Cited by 505Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Moser, Edvard I., Krobert, Kurt A., Moser, May-Britt, Morris, Richard G. M.·1998·Science

Abstract

If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.

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Crossref · 10.1126/science.281.5385.2038

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Although there is considerable evidence linking LTP to behavior memory, more evidence is needed to solidify this link.

    “However, although there is considerable evidence linking LTP to behavior memory (45, 441–443), more evidence is needed to solidify this link.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [442]

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Authors
Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M.
Affiliations
University of Oslo (NO)
Corresponding author
Moser, Edvard I.
Venue
Science
Published
1998-09-25
Volume
281
Issue
5385
Pages
2038-2042
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2095510381
Cited by
505
References
31
Citations by year
2026: 7 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 16 · 2015: 18 · 2014: 27 · 2013: 19 · 2012: 25
FWCI
10.83
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, spatial learning, hippocampus, hippocampal lesions, synaptic plasticity, hippocampal formation
MeSH terms
Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Synapses, Tetany, Long-Term Potentiation, Maze Learning, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats

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