Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works

Cloned Glutamate Receptors

Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works

Structural basis of long-term potentiation in single dendritic spines

Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works

Rett syndrome: Revised diagnostic criteria and nomenclature

Neul, J. L., Kaufmann, W. E., Glaze, D. G., Christodoulou, J., Clarke, A. J., Bahi‐Buisson, N., Leonard, H., Bailey, M. E. S., Schanen, N. C., Zappella, M., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22124 · Cited by 1,398 · see citing works

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275 · see citing works

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome

Guy, J., Gan, J., Selfridge, J., Cobb, S., & Bird, A. (2007) · Science · doi:10.1126/science.1138389 · Cited by 1,230 · see citing works

Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.

Lu, W.-Y., Man, H.-Y., Ju, W., Trimble, W., Macdonald, J., & Wang, Y.-T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00194-5 · Cited by 978 · see citing works

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works

AMPARs and Synaptic Plasticity: The Last 25 Years

Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850 · see citing works

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

Nusser, Z., Lujan, R., Laube, G., Roberts, J. D. B., Molnar, E., & Somogyi, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80565-6 · Cited by 804 · see citing works

The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745 · see citing works

Recycling Endosomes Supply AMPA Receptors for LTP

Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730 · see citing works

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660 · see citing works

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome

Dani, V. S., Chang, Q., Maffei, A., Turrigiano, G. G., Jaenisch, R., & Nelson, S. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506071102 · Cited by 639 · see citing works

Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome

Moretti, P., Levenson, J. M., Battaglia, F., Atkinson, R., Teague, R., Antalffy, B., Armstrong, D., Arancio, O., Sweatt, J. D., & Zoghbi, H. Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-05.2006 · Cited by 545 · see citing works

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505 · see citing works

Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation

Kopec, C. D., Li, B., Wei, W., Boehm, J., & Malinow, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-05.2006 · Cited by 486 · see citing works

Applicability of the coefficient of variation method for analyzing synaptic plasticity

Faber, D. S., & Korn, H. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82162-2 · Cited by 369 · see citing works

Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

Asaka, Y., Jugloff, D. G. M., Zhang, L., Eubanks, J. H., & Fitzsimonds, R. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.005 · Cited by 341 · see citing works

Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins

Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288 · see citing works

Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent

Otmakhov, N., Khibnik, L. A., Otmakhova, N. A., Carpenter, S. M., Riahi, S., Asrican, B., & Lisman, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00941.2003 · Cited by 254 · see citing works

Spine Expansion and Stabilization Associated with Long-Term Potentiation

Yang, Y., Wang, X.-B., Frerking, M., & Zhou, Q. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3998-07.2008 · Cited by 222 · see citing works

Early Environmental Enrichment Moderates the Behavioral and Synaptic Phenotype of MeCP2 Null Mice

Lonetti, G., Angelucci, A., Morando, L., Boggio, E. M., Giustetto, M., & Pizzorusso, T. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.022 · Cited by 201 · see citing works

Posttranslational regulation of AMPA receptor trafficking and function

Lü, W., & Roche, K. W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.008 · Cited by 197 · see citing works

Exogenous Brain-Derived Neurotrophic Factor Rescues Synaptic Dysfunction inMecp2-Null Mice

Kline, D. D., Ogier, M., Kunze, D. L., & Katz, D. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5503-09.2010 · Cited by 177 · see citing works

NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

Durand, S., Patrizi, A., Quast, K. B., Hachigian, L., Pavlyuk, R., Saxena, A., Carninci, P., Hensch, T. K., & Fagiolini, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.004 · Cited by 172 · see citing works

Correction of respiratory disorders in a mouse model of Rett syndrome

Abdala, A. P., Dutschmann, M., Bissonnette, J. M., & Paton, J. F. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012104107 · Cited by 170 · see citing works

Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons

Koike‐Tani, M., Iino, M., & Ozawa, S. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00067-9 · Cited by 165 · see citing works

The MeCP2‐null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability

Zhang, L., He, J., Jugloff, D. G. M., & Eubanks, J. H. (2007) · Hippocampus · doi:10.1002/hipo.20389 · Cited by 153 · see citing works

Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 145 · see citing works

Rett Syndrome: Exploring the Autism Link

Percy, A. K. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.149 · Cited by 144 · see citing works

