Impaired Spatial Learning after Saturation of Long-Term Potentiation
Abstract
If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.
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Although there is considerable evidence linking LTP to behavior memory, more evidence is needed to solidify this link.
“However, although there is considerable evidence linking LTP to behavior memory (45, 441–443), more evidence is needed to solidify this link.”
From Synaptic memory and CaMKII (2023) · cites this paper as [442]
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- Authors
- Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M.
- Affiliations
- University of Oslo (NO)
- Corresponding author
- Moser, Edvard I.
- Venue
- Science
- Published
- 1998-09-25
- Volume
- 281
- Issue
- 5385
- Pages
- 2038-2042
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095510381
- Cited by
- 505
- References
- 31
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 16 · 2015: 18 · 2014: 27 · 2013: 19 · 2012: 25
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, spatial learning, hippocampus, hippocampal lesions, synaptic plasticity, hippocampal formation
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Synapses, Tetany, Long-Term Potentiation, Maze Learning, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats
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