveira, C., Berthot, C., Besse, B., Marabelle, A., Danlos, F. X., Xavier Mariette, A., Chaput, N., et al. (2025) · Clinical & Experimental Immunology · doi:10.1093/cei/uxaf050
Sharma, R. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152881
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Figshare · doi:10.6084/m9.figshare.26085212
Lin, H., Chen, X., Pan, J., Ke, J., Zhang, A., Liu, Y., Wang, C., Chang, A. C. Y., & Gu, J. (2022) · Figshare · doi:10.6084/m9.figshare.20115869
Metadata
- Authors
- Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., Giorgadze, N., Jensen, M. D., LeBrasseur, N. K., & Kirkland, J. L.
- Affiliations
- Mayo Clinic (US)
- Robert and Arlene Kogod Center on Aging,Mayo Clinic, Rochester, MN 55905;
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-11-02
- Volume
- 112
- Issue
- 46
- Pages
- E6301-10
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4655580
- OpenAlex
- W1932046626
- Cited by
- 915
- References
- 68
- Citations by year
- 2026: 104 · 2025: 110 · 2024: 112 · 2023: 98 · 2022: 110 · 2021: 115 · 2020: 72 · 2019: 70 · 2018: 59 · 2017: 30 · 2016: 33 · 2015: 1
- FWCI
- 30.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- HHS | NIH | National Institute on Aging (AG041122, AG013925)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- JAK inhibition, cellular senescence, senescence-associated secretory phenotype, frailty, aging, age-related inflammation, adipose tissue, preadipocytes, macrophage migration, conditioned medium, endothelial cells, physical function, JAK inhibitors
- MeSH terms
- Adipose Tissue, Animals, Cell Movement, Extracellular Matrix, Humans, Macrophages, Signal Transduction, Cellular Senescence, Adipocytes, RNA, Small Interfering, Mice, Janus Kinases, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