Plasticity of the Synaptic Modification Range

Rioult-Pedotti, M.-S., Donoghue, J. P., & Dunaevsky, A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00164.2007 · Cited by 137 · see citing works

The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling

Qiu, Z., Sylwestrak, E., Lieberman, D. N., Zhang, Y., Liu, X., & Ghosh, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0175-11.2012 · Cited by 132 · see citing works

Altered Development of Glutamate and GABA Receptors in the Basal Ganglia of Girls with Rett Syndrome

Blue, M. E., Naidu, S., & Johnston, M. V. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7030 · Cited by 126 · see citing works

Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 ofMecp2knockout mice

Calfa, G. D., Li, W., Rutherford, J. M., & Pozzo‐Miller, L. D. (2014) · Hippocampus · doi:10.1002/hipo.22360 · Cited by 124 · see citing works

Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome

Dani, V. S., & Nelson, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-09.2009 · Cited by 121 · see citing works

The role of SAP97 in synaptic glutamate receptor dynamics

Howard, M. A., Elias, G. M., Elias, L. A. B., Swat, W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914422107 · Cited by 119 · see citing works

Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging

Calfa, G. D., Hablitz, J. J., & Pozzo‐Miller, L. D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00800.2010 · Cited by 106 · see citing works

Noncompliance With Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals: An Exploratory Analysis

Gomez, L. M., Conlee, K. M., & Stephens, M. L. (2010) · Journal of Applied Animal Welfare Science · doi:10.1080/10888700903579838 · Cited by 90 · see citing works

Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal

Weng, S.-M., McLeod, F., Bailey, M. E. S., & Cobb, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.061 · Cited by 88 · see citing works

Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model

Swanger, S. A., Yao, X., Groß, C., & Bassell, G. J. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-38 · Cited by 81 · see citing works

Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met

Shepherd, G. M., & Katz, D. M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.006 · Cited by 75 · see citing works

The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

Janc, O. A., & Müller, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00056 · Cited by 65 · see citing works

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

Xu, X., Kozikowski, A. P., & Pozzo‐Miller, L. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00068 · Cited by 62 · see citing works

Dopamine Enhances Spatiotemporal Spread of Activity in Rat Prefrontal Cortex

Bandyopadhyay, S., Gonzalez-Islas, C. E., & Hablitz, J. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00922.2004 · Cited by 61 · see citing works

Deficiency of GABAergic synaptic inhibition in the Kölliker–Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome

Abdala, A. P., Toward, M. A., Dutschmann, M., Bissonnette, J. M., & Paton, J. F. R. (2015) · The Journal of Physiology · doi:10.1113/jp270966 · Cited by 55 · see citing works

Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex ofMecp2Null Mice

Sceniak, M. P., Lang, M., Enomoto, A. C., Howell, C., Hermes, D. J., & Katz, D. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv002 · Cited by 53 · see citing works

Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome

McLeod, F., Ganley, R. P., Williams, L., Selfridge, J., Bird, A. P., & Cobb, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.058 · Cited by 52 · see citing works

Kindling of hippocampal field CA1 impairs spatial learning and retention in the Morris water maze

Gilbert, T. H., McNamara, R. K., & Corcoran, M. E. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)81108-4 · Cited by 51 · see citing works

Persistent Pain Maintains Morphine-Seeking Behavior after Morphine Withdrawal through Reduced MeCP2 Repression of Glua1 in Rat Central Amygdala

Hou, Y.-Y., Cai, Y.-Q., & Pan, Z. Z. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3453-14.2015 · Cited by 51 · see citing works

Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells

Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A. E., Nevarko, T., Sonenberg, N., & Lacaille, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3264-12.2013 · Cited by 49 · see citing works

Hippocampal CA1 Pyramidal Neurons of<i>Mecp2</i>Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

Chapleau, C. A., Boggio, E. M., Calfa, G., Percy, A. K., Giustetto, M., & Pozzo-Miller, L. (2012) · Neural Plasticity · doi:10.1155/2012/976164 · Cited by 48 · see citing works

Isoflurane Impairs Learning and Hippocampal Long-term Potentiation via the Saturation of Synaptic Plasticity

