The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
SARS-like WIV1-CoV poised for human emergence
Open accessAbstract
Significance: The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV highlights the continued risk of cross-species transmission leading to epidemic disease. This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential. Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.
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“previous reports have shown that human neutralizing antibodies protected mice challenged with SARS-CoV (12–14) and Middle East respiratory syndrome (MERS)-CoV (15)”
From An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates (2020) · cites this paper as [12]
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Cites
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
Ge, X.-Y., Li, J.-L., Yang, X.-L., Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., et al. (2013) · Nature · doi:10.1038/nature12711 · Cited by 1,778
Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology · doi:10.1128/jvi.00737-08 · Cited by 1,293
Severe acute respiratory syndrome
Peiris, M. J. S., Guan, Y., & Yuen, K. (2004) · Nature Medicine · doi:10.1038/nm1143 · Cited by 1,157
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J. B., Fausther‐Bovendo, H., Wei, H., Aviles, J., Hiatt, E., et al. (2014) · Nature · doi:10.1038/nature13777 · Cited by 984
Graham, R. L., & Baric, R. S. (2009) · Journal of Virology · doi:10.1128/jvi.01394-09 · Cited by 753
Self-citationTraggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R., Rappuoli, R., & Lanzavecchia, A. (2004) · Nature Medicine · doi:10.1038/nm1080 · Cited by 697
Self-citationA decade after SARS: strategies for controlling emerging coronaviruses
Graham, R. L., Donaldson, E., & Baric, R. S. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3143 · Cited by 689
Self-citationBolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., Funkhouser, W., Gralinski, L., Totura, A., Heise, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.06048-11 · Cited by 477
Self-citationA Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice
Roberts, A., Deming, D., Paddock, C. D., Cheng, A., Yount, B. L., Vogel, L., Herman, B. D., Sheahan, T., Heise, M. T., Genrich, G. L., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030005 · Cited by 447
Self-citationReverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Yount, B., Curtis, K. M., Fritz, E. A., Hensley, L. E., Jahrling, P., Prentice, E., Denison, M., Geisbert, T., & Baric, R. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1735582100 · Cited by 394
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Origin and evolution of pathogenic coronaviruses
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Ou, X., Liu, Y., Lei, X., Li, P., Mi, D., Ren, L., Guo, L., Guo, R., Chen, T., Hu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15562-9 · Cited by 3,097
Metadata
- Authors
- Menachery, V. D., Yount, B. L., Sims, A. C., Debbink, K., Agnihothram, S. S., Gralinski, L. E., Graham, R. L., Scobey, T., Plante, J. A., Royal, S. R., Swanstrom, J., Sheahan, T. P., Pickles, R. J., Corti, D., Randell, S. H., Lanzavecchia, A., Marasco, W. A., & Baric, R. S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
- National Center for Toxicological Research (US)
- ETH Zurich (CH)
- Harvard University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-03-14
- Volume
- 113
- Issue
- 11
- Pages
- 3048-3053
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4801244
- OpenAlex
- W2298153446
- Cited by
- 418
- References
- 27
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 37 · 2023: 36 · 2022: 44 · 2021: 84 · 2020: 117 · 2019: 17 · 2018: 16 · 2017: 19 · 2016: 10
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (U19AI109761, U19AI107810, F32AI102561)
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (AI1085524)
- HHS | NIH | National Institute on Aging (K99AG049092)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK065988)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-like coronaviruses, zoonotic viruses, viral emergence, metagenomics, reverse genetics, pathogenicity, reservoir hosts, human-to-human transmission
- MeSH terms
- Angiotensin-Converting Enzyme 2, Animals, Antibodies, Monoclonal, Antibodies, Viral, Cells, Cultured, Chlorocebus aethiops, Chiroptera, Coronaviridae, Coronaviridae Infections, Cross Reactions, Epithelial Cells, Humans, Peptidyl-Dipeptidase A, Lung, Mice, Inbred BALB C, Mice, Transgenic, Models, Molecular, Protein Conformation, Receptors, Virus, Recombinant Fusion Proteins, Species Specificity, Vero Cells, Virus Replication, Zoonoses, Point Mutation, Encephalitis, Viral, Communicable Diseases, Emerging, Severe acute respiratory syndrome-related coronavirus, Mice, Antibodies, Neutralizing, Host Specificity, Spike Glycoprotein, Coronavirus
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