The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
Open accessAbstract
Significance: The last decade has seen a rapid expansion of interest in extracellular vesicles (EVs), proposed to mediate cell–cell communication in patho/physiological conditions. Although heterogeneity of EVs has become obvious, as highlighted recently by the International Society for Extracellular Vesicles, the field is lacking specific tools to distinguish EVs of different intracellular origins, and thus probably different functions. Here, thanks to a comprehensive comparison of different types of EVs isolated from a single cell type, we define proteins generically present in EVs, small EV-specific and -excluded ones, and a few specific of endosome-derived exosomes or nonexosomal small EVs. This work will allow proper evaluation of the molecular mechanisms of biogenesis and secretion and the respective functions of subtypes of EVs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The results imply that CD81-containing EVs, multivesicular bodies, and CD9-positive small EVs derived from the plasma membrane could accumulate in the DNs [39, 44].”
From Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease (2023) · cites this paper as [39]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Most mitochondrial components have been reported to fractionate in larger EVs by proteomic analysis [395].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [395]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Furthermore, molecules encapsulated within blood-circulating EVs may also serve as diagnostic, prognostic, and predictive biomarkers.222,223”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [222]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Heterogeneity of these different fractions was confirmed by probing for different vesicular protein markers that are present in all types of EVs and larger vesicle fractions (Flotillin-1) (Kowal et al., 2016), those typically associated with exosomes and absent in 2,000 × g (ALIX and TSG101), and GAPDH found to be enriched in the 2,000 × g and cellular fraction (McNamara et al., 2018).”
From Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21 (2019) · cites this paper as Kowal et al., 2016
The cited source says what the claim attributes to it.
In the citing paper
“EC-Exo co-localize with CD9 and CD63 which are exosome markers21, thereby verifying the fluorescence as clusters of exosomes.”
From MiR-126 Mediates Brain Endothelial Cell Exosome Treatment–Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice (2019) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
The ade4 Package: Implementing the Duality Diagram for Ecologists
Dray, S., & Dufour, A. (2007) · Journal of Statistical Software · doi:10.18637/jss.v022.i04 · Cited by 6,740
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186
Self-citationBiological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Self-citationYang, Y., Dudoit, S., Luu, P., Lin, D., Peng, V., Ngai, J., & Speed, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.e15 · Cited by 3,722
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761
Self-citationRegulation of immune responses by extracellular vesicles
Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260
Cited by
Sorted by citations
Items 801–900 of 1,006
Proteomic and Metaproteomic Approaches to Understand Host–Microbe Interactions
Starr, A. E., Deeke, S. A., Li, L., Zhang, X., Daoud, R., Ryan, J., Ning, Z., Cheng, K., Nguyen, L. V. H., Abou-Samra, E., et al. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04340 · Cited by 68
Acetylcholinesterase is not a generic marker of extracellular vesicles
Liao, Z., Jaular, L. M., Soueidi, E., Jouve, M. J., Muth, D. C., Schøyen, T. H., Seale, T. S., Haughey, N. J., Ostrowski, M., Théry, C., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1628592 · Cited by 67