Uchimoto, K., Miyazaki, T., Kamiya, Y., Mihara, T., Koyama, Y., Taguri, M., Inagawa, G., Takahashi, T., & Goto, T. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000269 · Cited by 44 · see citing works

Heterogeneous spatial patterns of long‐term potentiation in rat hippocampal slices

Chang, P. Y., & Jackson, M. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112128 · Cited by 37 · see citing works

Beyond widespread Mecp2 deletions to model Rett syndrome: conditional spatio-temporal knockout, single-point mutations and transgenic rescue mice

Li, W. (2012) · Autism- Open Access · doi:10.4172/2165-7890.s1-005 · Cited by 35 · see citing works

Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission

Nelson, E. D., Bal, M., Kavalali, E. T., & Monteggia, L. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00751.2010 · Cited by 32 · see citing works

Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

Gambino, F., Khelfaoui, M., Poulain, B., Bienvenu, T., Chelly, J., & Humeau, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011399 · Cited by 30 · see citing works

Sequential Delivery of Synaptic GluA1- and GluA4-containing AMPA Receptors (AMPARs) by SAP97 Anchored Protein Complexes in Classical Conditioning

Zheng, Z., & Keifer, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.535179 · Cited by 19 · see citing works

Human autoantibodies against early endosome antigen-1 enhance excitatory synaptic transmission

Selak, S., Paternain, A. V., Fritzler, M. J., & Lerma, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.014 · Cited by 18 · see citing works

Untitled work

(1999) · doi:10.1002/1531-8249(199904)45:4

Autism spectrum disorder: neuropathology and animal models

Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works

Synaptopathology Involved in Autism Spectrum Disorder

Guang, S., Pang, N., Deng, X., Yang, L., He, F. P., Wu, L., Chen, C., Yin, F., & Peng, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00470 · Cited by 283 · see citing works

The Neurochemistry of Autism

Marotta, R., Risoleo, M. C., Messina, G., Parisi, L., Carotenuto, M., Vetri, L., & Roccella, M. (2020) · Brain Sciences · doi:10.3390/brainsci10030163 · Cited by 279 · see citing works

Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

Phillips, M. L., Robinson, H. A., & Pozzo-Miller, L. (2019) · eLife · doi:10.7554/elife.44182 · Cited by 205 · see citing works

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

Pagani, M., Barsotti, N., Bertero, A., Trakoshis, S., Ulysse, L., Locarno, A., Misevičiūtė, I., Felice, A. D., Canella, C., Supekar, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26131-z · Cited by 148 · see citing works

Glutamatergic synapses in neurodevelopmental disorders

Moretto, E., Murru, L., Martano, G., Sassone, J., & Passafaro, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.014 · Cited by 136 · see citing works

Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder

Banerjee, A., Miller, M. T., Li, K., Sur, M., & Kaufmann, W. E. (2018) · Brain · doi:10.1093/brain/awy323 · Cited by 109 · see citing works

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Hösli, L., Binini, N., Ferrari, K. D., Thieren, L., Looser, Z. J., Zuend, M., Zanker, H. S., Berry, S., Holub, M., Möbius, W., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110484 · Cited by 100 · see citing works

Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders

Kılınç, M., Creson, T. K., Rojas, C., Aceti, M., Ellegood, J., Vaissière, T., Lerch, J. P., & Rumbaugh, G. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.03.008 · Cited by 81 · see citing works

l -Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B -related pediatric encephalopathy

Soto, D., Olivella, M., Grau, C., Armstrong, J., Alcon, C., Gasull, X., Santos‐Gómez, A., Locubiche, S., de Salazar, M. G., García-Díaz, R., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw0936 · Cited by 82 · see citing works

AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder

Yennawar, M., White, R. S., & Jensen, F. E. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2041-18.2019 · Cited by 71 · see citing works

Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth

Lozovaya, N., Nardou, R., Tyzio, R., Chiesa, M., Pons-Bennaceur, A., Eftekhari, S., Bui, T.-T., Billon-Grand, M., Rasero, J., Bonifazi, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45635-9 · Cited by 68 · see citing works

Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

Rodrigues, D. C., Mufteev, M., Weatheritt, R. J., Djuric, U., Ha, K., Ross, P. J., Wei, W., Piekna, A., Sartori, M. A., Byres, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.02.107 · Cited by 67 · see citing works

Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives

Palmieri, M., Pozzer, D., & Landsberger, N. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1172805 · Cited by 65 · see citing works

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Li, W., Bellot-Saez, A., Phillips, M. L., Yang, T., Longo, F. M., & Pozzo‐Miller, L. D. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.029959 · Cited by 58 · see citing works

NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity

Rusconi, F., Grillo, B., Toffolo, E., Mattevi, A., & Battaglioli, E. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.11.002 · Cited by 49 · see citing works

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

Ang, G., McKillop, L. E., Purple, R. J., Blanco‐Duque, C., Peirson, S. N., Foster, F., Harrison, P. J., Sprengel, R., Davies, K. E., Oliver, P. L., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0199-2 · Cited by 44 · see citing works

Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism

Wu, H.-F., Lu, T.-Y., Chu, M.-C., Chen, P. S., Lee, C. J., & Lin, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107736 · Cited by 45 · see citing works

Neural plasticity and network remodeling: From concepts to pathology

Cohen, E. J., Quarta, E., Bravi, R., Granato, A., & Minciacchi, D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.048 · Cited by 43 · see citing works

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

Long, J., Li, H., Liu, Y., Liao, X., Tang, Z., Han, K., Chen, J., & Zhang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1364858 · Cited by 43 · see citing works

The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

Wall, M. J., & Corrêa, S. A. L. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.005 · Cited by 40 · see citing works

D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model

Wu, H.-F., Chen, P. S., Hsu, Y.-T., Lee, C. J., Wang, T.-F., Chen, Y., & Lin, H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0685-1 · Cited by 38 · see citing works

Critical aspects of neurodevelopment

Chakraborty, R., Kumar, M., & Clement, J. P. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107415 · Cited by 38 · see citing works

Excitation and Inhibition Imbalance in Rett Syndrome

Li, W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.825063 · Cited by 38 · see citing works

Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2−/y Mice

Murru, L., Vezzoli, E., Longatti, A., Ponzoni, L., Falqui, A., Folci, A., Moretto, E., Bianchi, V., Braida, D., Sala, M., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx221 · Cited by 36 · see citing works

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5

Tramarin, M., Rusconi, L., Pizzamiglio, L., Barbiero, I., Peroni, D., Scaramuzza, L., Guilliams, T., Cavalla, D., Antonucci, F., & Kilstrup‐Nielsen, C. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy108 · Cited by 35 · see citing works

Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain

Sanfeliu, A., Hokamp, K., Gill, M., & Tropea, D. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00278 · Cited by 34 · see citing works

EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice

Xu, X., & Pozzo‐Miller, L. D. (2017) · The Journal of Physiology · doi:10.1113/jp274450 · Cited by 33 · see citing works

Malfunction of astrocyte and cholinergic input is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function

Wang, T., Xu, G., Zhang, X., Ren, Y., Yang, T., Xiao, C., & Zhou, C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109191 · Cited by 30 · see citing works

Neurophysiological Signatures of Motor Impairment in Patients with Rett Syndrome

Bernardo, P., Cobb, S., Coppola, A., Tomasevic, L., Lazzaro, V. D., Bravaccio, C., Manganelli, F., & Dubbioso, R. (2020) · Annals of Neurology · doi:10.1002/ana.25712 · Cited by 27 · see citing works

The Potential Role of AMPA Receptor Trafficking in Autism and Other Neurodevelopmental Conditions

Niescier, R. F., & Lin, Y. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.013 · Cited by 22 · see citing works

Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions

Bach, S., Shovlin, S., Moriarty, M. J., Bardoni, B., & Tropea, D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.764761 · Cited by 23 · see citing works

Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

Jabarin, R., Levy, N. S., Abergel, Y., Berman, J. H., Zag, A., Netser, S., Levy, A. P., & Wagner, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01347-1 · Cited by 21 · see citing works

The Inhibitory Effect of α/β-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors

Wei, M., Jia, M., Zhang, J., Yu, L., Zhao, Y., Chen, Y., Ma, Y., Zhang, W., Shi, Y. S., & Zhang, C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00055 · Cited by 21 · see citing works

Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits

Wang, X., Kéry, R., & Xiong, Q. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.026 · Cited by 21 · see citing works

