Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Abstract
Synaptic transmission underlies every aspect of brain function. Excitatory synapses, which release the neurotransmitter glutamate, are the most numerous type of synapse in the brain. The trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors to and from these synapses controls the strength of excitatory synaptic transmission. However, the underlying mechanisms controlling this trafficking have remained elusive. Recent studies, drawing from advances in molecular biology and electrophysiology techniques, have established an essential role for a family of synaptic scaffolding molecules, known as membrane associate guanylate kinases (MAGUKs), in this trafficking process. These studies highlight the remarkable orchestration of AMPA-type glutamate receptor synaptic trafficking by multiple MAGUKs at different synapses within the same neuron and at different developmental stages.
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Ionotropic glutamate receptors interact with many proteins of the postsynaptic density.
“Ionotropic glutamate receptors do not work in isolation.They interact with many proteins of the postsynaptic density (PSD) (Elias and Nicoll 2007).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Elias and Nicoll 2007
Some postsynaptic density proteins modulate glutamate receptor function, whereas others control their membrane insertion and removal.
“Some of these proteins modulate glutamate receptor function, whereas others control their membrane insertion and removal.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Elias and Nicoll 2007
PSD-95 is a key determinant of synaptic levels of AMPARs.
“Accordingly, PSD-95 is a key determinant of synaptic levels of AMPARs [21],[22].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [21]
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- Authors
- Elias, G. M., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Elias, Guillermo M.
- Nicoll, Roger A.
- ORCID
- Nicoll, Roger A.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 17
- Issue
- 7
- Pages
- 343-352
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2055345063
- Cited by
- 288
- References
- 4
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 10 · 2017: 18 · 2016: 19 · 2015: 14 · 2014: 12 · 2013: 34 · 2012: 28
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- AMPA receptors, excitatory synapses, synaptic transmission, synaptic plasticity
- MeSH terms
- Animals, Brain, Humans, Models, Biological, Synaptic Transmission, Synapses, Receptors, N-Methyl-D-Aspartate, Receptors, Glutamate, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Glutamic Acid, Intracellular Signaling Peptides and Proteins
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