Self-citationMiyoshi, E., Bilousova, T. V., Melnik, M., Fakhrutdinov, D., Poon, W. W., Vinters, H. V., Miller, C. A., Corrada, M. M., Kawas, C. H., Bohannan, R. C., et al. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00644-z · Cited by 69
Seo, N., Nakamura, J., Kaneda, T., Tateno, H., Shimoda, A., Ichiki, T., Furukawa, K., Hirabayashi, J., Akiyoshi, K., & Shiku, H. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12205 · Cited by 67
Zhang, Z., Yu, K., You, Y., Jiang, P., Wu, Z., Deture, M. A., Dickson, D. W., Ikezu, S., Peng, J., & Ikezu, T. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12358 · Cited by 68
Kormelink, T. G., Arkesteijn, G. J. A., van de Lest, C. H. A., Geerts, W. J. C., Goerdayal, S. S., Altelaar, M. A. F., Redegeld, F. A., Hoen, E. N. M. N., & Wauben, M. H. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600614 · Cited by 67
Nakata, R., Shimada, H., Fernández, G. E., Fanter, R. K., Fabbri, M., Malvar, J., Zimmermann, P., & DeClerck, Y. A. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1332941 · Cited by 67
Yang, M., Du, Q., Goswami, J., Varley, P. R., Chen, B., Wang, R., Morelli, A. E., Stolz, D. B., Billiar, T. R., Li, J., et al. (2017) · Hepatology · doi:10.1002/hep.29605 · Cited by 68
Schuldner, M., Dörsam, B., Shatnyeva, O., Reiners, K. S., Kubarenko, A. V., Hansen, H. P., Finkernagel, F., Roth, K. S., Theurich, S., Nist, A., et al. (2019) · Theranostics · doi:10.7150/thno.36378 · Cited by 68
Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy
Hernández, A., Arab, J. P., Reyes, D., Lapitz, A., Moshage, H. J., Bañales, J. M., & Arrese, M. A. (2020) · Cells · doi:10.3390/cells9040817 · Cited by 67
Mansur, R. B., Delgado‐Peraza, F., Subramaniapillai, M., Lee, Y. L., Iacobucci, M., Rodrigues, N. B., Rosenblat, J. D., Brietzke, E. M., Cosgrove, V. E., Kramer, N. E., et al. (2020) · Cells · doi:10.3390/cells9040895 · Cited by 69
The Involvement of Exosomes in Glioblastoma Development, Diagnosis, Prognosis, and Treatment
Bălașa, A. F., Şerban, G. M., Chinezu, R., Hurghiș, C., Tămaș, F., & Manu, D. R. (2020) · Brain Sciences · doi:10.3390/brainsci10080553 · Cited by 69
Sulfatides in extracellular vesicles isolated from plasma of multiple sclerosis patients
Moyano, A. L., Li, G., Boullerne, A. I., Feinstein, D. L., Hartman, E., Skias, D. D., Balavanov, R., van Breemen, R. B., Bongarzone, E. R., Månsson, J., et al. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23899 · Cited by 66
Katsiougiannis, S., Chia, D., Kim, Y., Singh, R. P., & Wong, D. T. (2016) · The FASEB Journal · doi:10.1096/fj.201600984r · Cited by 66
Promise of extracellular vesicles for diagnosis and treatment of epilepsy
Upadhya, D., & Shetty, A. K. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106499 · Cited by 66
Mills, J., Capece, M., Cocucci, E., Tessari, A., & Palmieri, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246109 · Cited by 68
Measurement and Standardization Challenges for Extracellular Vesicle Therapeutic Delivery Vectors
Nelson, B. C., Maragh, S., Ghiran, I. C., Jones, J. C., DeRose, P. C., Elsheikh, E. B., Vreeland, W. N., & Wang, L. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0206 · Cited by 70
Sphingolipid composition of circulating extracellular vesicles after myocardial ischemia
Burrello, J., Biemmi, V., Dei, M., Amongero, M., Bolis, S., Lazzarini, E., Bollini, S., Vassalli, G., Paroni, R. C., & Barile, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-73411-7 · Cited by 66
Panda, B., Sharma, Y., Gupta, S., & Mohanty, S. (2021) · Life · doi:10.3390/life11080784 · Cited by 66
Microfluidic Platforms for the Isolation and Detection of Exosomes: A Brief Review
Raju, D., Bathini, S., Bǎdilescu, S., Ghosh, A., & Packirisamy, M. (2022) · Micromachines · doi:10.3390/mi13050730 · Cited by 67
Céspedes, P. F., Jainarayanan, A., Fernández‐Messina, L., Valvo, S., Saliba, D. G., Kurz, E., Kvalvaag, A. S., Chen, L., Ganskow, C. S. G., Colin‐York, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31160-3 · Cited by 66