The DNA repair protein ATM as a target in autism spectrum disorder

Pizzamiglio, L., Focchi, E., Cambria, C., Ponzoni, L., Ferrara, S., Bifari, F., Desiato, G., Landsberger, N., Murru, L., Passafaro, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133654 · Cited by 21 · see citing works

Imaging glutamate redistribution after acute N-acetylcysteine administration: A simultaneous PET/MR study

Tuura, R., Warnock, G., Ametamey, S. M., Treyer, V., Noeske, R., Buck, A., & Sommerauer, M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.017 · Cited by 20 · see citing works

RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviour

Mignogna, M. L., Musardo, S., Ranieri, G., Gelmini, S., Espinosa, P., Marra, P., Belloli, S., Murtaj, V., Moresco, R. M., Bellone, C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01155-5 · Cited by 17 · see citing works

Breathing abnormalities in animal models of Rett syndrome a female neurogenetic disorder

Jiang, C. L., Cui, N., Zhong, W., Johnson, C. M., & Wu, Y. (2016) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2016.11.011 · Cited by 17 · see citing works

Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain

Rosenberg, E. C., Bell, J. J. L., Handy, M., Soldan, S. S., Rakhade, S. N., Hilario‐Gomez, C., Folweiler, K., Jacobs, L., & Jensen, F. E. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.001 · Cited by 17 · see citing works

Altered trajectories of neurodevelopment and behavior in mouse models of Rett syndrome

Smith, E. S., Smith, D. R., Eyring, C., Braileanu, M., Smith-Connor, K., Tan, Y. E., Fowler, A., Hoffman, G. E., Johnston, M. V., Kannan, S., et al. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.007 · Cited by 16 · see citing works

SRF and SRFΔ5 Splicing Isoform Recruit Corepressor LSD1/KDM1A Modifying Structural Neuroplasticity and Environmental Stress Response

Gerosa, L., Grillo, B., Forastieri, C., Longaretti, A., Toffolo, E., Mallei, A., Bassani, S., Popoli, M., Battaglioli, E., & Rusconi, F. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01720-8 · Cited by 16 · see citing works

RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT

Cao, Z., Min, X., Xie, X., Huang, M., Liu, Y., Sun, W., Xu, G., He, M., He, K., Li, Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320383121 · Cited by 14 · see citing works

Electroacupuncture Ameliorates Cognitive Deficit and Improves Hippocampal Synaptic Plasticity in Adult Rat with Neonatal Maternal Separation

Guo, L., Liang, X., Liang, Z., Liu, X., Jiang, H., Zheng, Y., Yao, L., & Chen, Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/2468105 · Cited by 14 · see citing works

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

Medeiros, D., Ayala-Baylon, K., Egido‐Betancourt, H. X., Miller, E. C., Chapleau, C. A., Robinson, H., Phillips, M. L., Yang, T., Longo, F. M., Li, W., et al. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050612 · Cited by 13 · see citing works

Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approach

Pascual‐Alonso, A., Xiol, C., Smirnov, D., Kopajtich, R., Prokisch, H., & Armstrong, J. (2023) · Human Genomics · doi:10.1186/s40246-023-00532-1 · Cited by 13 · see citing works

Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome

Ruffolo, G., Cifelli, P., Miranda‐Lourenço, C., Felice, E. D., Limatola, C., Sebastião, A. M., Diógenes, M. J., Aronica, E., & Palma, E. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.015 · Cited by 13 · see citing works

Long-Term Treatment with Cannabidiol-Enriched Cannabis Extract Induces Synaptic Changes in the Adolescent Rat Hippocampus

Aguiar, A. F. L., Campos, R. M. P., Isaac, A. R., Paes-Colli, Y., Carvalho, V. M., Sampaio, L. D. S., & Reis, R. A. D. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411775 · Cited by 13 · see citing works

The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice

Xu, X., García, J. M., Ewalt, R., Nason, S. R., & Pozzo‐Miller, L. D. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00203 · Cited by 12 · see citing works

mRNA nuclear retention reduces AMPAR expression and promotes autistic behavior in UBE3A-overexpressing mice

Tian, Y., Yu, F., Yun, E. J., Lin, J., & Man, H. (2024) · EMBO Reports · doi:10.1038/s44319-024-00073-1 · Cited by 10 · see citing works

