The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core
Open accessAbstract
Significance: Treatment for many neurological diseases is hindered by the inability of therapeutic agents to cross the blood–brain barrier (BBB). Here, we show a method for increasing the ability of high-avidity, transferrin (Tf)-containing nanoparticles to enter the brain through transcytosis. Tf was attached to nanoparticles through an acid-cleavable linkage that facilities release of nanoparticles from Tf that are bound to Tf receptors (TfR) during transcytosis, promoting entry of the nanoparticles into the brain. This method is an improvement over previous high-affinity, TfR-targeted therapeutics that were restricted by BBB endothelium and mostly excluded from entering the brain. Increased brain accumulation of nanoparticles via this methodology should allow for greater delivery of encapsulated therapeutic agents at lower systemic doses.
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Cites
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The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 854
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
Nanomaterial-based blood-brain-barrier (BBB) crossing strategies
Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119491 · Cited by 604
Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain
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Metadata
- Authors
- Clark, A. J., & Davis, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-09-21
- Volume
- 112
- Issue
- 40
- Pages
- 12486-12491
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1896246110
- Cited by
- 280
- References
- 24
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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