Manufacture of extracellular vesicles derived from mesenchymal stromal cells
Lins, P. M. P., Pirlet, E., Szymonik, M., Bronckaers, A., & Nelissen, I. (2023) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.01.003 · Cited by 68
Exosome-based nanoparticles and cancer immunotherapy
Ye, J., Li, D., Jie, Y., Luo, H., Zhang, W., & Qiu, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117296 · Cited by 67
Tumor-derived exosomes in colorectal cancer progression and their clinical applications
Zhou, J., Li, X., Chen, Z., & Chng, W. J. (2017) · Oncotarget · doi:10.18632/oncotarget.20117 · Cited by 67
Buratta, S., Urbanelli, L., Sagini, K., Giovagnoli, S., Caponi, S., Fioretto, D., Mitro, N., Caruso, D., & Emiliani, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188840 · Cited by 68
Amosse, J., Durcin, M., Malloci, M., Vergori, L., Fleury, A., Gagnadoux, F., Dubois, S. G., Simard, G., Boursier, J., Hüe, O., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.001 · Cited by 72
Ageta, H., & Tsuchida, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03246-7 · Cited by 67
Extracellular Vesicles and MetastasisPreprint
Wang, S. E. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037275 · Cited by 67
Exosomes in HIV infection: A review and critical look
Ellwanger, J. H., Veit, T. D., & Chies, J. A. B. (2017) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2017.05.021 · Cited by 70
A Protocol for Isolation, Purification, Characterization, and Functional Dissection of Exosomes
Rai, A., Fang, H., Fatmous, M., Claridge, B., Poh, Q. H., Simpson, R. J., & Greening, D. W. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1186-9_9 · Cited by 66
Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases
Beatriz, M., Vilaça, R., & Lopes, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.635104 · Cited by 67
Jalilian, E., Massoumi, H., Bigit, B., Amin, S., Katz, E. A., Guaiquil, V. H., Anwar, K. N., Hematti, P., Rosenblatt, M. I., & Djalilian, A. R. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03128-z · Cited by 66
Engineered T cell extracellular vesicles displaying PD-1 boost anti-tumor immunity
Li, B., Fang, T., Li, Y., Xue, T., Zhang, Z., Li, L., Meng, F., Wang, J., Hou, L., Liang, X., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101606 · Cited by 66
Mambro, T. D., Pellielo, G., Agyapong, E. D., Carinci, M., Chianese, D., Giorgi, C., Morciano, G., Patergnani, S., Pinton, P., & Rimessi, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098181 · Cited by 68
The expanding organelle lipidomes: current knowledge and challenges
Sarmento, M. J., Llorente, A., Petan, T., Khnykin, D., Popa, I., Perković, M. N., Konjevod, M., & Jaganjac, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04889-3 · Cited by 74
Research progress on the role of extracellular vesicles in neurodegenerative diseases
Li, Z., Wang, X., Wang, X., Yi, X., Wong, Y. K., Wu, J., Xie, F., Hu, D., Wang, Q., Wang, J., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00375-9 · Cited by 67
von Lersner, A. K., Fernandes, F., Ozawa, P. M. M., Jackson, M., Masureel, M., Ho, H., Lima, S. M., Vagner, T., Sung, B. H., Wehbe, M., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c11561 · Cited by 65
Si, C., Gao, J., & Ma, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02045-4 · Cited by 65
Harnessing exosomes as cancer biomarkers in clinical oncology
Ghosh, S., Rajendran, R. L., Mahajan, A. A., Chowdhury, A., Bera, A., Guha, S., Chakraborty, K., Chowdhury, R., Paul, A., Jha, S., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03464-5 · Cited by 66
Menay, F., Herschlik, L., Toro, J. D., Cocozza, F., Tsacalian, R., Gravisaco, M. J., Sciullo, P. D., Alejandrina, V., Waldner, C., & Mongini, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00286 · Cited by 67
Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma
Mondal, A., Singh, D. K., Panda, S., & Shiras, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00144 · Cited by 65