Astroglial TNFR2 signaling regulates hippocampal synaptic function and plasticity in a sex dependent manner

Carney, B. N., Illiano, P., Pohl, T. M., Desu, H. L., Mini, A., Mudalegundi, S., Asencor, A. I., Jwala, S., Ascona, M. C., Singh, P. K., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.07.006 · Cited by 10 · see citing works

Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia

Yao, C., Fang, X., Ru, Q., Li, W., Li, J., Mehsein, Z., Tolias, K. F., & Li, L. (2024) · Brain · doi:10.1093/brain/awae106 · Cited by 9 · see citing works

Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved

Cabrera‐Pastor, A., Taoro‐González, L., López-Merino, E., Celma, F., Llansola, M., & Felipo, V. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.031 · Cited by 9 · see citing works

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved

Cabrera‐Pastor, A., Taoro‐González, L., Cuñat, A. N., Canet-López, D., Balzano, T., & Felipo, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-18024-3 · Cited by 9 · see citing works

Unraveling autophagic imbalances and therapeutic insights in Mecp2-deficient models

Esposito, A., Seri, T., Breccia, M., Indrigo, M. T., Rocco, G. D., Nuzzolillo, F., Denti, V., Pappacena, F., Tartaglione, G., Serrao, S., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00151-w · Cited by 8 · see citing works

Silver nanoparticles synthesized using Tualang honey ameliorate seizures, locomotor activity, and memory function in KA-induced status epilepticus in male rats

Hasim, H., Salam, S. K. N. M., Rao, P. V., Muthuraju, S., Mustapha, M., & Asari, M. A. (2022) · Biomedical Research and Therapy · doi:10.15419/bmrat.v9i9.766 · Cited by 8 · see citing works

Cell-Genotype Specific Effects of Mecp2 Mutation on Spontaneous and Nicotinic Acetylcholine Receptor-Evoked Currents in Medial Prefrontal Cortical Pyramidal Neurons in Female Rett Model Mice

Asgarihafshejani, A., Nashmi, R., & Delaney, K. R. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.008 · Cited by 7 · see citing works

Rett syndrome: from the involved gene(s) to treatment

Frasca, A., Kilstrup‐Nielsen, C., & Landsberger, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00002-2 · Cited by 6 · see citing works

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

Scheller, U., Pfisterer, K., Uebe, S., Ekici, A. B., Reis, A., Jamra, R. A., & Ferrazzi, F. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0358-6 · Cited by 6 · see citing works

Sculptor and Destroyer

Mattson, M. P. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14422.001.0001 · Cited by 4 · see citing works

Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism

Barón-Mendoza, I., Márquez, L. A., Arenas, A., Guzmán-Condado, J., Martínez-Rojas, V. A., Anguiano-Buenfil, J., Mejía-Hernández, M., Almazán, J. L., Pérez‐Martínez, L., Pedraza‐Alva, G., et al. (2025) · Scientific Reports · doi:10.1038/s41598-024-84521-x · Cited by 4 · see citing works

MeCP2 prevents against sustained ketamine-induced synaptic depression at inhibitory synapses

Piazza, M. K., Weit, A. R., Kavalali, E. T., Neul, J. L., & Monteggia, L. M. (2025) · iScience · doi:10.1016/j.isci.2025.112485 · Cited by 3 · see citing works

An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome

Maino, E., Scott, O., Rizvi, S. Z., Chan, W. S., Visuvanathan, S., Zablah, Y. B., Li, H., Sengar, A. S., Salter, M. W., Jia, Z., et al. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050528 · Cited by 3 · see citing works

Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/− mice

Smith, M., Dodis, G. E., Vanderplow, A. M., Gonzalez, S., Rhee, Y., Scrogin, K. E., & Gogliotti, R. G. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106859 · Cited by 3 · see citing works

Mutation of MeCP2 at T158M Leads to Distinct Molecular and Phenotypic Abnormalities in Male and Female Mice

Roberts, C.-T., Shahib, A. K., Arezoumand, K. S., Akhtar, G. B., Nejati‐Koshki, K., Jarmasz, J. S., Ziaee, S. M., Buist, M., Raabe, N., Mehrabadi, A. R., et al. (2025) · Cells · doi:10.3390/cells14161286 · Cited by 2 · see citing works

