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SARS-like WIV1-CoV poised for human emergence
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Significance: The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV highlights the continued risk of cross-species transmission leading to epidemic disease. This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential. Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans. In addition, while monoclonal antibody treatments prove effective, the SARS-based vaccine approach failed to confer protection. Together, the study indicates an ongoing threat posed by WIV1-related viruses and the need for continued study and surveillance.
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“previous reports have shown that human neutralizing antibodies protected mice challenged with SARS-CoV (12–14) and Middle East respiratory syndrome (MERS)-CoV (15)”
From An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates (2020) · cites this paper as [12]
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Self-citation
Metadata
- Authors
- Menachery, V. D., Yount, B. L., Sims, A. C., Debbink, K., Agnihothram, S. S., Gralinski, L. E., Graham, R. L., Scobey, T., Plante, J. A., Royal, S. R., Swanstrom, J., Sheahan, T. P., Pickles, R. J., Corti, D., Randell, S. H., Lanzavecchia, A., Marasco, W. A., & Baric, R. S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
- National Center for Toxicological Research (US)
- ETH Zurich (CH)
- Harvard University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-03-14
- Volume
- 113
- Issue
- 11
- Pages
- 3048-3053
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4801244
- OpenAlex
- W2298153446
- Cited by
- 418
- References
- 27
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 37 · 2023: 36 · 2022: 44 · 2021: 84 · 2020: 117 · 2019: 17 · 2018: 16 · 2017: 19 · 2016: 10
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (U19AI109761, U19AI107810, F32AI102561)
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (AI1085524)
- HHS | NIH | National Institute on Aging (K99AG049092)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK065988)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-like coronaviruses, zoonotic viruses, viral emergence, metagenomics, reverse genetics, pathogenicity, reservoir hosts, human-to-human transmission
- MeSH terms
- Angiotensin-Converting Enzyme 2, Animals, Antibodies, Monoclonal, Antibodies, Viral, Cells, Cultured, Chlorocebus aethiops, Chiroptera, Coronaviridae, Coronaviridae Infections, Cross Reactions, Epithelial Cells, Humans, Peptidyl-Dipeptidase A, Lung, Mice, Inbred BALB C, Mice, Transgenic, Models, Molecular, Protein Conformation, Receptors, Virus, Recombinant Fusion Proteins, Species Specificity, Vero Cells, Virus Replication, Zoonoses, Point Mutation, Encephalitis, Viral, Communicable Diseases, Emerging, Severe acute respiratory syndrome-related coronavirus, Mice, Antibodies, Neutralizing, Host Specificity, Spike Glycoprotein, Coronavirus
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