Davies, O. G., Cox, S. C., Williams, R. L., Tsaroucha, D., Dorrepaal, R. M., Lewis, M. P., & Grover, L. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-13027-6 · Cited by 65
Kholia, S., Sanchez, M. B. H., Cedrino, M., Papadimitriou, E., Tapparo, M., Deregibus, M. C., Brizzi, M. F., Tetta, C., & Camussi, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01639 · Cited by 65
Anand, S., Foot, N. J., Ang, C., Gembus, K. M., Keerthikumar, S., Adda, C. G., Mathivanan, S., & Kumar, S. (2018) · PROTEOMICS · doi:10.1002/pmic.201800266 · Cited by 65
Cerezo-Magaña, M., Bång-Rudenstam, A., & Belting, M. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.001 · Cited by 70
Dakhlallah, D. A., Wisler, J., Gencheva, M., Brown, C. M., Leatherman, E. R., Singh, K., Brundage, K., Karsies, T. J., Dakhlallah, A., Witwer, K. W., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1669881 · Cited by 66
Extracellular vesicles from the apoplastic fungal wheat pathogen Zymoseptoria tritici
Hill, E., & Solomon, P. S. (2020) · Fungal Biology and Biotechnology · doi:10.1186/s40694-020-00103-2 · Cited by 65
Chance, T. C., Rathbone, C. R., Kamucheka, R. M., Peltier, G. C., Cap, A. P., & Bynum, J. A. (2019) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000002225 · Cited by 64
Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders
Yao, X., Wei, W., Wang, X., Chenglin, L., Björklund, M., & Ouyang, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119492 · Cited by 65
Unraveling the mechanisms that specify molecules for secretion in extracellular vesicles
Leidal, A. M., & Debnath, J. (2020) · Methods · doi:10.1016/j.ymeth.2020.01.008 · Cited by 67
Orme, J. J., Enninga, E. A. L., Lucien, F., Dale, H., Burgstaler, E. A., Harrington, S. M., Ball, M. K., Mansfield, A. S., Park, S. S., Block, M. S., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001113 · Cited by 64
Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer
Pisano, S., Pierini, I., Gu, J., Gazze, A. S., Francis, L. W., González, D., Conlan, R. S., & Corradetti, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.553576 · Cited by 64
CD9, a tetraspanin target for cancer therapy?
Lorico, A., Lorico-Rappa, M., Karbanová, J., Corbeil, D., & Pizzorno, G. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370220981855 · Cited by 64
Plant extracellular vesicles: Trojan horses of cross‐kingdom warfare
He, B., Hamby, R., & Jin, H. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00040 · Cited by 66
Bond, S. T., Calkin, A. C., & Drew, B. G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.837001 · Cited by 67
Extracellular Vesicles: Biomarkers, Therapeutics, and Vehicles in the Visual System
van der Merwe, Y., & Steketee, M. B. (2017) · Current Ophthalmology Reports · doi:10.1007/s40135-017-0153-0 · Cited by 64
Wang, Z., Sun, H., Provazník, J., Hackert, T., & Zöller, M. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1129-8 · Cited by 63
RetractedZhou, X., Wang, W., Cui, F., Shi, C., Ma, Y., Yu, Y., Zhao, W., & Zhao, J. (2019) · International Journal for Parasitology · doi:10.1016/j.ijpara.2019.08.003 · Cited by 64
Quantum Dot Labeling and Visualization of Extracellular Vesicles
Zhang, M., Vojtech, L. N., Ye, Z., Hladik, F., & Nance, E. A. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01553 · Cited by 63
Sheybani, N., Batts, A. J., Mathew, A. S., Thim, E. A., & Price, R. J. (2020) · Theranostics · doi:10.7150/thno.46534 · Cited by 64
Zhang, D. X., Vu, L. T., Ismail, N. N., Le, M. T. N., & Grimson, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.01.007 · Cited by 64
Extracellular Vesicles in Organ Fibrosis: Mechanisms, Therapies, and Diagnostics
Brigstock, D. R. (2021) · Cells · doi:10.3390/cells10071596 · Cited by 65
Inhibition of endolysosome fusion increases exosome secretion
Shelke, G. V., Williamson, C. D., Jarník, M., & Bonifacino, J. S. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202209084 · Cited by 64
Bertolino, G. M., Maumus, M., Jørgensen, C., & Noël, D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01010-7 · Cited by 63
Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging
Severo, M. S., Landry, J. J. M., Lindquist, R. L., Goosmann, C., Brinkmann, V., Collier, P. G., Hauser, A. E., Beneš, V., Henriksson, J., Teichmann, S. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803062115 · Cited by 68
Extracellular Vesicles of Neutrophils
Hong, C.-W. (2018) · Immune Network · doi:10.4110/in.2018.18.e43 · Cited by 63
Abramowicz, A., Wojakowska, A., Marczak, Ł., Łysek-Gładysińska, M., Smolarz, M., Story, M. D., Polańska, J., Widłak, P., & Pietrowska, M. (2019) · Journal of Radiation Research · doi:10.1093/jrr/rrz001 · Cited by 63
Yamada, N. O., Heishima, K., Akao, Y., & Senda, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184406 · Cited by 63
Extracellular vesicles from organoids and 3D culture systems
Abdollahi, S. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27606 · Cited by 65
Role of ATP in Extracellular Vesicle Biogenesis and Dynamics
Lombardi, M., Gabrielli, M., Adinolfi, E., & Verderio, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.654023 · Cited by 63
Ohayon, L., Zhang, X., & Dutta, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105692 · Cited by 62
The role of Extracellular Vesicles during CNS development
Sangani, N. B., Gomes, A. R., Curfs, L., & Reutelingsperger, C. P. M. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102124 · Cited by 68
Liu, Q., Li, S., Dupuy, A., Le, H., Sailliet, N., Logé, C., Robert, J.-M. H., & Brouard, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157763 · Cited by 64
The Biology and Function of Extracellular Vesicles in Cancer Development
Zhang, X., Liu, D., Gao, Y., Lin, C., An, Q., Ye, F., Liu, Y., Liu, D., Luo, H., & Wang, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.777441 · Cited by 62
Aarsund, M., Segers, F. M., Wu, Y., & Inngjerdingen, M. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03161-0 · Cited by 62
Extracellular Vesicles in Aging: An Emerging Hallmark?
Manni, G., Buratta, S., Pallotta, M. T., Chiasserini, D., Michele, A. D., Emiliani, C., Giovagnoli, S., Pascucci, L., Romani, R., Bellezza, I., et al. (2023) · Cells · doi:10.3390/cells12040527 · Cited by 64
Isolation and usage of exosomes in central nervous system diseases
Wang, W., Sun, H., Duan, H., Sheng, G., Tian, N., Liu, D., & Sun, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14677 · Cited by 62
Hirosawa, K. M., Sato, Y., Kasai, R. S., Yamaguchi, E., Komura, N., Ando, H., Hoshino, A., Yokota, Y., & Suzuki, K. G. N. (2025) · Nature Communications · doi:10.1038/s41467-025-57617-9 · Cited by 63
Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma
Uotani, K., Fujiwara, T., Yoshida, A., Iwata, S., Morita, T., Kiyono, M., Yokoo, S., Kunisada, T., Takeda, K., Hasei, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12660-5 · Cited by 62
Gu, H., Liu, Z., Li, Y., Xie, Y., Yao, J., Zhu, Y., Xu, J., Dai, Q., Zhong, C., Zhu, H., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00348 · Cited by 62
Circulating exosomal microRNAs as novel potential detection biomarkers in pancreatic cancer
Wu, L., Zhou, W., Zhou, J., Wei, Y., Wang, H., Liu, X., Chen, X., Wang, W., Ye, L., Li, Y., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.11691 · Cited by 62
Zeng, A., Wei, Z., Rabinovsky, R., Jun, H. J., Fatimy, R. E., Deforzh, E., Arora, R., Yao, Y., Yao, S., Yan, W., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101420 · Cited by 64
Pathania, A. S., Prathipati, P., & Challagundla, K. B. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188624 · Cited by 62
Than, U. T. T., Guanzon, D., Broadbent, J. A., Leavesley, D. I., Salomón, C., & Parker, T. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00535 · Cited by 61
Spinelli, C., Adnani, L., Choi, D., & Rak, J. W. (2018) · Non-Coding RNA · doi:10.3390/ncrna5010001 · Cited by 66
Kovács, Á. F., Fekete, N., Turiák, L., Ács, A., Kőhidai, L., Buzás, E. I., & Pállinger, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143457 · Cited by 63
Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation
Jabbari, N., Karimipour, M., Khaksar, M., Akbariazar, E., Heidarzadeh, M., Mojarad, B., Aftab, H., Rahbarghazi, R., & Rezaie, J. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02880-8 · Cited by 63
Kahroba, H., & Taghipour, Y. D. (2020) · Biochimie · doi:10.1016/j.biochi.2020.02.011 · Cited by 61
Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
Halder, L. D., Jo, E. A. H., Hasan, M. Z., Ferreira‐Gomes, M., Krüger, T., Westermann, M., Palme, D. I., Rambach, G., Beyersdorf, N., Speth, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16241-5 · Cited by 61
Tear-Derived Exosome Proteins Are Increased in Patients with Thyroid Eye Disease
Han, J., Kim, S. E., Jin, J.-Q., Park, N. R., Lee, J.-Y., Kim, H. L., Lee, S., Yang, S.-W., & Lim, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031115 · Cited by 61
Cavallaro, S., Pevere, F., Stridfeldt, F., Görgens, A., Paba, C., Sahu, S. S., Mamand, D. R., Gupta, D., Andaloussi, S. E., Linnros, J., et al. (2021) · Small · doi:10.1002/smll.202008155 · Cited by 63
Prochlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbes
Biller, S. J., Lundeen, R. A., Hmelo, L. R., Becker, K. W., Arellano, A. A., Dooley, K. D., Heal, K. R., Carlson, L. T., Mooy, B. A. S. V., Ingalls, A. E., et al. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15834 · Cited by 64
Martínez‐López, R., Hernáez, M. L., Redondo, E., Calvo, G., Radau, S., Pardo, M., Gil, C., & Monteoliva, L. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00698-22 · Cited by 61
Extracellular vesicles as next generation immunotherapeutics
Greening, D. W., Xu, R., Ale, A., Hagemeyer, C. E., & Chen, W. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.02.002 · Cited by 61
Li, B., Kugeratski, F. G., & Kalluri, R. (2023) · eLife · doi:10.7554/elife.90390 · Cited by 64
Fluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array
Zeming, K. K., Salafi, T., Shikha, S., & Zhang, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-03596-z · Cited by 61
Chennakrishnaiah, S., Meehan, B., D’Asti, E., Montermini, L., Lee, T. H., Karatzas, N., Buchanan, M., Tawil, N., Choi, D., Divangahi, M., et al. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14222 · Cited by 61
Revascularization and endothelial progenitor cells in stroke
Esquiva, G., Grayston, A., & Rosell, A. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00200.2018 · Cited by 61
Romancino, D. P., Buffa, V., Caruso, S., Ferrara, I., Raccosta, S., Notaro, A., Campos, Y., Noto, R., Martorana, V., Cupane, A., et al. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.09.004 · Cited by 63
Mazzeo, A., Lopatina, T., Gai, C., Trento, M., Porta, M., & Beltramo, E. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.04.015 · Cited by 61
Metadata
- Authors
- Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C.
- Affiliations
- Inserm (FR)
- Université Paris Sciences et Lettres (FR)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-02-08
- Volume
- 113
- Issue
- 8
- Pages
- E968-77
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4776515
- OpenAlex
- W2259481044
- Cited by
- 3,426
- References
- 55
- Citations by year
- 2026: 247 · 2025: 296 · 2024: 336 · 2023: 322 · 2022: 455 · 2021: 454 · 2020: 444 · 2019: 312 · 2018: 278 · 2017: 213 · 2016: 63
- FWCI
- 150.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-10-IDEX-0001-02 PSL*, ANR-11-LABX-0043)
- Association pour la Recherche sur le Cancer (SL220120605293)
- Fondation pour la Recherche Médicale (DGE 20121125630)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- extracellular vesicles, exosomes, dendritic cells, exosomal biomarkers, CD63, CD81, CD9, proteomic profiling, vesicle heterogeneity
- MeSH terms
- Humans, Membrane Proteins, Biomarkers, Antigens, CD, HSP70 Heat-Shock Proteins, Proteomics, Cell-Derived Microparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