Altered activity of mPFC pyramidal neurons and parvalbumin-expressing interneurons during social interactions in a Mecp2 mouse model for Rett syndrome

Medeiros, D., Polepalli, L., Li, W., & Pozzo‐Miller, L. D. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00360.2025 · Cited by 2 · see citing works

Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity

Liiwand, M., Haikonen, J., Kokinovic, B., Molchanova, S. M., Aitta‐aho, T., Lauri, S. E., & Ryazantseva, M. (2026) · Molecular Autism · doi:10.1186/s13229-025-00699-5 · Cited by 2 · see citing works

Long-term cortical plasticity following sensory deprivation is reduced in male Rett model mice

Farhoomand, F., & Delaney, K. R. (2022) · Somatosensory & Motor Research · doi:10.1080/08990220.2022.2158799 · Cited by 1 · see citing works

Precision medicine for the rescue of specific impairments in social behavior associated with the A350V Iqsec2 mutationPreprint

Jabarin, R., Levy, N. S., Abergel, Y., Berman, J. H., Zag, A., Netser, S., Levy, A. P., & Wagner, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.04.368282 · Cited by 1 · see citing works

MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor LearningPreprint

Shen, J., Shen, P., Gonçalez, J. L., Jackson, M., Polepalli, L., Dheeravath, K., Li, T., Hamki, A., Hamki, M., Hicks, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.25.727684 · Cited by 1 · see citing works

Intervention to Extrasynaptic Gabaa Receptors for Symptom Relief in Mouse Models of Rett Syndrome

Zhong, W. (2022) · Digital Archive @ GSU · doi:10.57709/10039490

Induction of long-term potentiation at Schaffer collateral-CA1 synapses in mice hippocampus after IMPX977 administration

Song, N., Duan, C., Li, Y., Qian, T., Wang, Q., Zhao, W., & Wang, X. (2020) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2020.05.012

Central Respiratory Depression: Insight With Murine Models Of Rett Syndrome And Morphine Overdose

Xing, H. (2022) · Digital Archive @ GSU · doi:10.57709/24829597

MeCP2 represses the induction and maintenance of long-term synaptic plasticityPreprint

Liu, R.-Y., Zhang, Y., Smolen, P. D., & Byrne, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.25.513721

Mozaicul neurochimic şi neurobiologic al autismului

Istrate, B. M. (2024) · Pediatru ro · doi:10.26416/pedi.75.3.2024.10285

The chloride/potassium co-transporter KCC2 in synaptic plasticity, hippocampal rhythmogenesis and memory

Simonnet, C. (2019) · doi:10.70675/dcc67be7z8c6dz47b5z92e8z4d75367bfd48

Pathophysiological consequences of a Fragile X missense mutation

Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9

Etude de la contribution de l'hormone adipocytaire leptine dans la pathogenèse du syndrome de Rett

Belaïdouni, Y. (2022) · theses.fr (ABES) · doi:10.70675/f69d2875zfa9fz4465z917eza8e7b93935c6

Characterizing flunarizine’s neuroprotection in spinal muscular atrophy : Implication of the RNA-binding protein GEMIN5

Salman, B. (2024) · doi:10.70675/0a9b50fbz68bcz4397za4f0z0c96d33ba621

Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

Asaka, Y., Jugloff, D. G. M., Zhang, L., Eubanks, J. H., & Fitzsimonds, R. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.005 · Cited by 341 · see citing works

Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome

Dani, V. S., & Nelson, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-09.2009 · Cited by 121 · see citing works

Intact LTP but reduced connectivity between neocortical Layer 5 pyramidal neurons in a mouse model of Rett Syndrome

Dani, V. S., & Nelson, S. B. (2015)

Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome

Moretti, P., Levenson, J. M., Battaglia, F., Atkinson, R., Teague, R., Antalffy, B., Armstrong, D., Arancio, O., Sweatt, J. D., & Zoghbi, H. Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-05.2006 · Cited by 545 · see citing works

EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice

Xu, X., & Pozzo‐Miller, L. D. (2017) · The Journal of Physiology · doi:10.1113/jp274450 · Cited by 33 · see citing works